2025
Chapter 14 Molecular biology, genetic, and epigenetics of kidney tumor
Kazemi R, Rezaeian A, Deyhimfar R, Taheri D. Chapter 14 Molecular biology, genetic, and epigenetics of kidney tumor. 2025, 209-221. DOI: 10.1016/b978-0-443-27302-5.00003-6.Peer-Reviewed Original ResearchDNA damage repair genesKidney cancer developmentRenal cell carcinomaTumor suppressor genePlanning therapeutic strategiesRenal tumorsUrothelial carcinomaWilms tumorCell carcinomaRenal sarcomaKidney tumorsClinical manifestationsUrological cancersKidney cancerPredisposing genesSuppressor geneTherapeutic strategiesCancer developmentTumorRepair genesCancerCarcinomaKidneyGenetic basisGenetic changes
2024
Renal bleeding: imaging and interventions in patients with tumors
Singer E, Karbasian N, Katz D, Wong V, Abdelsalam M, Stanietzky N, Nguyen T, Shenoy-Bhangle A, Badawy M, Revzin M, Shehata M, Eltaher M, Elsayes K, Korivi B. Renal bleeding: imaging and interventions in patients with tumors. Diagnostic And Interventional Radiology 2024 PMID: 38874163, DOI: 10.4274/dir.2024.242822.Peer-Reviewed Original ResearchRenal bleedingComputed tomographyRenal tumorsSpontaneous renal bleedingMalignant renal tumorsRenal cell carcinomaCross-sectional imaging techniquesFollow-up evaluationEffective patient managementMagnetic resonance imagingAdvanced imaging techniquesCell carcinomaClinical presentationCoagulation disordersImaging techniquesImaging findingsVascular anomaliesUreteral obstructionTreatment optionsEnhancing massBleedingPatient managementTumorResonance imagingPatientsSarcomatoid and Rhabdoid Renal Cell Carcinoma
Adeniran A, Shuch B, Humphrey P. Sarcomatoid and Rhabdoid Renal Cell Carcinoma. The American Journal Of Surgical Pathology 2024, 48: e65-e88. PMID: 38736105, DOI: 10.1097/pas.0000000000002233.Peer-Reviewed Original ResearchRenal cell carcinomaSarcomatoid renal cell carcinomaGenomic alterationsRhabdoid differentiationRhabdoid cellsCell carcinomaWHO classification of renal tumorsClassification of renal tumorsInternational Collaboration on Cancer ReportingHistologic types of renal cell carcinomaPleomorphic undifferentiated sarcomaMalignant spindle cellsAggressive biological behaviorMolecular featuresMolecular mechanisms of tumorigenesisMechanisms of tumorigenesisSarcomatoid growthRhabdoid componentSarcomatoid componentRhabdoid featuresRenal tumorsClinical responseCollege of American PathologistsRhabdoid morphologySarcomatoid elements
2023
CD70 is Consistently Expressed in Primary and Metastatic Clear Cell Renal Cell Carcinoma
Huang R, Chen Z, Kroeger N, Pantuck A, Said J, Kluger H, Shuch B, Ye H. CD70 is Consistently Expressed in Primary and Metastatic Clear Cell Renal Cell Carcinoma. Clinical Genitourinary Cancer 2023, 22: 347-353. PMID: 38195301, DOI: 10.1016/j.clgc.2023.12.003.Peer-Reviewed Original ResearchRenal cell carcinomaClear cell renal cell carcinomaCell renal cell carcinomaMetastatic clear cell renal cell carcinomaMetastatic renal cell carcinomaCell carcinomaClear cell carcinomaCD70 expressionMetastatic tumorsRenal tumorsTherapeutic targetAdvanced renal cell carcinomaMetastatic clear cell carcinomaCancer-specific survivalPapillary renal cell carcinomaExpression of CD70Normal renal parenchymaPrimary renal tumorsPrimary tumor tissuesPromising therapeutic targetPotential therapeutic targetHypoxia pathway proteinsHypoxia-inducible factorSarcomatoid differentiationNormal human tissuesPediatric renal malignancy diagnosis is associated with significant burden of care for families
Leraas H, Thompson S, Sandoe E, Robles J, Wagner L, Scales C, Gow K, Ehrlich P, Greenup R, Tracy E. Pediatric renal malignancy diagnosis is associated with significant burden of care for families. Pediatric Blood & Cancer 2023, 70: e30494. PMID: 37337248, DOI: 10.1002/pbc.30494.Peer-Reviewed Original ResearchHealthcare utilizationRenal malignancySolid tumor diagnosisNorth Carolina MedicaidComplex care coordinationBurden of careChildhood cancer diagnosisRenal tumor diagnosisTumor diagnosisSubsequent nephrectomyMedian ageStudy criteriaCare coordinationRenal tumorsCancer regimensPatient visitsDiseases codesMalignancy diagnosisInternational ClassificationSignificant burdenMedical careDiagnosisCancer diagnosisMonthsMedical facilities
2021
929 Dissecting intratumoral immune organization: defining the comparative cellular composition of tertiary lymphoid structures T-cell supportive antigen presenting niches in renal tumors
Jansen C, Sobierajska E, Greenwald R, Carlisle J, Mullane P, Prokhnevska N, Cardenas M, Bilen M, Osunkoya A, Master V, Kissick H. 929 Dissecting intratumoral immune organization: defining the comparative cellular composition of tertiary lymphoid structures T-cell supportive antigen presenting niches in renal tumors. Journal For ImmunoTherapy Of Cancer 2021, 9: a975-a975. DOI: 10.1136/jitc-2021-sitc2021.929.Peer-Reviewed Original Research
2020
Is There a Role for Combination, Single-Session Selective Transarterial Embolization and Microwave Ablation for Large Renal Masses?
