2025
Statistical Methods for Chemical Mixtures: A Roadmap for Practitioners Using Simulation Studies and a Sample Data Analysis in the PROTECT Cohort
Hao W, Cathey A, Aung M, Boss J, Meeker J, Mukherjee B. Statistical Methods for Chemical Mixtures: A Roadmap for Practitioners Using Simulation Studies and a Sample Data Analysis in the PROTECT Cohort. Environmental Health Perspectives 2025, 133: 067019. PMID: 40392783, PMCID: PMC12178341, DOI: 10.1289/ehp15305.Peer-Reviewed Original ResearchConceptsEnvironmental risk scoreMixtures researchBirth outcomesSummary scoreSimulation studyBirth cohortIllustrative data analysisData analysisPolycyclic aromatic hydrocarbonsRisk scoreBinary outcomesEpidemiological studiesHealth impactsRisk stratificationCumulative measureInferential goalsIntegrated R packagePractitionersChemical mixturesImprove risk stratificationPROTECT cohortSimulation settingsCohortScoresExposure to chemical mixturesBenchmarking empirical severity for the Yale-Brown Obsessive Compulsive Scale-Second Edition
Pinciotti C, Avery J, Zhang C, Muñoz J, Berrones D, Cruz V, Wiese A, Anderberg J, Frederick R, Miño T, Lanzagorta N, Castro J, Ochoa-Panaifo M, Goodman W, Crowley J, Storch E, Cervin M, Adorno V, Agostini V, Aguilar W, Aguirre C, Alvarado-Quiroz V, Ancalade N, L M, Anderberg J, Aponte D, Espinosa A, Arnold P, Carmelo B, Atkinson E, Avanesyan T, Avery J, Ayala J, Aziz H, Aguirre T, Barrera C, Contreras J, Barry K, Belanger A, Benitez L, Berrones D, Best J, Bigdeli T, Bommiasamy H, Borda T, Boyajian L, Muñoz D, Browning L, Burton C, Busto C, Buxbaum J, Rivera R, Callahan J, Gomez C, Ponce L, Canchari E, Torres R, Cervin M, Chang A, Chazelle E, Cheng J, Chire J, Muñoz M, Cicero D, Cifuentes-Espinoza A, Quiroz P, Colombo G, Comer J, Condori-Apaza L, Cortina J, Crosbie J, Crowley J, Cruz V, Cruz I, Cunning A, Perez G, Dailey M, Dang B, Checco K, Dawson A, del Río D, Dev A, Diaz S, Fay L, Figueroa E, Flecha L, Flores-Garcia Á, Franklin M, Frederick R, Fujita R, Furr J, Gaeta A, Gamarra O, Garay-Contreras C, García-Bravo N, García-Jaimes C, Garrison S, Gil-Hernández D, Giusti-Rodriguez P, Gonzalez A, González R, Gonzalez-Barrios P, Goodman W, Gorosito J, Grice D, Guintivano J, Guttfreund D, Halvorsen M, Miles J, Núñez E, Hettema J, Hovey J, Ccarhuas B, Irreño-Sotomonte J, Jagannathan N, Jensen M, Reynolds A, Jiwani R, Johnson J, Joutteaux S, Lujambio J, Kehrer S, Kennedy J, Lanzagorta N, Lázaro-Muñoz G, Longhurst M, Martinez D, Luna E, MacLellan A, Quispe D, Marques A, Marquez M, Martinez M, Martínez G, Mallen M, Martinez-Gonzalez K, de Los Angeles Matos M, Mattheisen M, McCarty R, McGuire J, McKay D, McOmber C, Minaya C, Miño T, Mithani S, Morales-Rivero A, Moya P, Moyano M, Mukunda P, Muñoz M, Muñoz M, Nicolini H, Bracho A, Bracho B, Obando D, Ochoa M, Ochoa-Panaifo M, O'Higgins M, Castaman L, Balmaceda T, Tobar M, Onyeka O, Ortega I, Paredes-Linares V, Pato M, Paz y Miño M, de Leon E, Orellana J, Sossa N, Pereira S, Morales N, Duarte T, Phan A, Placencia M, Ponce L, Poovey K, Prieto M, Qiao T, Quiroz-Padilla M, Quispe-Correa M, Heros A, Ramos R, Ramos I, Ramsey K, Rancourt D, Gomez S, Espinosa R, Richter P, Rodriguez C, Barajas S, Romero M, Ruggero C, Ruiz-Chow A, Sagarnaga M, Montoya G, Salhadar