2025
Systematic Review and Meta‐Analysis of Dual‐Layered Stents Versus Single‐Layered Stents for Carotid Artery Stenosis
Mari T, Moeed A, Siddiqui A, Abbasi A, Arif Z, Jannat A, Akman Z, Rossi R, Unnar H, Bhatti H, Batool R, Khan M, Ali M, Batool F, Minahil, Iqbal J, Mena‐Hurtado C, Nanna M. Systematic Review and Meta‐Analysis of Dual‐Layered Stents Versus Single‐Layered Stents for Carotid Artery Stenosis. Catheterization And Cardiovascular Interventions 2025 PMID: 40518749, DOI: 10.1002/ccd.31684.Peer-Reviewed Original ResearchCarotid artery stentingCarotid artery stenosisSingle-layer stentsDual-layer stentsAll-cause mortalityPost-procedural strokeArtery stenosisRandomized controlled trialsStent occlusionHigher risk of peri-procedural strokePostprocedural strokeMeta-analysisRisk of peri-procedural strokeRisk ratioHigh riskCarotid artery stenting proceduresStroke riskPeri-procedural strokeRandom-effects meta-analysisPredictors of strokeTreat carotid artery stenosisLipid-rich carotid plaquesTreatment optionsArtery stentingPrimary outcomeRisk of Thyroid Tumors With GLP-1 Receptor Agonists: A Retrospective Cohort Study.
Morales D, Bu F, Viernes B, DuVall S, Matheny M, Simon K, Falconer T, Richter L, Ostropolets A, Lau W, Man K, Chattopadhyay S, Mathioudakis N, Minty E, Nishimura A, Sun F, Yin C, Seager S, Chai Y, Zhou J, Lu Y, Reyes C, Pistillo A, Duarte-Salles T, Blacketer C, Schuemie M, Ryan P, Krumholz H, Hripcsak G, Khera R, Suchard M. Risk of Thyroid Tumors With GLP-1 Receptor Agonists: A Retrospective Cohort Study. Diabetes Care 2025 PMID: 40465422, DOI: 10.2337/dc25-0154.Peer-Reviewed Original ResearchRisk of thyroid tumorThyroid tumorsGLP-1RADPP-4isHazard ratioThyroid malignancyCohort studyIncreased riskSodium-glucose cotransporter 2 inhibitorsElectronic health record databaseGlucagon-like peptide 1 receptor agonistsEstimate hazard ratiosRandom-effects meta-analysisGLP-1 receptor agonistsPeptide 1 receptor agonistsDipeptidyl peptidase 4 inhibitorsThyroid tumor incidenceUsers of SGLT2isHealth record databaseSecond-line treatmentType 2 diabetes mellitusNew-user cohort studyRetrospective cohort studyUsers of sulfonylureasIntention-to-treatJoint Exposure to Ozone and Temperature and Acute Myocardial Infarction Among Adults Aged 18 to 64 Years in the United States.
Chu L, Wang R, Gross C, Wei J, Lu Y, Krumholz H, Ma X, Chen K. Joint Exposure to Ozone and Temperature and Acute Myocardial Infarction Among Adults Aged 18 to 64 Years in the United States. Circulation 2025 PMID: 40458867, DOI: 10.1161/circulationaha.124.073614.Peer-Reviewed Original ResearchIncident acute myocardial infarctionAcute myocardial infarctionIncreased oddsRisk of acute myocardial infarctionHigher risk of acute myocardial infarctionProbability of acute myocardial infarctionOccurrence of acute myocardial infarctionRandom-effects meta-analysisCase-crossover studyMultivariate random-effects meta-analysisExposure to ozoneRegion-specific estimatesMyocardial infarctionStatistical interaction termsAmbient ozone pollutionPrevention strategiesUnited StatesJoint exposureMeta-analysisAdult ageYoung adultsHigh riskAdultsOddsInteraction termsThe Effect of Early Warning Systems for Sepsis on Mortality: A Systematic Review and Meta-analysis
Ein Alshaeba S, Marhoffer E, Holleck J, Theisen-Toupal J, Grimshaw A, Gunderson C. The Effect of Early Warning Systems for Sepsis on Mortality: A Systematic Review and Meta-analysis. Journal Of General Internal Medicine 2025, 1-6. PMID: 40360868, DOI: 10.1007/s11606-025-09569-5.Peer-Reviewed Original ResearchStrength of evidenceLength of stayScreening groupRandomized controlled studyCochrane risk of bias toolRisk of bias toolRandom-effects meta-analysisLow due to riskMeta-analysisEffectiveness of screeningEffectiveness of early warning systemsRisk of biasEffects meta-analysisMethodsA systematic literature searchPooled odds ratioControlled studiesScreened adult patientsSystematic literature searchSurviving Sepsis CampaignRecommendations AssessmentCochrane riskBias toolWeb of Science Core CollectionOdds ratioOvid MEDLINETraumatic vertebral artery occlusion is associated with high rates of recanalization: insights from a systematic review and meta-analysis
Sujijantarat N, Fathima B, Padmanaban V, Kosyakovsky J, Elsamadicy A, Haynes J, Koo A, Shankar G, Regenhardt R, Stapleton C, Rabinov J, Hebert R, Matouk C, Patel A. Traumatic vertebral artery occlusion is associated with high rates of recanalization: insights from a systematic review and meta-analysis. Neurosurgical Review 2025, 48: 306. PMID: 40097874, DOI: 10.1007/s10143-025-03460-x.Peer-Reviewed Original ResearchConceptsSpine interventionsSpinal cord injuryCervical deformityMeta-analysisSystematic reviewCord injuryRandom-effects meta-analysisAssociated with spinal cord injuryManual citation searchingEffects meta-analysisMeta-analysis of literaturePost-interventionFollow-upIncidence of strokeCitation searchingCervical injuryArtery occlusionAssociated with higher ratesNon-embolized patientsFollow-up periodVertebral artery occlusionInterventionInitial admissionClinical practicePatient populationEditorial: Where are the Trials on Adolescent Self-Harm and Suicide?
Kumpf K, Bloch M. Editorial: Where are the Trials on Adolescent Self-Harm and Suicide? Journal Of The American Academy Of Child & Adolescent Psychiatry 2025 PMID: 40088968, DOI: 10.1016/j.jaac.2025.03.002.Peer-Reviewed Original ResearchNonsuicidal self-injurySelf-harmModerators of treatment effectsRandomized controlled trialsPublic health problemEvidence-based treatmentsAdolescent self-harmPrevent self-harmSelf-injuryHealth problemsRandom-effects meta-analysisRandom-effects meta-analysis of studiesTherapeutic interventionsSuicideMeta-analysis of studiesSource of morbidityAdolescentsIndividual patient dataSecondary analysisTreatment effectsNo significant differenceControlled trialsAggregate dataMeta-analysisEffective treatmentEffect of Diabetes on Clinical Outcomes in Patients with Peripheral Arterial Disease undergoing Lower Extremity Revascularization: A Systematic Review and Meta-Analysis
Edjimbi J, Shah N, Kwaah P, Grimshaw A, Regan C, Nagpal S, Attaran R, Chaar C, Romain G, Smolderen K, Mena-Hurtado C. Effect of Diabetes on Clinical Outcomes in Patients with Peripheral Arterial Disease undergoing Lower Extremity Revascularization: A Systematic Review and Meta-Analysis. Journal Of Vascular Surgery 2025, 81: 1518-1528.e13. PMID: 40015609, DOI: 10.1016/j.jvs.2025.02.018.Peer-Reviewed Original ResearchLower extremity revascularizationPeripheral arterial diseaseHospital readmissionRelative riskDiabetes mellitusRandom-effects meta-analysisIncreased riskMeta-analysisAssociation of DMExtremity revascularizationMortality riskWound infectionRisk estimatesAssociated with diabetes mellitusClinical outcomesSystematic reviewArtery diseaseSystematic searchObservational studyWound infection riskReadmissionEffects of diabetesAmputationRiskHospitalRisk of aortic aneurysm or dissection following use of fluoroquinolones: a retrospective multinational network cohort study
Janetzki J, Kim J, Minty E, Lee J, Morales D, Khera R, Kim C, Alshammari T, DuVall S, Matheny M, Falconer T, Kim S, Phan T, Nguyen P, Hsu M, Hsu J, Park R, Man K, Seager S, Van Zandt M, Gilbert J, Ryan P, Schuemie M, Suchard M, Hripcsak G, Pratt N, You S. Risk of aortic aneurysm or dissection following use of fluoroquinolones: a retrospective multinational network cohort study. EClinicalMedicine 2025, 81: 103096. PMID: 39975698, PMCID: PMC11836508, DOI: 10.1016/j.eclinm.2025.103096.Peer-Reviewed Original ResearchUrinary tract infectionRisk of aortic aneurysmTreat urinary tract infectionsOutpatient settingAortic aneurysmIndex dateCohort studyHazard ratioUrinary tract infection treatmentYonsei University College of MedicineRetrospective cohort studyPropensity scoreCox proportional hazards modelsPropensity-matched pairsRandom-effects meta-analysisProportional hazards modelNational Health and Medical Research Council (NHMRCUniversity College of MedicineSystemic fluoroquinolonesTract infectionsNo significant differenceBayesian random-effects meta-analysisFollow-upPrimary outcomeIncreased riskThe association between clinical trial participation, drug costs, and performance in the Oncology Care Model
