2025
Addressing Peri-Device Leaks in Next-Generation Transcatheter Left Atrial Appendage Occluders: An Open Question
Roshanfar M, Jang S, Sinusas A, Wong S, Mosadegh B. Addressing Peri-Device Leaks in Next-Generation Transcatheter Left Atrial Appendage Occluders: An Open Question. Surgeries 2025, 6: 15. DOI: 10.3390/surgeries6010015.Peer-Reviewed Original ResearchPeri-device leakLeft atrial appendageFDA-approved devicesRisk of thrombo-embolic eventsNon-valvular atrial fibrillationLeft atrial appendage anatomyLong-term anticoagulationPercutaneous LAA occlusionCHA2DS2-VASc scoreThrombo-embolic eventsIncreased risk of strokeRisk of strokeCircular cross-sectionLeft atrial appendage occluderSystemic embolismAnticoagulant therapyLAA occlusionObservational registryCHA2DS2-VAScNon-pharmacological alternativeAdverse eventsAtrial fibrillationAtrial appendageClinical dataIncreased risk
2024
Cardiovascular Events in Adults with Type 2 Diabetes and ASCVD Initiating Once-Weekly Semaglutide vs DPP-4is in the USA
Inzucchi S, Tan X, Liang Y, Yedigarova L, Xie L, de Havenon A. Cardiovascular Events in Adults with Type 2 Diabetes and ASCVD Initiating Once-Weekly Semaglutide vs DPP-4is in the USA. Diabetes Therapy 2024, 16: 187-203. PMID: 39688779, PMCID: PMC11794941, DOI: 10.1007/s13300-024-01678-4.Peer-Reviewed Original ResearchHealth care resource utilizationAtherosclerotic cardiovascular diseaseDPP-4i usersDPP-4isGLP-1 RAsOnce-weekly semaglutideMedical costsType 2 diabetesDPP-4iDecreased risk of strokeRisk of cardiovascular outcomesCardiovascular eventsOnce-weekly GLP-1 RAsPeptide 1 receptor agonistsTotal medical costsDipeptidyl peptidase 4 inhibitorsOccurrence of cardiovascular eventsHigh-risk patientsRisk of strokeObservational cohort analysisData Mart DatabaseOutpatient visitsDecreased riskSemaglutide treatmentBaseline characteristicsSex Differences in Tryptophan Metabolism via the Kynurenine Pathway in Acute Ischemic Stroke
Dylla L, Higgins H, Poisson S, Vu T, Reisz J, Herson P, Monte A. Sex Differences in Tryptophan Metabolism via the Kynurenine Pathway in Acute Ischemic Stroke. Clinical Therapeutics 2024, 46: 960-966. PMID: 39603869, PMCID: PMC11637908, DOI: 10.1016/j.clinthera.2024.10.015.Peer-Reviewed Original ResearchAcute ischemic strokeQuinolinic acid levelsLevels of tryptophanNIHSS scoreTryptophan metabolismMetabolite levelsKynurenine pathwayLinear regression modelsIncreased lifetime risk of strokeLifetime risk of strokeMass spectrometry-based metabolomicsPotential sex differencesDownstream kynurenine metabolitesAssociated with poor outcomesIschemic strokeKynurenine pathway metabolitesDecreased tryptophan concentrationsIncreased lifetime riskRegression modelsMultivariate linear regression modelSex differencesExperience worse outcomesRisk of strokeAcid levelsKynurenine metabolitesAssociation of Chronic Kidney Disease and Kidney Failure with Replacement Therapy with Procedural and Long-Term Outcomes after First Generation Watchman Device: Insights from the NCDR LAAO Registry
Munir M, Tan Z, Pun P, Wang Y, Tandar A, Darden D, Hsu J, Friedman D, Curtis J, Freeman J. Association of Chronic Kidney Disease and Kidney Failure with Replacement Therapy with Procedural and Long-Term Outcomes after First Generation Watchman Device: Insights from the NCDR LAAO Registry. Heart Rhythm 2024 PMID: 39515495, DOI: 10.1016/j.hrthm.2024.10.071.Peer-Reviewed Original ResearchChronic kidney diseaseLong-term outcomesLeft atrial appendage occlusionAssociation of chronic kidney diseaseNational Cardiovascular Data Registry LAAO RegistryReplacement therapyAdverse eventsAtrial fibrillationKidney diseaseKidney failureAssociated with higher ratesIn-hospital deathRisk of strokeRate of strokeBilling claimsAF patientsProcedural complicationsAppendage occlusionWatchman deviceMultivariate analysisKFRTHigh riskPatientsRegistryComplicationsIdentifying Patients with Erythrocytosis Not Requiring JAK2 Testing: External Validation and Decision Analysis of the Jakpot Prediction Rule
