2025
Exercise Pulmonary Hypertension and Beyond: Insights in Exercise Pathophysiology in Pulmonary Arterial Hypertension (PAH) from Invasive Cardiopulmonary Exercise Testing
Tarras E, Singh I, Kreiger J, Joseph P. Exercise Pulmonary Hypertension and Beyond: Insights in Exercise Pathophysiology in Pulmonary Arterial Hypertension (PAH) from Invasive Cardiopulmonary Exercise Testing. Journal Of Clinical Medicine 2025, 14: 804. PMID: 39941482, PMCID: PMC11818252, DOI: 10.3390/jcm14030804.Peer-Reviewed Original ResearchInvasive cardiopulmonary exercise testingPulmonary arterial hypertensionCardiopulmonary exercise testingArterial hypertensionAssociated with pulmonary vascular remodelingExercise testRight heart failureExercise pulmonary hypertensionPulmonary vascular remodelingPulmonary hypertensionProgressive diseasePulmonary vasculatureTherapeutic optionsExercise pathophysiologyHigh morbidityHeart failureEarly diagnosisVascular remodelingTherapeutic approachesPersonalized treatmentHypertensionDisease subtypesDiagnosisSkeletal muscleDisease
2024
Mechanical clot disruption during pulmonary thromboembolectomy is safe: A propensity score-matched analysis
Thomas S, Deshmukh A, Mojibian H, Marino A, Lozada J, Cornman-Homonoff J. Mechanical clot disruption during pulmonary thromboembolectomy is safe: A propensity score-matched analysis. Clinical Imaging 2024, 118: 110381. PMID: 39637758, DOI: 10.1016/j.clinimag.2024.110381.Peer-Reviewed Original ResearchPulmonary thromboembolectomyPulmonary emboliPulmonary arteryRight pulmonary arteryLeft pulmonary arteryPulmonary artery pressureAdministration of anticoagulantsDuration of hospitalizationMechanical clot disruptionPropensity-score matchingSPESI scorePulmonary vasculatureArterial pressureClinical effectsOrganized thrombusThromboembolectomyPropensity-scoreClot disruptionInclusion criteriaPatientsMortality rateRisk categoriesCompare groupsStudy periodArtery
2022
Vascular pathobiology of pulmonary hypertension
Gallardo-Vara E, Ntokou A, Dave J, Jovin D, Saddouk F, Greif D. Vascular pathobiology of pulmonary hypertension. The Journal Of Heart And Lung Transplantation 2022, 42: 544-552. PMID: 36604291, PMCID: PMC10121751, DOI: 10.1016/j.healun.2022.12.012.Peer-Reviewed Original ResearchConceptsPulmonary hypertensionCell typesSmooth muscle cell proliferationEndothelial cell dysfunctionMuscle cell proliferationKruppel-like factor 4Extracellular matrix remodelingHypoxia-inducible factorBox proteinBlood pressurePulmonary arteryInflammatory cellsPulmonary vasculatureMain cell typesVascular pathogenesisVasoactive moleculesCell dysfunctionClinical impactVascular pathobiologyPathological remodelingIntercellular crosstalkLethal diseaseMesenchymal transitionMatrix remodelingGrowth factorUsing Routine Chest Computed Tomography to Diagnose Pulmonary Embolism
Chan J, Ho B, Ye K, Haramati L, Jain V. Using Routine Chest Computed Tomography to Diagnose Pulmonary Embolism. Journal Of Computer Assisted Tomography 2022, 46: 888-893. PMID: 36399535, DOI: 10.1097/rct.0000000000001372.Peer-Reviewed Original ResearchConceptsPulmonary embolismPulmonary artery enhancementContrast-enhanced chest CT scansHU thresholdContrast-enhanced chest CTAbsence of PEUnsuspected pulmonary embolismContrast-enhanced chestHounsfield unitsChest CT scanLogistic regression analysisPeripheral enhancementPulmonary vasculatureChest CTFemale sexRoutine chestContrast amountCT scanPulmonary enhancementTotal casesOlder ageEmbolismRegression analysisChestDescriptive statisticsDiseases of the pulmonary arteries: imaging appearances and pearls