LaRussa S, Vanden Berg RW, Craig KM, Madoff DC, McClure TD. Is There a Role for Combination, Single-Session Selective Transarterial Embolization and Microwave Ablation for Large Renal Masses? CardioVascular And Interventional Radiology 2020, 43: 1468-1473. PMID: 32613266, DOI: 10.1007/s00270-020-02568-5.Peer-Reviewed Original ResearchConceptsLarge renal massTransarterial embolizationRenal tumorsRenal massesMicrowave ablationCharleston Comorbidity IndexLarge renal tumorsEvidence of recurrencePost-procedure complicationsAverage tumor sizeSelective transarterial embolizationSmall renal tumorsClear cell carcinomaMeeting inclusion criteriaPatient demographic informationGroin hematomaComorbidity indexResultsEleven patientsAverage BMICase seriesSuccessful ablationTumor sizeCell carcinomaMean ageRENAL score
2019
Abstract 2700: CD8 T-cell infiltration into renal tumors requires a supportive antigen-presenting niche
Jansen C, Prokhnevska N, Master V, Carlisle J, Bilen M, Reyes A, Kissick H. Abstract 2700: CD8 T-cell infiltration into renal tumors requires a supportive antigen-presenting niche. Cancer Research 2019, 79: 2700-2700. DOI: 10.1158/1538-7445.am2019-2700.Peer-Reviewed Original ResearchCD8 T cell infiltrationT cell infiltrationTumor-infiltrating lymphocytesT cell responsesRenal cell carcinomaStem-like T cellsCancer-specific survivalT cellsRenal tumorsPatient survivalCD8 tumor-infiltrating lymphocytesPoor T-cell infiltrationDisease progressionAnti-tumor immune responseCD8 T cell responsesImmune responseTumor-infiltrating immune cellsFlow cytometryRenal cell carcinoma patientsCD8 T cellsStage III patientsIntensification of therapyRenal cell tumorsFollow-up timeEmory University HospitalCurrent Status of Immunotherapy for Localized and Locally Advanced Renal Cell Carcinoma
Ghali F, Patel S, Derweesh I. Current Status of Immunotherapy for Localized and Locally Advanced Renal Cell Carcinoma. Journal Of Oncology 2019, 2019: 7309205. PMID: 31057615, PMCID: PMC6463563, DOI: 10.1155/2019/7309205.Peer-Reviewed Original ResearchAdvanced renal cell carcinomaRenal cell carcinomaAdjuvant therapyNeoadjuvant therapyCell carcinomaMetastatic renal cell carcinomaTyrosine kinase inhibitor sunitinibPresurgical tumor reductionSystemic therapy strategiesFirst-line therapyPhase II studyNephron-sparing surgeryPrimary renal tumorsKinase inhibitor sunitinibNeoadjuvant immunotherapyNeoadjuvant strategiesII studyLine therapySurgical resectionRadical resectionCheckpoint inhibitionAdjuvant agentTumor reductionRenal tumorsClinical trials
2014
PAX-8 expression in renal tumours and distant sites: A useful marker of primary and metastatic renal cell carcinoma?
