2025
Brain connectivity correlates of the impact of a digital intervention for individuals with subjective cognitive decline on depression and IL-18
Catalogna M, Somerville Y, Saporta N, Nathansohn-Levi B, Shelly S, Edry L, Zagoory-Sharon O, Feldman R, Amedi A. Brain connectivity correlates of the impact of a digital intervention for individuals with subjective cognitive decline on depression and IL-18. Scientific Reports 2025, 15: 6863. PMID: 40011544, PMCID: PMC11865443, DOI: 10.1038/s41598-025-91457-3.Peer-Reviewed Original ResearchConceptsBrain connectivityCognitive declineResting-state functional connectivityEffect sizeCognitive behavioral therapyLate-life depressionSelf-reported depressionMedium effect sizeDigital interventionsInterventions targeting mental healthMood regulationBehavioral therapyDepressive symptomsDecreased connectivityPost-intervention changesFunctional connectivityTwo-week interventionCognitive functionSpatial cognitionDepression scoresBrain healthBehavioral outcomesBrain functionPsychological techniquesPsychological healthHypothalamic resting-state functional connectivity and self-evaluated aggression in young adults
Yao Y, Chen Y, Li C. Hypothalamic resting-state functional connectivity and self-evaluated aggression in young adults. Journal Of Psychiatric Research 2025, 182: 421-429. PMID: 39889403, PMCID: PMC11834083, DOI: 10.1016/j.jpsychires.2025.01.045.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityAggression scoresLateral hypothalamusSex differencesHuman Connectome ProjectFunctional connectivityAchenbach Adult Self-ReportAdult Self-ReportYoung adultsManifestations of aggressionVoxel-wise regressionPublished routinesMotivated behaviorOccipital gyriAggressive behaviorSelf-reportMental healthAggressionConnectome ProjectNeural pathwaysBehavioral traitsRSFCHypothalamusScoresAdultsPolygenic risk for depression and resting-state functional connectivity of subgenual anterior cingulate cortex in young adults
Chen Y, Li H, Luo X, Li G, Ide J, Li C. Polygenic risk for depression and resting-state functional connectivity of subgenual anterior cingulate cortex in young adults. Journal Of Psychiatry And Neuroscience 2025, 50: e31-e44. PMID: 39809531, PMCID: PMC11737878, DOI: 10.1503/jpn.240087.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityPolygenic risk scoresSubgenual anterior cingulate cortexAnterior cingulate cortexDepression severityCingulate cortexSubclinical depressionHealthy young adultsSomatic complaintsYoung adultsPolygenic riskAssociated with depression severitySeverity of somatic complaintsSeverity of depressive symptomsAssociated with polygenic riskWhole-brain regressionAlcohol use severityMarkers of depressionManifestations of depressionHuman Connectome ProjectDepressive disorderSubclinical populationsMode networkDepressive symptomsBrain structuresAltered hippocampal effective connectivity predicts BMI and food approach behavior in children with obesity
Li W, Chen X, Gao X, Pang Q, Guo C, Song S, Liu Y, Shi P, Chen H. Altered hippocampal effective connectivity predicts BMI and food approach behavior in children with obesity. International Journal Of Clinical And Health Psychology 2025, 25: 100541. PMID: 39877891, PMCID: PMC11773239, DOI: 10.1016/j.ijchp.2024.100541.Peer-Reviewed Original ResearchFood approach behaviorsApproach behaviorEffective connectivityPediatric obesityExcess weightEating behaviorsResting-state functional connectivityFood reward processingAssessment of eating behaviorModels of obesityLeft postcentral gyrusResting-state fMRIFollow-up assessmentReward processingNormal weightDynamic casual modelingHippocampal connectivityRight hippocampusPostcentral gyrusFunctional connectivityBMIAppetite regulationChildhood obesityAdult obesityObesityInfants’ Resting-State Functional Connectivity and Event-Related Potentials: A Multimodal Approach to Investigating the Neural Basis of Infant Novelty Detection
Kanel D, Morales S, Altman K, Richards J, Winkler A, Pine D, Fox N, Filippi C. Infants’ Resting-State Functional Connectivity and Event-Related Potentials: A Multimodal Approach to Investigating the Neural Basis of Infant Novelty Detection. Developmental Psychology 2025 PMID: 39760730, DOI: 10.1037/dev0001892.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingEvent-related potentialsEvent-related potential dataResting-state functional connectivityMismatch responsesFunctional connectivityRegions-of-interestRs-FCThree-stimulus auditory oddball taskResting-state functional magnetic resonance imagingFunctional magnetic resonance imaging dataSuperior parietal cortexPosterior cingulate cortexVentral attention networkSuperior parietal lobuleBilateral auditory corticesAuditory oddball taskNovelty detectionNovelty processingCingulate cortexNeural basisParietal lobuleNovel stimuliP3 responseSomatomotor networkErratum for: Alterations in Volume and Intrinsic Resting-State Functional Connectivity Detected at Brain MRI in Individuals with Opioid Use Disorder.