Cortopassi IO, Gosangi B, Asch D, Bader AS, Gange CP, Rubinowitz AN. Diseases of the pulmonary arteries: imaging appearances and pearls. Clinical Imaging 2022, 91: 111-125. PMID: 36067656, DOI: 10.1016/j.clinimag.2022.08.018.Peer-Reviewed Educational MaterialsConceptsContrast-enhanced chest CTChest X-rayPulmonary arteryEnlarged pulmonary arteryPulmonary vascular pathologyPulmonary artery anatomyEveryday clinical practiceAsymptomatic patientsImaging findingsPulmonary vasculatureArtery anatomyChest CTUrgent treatmentMediastinal structuresVascular pathologyArteryClinical practicePhysiologic dataEntire thoraxVessel wallPatientsDetailed evaluationPathologyWide spectrumQuantification of flowPulmonary Vascular Complication Associated With Coronavirus Infection and Role of Lung Resection
Wong L, Sukumar M, Fuss C, Thanawala R. Pulmonary Vascular Complication Associated With Coronavirus Infection and Role of Lung Resection. The Annals Of Thoracic Surgery 2022, 115: e89-e91. PMID: 35472408, PMCID: PMC9035613, DOI: 10.1016/j.athoracsur.2022.04.016.Peer-Reviewed Original ResearchConceptsPulmonary artery pseudoaneurysmArtery pseudoaneurysmAcute hypoxic respiratory failureHypoxic respiratory failureThoracic surgical proceduresLife-threatening complicationsComplication of ruptureCOVID-19 pneumoniaLung resectionStress cardiomyopathyRespiratory failurePulmonary vasculaturePerioperative planningSurgical proceduresPseudoaneurysmGranulomaPatientsCoronavirus infectionCOVID-19BacteremiaResectionHemothoraxBleedingCardiomyopathyPneumonia
2021
Chronic Thromboembolic Pulmonary Hypertension: the Bench
Alba GA, Atri D, Darbha S, Singh I, Tapson VF, Lewis MI, Chun HJ, Yu YR, Maron BA, Rajagopal S. Chronic Thromboembolic Pulmonary Hypertension: the Bench. Current Cardiology Reports 2021, 23: 141. PMID: 34410515, DOI: 10.1007/s11886-021-01572-6.Peer-Reviewed Original ResearchConceptsPulmonary embolismAcute pulmonary embolismThromboembolic pulmonary hypertensionPlatelet-rich thrombiPulmonary hypertensionUncommon complicationMedical therapyPulmonary vasculatureImmune cellsAnimal modelsEndothelial cellsPathobiologyPlatelet biologyThrombusHuman samplesTherapyCurrent knowledgeSummaryThe developmentCTEPHHypertensionVasculopathyCellsComplicationsEmbolismInflammationChronic Thromboembolic Pulmonary Hypertension: the Bedside
Matusov Y, Singh I, Yu YR, Chun HJ, Maron BA, Tapson VF, Lewis MI, Rajagopal S. Chronic Thromboembolic Pulmonary Hypertension: the Bedside. Current Cardiology Reports 2021, 23: 147. PMID: 34410530, PMCID: PMC8375459, DOI: 10.1007/s11886-021-01573-5.Peer-Reviewed Original ResearchConceptsPulmonary arterial hypertensionPulmonary embolismMedical therapyRight ventricular failureThromboembolic pulmonary hypertensionAcute pulmonary embolismArterial hypertensionPulmonary hypertensionVentricular failureUncommon complicationDisease mimicsPulmonary vasculatureMultimodality approachUnderlying pathologyPercutaneous interventionCurrent diagnosisCTEPHHypertensionTherapyDiagnosisTreatmentEmbolismComplicationsEmboliSurgeryQuantification of Arterial and Venous Morphologic Markers in Pulmonary Arterial Hypertension Using CT Imaging