Canavan M, Westvold S, Csik V, Franks J, Rocque G, Gross C, Adelson K. The association between clinical trial participation, drug costs, and performance in the Oncology Care Model. Journal Of The National Cancer Institute 2025, djaf008. PMID: 39842859, DOI: 10.1093/jnci/djaf008.Peer-Reviewed Original ResearchOncology Care ModelCare modelValue-based payment programsMedicare alternative payment modelsAlternative payment modelsRandom-effects meta-analysisImpact of clinical trialsClinical trial participationCT episodesEffects meta-analysisAcademic oncology practicesImprove careClinical trialsPatient complexityPayment modelsPayment programsMedicare costsTrial participantsOncology practiceCancer CenterMeta-analysisMedicareDrug costsParticipantsOncologyBuprenorphine versus full agonist opioids for acute postoperative pain management: a systematic review and meta-analysis of randomized controlled trials
Hickey T, Costa G, Oliveira D, Podosek A, Abelleira A, Avila-Quintero V, De Aquino J. Buprenorphine versus full agonist opioids for acute postoperative pain management: a systematic review and meta-analysis of randomized controlled trials. Regional Anesthesia & Pain Medicine 2025, rapm-2024-106014. PMID: 39753290, DOI: 10.1136/rapm-2024-106014.Peer-Reviewed Original ResearchAcute postoperative pain managementPostoperative pain managementAcute postoperative painDuration of analgesiaPain intensityPain managementRandomized controlled trialsRisk of biasAgonist opioidsPostoperative painControlled trialsRescue analgesiaMeta-analysis of randomized controlled trialsMean duration of analgesiaRescue analgesia useLong duration of actionCochrane Central Register of Controlled TrialsSafety of buprenorphineCentral Register of Controlled TrialsMeta-analysisRegister of Controlled TrialsRandom-effects meta-analysisAdverse effectsDuration of actionCochrane Central Register
2024
A meta‐analysis assessing reliability of the Yale Food Addiction Scale: Implications for compulsive eating and obesity
Jahrami H, Husain W, Trabelsi K, Ammar A, Pandi‐Perumal S, Saif Z, Potenza M, Lin C, Pakpour A. A meta‐analysis assessing reliability of the Yale Food Addiction Scale: Implications for compulsive eating and obesity. Obesity Reviews 2024, 26: e13881. PMID: 39715731, PMCID: PMC11884959, DOI: 10.1111/obr.13881.Peer-Reviewed Original ResearchConceptsYale Food Addiction ScaleRandom-effects meta-analysisReliability generalization meta-analysisMeta-analysisFood addictionTest-retest correlation coefficientTest-retest reliabilityComprehensive systematic reviewSixty-five studiesIntraclass coefficientSystematic reviewAddiction ScaleDisordered eatingCompulsive eatingObesitySample sizeEatingCorrelation coefficientEating disordersIntraclassReliability measuresReliabilityParticipantsScaleInceptionSystematic Review and Meta-Analysis: Placebo Response in Randomized Controlled Trials of Tourette’s Disorder Medications
Macul Ferreira de Barros P, Farhat L, Behling E, Nasir M, Landeros-Weisenberger A, Bloch M. Systematic Review and Meta-Analysis: Placebo Response in Randomized Controlled Trials of Tourette’s Disorder Medications. Journal Of The American Academy Of Child & Adolescent Psychiatry 2024, 64: 577-592. PMID: 39505141, DOI: 10.1016/j.jaac.2024.10.011.Peer-Reviewed Original ResearchDrug-placebo differencesMagnitude of placebo responseTourette's disorderPlacebo responseStandardized mean changeRandomized controlled trialsDrug responsePlacebo-controlled randomized controlled trialsDrug placeboMeta-analysisPsychiatry conditionsClinical-researchDisorder medicationsRandom-effects meta-analysisBetween-groupStandardized mean differencePharmacological interventionsStudy-level characteristicsWithin-groupPlaceboStudy-level factorsMean changeWeb of ScienceControlled trialsMean differenceIs Clot Composition Associated With Cause of Stroke? A Systematic Review and Meta‐Analysis
