2025
A comprehensive evaluation of gene expression-based signatures for detecting tertiary lymphoid structures (TLS) in metastatic renal cell carcinoma (mRCC).
Saad E, El Ahmar N, Simsek B, Jegede O, Matar S, Mohanna R, Yekeduz E, McDermott D, Plimack E, Sosman J, Haas N, Hurwitz M, Hammers H, Van Allen E, Choueiri T, Atkins M, Signoretti S, Braun D. A comprehensive evaluation of gene expression-based signatures for detecting tertiary lymphoid structures (TLS) in metastatic renal cell carcinoma (mRCC). Journal Of Clinical Oncology 2025, 43: 591-591. DOI: 10.1200/jco.2025.43.5_suppl.591.Peer-Reviewed Original ResearchMetastatic renal cell carcinomaMature tertiary lymphoid structuresTertiary lymphoid structuresTLS signatureArea under the receiver operating characteristicSignature scoreGene set variation analysisExpression-based signaturesCD8 densityStaining of tumor sectionsTertiary lymphoid structure densityResponse to immunotherapyTreatment naive patientsGene signature scoresGene expression-based signaturesRenal cell carcinomaSpearman correlationGene expression signaturesReceiver operating characteristicPrimary tumorAlternative diagnostic toolCell carcinomaTumor sectionsLymphoid structuresLymphoid aggregatesCD177, MYBL2, and RRM2 Are Potential Biomarkers for Musculoskeletal Infections.
Agidigbi T, Fram B, Molloy I, Riedel M, Wiznia D, Oh I. CD177, MYBL2, and RRM2 Are Potential Biomarkers for Musculoskeletal Infections. Clinical Orthopaedics And Related Research® 2025 PMID: 39915095, DOI: 10.1097/corr.0000000000003402.Peer-Reviewed Original ResearchPeripheral blood mononuclear cellsFracture-related infectionRibonucleotide reductase regulatory subunit M2Peripheral blood mononuclear cell levelsPeripheral blood mononuclear cell concentrationsPeriprosthetic joint infectionMusculoskeletal infectionsMonitoring treatment responseDiabetic foot infectionsTreatment responseReceiver operating characteristicPurulent drainageControl groupSerum levelsSinus tractInflammatory markersBlood samplesFoot infectionsInfection groupDiagnostic accuracyTranscriptomic analysis of peripheral blood mononuclear cellsDiagnosis of musculoskeletal infectionsNormalization of inflammatory markersPeripheral blood mononuclear cells of patientsInflammatory conditionsEvaluation of naturally occurring IgG anti-Vi antibody titers as predictors and correlates of typhoid fever in Dhaka, Bangladesh
Khanam F, Rickett N, Ahmmed F, Islam M, Mbae C, Im J, Aziz A, Ongadi B, Chowdhury F, Khan A, Akter A, Firoj M, Rahman S, Haile K, Park S, Mwebia M, Mwangi M, Ngugi B, Behute M, Kering K, Agampodi S, Kanungo S, Liu X, Pollard A, Zaman K, Kim D, Kariuki S, Qadri F, Clemens J. Evaluation of naturally occurring IgG anti-Vi antibody titers as predictors and correlates of typhoid fever in Dhaka, Bangladesh. BMC Infectious Diseases 2025, 25: 149. PMID: 39891051, PMCID: PMC11786536, DOI: 10.1186/s12879-025-10548-8.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAntibodies, BacterialBangladeshChildChild, PreschoolCohort StudiesEnzyme-Linked Immunosorbent AssayFemaleHumansImmunoglobulin GIncidenceInfantMaleMiddle AgedPolysaccharides, BacterialSalmonella typhiSeroepidemiologic StudiesTyphoid FeverTyphoid-Paratyphoid VaccinesYoung AdultConceptsAnti-Vi antibodiesTyphoid feverReceiver operating characteristicTyphoid riskIncidence of typhoid feverCulture-confirmed typhoid feverAntibody titersResultsThe ROC analysisCox proportional hazards modelsRisk of typhoidTyphoid infectionEnzyme-linked immunosorbent assayProportional hazards modelMethodsWe analyzed dataPresence of antibodiesTyphoidCohort studyTyphoid vaccineROC analysisAntibody levelsCrude analysisIncreased seroprevalenceFeverHazards modelNatural immunityDevelopment of a Clinical and Ultrasonic Parameter-Based Nomogram Model to Predict Restenosis after Superficial Femoral Artery Stenting
Wang Y, Gao M, Zhao X, Han P, Zhang L, Dardik A. Development of a Clinical and Ultrasonic Parameter-Based Nomogram Model to Predict Restenosis after Superficial Femoral Artery Stenting. Annals Of Vascular Surgery 2025, 113: 175-185. PMID: 39855385, DOI: 10.1016/j.avsg.2024.12.068.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAlloysDecision Support TechniquesEndovascular ProceduresFemaleFemoral ArteryHumansMaleMiddle AgedNomogramsPeripheral Arterial DiseasePredictive Value of TestsRecurrenceReproducibility of ResultsRetrospective StudiesRisk AssessmentRisk FactorsSelf Expandable Metallic StentsStentsTime FactorsTreatment OutcomeConceptsIn-stent restenosisSuperficial femoral arteryDecision curve analysisSuperficial femoral artery stentingLogistic regression analysisPeripheral arterial diseaseReceiver operating characteristicNomogram modelClinical utilityCurve analysisMultivariate logistic regression analysisSelf-expanding bare nitinol stentsTreated with stentingReceiver operating characteristic curveRisk of in-stent restenosisNomogram's clinical utilityBare nitinol stentsPrediction of in-stent restenosisExcellent discriminatory powerRegression analysisFemoral artery stentingArtery flow rateRetrospective studyTraining cohortSFA stentingOral microbiota among treatment-naïve adolescents with depression: A case-control study
Zeng Y, Jia X, Li H, Zhou N, Liang X, Liu K, Yang B, Xiang B. Oral microbiota among treatment-naïve adolescents with depression: A case-control study. Journal Of Affective Disorders 2025, 375: 93-102. PMID: 39855566, DOI: 10.1016/j.jad.2025.01.089.Peer-Reviewed Original ResearchMajor depressive disorderArea under the curveCognitive functionOral microbiotaCase-control studyReceiver operating characteristicAdolescent depressionDSM-5 major depressive disorderAssociated with major depressive disorderTreatment naive individualsNon-depressed individualsMorning saliva samplesHealthy control groupGroup of adolescentsDepressive disorderDSM-5Visual breadthDelayed memoryDepression groupOral healthOral bacteriaHC individualsGut microbiota changesHC groupOral microbesInterferon-Stimulated Genes and Immune Metabolites as Broad-Spectrum Biomarkers for Viral Infections
Huang C, Laurent-Rolle M, Grove T, Hsu J. Interferon-Stimulated Genes and Immune Metabolites as Broad-Spectrum Biomarkers for Viral Infections. Viruses 2025, 17: 132. PMID: 39861921, PMCID: PMC11768885, DOI: 10.3390/v17010132.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsInterferon-stimulated genesReceiver operating characteristicViral infectionAntiviral functionType I interferonTarget various stagesIFN-II interferonViral replicationClinical practiceDiagnostic potentialClinical applicationProtein levelsBiomarkersImmune defenseInfectionViral pathogensMetabolitesBroad spectrumGenesEffective translationImproving the Robustness of Deep-Learning Models in Predicting Hematoma Expansion from Admission Head CT.
Tran A, Karam G, Zeevi D, Qureshi A, Malhotra A, Majidi S, Murthy S, Park S, Kontos D, Falcone G, Sheth K, Payabvash S. Improving the Robustness of Deep-Learning Models in Predicting Hematoma Expansion from Admission Head CT. American Journal Of Neuroradiology 2025, ajnr.a8650. PMID: 39794133, DOI: 10.3174/ajnr.a8650.Peer-Reviewed Original ResearchFast Gradient Sign MethodDeep learning modelsRobustness of deep learning modelsAdversarial attacksAdversarial imagesAdversarial trainingSign MethodModel robustnessDeploying deep learning modelsDeep learning model performanceConvolutional neural networkImprove model robustnessAcute intracerebral hemorrhageHematoma expansionMulti-threshold segmentationReceiver operating characteristicIntracerebral hemorrhageGradient descentType attacksData perturbationNeural networkProjected GradientTraining setAntihypertensive Treatment of Acute Cerebral HemorrhageThreshold-based segmentation
2024
Predictors of Post-Hepatectomy Liver Failure in Klatskin Tumors: The Role of Preoperative Glucose, Future Liver Remnant to Spleen Ratio, and Early Bilirubin Monitoring
Kim S, Ku H, Moon H, Song S, Choi Y, Shin D, Koh Y, Oh N, Rhu J, Lee G, Yang W, Song J, Kang C, Ku S, Choi A. Predictors of Post-Hepatectomy Liver Failure in Klatskin Tumors: The Role of Preoperative Glucose, Future Liver Remnant to Spleen Ratio, and Early Bilirubin Monitoring. Diagnostics 2024, 14: 2716. PMID: 39682624, PMCID: PMC11640423, DOI: 10.3390/diagnostics14232716.Peer-Reviewed Original ResearchPost-hepatectomy liver failurePredictors of post-hepatectomy liver failureKlatskin tumorReceiver operating characteristicPreoperative glucoseLiver failurePredicting post-hepatectomy liver failureSpleen ratioChonnam National University Hwasun HospitalRisk of post-hepatectomy liver failureKosin University Gospel HospitalPreoperative glucose controlPreoperative glucose levelsFuture liver remnantAffecting patient prognosisReceiver operating characteristic analysisMonitoring of TBEarly postoperative monitoringHepatic resectionHemi-hepatectomyPostoperative predictorsRetrospective reviewLiver remnantSpleen volumeExtrahepatic cholangiocarcinomaSignatures of transmission in within-host Mycobacterium tuberculosis complex variation: a retrospective genomic epidemiology study
Walter K, Cohen T, Mathema B, Colijn C, Sobkowiak B, Comas I, Goig G, Croda J, Andrews J. Signatures of transmission in within-host Mycobacterium tuberculosis complex variation: a retrospective genomic epidemiology study. The Lancet Microbe 2024, 6: 100936. PMID: 39615498, PMCID: PMC11777664, DOI: 10.1016/j.lanmic.2024.06.003.Peer-Reviewed Original ResearchWithin-host variationMycobacterium tuberculosis complexTransmission inferenceSequence dataMinority variantsGenome Epidemiology StudyMTBC diversityWhole-genome sequencing dataPairs of isolatesAvailable sequence dataPublicly available sequencing dataRetrospective population-based studyPopulation-based studyIdentical genomesPPE genesGenetic differencesWalker etCulture isolatesTuberculosis complexHousehold transmission studyIsolatesEpidemiological linkageReceiver operating characteristicEpidemiological studiesCulture of sputumComparison of the GoCheck Kids and Spot Screener photoscreening devices for the detection of amblyopia risk factors using 2021 AAPOS recommendations
Applebaum S, Sopeyin A, Mohamedali A, Walsh E, Rotruck J, Njike V, Howard M. Comparison of the GoCheck Kids and Spot Screener photoscreening devices for the detection of amblyopia risk factors using 2021 AAPOS recommendations. Journal Of American Association For Pediatric Ophthalmology And Strabismus 2024, 28: 104035. PMID: 39528078, DOI: 10.1016/j.jaapos.2024.104035.Peer-Reviewed Original ResearchAmblyopia risk factorsComplete eye examinationPositive predictive valueAAPOS guidelinesVision screeningDetection of amblyopia risk factorsPediatric vision screeningFailed vision screeningReceiver operating characteristicRisk factorsPhotoscreening devicesPediatric ophthalmologistsAAPOSEye examinationPrimary outcomeStatistically significant differencePredictive valueGuidelinesSignificant differenceParticipantsPhotoscreeningStrabismusScreeningYearsOperating characteristicsInter-reader reliability and diagnostic accuracy of PI-RADS scoring between academic and community care networks: How wide is the gap?
Smani S, Jalfon M, Sundaresan V, Lokeshwar S, Nguyen J, Halstuch D, Khajir G, Cavallo J, Sprenkle P, Leapman M, Kim I. Inter-reader reliability and diagnostic accuracy of PI-RADS scoring between academic and community care networks: How wide is the gap? Urologic Oncology Seminars And Original Investigations 2024 PMID: 39438211, DOI: 10.1016/j.urolonc.2024.10.002.Peer-Reviewed Original ResearchClinically significant PCaPI-RADS scoreDetect clinically significant PCaReporting of prostate cancerInter-reader reliabilityProstate cancerPI-RADSDiagnostic accuracyReceiver operating characteristicInter-readerPresence of clinically significant PCaProstate Imaging Reporting & Data SystemDetect clinically significant diseasePI-RADS 3 lesionsTertiary academic care centerMRI fusion biopsyPI-RADS 3Significant PCaProstate cancer managementClinically significant diseaseInter-reader agreementSubgroup of lesionsAcademic care centerIntraclass correlationMpMRI interpretationUtility of Risk Analysis Index for Assessing Morbidity in Patients Undergoing Posterior Spinal Fusion for Adult Spinal Deformity
Elsamadicy A, Sadeghzadeh S, Serrato P, Sayeed S, Hengartner A, Belkasim S, Khalid S, Lo S, Sciubba D. Utility of Risk Analysis Index for Assessing Morbidity in Patients Undergoing Posterior Spinal Fusion for Adult Spinal Deformity. World Neurosurgery 2024, 192: e292-e305. PMID: 39321916, DOI: 10.1016/j.wneu.2024.09.089.Peer-Reviewed Original ResearchPosterior spinal fusionAdult spinal deformityRisk Analysis IndexLength of stayMFI-5Spinal fusionReceiver operating characteristicSpinal deformityFrail patientsMultivariate analysisModified 5-item frailty indexACS NSQIP databasePreoperative surgical planningRetrospective cohort studyNSQIP databasePatient ageAssess morbidityComplication riskPredicting 30-day readmissionCohort studySurgical planningNormal patientsAdvanced ageComplicationsPatientsAssessing a revised-risk analysis index for morbidity and mortality after spine surgery for metastatic spinal tumors
Elsamadicy A, Serrato P, Sadeghzadeh S, Sayeed S, Hengartner A, Khalid S, Lo S, Shin J, Mendel E, Sciubba D. Assessing a revised-risk analysis index for morbidity and mortality after spine surgery for metastatic spinal tumors. Journal Of Neuro-Oncology 2024, 171: 213-228. PMID: 39320656, DOI: 10.1007/s11060-024-04830-z.Peer-Reviewed Original ResearchModified frailty index-5Length of stayRAI-revMetastatic spinal tumorsPredicting 30-day mortalityReceiver operating characteristicArea under the curveSpine surgeryFrail patientsSpinal tumorsNo significant differenceSpinal pathologyMultivariate analysisMethodsA retrospective cohort studySignificant differenceExtended length of stayReceiver operating characteristic analysisACS NSQIP databasePredictors of extended length of stayRetrospective cohort studyMultidisciplinary decision makingMetastatic diseaseNSQIP databasePatient ageSpinal surgeryClinical Significance of Diffusion-Weighted Brain MRI Lesions After TAVR Results of a Patient-Level Pooled Analysis
Lansky A, Grubman D, Dwyer M, Zivadinov R, Parise H, Moses J, Shah T, Pietras C, Tirziu D, Gambone L, Leon M, Nazif T, Messé S. Clinical Significance of Diffusion-Weighted Brain MRI Lesions After TAVR Results of a Patient-Level Pooled Analysis. Journal Of The American College Of Cardiology 2024, 84: 712-722. PMID: 39142725, DOI: 10.1016/j.jacc.2024.05.055.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementClinical ischemic strokeAcute brain infarctionDW-MRIReceiver operating characteristicIschemic strokeTranscatheter aortic valve replacement resultBrain infarctionPatient-level pooled analysisC-statisticBrain MRI lesionsAcute ischemic brain injuryDiffusion-weighted magnetic resonance imagingAortic valve replacementIndividual lesion volumesCore laboratory analysisIschemic brain injuryPredicting ischemic strokeMagnetic resonance imagingStroke Prevention TrialMRI lesionsValve replacementDW-MRI acquisitionsPatient-level dataPooled analysisThe prognostic role of high-density lipoprotein cholesterol/C-reactive protein ratio in idiopathic pulmonary fibrosis
Ouyang X, Qian Y, Tan Y, Shen Q, Zhang Q, Song M, Shi J, Peng H. The prognostic role of high-density lipoprotein cholesterol/C-reactive protein ratio in idiopathic pulmonary fibrosis. QJM 2024, 117: 858-865. PMID: 39078215, PMCID: PMC11760493, DOI: 10.1093/qjmed/hcae147.Peer-Reviewed Original ResearchIdiopathic pulmonary fibrosis patientsIdiopathic pulmonary fibrosisC-reactive proteinPrognosis of IPF patientsIPF-related deathsHigh C-reactive proteinLow HDL-CIndependent risk factorLung transplantationAll-cause deathNon-IPF controlsHDL-CReceiver operating characteristicIPF patientsPulmonary fibrosisLipid parametersEffect of lipid parametersPrognosis of idiopathic pulmonary fibrosisPredictor of clinical outcomeRisk factorsPredicting all-cause deathDevelopment of idiopathic pulmonary fibrosisCox proportional hazards modelsShorter survival timeProportional hazards modelA nomogram combining neutrophil to lymphocyte ratio (NLR) and prognostic nutritional index (PNI) to predict distant metastasis in gastric cancer
Liu J, Sun R, Cai K, Xu Y, Yuan W. A nomogram combining neutrophil to lymphocyte ratio (NLR) and prognostic nutritional index (PNI) to predict distant metastasis in gastric cancer. Scientific Reports 2024, 14: 15391. PMID: 38965325, PMCID: PMC11224267, DOI: 10.1038/s41598-024-65307-7.Peer-Reviewed Original ResearchConceptsNeutrophil-to-lymphocyte ratioPrognostic nutritional indexPlatelet-to-lymphocyte ratioSystemic immune-inflammatory indexLymphocyte to monocyte ratioMultivariate logistic regression analysisDistant metastasisLogistic regression analysisLymphocyte ratioReceiver operating characteristicGastric cancerValidation cohortPredictive factorsRisk factors of distant metastasisDistant metastasis of gastric cancerNutritional indexImmune-inflammatory indexClinical practiceNomogram's predictive performanceDecision curve analysisGastric cancer patientsMetastasis of gastric cancerEfficient nomogramRegression analysisMonocyte ratioDevelopment and validation of an individualized nomogram for gastric cancer patients treated with perioperative chemotherapy followed by radical surgery
Wang Y, Zhang S, Ding B, Tang Z, Ji Y, Yu Y, Cui Y, Wang X, Sun Y, Liu T. Development and validation of an individualized nomogram for gastric cancer patients treated with perioperative chemotherapy followed by radical surgery. Translational Gastroenterology And Hepatology 2024, 0: 0-0. PMID: 39091661, PMCID: PMC11292059, DOI: 10.21037/tgh-23-75.Peer-Reviewed Original ResearchLocally advanced GC patientsProgression-free survivalAdvanced GC patientsOverall survivalDecision curve analysisTumor-node-metastasisRadical surgeryGC patientsReceiver operating characteristicNeoadjuvant chemotherapyPerioperative chemotherapyPrognostic factorsStaging systemC-indexTumor-node-metastasis (TNM) staging systemGastric cancerLocally advanced gastric cancerPatients treated with perioperative chemotherapyMultivariate Cox regression modelAssociated with clinical characteristicsAdvanced gastric cancerRisk group classificationExternal validation cohortIndependent external cohortLow-risk groupCorrelation of TILs indices generated by visual review and digital computational algorithm with outcomes from preoperative chemotherapy for TNBC in TBCRC 030.