Lam B, Ito S, Ryu J, O'Sullivan K, Potnis K, Lu R, Bidikian A, Freed J, La J, Goshua G. Identifying Patients with Erythrocytosis Not Requiring JAK2 Testing: External Validation and Decision Analysis of the Jakpot Prediction Rule. Blood 2024, 144: 3669-3669. DOI: 10.1182/blood-2024-198033.Peer-Reviewed Original ResearchNegative predictive valueBeth Israel Deaconess Medical CenterClinical prediction rulePolycythemia veraIncremental net monetary benefitHealth resource utilizationPV patientsMyeloproliferative neoplasmsVA cohortTest characteristicsUS health system perspectivePrediction ruleAssociated with increased riskNon-fatal cardiovascular eventsExternal validation cohortAssociated with increased risk of strokeRandomized trial dataMarkov cohort modelLifetime time horizonProbabilistic sensitivity analysesRisk of strokePersistent erythrocytosisMedian ageHematologic malignanciesDiagnostic workupPrimary Prevention of Stroke: Identifying High-Risk Patients
Kaslow J, Kernan W. Primary Prevention of Stroke: Identifying High-Risk Patients. 2024, 431-443. DOI: 10.1007/978-3-031-66289-8_36.Peer-Reviewed Original ResearchRisk factorsPrimary careHealthy behaviorsPatient-centeredCoronary artery diseaseRisk of strokeChronic diseasesPreventable deathsMedical practicePublic healthUnhealthy onesIncreased riskRisk reductionHigh riskHigh-risk patientsStrokeRiskArtery diseaseCareHealthDisabilityPatientsMedicationFactorsGuidelinesThe predictive validity of a Brain Care Score for late-life depression and a composite outcome of dementia, stroke, and late-life depression: data from the UK Biobank cohort
Singh S, Rivier C, Papier K, Chemali Z, Gutierrez-Martinez L, Parodi L, Mayerhofer E, Senff J, Clocchiatti-Tuozzo S, Nunley C, Newhouse A, Ouyang A, Westover M, Tanzi R, Lazar R, Pikula A, Ibrahim S, Brouwers H, Howard V, Howard G, Yechoor N, Littlejohns T, Sheth K, Rosand J, Fricchione G, Anderson C, Falcone G. The predictive validity of a Brain Care Score for late-life depression and a composite outcome of dementia, stroke, and late-life depression: data from the UK Biobank cohort. Frontiers In Psychiatry 2024, 15: 1373797. PMID: 39109366, PMCID: PMC11301016, DOI: 10.3389/fpsyt.2024.1373797.Peer-Reviewed Original ResearchIncident late-life depressionLate-life depressionBrain health outcomesCare scoresHealth outcomesHealthy lifestyle choicesOutcome of dementiaUK Biobank cohortRisk factorsComposite outcomeCox proportional hazards modelsCare providersBiobank cohortProportional hazards modelIncident casesMultivariate Cox proportional hazards modelRisk of strokeLifestyle changesClinical careLifestyle choicesDementiaBrain healthFuture depressionBaseline evaluationComplete dataSex Differences in the Blood Metabolome During Acute Response to Ischemic Stroke
Dylla L, Higgins H, Stephenson D, Reisz J, Vu T, Poisson S, Herson P, Monte A. Sex Differences in the Blood Metabolome During Acute Response to Ischemic Stroke. Journal Of Women's Health 2024, 33: 1378-1384. PMID: 38946610, PMCID: PMC11564668, DOI: 10.1089/jwh.2023.1133.Peer-Reviewed Original ResearchIschemic strokeLinear regression modelsMass spectrometry-based metabolomicsLifetime risk of strokeAssociated with neurological outcomeDifferentially expressed metabolitesRegression modelsAcute ischemic strokeRisk of strokeComprehensive stroke centerBlood metabolomeNeurological outcomeAcute treatmentMetabolomic profilesLifetime riskNeurological functionIndividual metabolitesTherapeutic potentialStroke centersAcute responseResults:</i></b>Study objectiveMetabolomicsStrokeNIHSSAssociation of Traditional and Nontraditional Risk Factors in the Development of Strokes Among Young Adults by Sex and Age Group: A Retrospective Case-Control Study