Sujijantarat N, Templeton K, Antonios J, Renedo D, Koo A, Haynes J, Fathima B, Amllay A, Nowicki K, Huttner A, Giles J, Navaratnam D, Sansing L, Hebert R, King J, Matouk C. Is Clot Composition Associated With Cause of Stroke? A Systematic Review and Meta‐Analysis. Stroke Vascular And Interventional Neurology 2024, 4 DOI: 10.1161/svin.124.001426.Peer-Reviewed Original ResearchCause of strokeRed blood cellsWhite blood cellsBlood cellsMechanical thrombectomyCardioembolic groupHistological compositionMeta-analysisLow red blood cellQuantity of red blood cellsRandom-effects meta-analysisAcute ischemic strokeEffects meta-analysisEnglish-language articlesMean percentage differenceAdult patientsMEDLINE databaseCochrane LibraryClinical utilityIschemic strokeLanguage articlesPatientsPercentage differenceArteryCellular compositionMeta-analysis: The utility of the anterior quadratus lumborum block in abdominal surgery
Evans B, Ihnat J, Zhao K, Kim L, Pierson D, Yu C, Lin H, Li J, Golshan M, Ayyala H. Meta-analysis: The utility of the anterior quadratus lumborum block in abdominal surgery. The American Journal Of Surgery 2024, 239: 116014. PMID: 39454308, DOI: 10.1016/j.amjsurg.2024.116014.Peer-Reviewed Original ResearchAnterior quadratus lumborum blockTransversus abdominis planeTransversus abdominis plane blockQuadratus lumborum blockAbdominal surgeryRandomized controlled trialsMorphine equivalentsPost-operativelyMeta-analysisTotal oral morphine equivalentsPost-operative opioid consumptionPost-operative pain scoresOral morphine equivalentsPost-operative recovery timeRandom-effects meta-analysisOpioid consumptionPain scoresOpioid useSurgery typeNon-inferioritySurgeryPresence of confounding variablesRegional anesthesiaQuadratus lumborumSurgery pathway12426 Performance Of Dehydroepiandrosterone-Sulphate In Diagnosing Mild Autonomous Cortisol Secretion: A Systematic Review And Meta-Analysis
Saini J, Salama B, Chacko S, Yu K, Bancos I. 12426 Performance Of Dehydroepiandrosterone-Sulphate In Diagnosing Mild Autonomous Cortisol Secretion: A Systematic Review And Meta-Analysis. Journal Of The Endocrine Society 2024, 8: bvae163.256. PMCID: PMC11454422, DOI: 10.1210/jendso/bvae163.256.Peer-Reviewed Original ResearchMild autonomous cortisol secretionRisk of biasMeta-analysisAutonomous cortisol secretionSystematic reviewDehydroepiandrosterone sulfateReference groupRandom-effects meta-analysisEffects meta-analysisOvid Cochrane Central Register of Controlled TrialsNon-Indexed CitationsCochrane Central Register of Controlled TrialsCentral Register of Controlled TrialsMeta-analysis of published literatureRegister of Controlled TrialsDiagnostic accuracy studiesMeta-analysis of studiesDiagnostic accuracy estimatesMeasurement of dehydroepiandrosterone sulfateDatabase inceptionCortisol secretionBaseline dehydroepiandrosterone sulfateMeasured dehydroepiandrosterone sulfateOvid MEDLINEReference standardF96. ALCOHOL USE AND DEMENTIA IN DIVERSE POPULATIONS
Topiwala A, Levey D, Zhou H, Deak J, Adhikari K, Ebmeier K, Bell S, Burgess S, Nichols T, Gaziano M, Stein M, Gelernter J. F96. ALCOHOL USE AND DEMENTIA IN DIVERSE POPULATIONS. European Neuropsychopharmacology 2024, 87: 256-257. DOI: 10.1016/j.euroneuro.2024.08.507.Peer-Reviewed Original ResearchMillion Veteran ProgramDementia riskMendelian randomizationDementia casesAlcohol usePrevalence of alcohol use disordersImpact of alcohol useRandom-effects meta-analysisAlcohol use disorder prevalenceProspective cohort studyStandard deviation increaseObservational associationsUK BiobankVeteran ProgramLevels of drinkingPopulation prevalenceAlcohol consumptionAlcohol use disorderCohort studyDisorder prevalenceDementiaDependent drinkersDose-response relationshipGenetic associationLight drinkersImprovement in cranial nerve palsies following treatment of intracranial aneurysms with flow diverters: Institutional outcomes, systematic review and study-level meta-analysis
Sujijantarat N, Antonios J, Renedo D, Koo A, Haynes J, Fathima B, Jiang J, Hengartner A, Shekhar A, Amllay A, Nowicki K, Hebert R, Gilmore E, Sheth K, King J, Matouk C. Improvement in cranial nerve palsies following treatment of intracranial aneurysms with flow diverters: Institutional outcomes, systematic review and study-level meta-analysis. Clinical Neurology And Neurosurgery 2024, 246: 108555. PMID: 39357321, DOI: 10.1016/j.clineuro.2024.108555.Peer-Reviewed Original ResearchStudy-level meta-analysisRate of improvementCN deficitsMeta-analysisIntracranial aneurysmsCN palsySystematic reviewFactors associated with recoveryPooled rateRandom-effects meta-analysisCranial nervesManual citation searchingEffects meta-analysisRate of clinical improvementCranial nerve palsyMechanism of injuryIncreased rate of improvementFlow diversionRare presenting symptomSymptomatic intracranial aneurysmsTreatment of intracranial aneurysmsCitation searchingPalsyNerve palsyRetrospective reviewBeta-blockers for secondary prevention following myocardial infarction in patients without reduced ejection fraction or heart failure: an updated meta-analysis
Chi K, Lee P, Chowdhury I, Akman Z, Mangalesh S, Song J, Satish V, Babapour G, Kang Y, Schwartz R, Chang Y, Borkowski P, Nanna M, Damluji A, Nanna M. Beta-blockers for secondary prevention following myocardial infarction in patients without reduced ejection fraction or heart failure: an updated meta-analysis. European Journal Of Preventive Cardiology 2024, 32: 633-646. PMID: 39298680, PMCID: PMC11922798, DOI: 10.1093/eurjpc/zwae298.Peer-Reviewed Original ResearchReduced ejection fractionBeta-blockersEjection fractionHeart failureMortality benefitBB useReduced EFCV mortalityPost-MIRandom-effects meta-analysisMeta-analysisHistory of HFAll-cause mortalityTemporal trendsPrespecified subgroup analysesEvent-free periodCardiovascular (CVIncreased CV mortalityStudy inclusion periodPost-myocardial infarctionContemporary dataAssociated with detrimental effectsNon-significant trendSecondary preventionBB usersEffect modification of air pollution on the association between heat and mortality in five European countries
Zhang S, Breitner S, Stafoggia M, Donato F, Samoli E, Zafeiratou S, Katsouyanni K, Rao S, Diz-Lois Palomares A, Gasparrini A, Masselot P, Nikolaou N, Aunan K, Peters A, Schneider A. Effect modification of air pollution on the association between heat and mortality in five European countries. Environmental Research 2024, 263: 120023. PMID: 39293751, DOI: 10.1016/j.envres.2024.120023.Peer-Reviewed Original ResearchHigh PM levelsEffect modificationAir pollutionHeat-related mortalityEffect modification of air pollutantsPM levelsRural dataHighest O<sub>3</sub> level waDaily non-accidental deathsPotential effect modificationMixed-effects meta-regressionRandom-effects meta-analysisAttica region of GreecePoisson regression modelsHeat-mortality associationsAir pollutant concentrationsAir pollution levelsImprove air qualityTime-series studyHeat-related mortality riskHeat-related health impactsNon-accidental deathsSmall area dataTemperature-mortality relationshipPollutant concentrationsHeat and cause-specific cardiopulmonary mortality in Germany: a case-crossover study using small-area assessment
Zhang S, Breitner S, de' Donato F, Stafoggia M, Nikolaou N, Aunan K, Peters A, Schneider A. Heat and cause-specific cardiopulmonary mortality in Germany: a case-crossover study using small-area assessment. The Lancet Regional Health - Europe 2024, 46: 101049. PMID: 39290807, PMCID: PMC11406445, DOI: 10.1016/j.lanepe.2024.101049.Peer-Reviewed Original ResearchCase-crossover studyRelative riskImprove public health practiceConditional quasi-Poisson regressionAssociated with increased mortality riskPublic health practiceRandom-effects meta-analysisQuasi-Poisson regressionHeat-related health impactsDistrict-level characteristicsSmall area dataHealth practicesRespiratory mortalityAssociated with increased mortalityPotential individual-Cardiopulmonary mortalityMortality riskRespiratory deathsSub-causesVulnerability factorsMeta-regressionHealth impactsRural areasMeta-analysisSubgroup analysis
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