Rahaghi FN, Nardelli P, Harder E, Singh I, Sánchez-Ferrero GV, Ross JC, San José Estépar R, Ash SY, Hunsaker AR, Maron BA, Leopold JA, Waxman AB, San José Estépar R, Washko GR. Quantification of Arterial and Venous Morphologic Markers in Pulmonary Arterial Hypertension Using CT Imaging. CHEST Journal 2021, 160: 2220-2231. PMID: 34270966, PMCID: PMC8692106, DOI: 10.1016/j.chest.2021.06.069.Peer-Reviewed Original ResearchConceptsExercise pulmonary hypertensionPulmonary arterial hypertensionControl subjectsPulmonary hypertensionSmall vessel volumeArterial hypertensionPulmonary arteryPulmonary vasculatureVascular tortuosityVascular volumeArterial volumePrecapillary pulmonary hypertensionCohort of patientsPulmonary vascular volumeVenous manifestationsThromboembolic diseaseCT angiogramArterial tortuosityHypertensionCT scanVessel volumeHeterogeneous diseasePatientsStudy designArtery
2020
Double valve involvement: papillary fibroelastoma in a patient with severe mitral and aortic valve regurgitation
Ajiboye O, Racoma J, Hussain K, Mba B. Double valve involvement: papillary fibroelastoma in a patient with severe mitral and aortic valve regurgitation. BMJ Case Reports 2020, 13: e234828. PMID: 32675116, PMCID: PMC7368505, DOI: 10.1136/bcr-2020-234828.Peer-Reviewed Original ResearchConceptsAortic valve regurgitationValve regurgitationPapillary fibroelastomaSevere mitralValve replacementDouble valve replacementCardiac papillary fibroelastomaSevere regurgitationTransthoracic echocardiographyEmbolic phenomenaInfective endocarditisClinical manifestationsPulmonary vasculatureIncidental findingBenign neoplasmsMobile massRegurgitationFibroelastomaPatientsMitralEndocarditisEchocardiographySequelaeNeoplasmsLesions
2017
Surgical Management of Pulmonary Embolism
Jung J, Bonde P. Surgical Management of Pulmonary Embolism. 2017, 405-418. DOI: 10.1007/978-3-319-65226-9_31.Peer-Reviewed Original ResearchChronic thromboembolic pulmonary hypertensionDeep vein thrombosisPulmonary embolismVenous thromboembolismPathophysiology of PERight heart dysfunctionThromboembolic pulmonary hypertensionAcute pulmonary embolismSpectrum of disordersPulmonary endarterectomyPulmonary embolectomyPulmonary hypertensionVein thrombosisHeart failureSurgical managementOperative managementPulmonary vasculatureSurgical interventionHeart dysfunctionEffective treatmentMechanical occlusionEmbolismSignificant riskEndarterectomyEmbolectomyEfficient and Functional Endothelial Repopulation of Whole Lung Organ Scaffolds
Le AV, Hatachi G, Beloiartsev A, Ghaedi M, Engler AJ, Baevova P, Niklason LE, Calle EA. Efficient and Functional Endothelial Repopulation of Whole Lung Organ Scaffolds. ACS Biomaterials Science & Engineering 2017, 3: 2000-2010. PMID: 33440555, DOI: 10.1021/acsbiomaterials.6b00784.Peer-Reviewed Original ResearchLong-term functionNative lungBarrier functionRat lungEndothelial cellsEndothelial nitric oxide synthaseLung microvascular endothelial cellsNitric oxide synthaseTissue plasminogen activatorVascular surface areaExposure of bloodMicrovascular endothelial cellsGas exchange functionRat lung microvascular endothelial cellsMechanical ventilationPulmonary arteryPulmonary vasculatureImproved barrier functionOxide synthaseVascular pressuresLung tissueFunctional endotheliumVE-cadherin gene expressionAntithrombotic substancesLung
2015
