2025
Fluoroquinolones for Dermatologists: A Practical Guide to Clinical Use and Risk Management
Wahood S, Alani O, Draw I, Shqair L, Wang D, Bunick C, Damiani G, Ho J, Obagi S, Akbarialiabad H, Galimberti F, Ghannoum M, Grada A. Fluoroquinolones for Dermatologists: A Practical Guide to Clinical Use and Risk Management. Pharmaceuticals 2025, 18: 800. PMID: 40573197, PMCID: PMC12196204, DOI: 10.3390/ph18060800.Peer-Reviewed Original ResearchSoft tissue infectionsTissue infectionsMultidrug-resistant Gram-negative organismsRisk of torsade de pointesClinical useLiterature search of PubMedResistant to ciprofloxacinComplicated skin infectionsHigh-risk patientsQT interval prolongationCorrected QT intervalShort treatment courseGram-negative organismsPatient risk factorsSearch of PubMedBacterial skinOral fluoroquinolonesInterval prolongationTreatment courseOral formulationResistance patternsCure rateQT intervalTopical treatmentSkin infectionsImetelstat in myeloid malignancies: current data and future directions
Bidikian A, Bewersdorf J, Kewan T, Podoltsev N, Stahl M, Zeidan A. Imetelstat in myeloid malignancies: current data and future directions. Expert Review Of Anticancer Therapy 2025, 25: 517-528. PMID: 40116730, DOI: 10.1080/14737140.2025.2482721.Peer-Reviewed Original ResearchMyelodysplastic syndromeLR-MDSClinical trialsPotential disease-modifying propertiesLow-risk myelodysplastic syndromesElevated liver enzymesLR-MDS patientsTreat myelodysplastic syndromeSearch of PubMedTransfusion independenceEssential thrombocythemiaInfusion reactionsMyeloid malignanciesDisease-modifying propertiesCombination therapySurvival benefitEffective telomerase inhibitorImetelstatTelomerase reactivationPatient populationLiver enzymesMyelofibrosisCancer cellsMalignancyConference abstractsComparison of Endovascular Interventions for the Treatment of Superficial Femoral Artery Disease: A Network Meta-analysis
Schwartz A, Shah Y, Huang H, Nathan A, Fanaroff A, Giri J, Parikh S, Lansky A, Shah T. Comparison of Endovascular Interventions for the Treatment of Superficial Femoral Artery Disease: A Network Meta-analysis. Journal Of The Society For Cardiovascular Angiography & Interventions 2025, 4: 102432. PMID: 40061407, PMCID: PMC11887560, DOI: 10.1016/j.jscai.2024.102432.Peer-Reviewed Original ResearchPercutaneous transluminal angioplastyCutting balloon angioplastyDrug-coated balloonBare metal stentsDrug-eluting stentsTreatment of SFA diseaseNetwork meta-analysisSuperficial femoral arteryPrimary patencyTechnical successEndovascular techniquesEndovascular interventionSystematic literature search of PubMedLiterature search of PubMedEndovascular treatment modalitiesMeta-analysisSFA diseaseDe novo lesionsTarget lesion revascularizationSearch of PubMedCritical limb ischemiaSystematic literature searchTreatment modalitiesSuperficial femoral artery diseaseLesion revascularization
2024
Electrochemotherapy in the Locoregional Treatment of Metastatic Colorectal Liver Metastases: A Systematic Review
Barbieri P, Posa A, Lancellotta V, Madoff D, Maresca A, Cornacchione P, Tagliaferri L, Iezzi R. Electrochemotherapy in the Locoregional Treatment of Metastatic Colorectal Liver Metastases: A Systematic Review. Current Oncology 2024, 31: 7403-7413. PMID: 39590176, PMCID: PMC11592455, DOI: 10.3390/curroncol31110546.Peer-Reviewed Original ResearchConceptsCRC liver metastasesLiver metastasesColorectal cancerComplete responseOverall survivalProgressive diseaseInclusion criteriaResection of CRC liver metastasesTreatment of CRC liver metastasisColorectal cancer liver metastasesSystematic searches of PubMedFrequent liver metastasesMedian overall survivalSecondary liver cancerFollow-up durationColorectal Liver MetastasesMultiple risk factorsCancer-related mortalitySearch of PubMedECT-related complicationsEvidence qualityLocoregional treatmentSurgical resectionIdentified articlesGRADE approachVariability in the Spectrum of Reporting on the Schenck KD I Classification in the Orthopaedic Literature: A Systematic Review and Meta-analysis
