2025
The implications of the American Board of Radiology's decision to relinquish its specialty board designation on prospective authorized medical physicists (AMPs) and radiation safety officers (RSOs)
Tien C, Simiele S, Prisciandaro J, Zoberi J, Huang Y, Hinchcliffe W, Al‐Hallaq H. The implications of the American Board of Radiology's decision to relinquish its specialty board designation on prospective authorized medical physicists (AMPs) and radiation safety officers (RSOs). Journal Of Applied Clinical Medical Physics 2025, e70001. PMID: 39989241, DOI: 10.1002/acm2.70001.Peer-Reviewed Original ResearchRadiation safety officerMedical use of byproduct materialAmerican Board of RadiologyCode of Federal RegulationsNuclear Regulatory CommissionSafety officersUnited StatesFederal regulationsMedical physicistsRegulatory CommissionOfficeResidency program directorsByproduct materialAmerican BoardRadiological decisionsSpecialty boardsCertificationRepercussionsMedication useCommissionApplication pathwaysOffice applicationsPhysicistsProgram directorsRadiationComputational Nuclear Oncology Toward Precision Radiopharmaceutical Therapies: Current Tools, Techniques, and Uncharted Territories.
Yusufaly T, Roncali E, Brosch-Lenz J, Uribe C, Jha A, Currie G, Dutta J, El-Fakhri G, McMeekin H, Pandit-Taskar N, Schwartz J, Shi K, Strigari L, Zaidi H, Saboury B, Rahmim A. Computational Nuclear Oncology Toward Precision Radiopharmaceutical Therapies: Current Tools, Techniques, and Uncharted Territories. Journal Of Nuclear Medicine 2025, jnumed.124.267927. PMID: 39947910, DOI: 10.2967/jnumed.124.267927.Peer-Reviewed Original ResearchRadiopharmaceutical therapyImage-based dosimetryPrediction of doseInternal dosimetryPersonalized treatment plansMetastatic diseaseDosimetryNuclear oncologyClinical outcomesNuclear medicineClinical endpointsTreatment planningOncology communityDose responseEtiological mechanismsTargeted deliveryRadiobiologyRadiotherapyMalignancyRadiationLong-termTherapyPharmacotherapyDoseRadiopharmacokinetics
2024
An Investigation on Cross-Tracer Generalizability of Deep Learning-based PET Attenuation Correction
Hou J, Chen T, Zhou Y, Chen X, Xie H, Liu Q, Xia M, Panin V, Liu C, Zhou B, Toyonaga T. An Investigation on Cross-Tracer Generalizability of Deep Learning-based PET Attenuation Correction. 2024, 00: 1-1. DOI: 10.1109/nss/mic/rtsd57108.2024.10657095.Peer-Reviewed Original ResearchAttenuation correctionPET attenuation correctionQuantitative PET imagingAttenuation mapDL modelsDeep learning (DL)-based methodsTumor quantificationDL model trainingRadiation doseImmediate future workCompetitive performancePET imagingModel trainingPET signalCorrectionAnalysis of PETFuture workPreliminary resultsData availabilityRadiationBiology of Exfoliation of Plasma Membrane-Derived Vesicles and the Radiation Response: Historical Background, Applications in Biodosimetry and Cell-Free Therapeutics, and Quantal Mechanisms for Their Release and Function with Implications for Space Travel
Dainiak N. Biology of Exfoliation of Plasma Membrane-Derived Vesicles and the Radiation Response: Historical Background, Applications in Biodosimetry and Cell-Free Therapeutics, and Quantal Mechanisms for Their Release and Function with Implications for Space Travel. Radiation Research 2024, 202: 328-354. PMID: 38981604, DOI: 10.1667/rade-24-00078.1.Peer-Reviewed Original ResearchCell-free therapeuticsPlasma membrane-derived vesiclesExtracellular vesiclesExposure to ionizing radiationIndividual radiation dosesMembrane-derived vesiclesExposure to radiationProperties of extracellular vesiclesPathogenesis of diseaseSpace travelDeep spaceRadiation doseInhibitory moleculesSignal traffickingHuman cellsClinical disordersQuantal mechanismRadiation responseMembrane turnoverVesiclesNucleic acidsVesicle surfaceBiophysical propertiesCell-freeRadiationRadiosynthesis automation, non-human primate biodistribution and dosimetry of K+ channel tracer [11C]3MeO4AP