N, Schachar R, Segovia L, Seligman L, Siegel I, Spencer S, Staples C, Stewart S, Storch E, Tapia-Cuevas V, Thompson P, Timpano K, Tonarelli S, la Garza B, Trujillo A, Villar C, Valdés C, Vallejo-Silva A, Mamani K, Vargas-Medrano J, Vásquez-Suyo M, Mellstrieng A, Vergara M, Vidal-Martinez G, Huaman M, Vollaro C, Wiese A, Wilkerson S, Zai G, Zappa L, Cruz V, Zepeda-Burgos R, Zoghbi A, Alves G, Alves G, Barbosa I, Cappi C, Carneiro M, Costa D, Delage F, Dreher C, Ferrão Y, Ferreira G, Fontenelle L, Fragoso D, Lima M, Menezes G, Miguel E, Moreira-de-Oliveira M, Stumpf B, Quarantini L, Quarantini-Alvim Y, Ramos V, Rosario M, Sampaio A, Saraiva L, Shavitt R. Benchmarking empirical severity for the Yale-Brown Obsessive Compulsive Scale-Second Edition. Journal Of Affective Disorders 2025, 119719. PMID: 40541829, DOI: 10.1016/j.jad.2025.119719.Peer-Reviewed Original ResearchYale-Brown Obsessive Compulsive ScaleY-BOCS-IIObsessive-compulsive disorderYale-Brown Obsessive Compulsive Scale - Second EditionSeverity of obsessive-compulsive disorderSample of OCD patientsObsessive Compulsive ScaleResearch settingsOCD presentationsOCD severityCompulsive ScaleObsessive-compulsiveOCD patientsPsychometric propertiesDiverse sampleSeveral benchmarksEmpirical critiqueHoldout sampleSeverityScoresDisordersAge groupsMore than taking a pill: the effects of intersectional microaggressions on pre-exposure prophylaxis adherence among Black MSM
Whitfield D, Mammadli T, Gordon J, Dācus J, Chandler C, Turpin R, Douaihy A. More than taking a pill: the effects of intersectional microaggressions on pre-exposure prophylaxis adherence among Black MSM. Journal Of HIV/AIDS & Social Services 2025, ahead-of-print: 1-14. DOI: 10.1080/15381501.2025.2517604.Peer-Reviewed Original ResearchBlack MSMPrEP adherenceLevels of PrEP adherencePre-exposure prophylaxis adherenceAdaptive coping skillsIntersectional microaggressionsDistress scoresBlack menCoping skillsMicroaggressionsAdherence level groupsMSMProphylaxis adherencePrEPSignificant stressorsAdherenceKruskal-Wallis testPilot studyLevel groupKruskal-WallisScoresMenDistressParticipantsPerceived understanding and psychosocial outcomes: employees’ responses to learning results of workplace genetic testing
Charnysh E, McCain S, Truhlar A, Pal S, Reader J, Sanghavi K, Uhlmann W, Hendy K, Leader A, Blasco D, Prince A, Feero W, Brandt R, Giri V, Lee C, Roberts J. Perceived understanding and psychosocial outcomes: employees’ responses to learning results of workplace genetic testing. Personalized Medicine 2025, ahead-of-print: 1-11. PMID: 40497788, DOI: 10.1080/17410541.2025.2515003.Peer-Reviewed Original ResearchPsychosocial responsesGenetic testingIncreased riskUS healthcare systemAbstractText Label="MATERIALS &Open-ended responsesPositive feelingsPredictors of scoresAssociated with lower levelsPsychosocial supportPsychosocial harmPsychosocial outcomesHealthcare systemAfrican American/BlackMean scoreResults QuestionnairesPerceived understandingNegative emotionsDifficulty interpretingAbstractText Label="AIMTesting understandingUncertainty scoreRegression analysisScoresFeelingsThe Development and Validation of Novel 3-Dimensional Models for Simulation Training in Sinonasal and Skull Base Surgery.