Diverse contribution of bone marrow-derived late-outgrowth endothelial progenitor cells to vascular repair under pulmonary arterial hypertension and arterial neointimal formation
Ikutomi M, Sahara M, Nakajima T, Minami Y, Morita T, Hirata Y, Komuro I, Nakamura F, Sata M. Diverse contribution of bone marrow-derived late-outgrowth endothelial progenitor cells to vascular repair under pulmonary arterial hypertension and arterial neointimal formation. Journal Of Molecular And Cellular Cardiology 2015, 86: 121-135. PMID: 26231083, DOI: 10.1016/j.yjmcc.2015.07.019.Peer-Reviewed Original ResearchConceptsPulmonary arterial hypertensionEndothelial progenitor cellsLate outgrowth endothelial progenitor cellsEarly endothelial progenitor cellsFemoral arteryVascular repairEPC subpopulationsArterial hypertensionArterial neointimal formationProgenitor cellsBM mononuclear cellsNeointimal lesion formationFisher 344 ratsEPC treatmentEnhanced proliferation potentialPulmonary arteriolesPulmonary arteryPulmonary vasculatureEndovascular injuryMononuclear cellsVascular diseaseSystemic arteriesTherapeutic effectNeointimal formationInflammatory genes
2014
Pathological Changes in Pulmonary Circulation in Carbon Tetrachloride (ccl4)-Induced Cirrhotic Mice
Das M, Boerma M, Goree JR, Lavoie EG, Fausther M, Gubrij IB, Pangle AK, Johnson LG, Dranoff JA. Pathological Changes in Pulmonary Circulation in Carbon Tetrachloride (ccl4)-Induced Cirrhotic Mice. PLOS ONE 2014, 9: e96043. PMID: 24763616, PMCID: PMC3999097, DOI: 10.1371/journal.pone.0096043.Peer-Reviewed Original ResearchConceptsPulmonary acceleration timeCirrhotic micePortopulmonary hypertensionPulmonary circulationPathological changesSpleen weight/body weight ratioVentricle weight/body weightWeight/body weight ratioChronic CCl4 treatmentPulmonary vascular diseaseMale C57BL/6 miceBody weight ratioTimes/weekOxidative stress markersNovel therapeutic interventionsPicrosirius red stainingSterile olive oilPortal hypertensionEffects of CCl4Pulmonary arteryC57BL/6 micePathophysiological mechanismsPulmonary vasculaturePerivascular collagenVascular diseaseRecapitulation of Developing Artery Muscularization in Pulmonary Hypertension
Sheikh AQ, Lighthouse JK, Greif DM. Recapitulation of Developing Artery Muscularization in Pulmonary Hypertension. Cell Reports 2014, 6: 809-817. PMID: 24582963, PMCID: PMC4015349, DOI: 10.1016/j.celrep.2014.01.042.Peer-Reviewed Original ResearchConceptsPulmonary artery hypertensionArtery hypertensionArteriole smooth muscle cellsSmooth muscle accumulationPulmonary artery complianceModest clinical benefitStrong independent predictorMuscle cell dedifferentiationSmooth muscle cellsPulmonary hypertensionArtery complianceIndependent predictorsClinical benefitPulmonary vasculatureDistal migrationVascular disordersAlveolar myofibroblastsSmooth muscleHypertensionMuscle accumulationMuscularizationMuscle cellsCell dedifferentiationPoor understandingAtherosclerosisBeyond a Broken Heart: Circulatory Dysfunction in the Failing Fontan