Barr ML, Jilaveanu LB, Camp RL, Adeniran AJ, Kluger HM, Shuch B. PAX-8 expression in renal tumours and distant sites: A useful marker of primary and metastatic renal cell carcinoma? Journal Of Clinical Pathology 2014, 68: 12. PMID: 25315900, PMCID: PMC4429054, DOI: 10.1136/jclinpath-2014-202259.Peer-Reviewed Original ResearchConceptsRenal cell carcinomaPAX-8 expressionMetastatic renal cell carcinomaRenal tumorsMetastatic sitesCell carcinomaClear cell renal cell carcinomaPAX-8 stainingCell renal cell carcinomaPAX-8Distant sitesNormal renal tissueUseful diagnostic markerAdjacent normal kidneyHistological typePrimary tumorDistant tumorsLack of expressionRenal originImmunohistochemical stainsChromophobe tumorsClear cellsRenal tissueNormal kidneyTissue microarrayOutcomes in patients undergoing nephrectomy for renal cancer on chronic anticoagulation therapy
Sfakianos J, Hakimi A, Kim P, Zabor E, Mano R, Bernstein M, Karellas M, Russo P. Outcomes in patients undergoing nephrectomy for renal cancer on chronic anticoagulation therapy. European Journal Of Surgical Oncology 2014, 40: 1700-1705. PMID: 24813810, PMCID: PMC4208948, DOI: 10.1016/j.ejso.2014.04.010.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAnticoagulantsAspirinBlood TransfusionFemaleFibrinolytic AgentsHumansIncidenceIntraoperative ComplicationsKidney NeoplasmsLength of StayMaleMiddle AgedNeoplasm StagingNephrectomyPlatelet Aggregation InhibitorsPostoperative ComplicationsRetrospective StudiesRisk FactorsSeverity of Illness IndexTreatment OutcomeUnited StatesConceptsOverall complication rateComplication rateChronic anticoagulationRenal tumorsChronic anticoagulation therapyLength of stayLogistic regression modelsACT patientsAspirin patientsChronic aspirinHigher transfusionAnticoagulation therapyASA scoreAspirin useTransfusion rateAnticoagulation groupSurgical resectionMedian lengthOpen surgeryClinical differencesRenal surgeryGrade 3Renal cancerRetrospective analysisAnticoagulation
2008
Survival rates after resection for localized kidney cancer: 1989 to 2004
Russo P, Jang T, Pettus J, Huang W, Eggener S, O'Brien M, Karellas M, Karanikolas N, Kagiwada M. Survival rates after resection for localized kidney cancer: 1989 to 2004. Cancer 2008, 113: 84-96. PMID: 18470927, PMCID: PMC3985136, DOI: 10.1002/cncr.23520.Peer-Reviewed Original ResearchConceptsProgression-free survivalNumber of nephrectomiesProportion of patientsOverall patient survivalDisease progressionKidney cancerOverall survivalLocal recurrenceDistant metastasisPatient survivalTumor sizeRenal tumorsFive-year progression-free survivalMemorial Sloan-Kettering Cancer CenterMultivariate Cox regression analysisConcomitant lymph node dissectionSelect renal tumorsSurgery-related characteristicsLymph node dissectionYear of surgeryKaplan-Meier methodCox regression analysisCurrent treatment paradigmsSmall renal tumorsTumor size categories
2005
Percutaneous Radiofrequency Ablation of Renal Tumors: Technique, Complications, and Outcomes
Ahrar K, Matin S, Wood CG, Wallace MJ, Gupta S, Madoff DC, Rao S, Tannir NM, Jonasch E, Pisters LL, Rozner MA, Kennamer DL, Hicks ME. Percutaneous Radiofrequency Ablation of Renal Tumors: Technique, Complications, and Outcomes. Journal Of Vascular And Interventional Radiology 2005, 16: 679-688. PMID: 15872323, DOI: 10.1097/01.rvi.0000153589.10908.5f.Peer-Reviewed Original ResearchConceptsPercutaneous radiofrequency ablationPercutaneous RF ablationRenal tumorsGross hematuriaPrimary tumorTechnical successRF ablationRadiofrequency ablationHigh technical success rateAbdominal wall weaknessTechnical success rateSignificant clinical sequelaeAnterior abdominal wallComputed tomography guidanceClinical sequelaeMinor complicationsRenal functionTransient paresthesiaConsecutive patientsMajor complicationsUrinary obstructionOvernight observationGeneral anesthesiaTomography guidanceMedical records649: Comparison of Laparoscopic Microwave Thermotherapy, Cryotherapy, and Radiofrequency Ablation for Destruction of Experimental VX-2 Renal Tumors in Rabbits
Kim I, Eichel L, Chou D, Abdelshehid C, Ahlering M, McDougall E, Clayman R. 649: Comparison of Laparoscopic Microwave Thermotherapy, Cryotherapy, and Radiofrequency Ablation for Destruction of Experimental VX-2 Renal Tumors in Rabbits. Journal Of Urology 2005, 173: 177. DOI: 10.1016/s0022-5347(18)34889-4.Peer-Reviewed Original Research
1995
Secretion of a Large Molecular‐Weight Form of Insulin‐Like Growth Factor by a Primary Renal Tumor
Korn E, van Hoff J, Buckley P, Daughaday W, Carpenter T. Secretion of a Large Molecular‐Weight Form of Insulin‐Like Growth Factor by a Primary Renal Tumor. Pediatric Blood & Cancer 1995, 24: 392-396. PMID: 7715546, DOI: 10.1002/mpo.2950240610.Peer-Reviewed Original ResearchConceptsPrimary renal tumorsIGF-IIRenal tumorsInsulin-like growth factor-II levelsInsulin-like growth factorIGF-II contentPost-operative serumTotal IGF-IIFactor II levelsPediatric renal tumorsLarge molecular weight formsPreoperative serumAbdominal massTumor resectionII levelsBiochemical hypoglycemiaHypoglycemiaTumor tissueTumorsGrowth factorResectionMolecular weight formsSerumPatientsHistology
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