Mehta S, Peterson H, Ye J, Ibrahim A, Saeed G, Linsky S, Kreinin I, Tsang S, Nwanaji-Enwerem U, Raso A, Arora J, Tokoglu F, Yip S, Hahn C, Lacadie C, Greene A, Jeon S, Constable R, Barry D, Redeker N, Yaggi H, Scheinost D. Erratum for: Alterations in Volume and Intrinsic Resting-State Functional Connectivity Detected at Brain MRI in Individuals with Opioid Use Disorder. Radiology 2025, 314: e249023. PMID: 39873610, PMCID: PMC11788710, DOI: 10.1148/radiol.249023.Peer-Reviewed Original ResearchFunctional connectivityIntrinsic resting-state functional connectivityResting-state functional connectivityOpioid use disorderBrain MRIUse disorderOpioidMRI
2024
Consistent frontal-limbic-occipital connections in distinguishing treatment-resistant and non-treatment-resistant schizophrenia
Zhang Y, Gao S, Liang C, Bustillo J, Kochunov P, Turner J, Calhoun V, Wu L, Fu Z, Jiang R, Zhang D, Jiang J, Wu F, Peng T, Xu X, Qi S. Consistent frontal-limbic-occipital connections in distinguishing treatment-resistant and non-treatment-resistant schizophrenia. NeuroImage Clinical 2024, 45: 103726. PMID: 39700898, PMCID: PMC11721508, DOI: 10.1016/j.nicl.2024.103726.Peer-Reviewed Original ResearchNon-treatment-resistant schizophreniaTreatment-resistant schizophreniaFunctional connectivityDiagnosis of SZHealthy controlsFrontal-parietalResting-state functional connectivityAutomated anatomical labelingDysfunctional brain connectivityBrain functional connectivityAffiliated Brain Hospital of Nanjing Medical UniversityFrontal limbBrain connectivitySchizophreniaMedication dosageTreatment resistanceNeural pathwaysNanjing Medical UniversityDisease progressionMedical UniversityClinical practiceSpecific biomarkersDiagnosisAnatomical labelingNeuroimaging Correlates of the NIH-Toolbox-Driven Cognitive Metrics in Children
Acosta-Rodriguez H, Yuan C, Bobba P, Stephan A, Zeevi T, Malhotra A, Tran A, Kaltenhauser S, Payabvash S. Neuroimaging Correlates of the NIH-Toolbox-Driven Cognitive Metrics in Children. Journal Of Integrative Neuroscience 2024, 23: 217. PMID: 39735971, PMCID: PMC11851640, DOI: 10.31083/j.jin2312217.Peer-Reviewed Original ResearchConceptsCognitive composite scoreAdolescent Brain Cognitive DevelopmentFluid cognition composite scoresStructural magnetic resonance imagingComposite scoreDiffusion tensor imagingNeuroimaging correlatesCognitive functionRs-fMRINational Institutes of Health (NIH) Toolbox Cognition BatteryCognitive scoresMicrostructural integrityResting-state functional connectivityCrystallized cognition composite scoreCortical surface areaTotal cognitive scoreWM microstructural integrityCognitive batteryCrystallized cognitionNeuroanatomical correlatesWhite matterCognitive performanceNeuroimaging metricsFunctional connectivityNeuroimaging dataAlterations in Volume and Intrinsic Resting-State Functional Connectivity Detected at Brain MRI in Individuals with Opioid Use Disorder.