Zhou Y, Wilks M, Dhaynaut M, Guehl N, Vesper D, Moon S, Rice P, El Fakhri G, Normandin M, Brugarolas P. Radiosynthesis automation, non-human primate biodistribution and dosimetry of K+ channel tracer [11C]3MeO4AP. EJNMMI Research 2024, 14: 43. PMID: 38683467, PMCID: PMC11058135, DOI: 10.1186/s13550-024-01092-8.Peer-Reviewed Original ResearchRadiation dosimetryAverage effective doseWhole-body biodistributionTotal scan timeNon-decayEffective doseNon-human primatesSymptomatic treatment of multiple sclerosisIn vivo binding affinityBed positionTreatment of multiple sclerosisHigh-resolution CTDynamic acquisition protocolDosimetryPET dataAdult rhesus macaquesScan timeImaging demyelinationOLINDA softwareRadiationAcquisition protocolsPreclinical studiesNo significant changesHigh dosesPET imagingPractical Implications of the American Society for Radiation Oncology Radiation Oncology Case Rate Program Proposal for Radiation Oncologists
Yu J, Luh J, Mantz C. Practical Implications of the American Society for Radiation Oncology Radiation Oncology Case Rate Program Proposal for Radiation Oncologists. Practical Radiation Oncology 2024, 14: 196-199. PMID: 38237890, DOI: 10.1016/j.prro.2023.12.010.Peer-Reviewed Original Research
2023
Practical Steps to Mitigate Cybersecurity Attacks on Radiation Oncology Practices
Yu J, Dicker A, Lester-Coll N, Tsai C, Zawalich M. Practical Steps to Mitigate Cybersecurity Attacks on Radiation Oncology Practices. Practical Radiation Oncology 2023, 13: 429-433. PMID: 37230461, DOI: 10.1016/j.prro.2023.05.001.Peer-Reviewed Original Research
2021
Deep learning-based GTV contouring modeling inter- and intra- observer variability in sarcomas
Marin T, Zhuo Y, Lahoud R, Tian F, Ma X, Xing F, Moteabbed M, Liu X, Grogg K, Shusharina N, Woo J, Lim R, Ma C, Chen Y, El Fakhri G. Deep learning-based GTV contouring modeling inter- and intra- observer variability in sarcomas. Radiotherapy And Oncology 2021, 167: 269-276. PMID: 34808228, PMCID: PMC8934266, DOI: 10.1016/j.radonc.2021.09.034.Peer-Reviewed Original ResearchConceptsGross tumor volumeRadiation therapy treatment planningGross tumor volume contoursGross tumor volume delineationTherapy treatment planningIntra-observer variabilityConsensus contoursGTV contoursPre-operative CT imagesSoft tissue sarcomasRadiation oncologistsTumor volumeBone sarcomasTreatment planningAccurate contoursCT imagesDelineation procedureSarcomaSoft tissueConfidence levelRadiationPatientsHausdorff distanceMultiple contoursX-ray
2018
On the damage done to the structure of the Thermoplasma acidophilum proteasome by electron radiation
Wang J, Liu Z, Crabtree RH, Frank J, Moore PB. On the damage done to the structure of the Thermoplasma acidophilum proteasome by electron radiation. Protein Science 2018, 27: 2051-2061. PMID: 30242932, PMCID: PMC6237698, DOI: 10.1002/pro.3511.Peer-Reviewed Original ResearchConceptsLocal chemical effectsElectron beamElectron radiationChemical mechanismStructure effectsChemical effectsElectron microscopeBackbone atomsChemical damageΑ-helixThermoplasma acidophilumMoleculesDose-dependent degradationQuaternary structureElectronsBeamAtomsEM mapsRadiationStructureMicroscopeResolutionSmall changesAcidophilum
2016