Leppert M, Poisson S, Scarbro S, Suresh K, Lisabeth L, Putaala J, Schwamm L, Daugherty S, Bradley C, Burke J, Ho P. Association of Traditional and Nontraditional Risk Factors in the Development of Strokes Among Young Adults by Sex and Age Group: A Retrospective Case-Control Study. Circulation Cardiovascular Quality And Outcomes 2024, 17: e010307. PMID: 38529631, PMCID: PMC11021148, DOI: 10.1161/circoutcomes.123.010307.Peer-Reviewed Original ResearchConceptsTraditional risk factorsDevelopment of strokeNontraditional risk factorsCase-control studyRisk factorsRetrospective case-control studyAge groupsContribution of traditional risk factorsYoung adultsConditional logistic regression modelsPopulation attributable riskCount of risk factorsStroke-free controlsAll Payer Claims DatabaseAssociation of strokeColorado All Payer Claims DatabaseLogistic regression modelsPayer Claims DatabaseIncreased risk of strokeAttributable riskRisk of strokeStroke eventsYears of ageInsurance typeIncreased riskWhy selective screening for asymptomatic carotid stenosis is currently appropriate: a special report
Paraskevas K, Dardik A, Schermerhorn M, Liapis C, Mansilha A, Lal B, Gray W, Brown M, Myrcha P, Lavie C, Zeebregts C, Secemsky E, Saba L, Blecha M, Gurevich V, Silvestrini M, Blinc A, Svetlikov A, Fernandes e Fernandes J, Schneider P, Gloviczki P, White C, AbuRahma A. Why selective screening for asymptomatic carotid stenosis is currently appropriate: a special report. Expert Review Of Cardiovascular Therapy 2024, 22: 159-165. PMID: 38480465, DOI: 10.1080/14779072.2024.2330660.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsScreening programMass screening programPopulation-wide screening programsRisk factor modificationHigh riskHigh risk of strokeMyocardial infarctionInitiation of preventive measuresRisk of strokeIntensive medical therapyAsymptomatic carotid artery stenosisFactor modificationCost-effectiveLifestyle measuresPrevent future strokeAsymptomatic carotid stenosisTargeted screeningCarotid artery stenosisFuture strokeScreening of populationsCarotid revascularization proceduresProphylactic carotid interventionMedical therapyPreventive measuresCV eventsTrends in American Indian/Alaskan native self-reported stroke prevalence and associated modifiable risk factors in the United States from 2011-2021
Heath T, Shrishail N, Wong K, Johnston K, Sharma R, Ney J, Sheth K, de Havenon A. Trends in American Indian/Alaskan native self-reported stroke prevalence and associated modifiable risk factors in the United States from 2011-2021. Journal Of Stroke And Cerebrovascular Diseases 2024, 33: 107650. PMID: 38460776, PMCID: PMC11253029, DOI: 10.1016/j.jstrokecerebrovasdis.2024.107650.Peer-Reviewed Original ResearchBehavioral Risk Factor Surveillance SystemSelf-reported strokeModifiable vascular risk factorsVascular risk factorsPrevalence of strokeStroke prevalenceRisk factorsPrevalence of self-reported strokeWhite adultsBehavioral Risk Factor Surveillance System surveyRisk Factor Surveillance SystemPersistent health disparitiesAmerican Indian/Alaskan NativesSurvey of adultsModifiable risk factorsHigher overall burdenSurvey-weighted prevalenceUnited StatesHealth disparitiesRace/ethnic groupsRisk of strokeAI/ANOverall burdenRate of strokeSelf-report
2023
Age at Menopause and the Risk of Stroke: Observational and Mendelian Randomization Analysis in 204 244 Postmenopausal Women
Tschiderer L, Peters S, van der Schouw Y, van Westing A, Tong T, Willeit P, Seekircher L, Moreno‐Iribas C, Huerta J, Crous‐Bou M, Söderholm M, Schulze M, Johansson C, Själander S, Heath A, Macciotta A, Dahm C, Ibsen D, Pala V, Mellemkjær L, Burgess S, Wood A, Kaaks R, Katzke V, Amiano P, Rodriguez‐Barranco M, Engström G, Weiderpass E, Tjønneland A, Halkjær J, Panico S, Danesh J, Butterworth A, Onland‐Moret N. Age at Menopause and the Risk of Stroke: Observational and Mendelian Randomization Analysis in 204 244 Postmenopausal Women. Journal Of The American Heart Association 2023, 12: e030280. PMID: 37681566, PMCID: PMC10547274, DOI: 10.1161/jaha.123.030280.Peer-Reviewed Original ResearchConceptsMendelian randomization analysisRisk of strokeStatistically significant associationRandomization analysisSignificant associationHistory of strokeEPIC-CVDPooled mean ageHigh risk of strokeUK BiobankYears younger ageBaseline ageHazard ratioStroke subtypesObservational studyPooled hazard ratioHemorrhagic strokeEarly menopauseYounger ageMean ageHigh riskMedian follow-upStrokeRegression analysisWomenLeft ventricular hypertrophy and left atrial size are associated with ischemic strokes among non-vitamin K antagonist oral anticoagulant users