Mori M, Aguirre AJ, Elder RW, Kashkouli A, Farris AB, Ford RM, Book WM. Beyond a Broken Heart: Circulatory Dysfunction in the Failing Fontan. Pediatric Cardiology 2014, 35: 569-579. PMID: 24531876, DOI: 10.1007/s00246-014-0881-y.Peer-Reviewed Original ResearchConceptsAdult Fontan patientsFontan patientsCirculatory dysfunctionPortal hypertensionPostsinusoidal portal hypertensionMultiple organ involvementPulmonary blood flowFailing FontanClinical deteriorationFontan palliationHeart transplantationHepatic dysfunctionLate morbidityVentricular dysfunctionOrgan involvementUniventricular heartVentricular functionLiver diseaseHepatic perfusionPulmonary vasculatureCardiac functionLiver histopathologyBlood flowCirrhotic diseaseClinicopathologic states
2010
Chronic Thromboembolic Pulmonary Hypertension
Auger WR, Kim NH, Trow TK. Chronic Thromboembolic Pulmonary Hypertension. Clinics In Chest Medicine 2010, 31: 741-758. PMID: 21047580, DOI: 10.1016/j.ccm.2010.07.006.Peer-Reviewed Original ResearchConceptsChronic thromboembolic pulmonary hypertensionThromboembolic pulmonary hypertensionPulmonary hypertensionSpecific medical therapySmall vessel arteriopathyMedical therapyPreoperative evaluationMechanical obstructionPulmonary vasculatureAcute embolusRisk factorsHypertensionPatientsNatural historyPutative mechanismsLimited dataSole causeArteriopathyEndartectomyEmboliObstructionTherapyNoncandidatesEpidemiologyDiagnosis
1998
PULMONARY MANIFESTATIONS OF RHEUMATOID ARTHRITIS
Tanoue L. PULMONARY MANIFESTATIONS OF RHEUMATOID ARTHRITIS. Clinics In Chest Medicine 1998, 19: 667-685. PMID: 9917959, DOI: 10.1016/s0272-5231(05)70109-x.Peer-Reviewed Original ResearchConceptsRheumatoid arthritisClassic connective tissue diseasesTherapy-related toxicityConnective tissue diseasePulmonary manifestationsPulmonary evaluationRespiratory complaintsTissue diseasePulmonary vasculatureRadiographic findingsPhysiologic abnormalitiesLung parenchymaArthritisPatientsManifestationsAirwayPleuraChestAbnormalitiesDiseaseComplaintsParenchymaVasculature
1994
Characterization of acetylcholinesterase in rabbit intrapulmonary arteries
Altiere R, Travis D, Thompson D. Characterization of acetylcholinesterase in rabbit intrapulmonary arteries. American Journal Of Physiology 1994, 267: l745-l752. PMID: 7810679, DOI: 10.1152/ajplung.1994.267.6.l745.Peer-Reviewed Original ResearchConceptsAction of acetylcholinePulmonary blood vesselsCholinesterase activityLobar arteryIntrapulmonary arteriesBlood vesselsRabbit intrapulmonary arteriesACh-induced contractionConcentration-dependent inhibitionPulmonary arteryIntrapulmonary veinsPulmonary vasculatureTrachealis muscleMicroM neostigminePeripheral tissuesArteryEnzyme activityAcetylcholineCholinesterase inhibitionArterial enzymeSelective inhibitorMin/NeostigmineAortaCholinesterase enzymes
1989
Pulmonary and Pleural Complications of Cardiac Disease
Remetz M, Cleman M, Cabin H. Pulmonary and Pleural Complications of Cardiac Disease. Clinics In Chest Medicine 1989, 10: 545-592. PMID: 2689066, DOI: 10.1016/s0272-5231(21)00655-9.Peer-Reviewed Original ResearchConceptsCongestive heart failurePulmonary vascular resistanceHeart failureCongenital heart diseasePulmonary vasculatureVascular resistancePulmonary dysfunctionPulmonary hypertensionRight shuntingMitral stenosisSevere gradesHeart diseaseLeft-sided congestive heart failureNonsteroidal anti-inflammatory agentsIrreversible pulmonary hypertensionPostcardiac injury syndromePulmonary arterial toneLeft heart failureRight heart failureRheumatic mitral stenosisPulmonary function testingPulmonary venous pressurePleural fluid accumulationPulmonary artery flowPulmonary blood flow
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