Nader Marta G, Chu X, Mukhopadhyay S, Abramson V, Brufsky A, Stringer-Reasor E, Dent S, Traina T, Carey L, Rimawi M, Specht J, Miller K, Santa-Maria C, Dasgupta T, Binboğa Kurt B, Tayob N, Krop I, Tung N, Schnitt S, Mayer E. Correlation of TILs indices generated by visual review and digital computational algorithm with outcomes from preoperative chemotherapy for TNBC in TBCRC 030. Journal Of Clinical Oncology 2024, 42: 555-555. DOI: 10.1200/jco.2024.42.16_suppl.555.Peer-Reviewed Original ResearchTriple negative breast cancerTumor-infiltrating lymphocytesArea under the curveEvaluation of tumor-infiltrating lymphocytesCore needle biopsyNeoadjuvant chemotherapyPredictive of responseOdds ratioReceiver operating characteristicImmune microenvironmentEarly-stage triple negative breast cancerPre-treatment core needle biopsyPrediction of response to NACBaseline tumor-infiltrating lymphocytesEvaluate tumor-infiltrating lymphocytesStromal tumor-infiltrating lymphocytesResponse to NACTumor-infiltrating lymphocyte scoresResponse to neoadjuvant chemotherapyImmune responseCombined immune responseNegative breast cancerH&E-stained slidesCell cycle aberrationsCell cycle signatureThe optimal cutoff for intertwin delivery interval: A retrospective cohort study
Justman N, Somer S, Goldfreind R, Abu‐Rass H, Siegler Y, Shahak G, Bachar G, Copel J, Zipori Y, Khatib N, Weiner Z, Vitner D. The optimal cutoff for intertwin delivery interval: A retrospective cohort study. International Journal Of Gynecology & Obstetrics 2024, 166: 760-766. PMID: 38258901, DOI: 10.1002/ijgo.15382.Peer-Reviewed Original ResearchIntertwin delivery intervalNeonatal outcomesCesarean deliveryDelivery intervalVaginal deliveryReceiver operating characteristicNeonatal acidemiaRate of cesarean deliveryApgar scoreVaginal delivery of twinsStage of laborPrevent adverse neonatal outcomesPlacental abruption rateAdverse neonatal outcomesDelivery of twinsTertiary care centerAssociated with increased ratesRetrospective cohort studyYouden's J statisticPlacental abruptionTwin pregnanciesCohort studyCare centerOptimal cutoffCutoff point
2023
Surgical phenotype of patients with peritoneal mesothelioma and a germline mutation
Berger Y, Gadiraju M, Dhiman A, Gilliam K, Opalecky B, Chen H, Helgeson M, Eng O, Husain A, Drazer M, Kindler H, Churpek J, Turaga K. Surgical phenotype of patients with peritoneal mesothelioma and a germline mutation. Cancer 2023, 129: 2152-2160. PMID: 37042570, DOI: 10.1002/cncr.34763.Peer-Reviewed Original ResearchConceptsBRCA1-associated protein 1Low platelet countPlatelet countGermline mutationsPeritoneal mesotheliomaPM patientsReceiver operating characteristicMitotic scoreGermline testingHigher peritoneal cancer indexMitotic count scorePeritoneal cancer indexHyperthermic intraperitoneal chemotherapyReceiver operating characteristic analysisArea under the curvePhenotype of patientsCytoreductive surgeryGermline statusIntraperitoneal chemotherapyTumor burdenCancer indexSurgical characteristicsSurvival outcomesSurgical dataProspective study
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