Das A, Gökçal E, Fouks A, Horn M, Regenhardt R, Viswanathan A, Singhal A, Schwamm L, Greenberg S, Gurol M. Left ventricular hypertrophy and left atrial size are associated with ischemic strokes among non-vitamin K antagonist oral anticoagulant users. Journal Of Neurology 2023, 270: 5578-5588. PMID: 37548681, PMCID: PMC11111216, DOI: 10.1007/s00415-023-11916-7.Peer-Reviewed Original ResearchPrior cerebrovascular eventsAtrial volume indexVentricular hypertrophyCerebrovascular eventsNOAC usersAtrial sizeIS recurrenceSevere white matter hyperintensitiesVolume indexCerebral small vessel diseaseOral anticoagulant usersChronic renal failureRisk of strokeCox regression analysisQuaternary care centerSmall vessel diseaseAge-matched controlsWhite matter hyperintensitiesMultivariable regression modelsAnticoagulant usersApixaban useDabigatran useResults112 patientsMultivariable adjustmentOral anticoagulantsHigher Hospital Frailty Risk Score Is Associated With Increased Risk of Stroke: Observational and Genetic Analyses
Renedo D, Acosta J, Koo A, Rivier C, Sujijantarat N, de Havenon A, Sharma R, Gill T, Sheth K, Falcone G, Matouk C. Higher Hospital Frailty Risk Score Is Associated With Increased Risk of Stroke: Observational and Genetic Analyses. Stroke 2023, 54: 1538-1547. PMID: 37216451, PMCID: PMC10212531, DOI: 10.1161/strokeaha.122.041891.Peer-Reviewed Original ResearchConceptsHospital Frailty Risk ScoreRisk of strokeHighest Hospital Frailty Risk ScoresDate of consentFrailty Risk ScoreMendelian randomization analysisStroke riskRisk scoreRandomization analysisTime of enrollmentAvailable electronic health recordsMendelian randomizationElectronic health recordsLook-back periodIncident strokeDose-response wayFrailty statusHemorrhagic strokeMultivariable analysisStroke eventsObservational studyHigh riskFrailtySignificant associationSimilar associationCerebral Embolic Protection in Transcatheter Aortic Valve Replacement
Iskander M, Jamil Y, Forrest J, Madhavan M, Makkar R, Leon M, Lansky A, Ahmad Y. Cerebral Embolic Protection in Transcatheter Aortic Valve Replacement. Structural Heart 2023, 7: 100169. PMID: 37520138, PMCID: PMC10382985, DOI: 10.1016/j.shj.2023.100169.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementCerebral embolic protection devicesCerebral embolic protectionAortic valve replacementEmbolic protection devicesValve replacementEmbolic protectionSymptomatic severe aortic stenosisSevere aortic stenosisLow-risk patientsPredictors of strokeOccurrence of complicationsRisk of strokeRecent trial dataRelevant clinical studiesOverall evidence baseExpansion of TAVRFeared complicationAortic stenosisSurgical riskTreatment optionsWorse outcomesClinical studiesPatientsTrial dataOff-pump surgical thrombectomy for subacute right atrial thrombus: A case report
Shang M, Kumbasar U, B S, Bonde P. Off-pump surgical thrombectomy for subacute right atrial thrombus: A case report. Turkish Journal Of Thoracic And Cardiovascular Surgery 2023, 31: 282-285. PMID: 37484646, PMCID: PMC10357855, DOI: 10.5606/tgkdc.dergisi.2023.24477.Peer-Reviewed Original ResearchSurgical thrombectomyCardiopulmonary bypassRight atrial clotRight atrial thrombectomyRight heart thrombusRight atrial thrombusAcute pulmonary embolismHigh-risk patientsMinority of patientsRisk of strokeOptimal treatment optionsCatheter-based interventionsAtrial clotAtrial thrombectomyAtrial thrombusHeart thrombusPulmonary embolectomyPulmonary embolismOpen surgeryRespiratory dysfunctionTreatment optionsCase reportMortality riskThrombectomyPatientsChange in Smoking Behavior and Outcome After Ischemic Stroke: Post-Hoc Analysis of the SPS3 Trial