Rehman U, Okhovat S, Woods R, London N, Verillaud B, von Buchwald C, Gallia G, Omay S, Bennett W, Abhinav K, Choby G, Nayak J, Leong S, Vyskocil E, Lechner M. The Development and Validation of Novel 3-Dimensional Models for Simulation Training in Sinonasal and Skull Base Surgery. Annals Of Otology Rhinology & Laryngology 2025, 34894251340879. PMID: 40426328, DOI: 10.1177/00034894251340879.Peer-Reviewed Original ResearchSkull base surgeryOSATS scoresSelf-reported confidenceSkull base cancerWorkforce challengesSurgical performanceObjective Structured AssessmentPrinted modelsSimulation trainingNeck modelSkull base modelTotal confidenceSurgerySurgery trainingHead and neck modelTraining challengesWorkforceTrainingTechnical skillsStructural assessmentScoresConfidenceDissection courseFacultyOSATSFactors influencing the decision to discontinue treatment due to chemotherapy-induced peripheral neuropathy among patients with metastatic breast cancer: a best–worst scaling
Radwan R, Bridges J, Hertz D, Lustberg M, Vachhani H, Hickey Zacholski E, Sheppard V, Salgado T. Factors influencing the decision to discontinue treatment due to chemotherapy-induced peripheral neuropathy among patients with metastatic breast cancer: a best–worst scaling. Supportive Care In Cancer 2025, 33: 467. PMID: 40347310, PMCID: PMC12065726, DOI: 10.1007/s00520-025-09508-4.Peer-Reviewed Original ResearchConceptsChemotherapy-induced peripheral neuropathyMetastatic breast cancerRisk of treatment discontinuationLong-term neuropathyCancer treatment optionsTreatment discontinuationTreatment optionsPeripheral neuropathyBreast cancerReduced riskNeuropathy symptomsBest-worst scalingNeurotoxic chemotherapyTherapeutic outcomesLoved onesNeuropathyPatientsCancerResultsThe sampleMethodsAn online surveyWomenScoresConclusionWhenRiskChemotherapyEnhancing Coordinated Specialty Care Through Early Detection: Impact of Reduced Duration of Untreated Psychosis
Hazan H, Ferrara M, Zhou B, Li F, Imetovski S, Sykes L, Pollard J, Cahill J, Gibbs-Dean T, Corbera S, Karmani S, Riley S, Tayfur S, Tek C, Keshavan M, Srihari V. Enhancing Coordinated Specialty Care Through Early Detection: Impact of Reduced Duration of Untreated Psychosis. Schizophrenia Bulletin 2025, sbaf044. PMID: 40339151, DOI: 10.1093/schbul/sbaf044.Peer-Reviewed Original ResearchDuration of untreated psychosisFirst-episode psychosisCoordinated specialty careUntreated psychosisMediation analysisShorter duration of untreated psychosisFirst-episode psychosis patientsEarly interventionEarly psychosisBenefits of early interventionPsychosisGAFFunctional outcomesGlobal assessmentEarly detection campaignsSpecialty careIntake processRecovery outcomesSpecial treatmentQuality of lifeStreamlining referralsFunctional recoveryScoresPatientsInterventionContent Validity of Creativity Self‐Report Questionnaires From PISA 2022
Goecke B, Weiss S, Barbot B. Content Validity of Creativity Self‐Report Questionnaires From PISA 2022. The Journal Of Creative Behavior 2025, 59 DOI: 10.1002/jocb.70026.Peer-Reviewed Original ResearchSelf-report scalesSelf-report scale scoresJingle-jangle fallaciesSelf-report questionnairesContent validitySelf-reported dataContext QuestionnaireValidity of inferencesScale scoreTest contentConstruct underrepresentationItemsScaleScoresPISAValidityQuestionnaireTheoretical angleResearchContent definitionResearch teamA flexible Bayesian g-formula for causal survival analyses with time-dependent confounding
Chen X, Hu L, Li F. A flexible Bayesian g-formula for causal survival analyses with time-dependent confounding. Lifetime Data Analysis 2025, 31: 394-421. PMID: 40227517, DOI: 10.1007/s10985-025-09652-3.Peer-Reviewed Original ResearchConceptsG-formulaBalance scoresHealth system electronic health recordDiscrete survival dataTime-to-event outcomesPosterior sampling algorithmParametric g-formulaElectronic health recordsBayesian additive regression treesTime-varying treatmentsHypothetical intervention scenariosAdditive regression treesLongitudinal observational studyGeneral classModel misspecificationHealth recordsEmpirical performanceSampling algorithmObservational studySurvival dataIntervention scenariosScoresTreatment strategiesMisspecificationCausality analysisThe inflammatory and genetic mechanisms underlying the cumulative effect of co-occurring pain conditions on depression