Green J, Marcel A, Li Z, Moran J, Schenck R, Alaia M, Medvecky M. Variability in the Spectrum of Reporting on the Schenck KD I Classification in the Orthopaedic Literature: A Systematic Review and Meta-analysis. Orthopaedic Journal Of Sports Medicine 2024, 12: 23259671241264214. PMID: 39291123, PMCID: PMC11406613, DOI: 10.1177/23259671241264214.Peer-Reviewed Original ResearchMultiligament kneeKnee dislocationOdds ratioNeurological injuryConcomitant neurologic injurySchenck Knee DislocationTear patternsSystematic literature search of PubMedLiterature search of PubMedConcomitant vascular injuryPooled odds ratioSearch of PubMedSystematic reviewLevel of evidenceMeta-analysesCollateral ligamentSystematic literature searchPublished clinical resultsClinical resultsPooled analysisNeurovascular injuryVascular injuryWeb of ScienceCochrane LibraryPatientsGlial modulators as novel therapeutics for comorbid pain and opioid use disorder
Schwartz E, De Aquino J, Sofuoglu M. Glial modulators as novel therapeutics for comorbid pain and opioid use disorder. British Journal Of Clinical Pharmacology 2024, 90: 3054-3066. PMID: 38752593, DOI: 10.1111/bcp.16094.Peer-Reviewed Original ResearchOpioid use disorderChronic painGlial modulationNovel treatment approachesComorbid painPublic health problemTreatment approachesImproved pain measuresLiterature search of PubMedIncreased opioid prescriptionsSearch of PubMedAddiction-related outcomesSignificant public health problemComorbid disordersOpioid prescriptionsGoogle Scholar databasesPain measuresHealth problemsPain managementClinical studiesTreatment challengesClinical trialsPatient populationPainGlial activationFocus areas and methodological characteristics of North American-based health disparity research in sports medicine: a scoping review
Kliethermes S, Asif I, Blauwet C, Christensen L, Coleman N, Lavallee M, Moeller J, Phillips S, Rao A, Rizzone K, Sund S, Tanji J, Tuakli-Wosornu Y, Stafford C. Focus areas and methodological characteristics of North American-based health disparity research in sports medicine: a scoping review. British Journal Of Sports Medicine 2024, 58: 164-171. PMID: 38216322, PMCID: PMC10961938, DOI: 10.1136/bjsports-2023-107607.Peer-Reviewed Original ResearchConceptsHealth disparities researchHealth disparitiesDisparities researchConsequences of health disparitiesHealth-related outcomesCochrane Central Register of Controlled TrialsCentral Register of Controlled TrialsSystematic literature search of PubMedPeer-reviewed manuscriptsRegister of Controlled TrialsExercise medicineSystematic literature searchCINAHL PlusLiterature search of PubMedSearch of PubMedSports medicineOrganised sportCochrane Central RegisterSocioeconomic statusReview objectivesWeb of Science Core CollectionEducation levelEvidence baseInclusion criteriaFull-text
2023
Ocular complications of plasma cell dyscrasias
Singh R, Singhal S, Sinha S, Cho J, Nguyen A, Dhingra L, Kaur S, Sharma V, Agarwal A. Ocular complications of plasma cell dyscrasias. European Journal Of Ophthalmology 2023, 33: 1786-1800. PMID: 36760117, PMCID: PMC10472748, DOI: 10.1177/11206721231155974.Peer-Reviewed Original ResearchConceptsPlasma cell dyscrasiaMonoclonal gammopathyMultiple myelomaMalignant plasma cellsEfficacious treatment strategiesSearch of PubMedOcular presentationOcular complicationsTreating ophthalmologistClinical suspicionAsymptomatic patientsOphthalmological signsWaldenstrom's macroglobulinemiaSystemic findingsOphthalmologic disordersPre-malignantUnderlying diseasePosterior segmentPlasma cellsSkin changesTreatment strategiesOver-secretionEarly diagnosisCochrane DatabaseSystemic amyloidosis
2021
Risks and Benefits of Cannabis and Cannabinoids in Psychiatry
Hill KP, Gold MS, Nemeroff CB, McDonald W, Grzenda A, Widge AS, Rodriguez C, Kraguljac NV, Krystal JH, Carpenter LL. Risks and Benefits of Cannabis and Cannabinoids in Psychiatry. American Journal Of Psychiatry 2021, 179: 98-109. PMID: 34875873, DOI: 10.1176/appi.ajp.2021.21030320.Peer-Reviewed Original ResearchConceptsPsychiatric disordersRandomized double-blind placebo-controlled trialDouble-blind placebo-controlled trialTherapeutic useEvidence basePlacebo-controlled trialManagement of painBenefits of cannabisSearch of PubMedMental health cliniciansCurrent evidence basePotential side effectsSpecific medical conditionsPsychiatric indicationsFDA indicationClinical trialsHealth cliniciansMedical conditionsReference listsSide effectsChronic cannabisPsychotic disordersDrug AdministrationAdditional articlesMedicinal cannabis
2020
Role of Prophylactic Cholecystectomy After Endoscopic Sphincterotomy for Biliary Stone Disease: A Systematic Review and Meta-analysis.
McCarty TR, Farrelly J, Njei B, Jamidar P, Muniraj T. Role of Prophylactic Cholecystectomy After Endoscopic Sphincterotomy for Biliary Stone Disease: A Systematic Review and Meta-analysis. Annals Of Surgery 2020, 273: 667-675. PMID: 32590541, DOI: 10.1097/sla.0000000000003977.Peer-Reviewed Original ResearchConceptsRecurrent biliary painProphylactic cholecystectomyBile duct stonesMeta-AnalysisSystematic reviewBiliary painDuct stonesCommon bile duct stonesBiliary stone diseaseSubset of patientsCochrane Library databasesRisk of mortalityConfidence intervalsRate of pancreatitisPooled effect sizeSearch of PubMedPreferred Reporting ItemsRandom-effects modelWeb of ScienceBiliary complicationsEventual cholecystectomyComplication rateEndoscopic cholangiopancreatographyEndoscopic sphincterotomyBiliary sphincterotomyGlobal opioid agonist treatment: a review of clinical practices by country
Jin H, Marshall B, Degenhardt L, Strang J, Hickman M, Fiellin D, Ali R, Bruneau J, Larney S. Global opioid agonist treatment: a review of clinical practices by country. Addiction 2020, 115: 2243-2254. PMID: 32289189, PMCID: PMC7554123, DOI: 10.1111/add.15087.Peer-Reviewed Original ResearchConceptsOpioid agonist treatmentOpioid use disorderUrine drug screeningRoutine clinical practiceClinical practiceUnsupervised dosingUse disordersObservational cohort studySignificant clinical benefitSearch of PubMedGrey literature databasesCohort studyMedian dosesOpioid dependenceAgonist treatmentClinical benefitPrescribing practicesEligible studiesOAT programsScreening practicesEligibility criteriaBuprenorphineMethadoneTreatment practicesLiterature databasesRole of Nutrition in Prevention of Neonatal Spontaneous Intestinal Perforation and Its Complications: A Systematic Review
Olaloye O, Swatski M, Konnikova L. Role of Nutrition in Prevention of Neonatal Spontaneous Intestinal Perforation and Its Complications: A Systematic Review. Nutrients 2020, 12: 1347. PMID: 32397283, PMCID: PMC7284579, DOI: 10.3390/nu12051347.Peer-Reviewed Original ResearchMeSH KeywordsEatingEnteral NutritionFeeding MethodsFemaleHumansInfant, Extremely Low Birth WeightInfant, NewbornIntestinal PerforationLength of StayMaleNeurodevelopmental DisordersNutritional Physiological PhenomenaParenteral NutritionPostoperative CarePostoperative ComplicationsSpontaneous PerforationTime FactorsConceptsSpontaneous intestinal perforationIncidence of SIPRole of nutritionEnteral nutritionIntestinal perforationFeeding practicesSystematic reviewEarly enteral nutritionFull enteral feedsPost-operative nutritionLow birthweight infantsLength of stayHistorical control studySearch of PubMedDays of lifeMeta-Analyses (PRISMA) guidelinesPreferred Reporting ItemsRelevant search termsELBW infantsNutrition initiationCohort studyDevastating complicationParenteral nutritionSecondary outcomesEnteral feeds
2019
Comparison of Biomarker Modalities for Predicting Response to PD-1/PD-L1 Checkpoint Blockade
Lu S, Stein JE, Rimm DL, Wang DW, Bell JM, Johnson DB, Sosman JA, Schalper KA, Anders RA, Wang H, Hoyt C, Pardoll DM, Danilova L, Taube JM. Comparison of Biomarker Modalities for Predicting Response to PD-1/PD-L1 Checkpoint Blockade. JAMA Oncology 2019, 5: 1195-1204. PMID: 31318407, PMCID: PMC6646995, DOI: 10.1001/jamaoncol.2019.1549.Peer-Reviewed Original ResearchAnti-PD-1/PD-L1 therapyPD-L1 immunohistochemistryTumor mutational burdenPD-L1 therapyGene expression profilingMutational burdenAnti-PD-1/PD-L1 treatmentPD-1/PD-L1 checkpoint blockadeAnti-PD-1/PD-L1Tumor typesPD-L1 checkpoint blockadeDifferent solid tumor typesPD-L1 treatmentPretreatment tumor tissueImmunotherapy of cancerDrug Administration approvalSearch of PubMedMeta-Analyses (PRISMA) guidelinesSolid tumor typesNegative predictive valuePreferred Reporting ItemsAnnual meeting abstractsNegative likelihood ratioRelative diagnostic performanceCheckpoint blockade
2018
Consensus Recommendations for RBC Transfusion Practice in Critically Ill Children From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative
Valentine SL, Bembea MM, Muszynski JA, Cholette JM, Doctor A, Spinella PC, Steiner ME, Tucci M, Hassan NE, Parker RI, Lacroix J, Argent A, Carson JL, Remy KE, Demaret P, Emeriaud G, Kneyber MCJ, Guzzetta N, Hall MW, Macrae D, Karam O, Russell RT, Stricker PA, Vogel AM, Tasker RC, Turgeon AF, Schwartz SM, Willems A, Josephson CD, Luban NLC, Lehmann LE, Stanworth SJ, Zantek ND, Bunchman TE, Cheifetz IM, Fortenberry JD, Delaney M, van de Watering L, Robinson KA, Malone S, Steffen KM, Bateman ST. Consensus Recommendations for RBC Transfusion Practice in Critically Ill Children From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatric Critical Care Medicine 2018, 19: 884-898. PMID: 30180125, PMCID: PMC6126913, DOI: 10.1097/pcc.0000000000001613.Peer-Reviewed Original ResearchConceptsPediatric Critical Care TransfusionAnemia Expertise InitiativeRBC transfusion managementRBC transfusionIll childrenTransfusion managementConsensus recommendationsAnemia Expertise Initiative Consensus ConferenceDevelopment/UCLA Appropriateness MethodExpert consensus-based recommendationsImportant clinical guidanceRBC transfusion practicesAcute brain injuryCongenital heart diseaseConsensus-based recommendationsSearch of PubMedExpert consensus recommendationsUnnecessary RBC transfusionsNonhemorrhagic shockRecommendations AssessmentRespiratory failureCritical illnessHemorrhagic shockTransfusion practiceCochrane LibraryAntibiotics for the Prevention and Treatment of Postsurgical Obstetric Infections
DeNoble AE, Kuller JA, Heine RP, Dotters-Katz S. Antibiotics for the Prevention and Treatment of Postsurgical Obstetric Infections. Obstetrical & Gynecological Survey 2018, 73: 475-485. PMID: 30169886, DOI: 10.1097/ogx.0000000000000590.Peer-Reviewed Original ResearchConceptsPostsurgical infectionsObstetric infectionsProphylactic antibioticsCesarean deliverySystematic reviewAvailable evidenceLimited retrospective studyUnlabored cesarean deliveryCornerstone of preventionEvidence-based guidelinesCommon bacterial isolatesEffective antibiotic regimenSecond-generation cephalosporinsAntibiotic resistanceSearch of PubMedAntibiotic selectionFirst-generation cephalosporinsRelevant original research articlesGlobal health threatAdjunctive azithromycinAntibiotic prophylaxisInfectious complicationsMaternal morbidityAntibiotic regimenOperative interventionBullous hemorrhagic dermatosis is an under-recognized side effect of full dose low-molecular weight heparin: a case report and review of the literature
Russo A, Curtis S, Balbuena-Merle R, Wadia R, Wong E, Chao HH. Bullous hemorrhagic dermatosis is an under-recognized side effect of full dose low-molecular weight heparin: a case report and review of the literature. Experimental Hematology & Oncology 2018, 7: 15. PMID: 29989046, PMCID: PMC6035443, DOI: 10.1186/s40164-018-0108-7.BooksLow molecular weight heparinBullous hemorrhagic dermatosisWeight heparinCoagulation testingFull-dose low molecular weight heparinMajority of patientsSmall case seriesMolecular weight heparinDays of administrationSearch of PubMedSite of injectionCase seriesIntracranial hemorrhageOvid EmbaseCase reportElderly menLate diagnosisTherapeutic rangeOvid MEDLINEAnticoagulationSide effectsPatientsTherapeutic interventionsNew casesDifferent anticoagulants
2013
Pulmonary complications with the use of mTOR inhibitors in targeted cancer therapy: A systematic review and meta-analysis.
Gartrell B, Ying J, Sivendran S, Agarwal N, Boucher K, Choueiri T, Sonpavde G, Oh W, Galsky M. Pulmonary complications with the use of mTOR inhibitors in targeted cancer therapy: A systematic review and meta-analysis. Journal Of Clinical Oncology 2013, 31: 362-362. DOI: 10.1200/jco.2013.31.6_suppl.362.Peer-Reviewed Original ResearchPulmonary adverse eventsIncidence rates of grade 3Rates of grade 3Renal cell carcinomaIncidence rate ratiosGrade 3Adverse eventsMTOR inhibitorsIncidence ratePulmonary complicationsGrade pneumonitisSolid tumorsRelative to controlsDevelopment of grade 3Clinical trials of mTOR inhibitorsSolid tumor patientsPhase III trialsMeta-analysisSearch of PubMedSystematic reviewRate ratiosTargeted cancer therapyAdverse event dataASCO abstractsPulmonary toxicity
2011
Perinatal and Neonatal Risk Factors for Autism: A Comprehensive Meta-Analysis
Gardener H, Spiegelman D, Buka S. Perinatal and Neonatal Risk Factors for Autism: A Comprehensive Meta-Analysis. Obstetrical & Gynecological Survey 2011, 66: 749-751. DOI: 10.1097/ogx.0b013e31824024d4.Peer-Reviewed Original ResearchNeonatal factorsRisk of autismNeonatal complicationsBirth weightRisk factorsAbnormal fetal presentationEffect estimatesUmbilical cord complicationsNeonatal risk factorsLow birth weightHigh birth weightSearch of PubMedSummary effect estimatesRandom-effects modelExtensive epidemiologic researchComprehensive Meta-AnalysisRisk factor effectsApgar scoreFirst systematic reviewFetal distressMeconium aspirationBirth injuryMaternal hemorrhageVaginal deliveryGestational ageBarriers to diabetes management: Patient and provider factors
Nam S, Chesla C, Stotts NA, Kroon L, Janson SL. Barriers to diabetes management: Patient and provider factors. Diabetes Research And Clinical Practice 2011, 93: 1-9. PMID: 21382643, DOI: 10.1016/j.diabres.2011.02.002.Peer-Reviewed Original ResearchConceptsType 2 diabetesHealth beliefsDiabetes managementMetabolic controlInadequate metabolic controlPoor glycemic controlPatients' health beliefsSearch of PubMedHealth care systemPatients' financial resourcesClinician barriersGlycemic controlPatient barriersPatient adherenceProvider factorsClinicians' attitudesDiabetes carePatients' perceptionsHealth literacyDiabetesSystematic reviewPatientsCare systemCliniciansIntervention strategies
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