Mehta S, Peterson H, Ye J, Ibrahim A, Saeed G, Linsky S, Kreinin I, Tsang S, Nwanaji-Enwerem U, Raso A, Arora J, Tokoglu F, Yip S, Hahn C, Lacadie C, Greene A, Jeon S, Constable R, Barry D, Redeker N, Yaggi H, Scheinost D. Alterations in Volume and Intrinsic Resting-State Functional Connectivity Detected at Brain MRI in Individuals with Opioid Use Disorder. Radiology 2024, 313: e240514. PMID: 39656127, PMCID: PMC11694074, DOI: 10.1148/radiol.240514.Peer-Reviewed Original ResearchConceptsHealthy control participantsRight medial temporal lobeOpioid use disorderFunctional brain alterationsMedial temporal lobeOpioid use disorder groupFunctional connectivityUse disorderControl participantsBrain alterationsIntrinsic resting-state functional connectivityTemporal lobeMedial prefrontal cortex volumesVoxel-wise linear regressionT1-weighted MRIResting-state functional connectivityFamily-wise error correctionPrefrontal cortex volumeResting-state functional MRIIncreased functional connectivityIntrinsic connectivity distributionFunctional MRI studiesFemale participantsRegional brain volumesAssess group differencesAssociation between cannabis use and brain structure and function: an observational and Mendelian randomisation study
Ishrat S, Levey D, Gelernter J, Ebmeier K, Topiwala A. Association between cannabis use and brain structure and function: an observational and Mendelian randomisation study. BMJ Mental Health 2024, 27: e301065. PMID: 39477366, PMCID: PMC11529520, DOI: 10.1136/bmjment-2024-301065.Peer-Reviewed Original ResearchConceptsCannabis useBrain structuresFunctional connectivityHistory of cannabis useResting-state functional connectivityMeasures of brain structureLifetime cannabis useCentral executive networkLifetime cannabis usersWhite matter integrityGenu of the corpus callosumMendelian randomisation analysisAssociated with multiple measuresPoorer white matter integrityInvestigate potential causal relationshipsCannabis usersExecutive networkBrain regionsImaging-derived phenotypesBrain healthCannabisRandomisation analysesTwo-sample Mendelian randomisation analysisFractional anisotropyYoung adulthoodLongitudinal development of resting-state functional connectivity in adolescents with and without internalizing disorders
Roelofs E, Bas-Hoogendam J, Winkler A, van der Wee N, Vermeiren R. Longitudinal development of resting-state functional connectivity in adolescents with and without internalizing disorders. Neuroscience Applied 2024, 3: 104090. PMID: 39634556, PMCID: PMC11615185, DOI: 10.1016/j.nsa.2024.104090.Peer-Reviewed Original ResearchRight laterobasal amygdalaLaterobasal amygdalaWhole-brain networksAmygdala subregionsFunctional connectivityCentromedial amygdalaSymptom changeFrontal poleInternalizing disordersPostcentral gyrusResting-state functional magnetic resonance imagingResting-state functional connectivityFunctional magnetic resonance imagingICA-derived networksClinically representative sampleFC developmentNonspecific treatment effectsRs-fMRI scansIndependent component analysisResting-state networksLongitudinal developmentCare-as-usualComorbid anxietyNeuroimaging researchBilateral seedsDiverging Effects of Violence Exposure and Psychiatric Symptoms on Amygdala-Prefrontal Maturation during Childhood and Adolescence
Keding T, Russell J, Zhu X, He Q, Li J, Herringa R. Diverging Effects of Violence Exposure and Psychiatric Symptoms on Amygdala-Prefrontal Maturation during Childhood and Adolescence. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2024 PMID: 39182725, PMCID: PMC11885587, DOI: 10.1016/j.bpsc.2024.08.003.Peer-Reviewed Original ResearchBasolateral amygdalaFunctional connectivityPsychiatric symptomsViolence exposureCircuit maturationOrbitofrontal cortex functional connectivityDevelopment of psychiatric symptomsResting-state functional connectivityEffects of violence exposureAmygdala-prefrontal cortexSeverity of psychopathologyBrain age gap estimationIncreased psychiatric symptomsPhiladelphia Neurodevelopmental CohortThreat appraisal processEffects of adversityExposure to violenceNeurobiological correlatesAssociated with delayed maturationBrain circuitryNeurodevelopmental mechanismsPsychiatric riskIndividual differencesNeurodevelopmental CohortAtypical neurodevelopmentNeurodevelopmental subtypes of functional brain organization in the ABCD study using a rigorous analytic framework
DeRosa J, Friedman N, Calhoun V, Banich M. Neurodevelopmental subtypes of functional brain organization in the ABCD study using a rigorous analytic framework. NeuroImage 2024, 299: 120827. PMID: 39245397, PMCID: PMC11779700, DOI: 10.1016/j.neuroimage.2024.120827.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityAdolescent Brain Cognitive DevelopmentIndividual’s resting-state functional connectivityAdolescent Brain Cognitive Development StudyFunctional brain organizationMental health profilesMental health characteristicsRsFC dataBrain organizationFunctional connectivityDevelopmental trajectoriesChildren aged 9Emotional functioningCognitive developmentLate childhoodAged 9SubtypesAdolescentsHealth characteristicsHealth profileChildhoodPost-treatment alterations in white matter integrity in PTSD: Effects on symptoms and functional connectivity a secondary analysis of an RCT
Korem N, Duek O, Ben-Zion Z, Spiller T, Gordon C, Amen S, Levy I, Harpaz-Rotem I. Post-treatment alterations in white matter integrity in PTSD: Effects on symptoms and functional connectivity a secondary analysis of an RCT. Psychiatry Research Neuroimaging 2024, 343: 111864. PMID: 39111111, DOI: 10.1016/j.pscychresns.2024.111864.Peer-Reviewed Original ResearchReduced resting-state functional connectivityPost-traumatic stress disorderPost-traumatic stress disorder symptomsFunctional connectivityPost-treatment changesReducing PTSD symptom severityFollow-up changesResting-state functional connectivityIntensive exposure therapyExposure-based psychotherapyVentromedial prefrontal cortexPTSD symptom severityReduced structural connectivityFunctional connectivity patternsPost-treatmentWhite matter integrityPrefrontal cortexExposure therapyPTSD symptomsStress disorderSymptom severityUncinate fasciculusLimbic systemSecondary analysisAssociated with sustained changesCross‐cohort replicable resting‐state functional connectivity in predicting symptoms and cognition of schizophrenia
Zhao C, Jiang R, Bustillo J, Kochunov P, Turner J, Liang C, Fu Z, Zhang D, Qi S, Calhoun V. Cross‐cohort replicable resting‐state functional connectivity in predicting symptoms and cognition of schizophrenia. Human Brain Mapping 2024, 45: e26694. PMID: 38727014, PMCID: PMC11083889, DOI: 10.1002/hbm.26694.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingNegative symptomsFunctional connectivityCognitive impairmentPrediction of negative symptomsResting-state functional connectivityAssociated with reduced cognitive functionDebilitating mental illnessHealthy controlsPredicting functional connectivityEarly adulthood onsetPositive symptomsNeural underpinningsSchizophreniaCognitive functionSensorimotor networkPredicting symptomsMental illnessConnectivity patternsClinical interventionsMagnetic resonance imagingAdulthood onsetSymptomsImpairmentResonance imagingKetamine induces multiple individually distinct whole-brain functional connectivity signatures
Moujaes F, Ji J, Rahmati M, Burt J, Schleifer C, Adkinson B, Savic A, Santamauro N, Tamayo Z, Diehl C, Kolobaric A, Flynn M, Rieser N, Fonteneau C, Camarro T, Xu J, Cho Y, Repovs G, Fineberg S, Morgan P, Seifritz E, Vollenweider F, Krystal J, Murray J, Preller K, Anticevic A. Ketamine induces multiple individually distinct whole-brain functional connectivity signatures. ELife 2024, 13: e84173. PMID: 38629811, PMCID: PMC11023699, DOI: 10.7554/elife.84173.Peer-Reviewed Original ResearchConceptsResponse to ketamineAcute ketamineBehavioral effectsQuantified resting-state functional connectivityEffects of acute ketamineSymptom variationResting-state functional connectivityTreatment-resistant depressionFunctional connectivity signaturesGlobal brain connectivitySingle-subject levelInter-individual variabilityPlacebo-controlled studyFunctional connectivityConnectivity signaturesBrain connectivityHealthy participantsSingle-blind placebo-controlled studyNeural variationsTreatment conditionsKetamineGene expression targetsPharmacological biomarkersPilot awardParvalbuminPreliminary examination of the effects of an early parenting intervention on amygdala-orbitofrontal cortex resting-state functional connectivity among high-risk children: A randomized clinical trial.
Korom M, Valadez E, Tottenham N, Dozier M, Spielberg J. Preliminary examination of the effects of an early parenting intervention on amygdala-orbitofrontal cortex resting-state functional connectivity among high-risk children: A randomized clinical trial. Development And Psychopathology 2024, 37: 384-392. PMID: 38247369, PMCID: PMC11260902, DOI: 10.1017/s0954579423001669.Peer-Reviewed Original ResearchResting-state functional connectivityMiddle childhoodFunctional connectivityResting-state functional MRI scansChildren's emotion regulationFunctional MRI scansChild protective servicesRs-FC analysisEarly parenting interventionsCPS-involved familiesEmotion regulationRs-FCSeed-based RS FC analysisFoster care programsEvidence-based parenting programsParenting interventionsHigh-risk childrenGroup-level predictorsComparison groupParenting programsGroup of familiesMRI scansChildrenRandomized clinical trialsChildhoodAtypical Interpersonal Problem-Solving and Resting-state Functional Connectivity in Adolescents with Maltreatment Experience
Gerin M, Viding E, Puetz V, Armbruster-Genc D, Rankin G, McCrory E. Atypical Interpersonal Problem-Solving and Resting-state Functional Connectivity in Adolescents with Maltreatment Experience. Current Neuropharmacology 2024, 22: 290-301. PMID: 37818587, PMCID: PMC10788892, DOI: 10.2174/1570159x22666231002145440.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityPosterior cingulate cortexMedial prefrontal cortexMental health symptomsMaltreatment experiencesSocial functioningLingual gyrusFunctional connectivityHealth symptomsInterpersonal problem-solving skillsRetrosplenial cortexElevated mental health symptomsDefault mode network hubInterpersonal problem solvingPoor social functioningAdverse environmental experiencesProblem-solving performanceNon-maltreated peersProblem-solving skillsExperiences of abuseSeed-based analysisNeurocognitive processingNeurocognitive functioningMental health disordersEarly adversity
2023
Relationship between loss of awareness of cognitive decline and tau pathology in the Alzheimer’s disease spectrum: modulatory role of resting‐state functional connectivity
Cacciamani F, Gagliardi G, Mimmack K, Qiao K, Bueichekú E, Marshall G, Sepulcre J, Diez I, Vannini P. Relationship between loss of awareness of cognitive decline and tau pathology in the Alzheimer’s disease spectrum: modulatory role of resting‐state functional connectivity. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.079806.Peer-Reviewed Original ResearchAwareness of cognitive declineResting-state functional connectivityLinear regression modelsSelf-referential networkHigher tau burdenFunctional connectivityCognitive declineRegression modelsTau accumulationAlzheimer's diseaseImpaired resting-state functional connectivityAlzheimer's disease spectrumResting-state fMRI dataAssociated with tau accumulationDorsal attention networkReduced awarenessWithin-network connectivityModulatory roleLow awarenessTau burdenEffects of tauCognitive function indicesTau interactionsSalience networkTau pathologyA systematic review of childhood maltreatment and resting state functional connectivity
Gerin M, Viding E, Herringa R, Russell J, McCrory E. A systematic review of childhood maltreatment and resting state functional connectivity. Developmental Cognitive Neuroscience 2023, 64: 101322. PMID: 37952287, PMCID: PMC10665826, DOI: 10.1016/j.dcn.2023.101322.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityAnterior cingulate cortexFunctional connectivityCingulate cortexChildhood maltreatmentAltered functional connectivityState functional connectivityDorsal anterior cingulate cortexNegative psychiatric outcomesVentral anterior cingulate cortexDorsolateral prefrontal cortexRsFC alterationsAltered connectivityInclusion criteriaAmygdala connectivityNineteen studiesPsychiatric outcomesFuture symptomsSystematic reviewBrain regionsClinical disordersBrain circuitsAnterior insulaPrefrontal cortexMaltreatment exposure
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