Jiang R, Geha P, Rosenblatt M, Wang Y, Fu Z, Foster M, Dai W, Calhoun V, Sui J, Spann M, Scheinost D. The inflammatory and genetic mechanisms underlying the cumulative effect of co-occurring pain conditions on depression. Science Advances 2025, 11: eadt1083. PMID: 40173244, PMCID: PMC11964001, DOI: 10.1126/sciadv.adt1083.Peer-Reviewed Original ResearchConceptsDepression riskChronic pain conditionsPain conditionsPrevalence of comorbid depressionPain scoresUK Biobank participantsPain-free individualsComposite pain scoresHigh-risk individualsPain screeningMendelian randomizationBiobank participantsPain sitesDepression incidenceComorbid depressionIncreased riskBody sitesDepressionC-reactive proteinPainCausal inferenceFollow-upScoresRiskInflammatory markersAutomated computation of the HEART score with the GPT-4 large language model
Wright D, Socrates V, Huang T, Safranek C, Sangal R, Dilip M, Boivin Z, Srica N, Wright C, Feher A, Miller E, Chartash D, Taylor R. Automated computation of the HEART score with the GPT-4 large language model. The American Journal Of Emergency Medicine 2025, 93: 120-125. PMID: 40184662, PMCID: PMC12202168, DOI: 10.1016/j.ajem.2025.03.065.Peer-Reviewed Original ResearchConceptsClinical decision supportHEART scoreChest pain observation unitAverage heart scoreCohen's weighted kappaDecision supportNurse practitionersPhysician assistantsRetrospective cohort studyRoutine careCases of disagreementProspective InvestigationAPP scoresCohort studySafety interventionsPhysician judgmentObservation unitAdverse cardiac eventsInstitutional registryScoresPhysiciansInterventionParticipantsNo significant differenceAppsEating Disorder Screening Measures in Post-9/11 Veteran Men and Women
Mitchell K, Serier K, Vogt D, Smith B, Cooper Z. Eating Disorder Screening Measures in Post-9/11 Veteran Men and Women. Psychological Assessment 2025, 37: 172-179. PMID: 40167541, DOI: 10.1037/pas0001369.Peer-Reviewed Original ResearchConceptsEating disordersCut scoresScreening measuresTreating eating disordersVeteran sampleDiagnostic InterviewPsychiatric disordersFemale subsampleVeteran menInternal consistencyWell-validatedHealth care settingsCare settingsDisordersSCOFFVulnerable populationsSubsampleEffective screeningScoresPost-9/11Investigate performancePotential casesEatingVeteransWomenThe Longitudinal Impact of Psychosocial Syndemic Variables on Adherence to Antiretroviral Therapy Among People With HIV in Brazil, Thailand, and Zambia: An Analysis by HIV Transmission Groups in HPTN 063.
Rodríguez-Díaz C, Zangeneh S, Chen Y, Guo X, Tsuyuki K, Ransome Y, Friedman R, Srithanaviboonchai K, Roberts S, Mimiaga M, Mayer K, Safren S. The Longitudinal Impact of Psychosocial Syndemic Variables on Adherence to Antiretroviral Therapy Among People With HIV in Brazil, Thailand, and Zambia: An Analysis by HIV Transmission Groups in HPTN 063. AIDS Education And Prevention 2025, 37: 89-106. PMID: 40323670, DOI: 10.1521/aeap.2025.37.2.89.Peer-Reviewed Original ResearchConceptsSyndemic problemsSyndemic scoreART adherenceHIV transmission groupFear of discriminationOne-year longitudinal dataSuboptimal ART adherenceTransmission groupAssociated with lower ART adherenceSyndemic variableLow ART adherenceHIV preventionTransmission categoryLongitudinal dataAntiretroviral therapyAlcohol useStimulant usePolydrug useLongitudinal impactPWHAdherenceHIVZambiaCareScoresUK Hand and Upper Limb Transplant Service, functional outcomes of the first six patients: A case series.