Anadani M, Turan T, Yaghi S, Spiotta A, Gory B, Sharma R, Sheth K, de Havenon A. Change in Smoking Behavior and Outcome After Ischemic Stroke: Post-Hoc Analysis of the SPS3 Trial. Stroke 2023, 54: 921-927. PMID: 36876480, PMCID: PMC10050138, DOI: 10.1161/strokeaha.121.038202.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsAdverse cardiovascular eventsAcute ischemic strokeIschemic strokeCardiovascular eventsPersistent smokersPersistent smokingSPS3 trialSmoking statusMyocardial infarctionMajor adverse cardiovascular events outcomesCardiovascular event outcomesMajor cardiovascular outcomesSubsequent cardiovascular eventsHistory of hypertensionRisk of strokeEnd of studyPost Hoc AnalysisPrior smokersRandomization armCardiovascular outcomesFormer smokersMonth 3Primary outcomeTotal cohortAssociation Between Hospital-Documented Atrial Fibrillation and Central Retinal Artery Occlusion
Lusk J, Song A, Unnithan S, Al-Khalidi H, Delic A, de Havenon A, Biousse V, Schrag M, Poli S, Piccini J, Xian Y, O’Brien E, Mac Grory B. Association Between Hospital-Documented Atrial Fibrillation and Central Retinal Artery Occlusion. Stroke 2023, 54: 983-991. PMID: 36729390, PMCID: PMC11173326, DOI: 10.1161/strokeaha.122.042292.Peer-Reviewed Original ResearchConceptsCentral retinal artery occlusionRetinal artery occlusionCardiovascular comorbiditiesArtery occlusionAtrial fibrillationInverse associationNon-Hispanic white race/ethnicityState Emergency Department DatabasesWhite race/ethnicityPrespecified sensitivity analysisPrimary end pointRisk of strokeCause-specific hazards modelEmergency Department DatabasesEmergency department settingPrimary risk factorState Inpatient DatabasesPositive control outcomesRace/ethnicityMedian followCohort studyCumulative incidenceIschemic strokeAF statusInpatient DatabaseStroke in Parkinson’s disease: a review of epidemiological studies and potential pathophysiological mechanisms
Elfil M, Bayoumi A, Sayed A, Aladawi M, Aboutaleb P, Grieb L, Tolba H, Tinaz S. Stroke in Parkinson’s disease: a review of epidemiological studies and potential pathophysiological mechanisms. Acta Neurologica Belgica 2023, 123: 773-783. PMID: 36710306, DOI: 10.1007/s13760-023-02202-4.Peer-Reviewed Original ResearchConceptsParkinson's diseaseEpidemiological studiesNeurological disordersRate of PDCumulative cardiovascular riskRisk of strokePost-stroke complicationsPotential pathophysiological mechanismsRecent epidemiological studiesQuality of lifeCardiovascular riskIschemic insultPathophysiological mechanismsPD patientsNeurological causesEtiological factorsSleep disordersMotor impairmentStrokeDiseasePathological processesDisordersRiskReviewMorbidity
2022
Effect of intravenous antihypertensives on outcomes of severe hypertension in hospitalized patients without acute target organ damage
Ghazi L, Li F, Simonov M, Yamamoto Y, Nugent J, Greenberg J, Bakhoum C, Peixoto A, Wilson F. Effect of intravenous antihypertensives on outcomes of severe hypertension in hospitalized patients without acute target organ damage. Journal Of Hypertension 2022, 41: 288-294. PMID: 36583354, PMCID: PMC9799038, DOI: 10.1097/hjh.0000000000003328.Peer-Reviewed Original ResearchConceptsAcute target organ damageTarget organ damageSevere hypertensionOrgan damageIntravenous antihypertensivesBP elevationClinical outcomesMyocardial injuryTarget end-organ damageOverlap propensity scoreSevere BP elevationAcute kidney injuryBlood pressure reductionEnd-organ damageRisk of strokeInpatient hypertensionCardiovascular eventsIndex hospitalizationKidney injuryRetrospective studyHypertensionAntihypertensivesHospitalizationCox modelPatients
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