ORAL02.03: Robust Correlation Between Metabolic Response Measured with 18F-FDG PET Soon After Therapy and Clinical Outcome in Lung Cancer Topic: Radiation Oncology
Choi N, Gainor J, Ackman J, Lim R, Sharp G, Fakhri G, Niemierko A. ORAL02.03: Robust Correlation Between Metabolic Response Measured with 18F-FDG PET Soon After Therapy and Clinical Outcome in Lung Cancer Topic: Radiation Oncology. Journal Of Thoracic Oncology 2016, 11: s253-s254. DOI: 10.1016/j.jtho.2016.09.012.Peer-Reviewed Original ResearchDestruction‐and‐diffraction by X‐ray free‐electron laser
Wang J. Destruction‐and‐diffraction by X‐ray free‐electron laser. Protein Science 2016, 25: 1585-1592. PMID: 27262052, PMCID: PMC5338243, DOI: 10.1002/pro.2959.Peer-Reviewed Original ResearchConceptsX-ray free-electron lasersFree-electron laserSingle femtosecond pulseAtomic scattering factorsFemtosecond pulsesRecent theoretical studiesScattering factorsSuch pulsesElectronic processesDifferent atomsCrystallographic data collectionRadiation damageSingle pulseX-rayPulsesLaserSuch crystalsTheoretical studyCrystalsDiffractionMacromolecular crystalsFemtosecondExperimental evidenceAtomsRadiationRadiation Safety in Nuclear Medicine Procedures
Cho S, Kim J, Song H. Radiation Safety in Nuclear Medicine Procedures. Nuclear Medicine And Molecular Imaging 2016, 51: 11-16. PMID: 28250853, PMCID: PMC5313457, DOI: 10.1007/s13139-016-0406-0.Peer-Reviewed Original Research
2015
Improved Local Tumor Control With Supplementary Dose of Radiation Guided by 18F-FDG PET Soon After Standard Dose Radiation Therapy and Concurrent Chemotherapy in Inoperable Stages II and III Non-Small Cell Lung Cancer
Choi N, Gainor J, Ackman J, Lim R, Sharp G, Fakhri G, Niemierko A. Improved Local Tumor Control With Supplementary Dose of Radiation Guided by 18F-FDG PET Soon After Standard Dose Radiation Therapy and Concurrent Chemotherapy in Inoperable Stages II and III Non-Small Cell Lung Cancer. International Journal Of Radiation Oncology • Biology • Physics 2015, 93: e438-e439. DOI: 10.1016/j.ijrobp.2015.07.1664.Peer-Reviewed Original ResearchMulti-Institutional Implementation and Evaluation of a Curriculum for the Medical Student Clerkship in Radiation Oncology
Group R, Golden D, Braunstein S, Jimenez R, Mohindra P, Spektor A, Ye J, Members R, Bradley K, Chmura S, Currey A, Das P, Du K, Haas-Kogan D, Howard A, Higgins S, Hung A, Kharofa J, Krishnan M, MacDonald S, Mancini B, Parashar B, Thaker N, Thomas C, Viswanathan A, Wheatley M. Multi-Institutional Implementation and Evaluation of a Curriculum for the Medical Student Clerkship in Radiation Oncology. Journal Of The American College Of Radiology 2015, 13: 203-209. PMID: 26410347, PMCID: PMC4744090, DOI: 10.1016/j.jacr.2015.06.036.Peer-Reviewed Original ResearchConceptsRadiation oncology residentsRadiation oncologyAcademic medical centerOncology residentsMedical CenterMedical student clerkshipCurriculum developmentStandard curriculumInterquartile rangeResponse rateNational standardized curriculumStudent clerkshipOncologySurvey response rateMulti-institutional implementationPlanning workshopCurricular contentAcademic yearClerkship curriculumRadiationStudent ratingsLikert-type scaleCurriculumStudentsResearch modelMonitoring proton therapy with PET
Paganetti H, Fakhri G. Monitoring proton therapy with PET. British Journal Of Radiology 2015, 88: 20150173. PMID: 25989699, PMCID: PMC4628541, DOI: 10.1259/bjr.20150173.Peer-Reviewed Original ResearchConceptsPatient set-upDose conformityDose shapingInterfractional changesProton beamBeam deliveryDose calculationProton therapyTumor coveragePhotonic techniquesTreatment volumeTotal energyPatient anatomyBeamRadiation therapyProtonPatientsTherapyReduced total energyDoseSet-upRangeCalculationsRadiationEnergyPicosecond and Terahertz Perturbation of Interfacial Water and Electropermeabilization of Biological Membranes