Burdon J, Taplin S, Leonard D, Natalwala I, Bourke G, Kay S. UK Hand and Upper Limb Transplant Service, functional outcomes of the first six patients: A case series. Journal Of Hand Surgery (European Volume) 2025, 17531934251325654. PMID: 40119684, DOI: 10.1177/17531934251325654.Peer-Reviewed Original ResearchCanadian Occupational Performance Measure performanceHand Transplantation Score SystemReport functional outcomesArm Shoulder and Hand scoreUpper limb transplantationFunctional outcomesSatisfaction scoresHand scoreProtective sensationPower gripBilateral handsScoresTransplant servicesTransplant scoreHand transplantationCase seriesScoring systemOutcomesPatientsEffective treatmentTransplantationTransplant programmeLimb transplantationDisabilityGripDeveloping a digital video to support lung cancer screening in diverse populations
Lindsay M, Odole I, Belliveau O, Abujarad F, Gross C, Richman I. Developing a digital video to support lung cancer screening in diverse populations. PEC Innovation 2025, 6: 100388. PMID: 40212805, PMCID: PMC11982046, DOI: 10.1016/j.pecinn.2025.100388.Peer-Reviewed Original ResearchLung cancer screeningKnowledge of lung cancer screeningCancer screeningLevels of educational attainmentEducational attainmentKnowledge scoresDiverse populationsPrimary care clinicsLung cancer mortalityParticipants' knowledge scoresLower educational attainmentOpen-ended feedbackScreening behaviorLow dose computed tomographyPatient engagementCare clinicsCancer mortalityAssess knowledgeParticipant feedbackIncreased knowledgeParticipantsAdultsScreeningAttainmentScoresFacial Determinants of Artificial Intelligence–Perceived Gender and Age Following Facial Feminization Surgery
Vassallo M, Ihnat J, Flores-Pérez P, Rancu A, Allam O, Alperovich M. Facial Determinants of Artificial Intelligence–Perceived Gender and Age Following Facial Feminization Surgery. Journal Of Craniofacial Surgery 2025, 36: 734-738. DOI: 10.1097/scs.0000000000011135.Peer-Reviewed Original ResearchFacial feminization surgeryFacial thirdFeminization surgeryUpper thirdPostoperative imagingPostoperative changesFacial recognition softwarePostoperative ageYounger cohortsArtificial intelligence evaluationArtificial intelligenceLower thirdCohortRecognition softwareIntelligent evaluationTransgender womenSurgeryAgeAge scoresScoresEmpowering genome-wide association studies via a visualizable test based on the regional association score
Jiang Y, Zhang H. Empowering genome-wide association studies via a visualizable test based on the regional association score. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2419721122. PMID: 39999171, PMCID: PMC11892588, DOI: 10.1073/pnas.2419721122.Peer-Reviewed Original ResearchIs There More to POCUS Than the Heart and Lungs in the Parturient-Venous Excess Ultrasound Score?
Munoz-Acuna R, Charchaflieh J, Deshpande R. Is There More to POCUS Than the Heart and Lungs in the Parturient-Venous Excess Ultrasound Score? Obstetric Anesthesia Digest 2025, 45: 19-20. DOI: 10.1097/01.aoa.0001097560.30255.cc.Peer-Reviewed Original ResearchUltrasound scoreVenous excess ultrasound scoreVenous hemodynamic dysfunctionVolume overloadPulmonary edemaCardiac functionHemodynamic dysfunctionEndothelial dysfunctionVenous disordersTailored treatmentCapillary permeabilityMultisystem conditionPreeclampsiaDysfunctionScoresEdemaVExUSPathophysiologyMultisystemUsing twin-pairs to assess potential bias in polygenic prediction of externalising behaviours across development
Bright J, Rayner C, Freeman Z, Zavos H, Ahmadzadeh Y, Viding E, McAdams T. Using twin-pairs to assess potential bias in polygenic prediction of externalising behaviours across development. Molecular Psychiatry 2025, 30: 3129-3137. PMID: 39972057, PMCID: PMC12185310, DOI: 10.1038/s41380-025-02920-6.Peer-Reviewed Original ResearchPolygenic scoresTwin pairsGenetic influencesPassive gene-environment correlationConduct problemsCallous-unemotional traitsGene-environment correlationADHD-related symptomsGenome-wide association studiesIndirect genetic effectsCU traitsADHD symptomologyExternalising behaviourPost hoc analysisGenomic dataAssociation studiesPolygenic predictionEnvironmental influencesWithin-familyGenetic effectsPost-hocTraitsScoresADHDRGEExposome-Wide Gene-By-Environment Interaction Study of Psychotic Experiences in the UK Biobank
Lin B, Pries L, Arias-Magnasco A, Klingenberg B, Linden D, Blokland G, van der Meer D, Luykx J, Rutten B, Guloksuz S. Exposome-Wide Gene-By-Environment Interaction Study of Psychotic Experiences in the UK Biobank. Biological Psychiatry Global Open Science 2025, 5: 100460. PMID: 40206033, PMCID: PMC11981733, DOI: 10.1016/j.bpsgos.2025.100460.Peer-Reviewed Original ResearchGene-by-environment interactionsPRS-SCZUK BiobankExposome-wide association studyPsychotic experiencesPolygenic risk scoresAssociated with psychotic experiencesMental distressRisk scoreAssociation studiesSleep problemsBiobankAdditive interactionPsychosis riskAgnostic analysisCorrelation testXWASGenetic vulnerabilityDistressParticipantsScoresCorrelation analysisExposureStudyRisk
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply