2025
Chronotherapeutic intervention targeting emotion regulation brain circuitry, symptoms, and suicide risk in adolescents and young adults with bipolar disorder: a pilot randomised trial
Kim J, Sankar A, Marks R, Carrubba E, Lecza B, Quatrano S, Spencer L, Constable R, Pittman B, Lebowitz E, Silverman W, Swartz H, Blumberg H. Chronotherapeutic intervention targeting emotion regulation brain circuitry, symptoms, and suicide risk in adolescents and young adults with bipolar disorder: a pilot randomised trial. BMJ Mental Health 2025, 28: e301338. PMID: 39971594, PMCID: PMC11840897, DOI: 10.1136/bmjment-2024-301338.Peer-Reviewed Original ResearchConceptsBipolar disorderEmotion regulationSuicide riskBrain circuitryChronotherapeutic interventionsEmotional face stimuliLeft amygdala responseRisk of bipolar disorderTargeting emotion regulationReduce suicide riskHigher suicide riskYoung adultsFunctional MRI dataPost-treatment improvementAmygdala responsePotential intervention targetsEmotion dysregulationMania symptomsMood episodesFace stimuliCircuitry dysfunctionRegulation therapyDaily rhythmsWeekly sessionsSelf-monitoring
2021
Telehealth Social Rhythm Therapy to Reduce Mood Symptoms and Suicide Risk Among Adolescents and Young Adults With Bipolar Disorder
Sankar A, Panchal P, Goldman DA, Colic L, Villa LM, Kim JA, Lebowitz ER, Carrubba E, Lecza B, Silverman WK, Swartz HA, Blumberg HP. Telehealth Social Rhythm Therapy to Reduce Mood Symptoms and Suicide Risk Among Adolescents and Young Adults With Bipolar Disorder. American Journal Of Psychotherapy 2021, 74: 172-177. PMID: 34293928, PMCID: PMC9588254, DOI: 10.1176/appi.psychotherapy.20210011.Peer-Reviewed Original ResearchConceptsSocial rhythm therapyMood symptomsSocial rhythm regularityBipolar disorderYoung adultsRhythm therapySuicide riskRhythm regularityTherapeutic allianceSecondary outcome measuresRhythm irregularitiesClient Satisfaction QuestionnaireBipolar disorder symptomsStrong therapeutic allianceWorking Alliance InventoryPostintervention changesOutcome measuresSuicide propensitySecondary aimSymptomsRegulation therapyIntervention impactSatisfaction questionnaireTherapyGlobal score
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