Vernier PT, Levine ZA, Ho MC, Xiao S, Semenov I, Pakhomov AG. Picosecond and Terahertz Perturbation of Interfacial Water and Electropermeabilization of Biological Membranes. The Journal Of Membrane Biology 2015, 248: 837-847. PMID: 25796485, PMCID: PMC4565733, DOI: 10.1007/s00232-015-9788-7.Peer-Reviewed Original ResearchConceptsSubnanosecond Electric PulsesTerahertz electromagnetic radiationComplementary molecular dynamics simulationsTerahertz frequenciesElectromagnetic radiationField reversalElectric pulsesElectric fieldInterfacial waterElectropore formationMolecular dynamics simulationsPulsesElectric potentialConductive structuresWater dipolesDynamics simulationsPhospholipid bilayersBilayersPicosecondsRemote monitoringBiological membranesModel membranesFieldPSRadiationChemiexcitation of melanin derivatives induces DNA photoproducts long after UV exposure
Premi S, Wallisch S, Mano CM, Weiner AB, Bacchiocchi A, Wakamatsu K, Bechara EJ, Halaban R, Douki T, Brash DE. Chemiexcitation of melanin derivatives induces DNA photoproducts long after UV exposure. Science 2015, 347: 842-847. PMID: 25700512, PMCID: PMC4432913, DOI: 10.1126/science.1256022.Peer-Reviewed Original ResearchConceptsDark cyclobutane pyrimidine dimersExcited electronic statesUltraviolet photonsUV photonsElectronic statesTriplet stateSunlight-induced melanomaCytosine-containing cyclobutane pyrimidine dimersEnergy transferPhotonsPicosecondsElectronsUV exposureRadiationChemiexcitationEnergyStatePhotoproducts
2012
4D Dynamic Simulation of Patients Undergoing Radiotherapy
Deng J, Nath R. 4D Dynamic Simulation of Patients Undergoing Radiotherapy. 2012, 1: 1-4. DOI: 10.1109/vecims.2012.6273228.Peer-Reviewed Original ResearchMonte Carlo radiation transport simulationsX-ray imagerRadiation transport simulationsExternal ionizing radiationMultiple source modelImage-guided radiotherapyLinear acceleratorDigital phantomAdvanced medical imaging technologiesIonizing RadiationTransport simulationsDose registrationDose distributionOrgan dosesRadiationPhantomMedical imaging technologyImaging technologyDynamics simulationsMedical imaging proceduresAdaptive radiotherapyAcceleratorImagerCT informationSource model
2011
Black hole growth in the early Universe is self-regulated and largely hidden from view
Treister E, Schawinski K, Volonteri M, Natarajan P, Gawiser E. Black hole growth in the early Universe is self-regulated and largely hidden from view. Nature 2011, 474: 356-358. PMID: 21677753, DOI: 10.1038/nature10103.Peer-Reviewed Original Research
1980
Evidence for the absence of photoreduction of the metal centers of cytochrome c oxidase by x-irradiation
Brudvig G, Bocian D, Gamble R, Chan S. Evidence for the absence of photoreduction of the metal centers of cytochrome c oxidase by x-irradiation. Biochimica Et Biophysica Acta 1980, 624: 78-89. PMID: 6250634, DOI: 10.1016/0005-2795(80)90227-5.Peer-Reviewed Original ResearchConceptsConventional X-ray sourceStanford Synchrotron Radiation LaboratoryX-ray absorption measurementsX-ray photonsPhotons/sX-ray fluxX-ray sourcesSynchrotron Radiation LaboratoryMetal centerOptical spectroscopyRadiation LaboratoryAbsorption measurementsElectron paramagnetic resonanceParamagnetic resonanceCytochrome c oxidasePhotonsPhotoreductionC oxidaseRadiationResonanceSpectroscopyOxidaseSourceMeasurementsFlux
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