2024
Next-generation digital chest tomosynthesis
Gange C, Ku J, Gosangi B, Liu J, Maolinbay M. Next-generation digital chest tomosynthesis. Journal Of Clinical Imaging Science 2024, 14: 22. PMID: 38975057, PMCID: PMC11225395, DOI: 10.25259/jcis_4_2024.Peer-Reviewed Original ResearchRadiation doseLow dose chest CTLung phantomLung nodulesEffective radiation dosePlane resolutionLow radiation doseLow dose CTPhantomSimulated pulmonary nodulesChest CTChest radiologistsHealthy volunteersPulmonary nodulesDose CTAnatomical locationNodule detectionImaging characteristicsTomosynthesisNodulesLungDoseDetect lung nodulesDevicesPotential utility
2023
Combining Low-Dose Computer-Tomography-Based Radiomics and Serum Metabolomics for Diagnosis of Malignant Nodules in Participants of Lung Cancer Screening Studies
Zyla J, Marczyk M, Prazuch W, Sitkiewicz M, Durawa A, Jelitto M, Dziadziuszko K, Jelonek K, Kurczyk A, Szurowska E, Rzyman W, Widłak P, Polanska J. Combining Low-Dose Computer-Tomography-Based Radiomics and Serum Metabolomics for Diagnosis of Malignant Nodules in Participants of Lung Cancer Screening Studies. Biomolecules 2023, 14: 44. PMID: 38254644, PMCID: PMC10813699, DOI: 10.3390/biom14010044.Peer-Reviewed Original ResearchSerum metabolomicsComputed tomography lung cancer screeningLow-dose computed tomography (LDCT) lung cancer screeningLung cancer screening studyTomography lung cancer screeningLung cancer screeningCancer screening studyLung cancer diagnosisCollected cohortCancer screeningLung cancerSerum metabolomeBenign lesionsPulmonary nodulesMetabolomic evaluationAuxiliary biomarkerLogistic regressionDiagnosisCancer diagnosisLung nodulesMalignant nodulesScreening studyPatientsRadiomicsMolecular featuresChest Wall Anomaly Presenting as Pulmonary Nodule
Ely S, Van Udelsman B, Bader A, Woodard G. Chest Wall Anomaly Presenting as Pulmonary Nodule. Annals Of Thoracic Surgery Short Reports 2023, 2: 88-90. PMID: 39790260, PMCID: PMC11708574, DOI: 10.1016/j.atssr.2023.11.021.Peer-Reviewed Original ResearchA Highly Sensitive and Specific Non‐Invasive Test through Genome‐Wide 5‐Hydroxymethylation Mapping for Early Detection of Lung Cancer
Ren Y, Zhang Z, She Y, He Y, Li D, Shi Y, He C, Yang Y, Zhang W, Chen C. A Highly Sensitive and Specific Non‐Invasive Test through Genome‐Wide 5‐Hydroxymethylation Mapping for Early Detection of Lung Cancer. Small Methods 2023, 8: e2300747. PMID: 37990399, DOI: 10.1002/smtd.202300747.Peer-Reviewed Original ResearchConceptsNon-small-cell lung cancerArea under the curveCell-free DNACell lung cancerBlood-based testLung cancerNon-small cell lung cancerLow-dose computed tomography screeningSmall cell lung cancerComputed tomography screeningCell-free DNA samplesEarly detection of lung cancerNon-invasive testsDetect cell-free DNADetection of lung cancerDetect lung cancerPulmonary nodulesSerum biomarkersDiagnostic accuracyHealthy controlsCancerTissue originLungEarly detectionPatientsClinical Implementation of a Combined Artificial Intelligence and Natural Language Processing Quality Assurance Program for Pulmonary Nodule Detection in the Emergency Department Setting
Cavallo J, de Oliveira Santo I, Mezrich J, Forman H. Clinical Implementation of a Combined Artificial Intelligence and Natural Language Processing Quality Assurance Program for Pulmonary Nodule Detection in the Emergency Department Setting. Journal Of The American College Of Radiology 2023, 20: 438-445. PMID: 36736547, DOI: 10.1016/j.jacr.2022.12.016.Peer-Reviewed Original ResearchConceptsEmergency department settingPulmonary nodulesCT examinationsDepartment settingSecondary reviewNumber of patientsQuality assurance studyMedian timeEmergent settingPatient followImaging recommendationsAppropriate followMajority of reviewsRadiological reportsAssurance studyClinical implementationLung anatomyQuality assurance programPatientsSignificant delayNodulesFollowExaminationPulmonary nodule detectionNodule detection
2022
Precise characterization of a solitary pulmonary nodule using tumor shadow disappearance rate-corrected F-18 FDG PET and enhanced CT
Park K, Seon H, Yun J, Yoo S, Lee C, Kang S, Kim J, Cho S, Song H, Bom H, Min J, Kwon S. Precise characterization of a solitary pulmonary nodule using tumor shadow disappearance rate-corrected F-18 FDG PET and enhanced CT. Medicine 2022, 101: e28764. PMID: 35119036, PMCID: PMC8812657, DOI: 10.1097/md.0000000000028764.Peer-Reviewed Original ResearchConceptsTumor shadow disappearance rateSolitary pulmonary nodulesF-18 fluorodeoxyglucoseCharacterization of SPNsEnhanced CTPulmonary nodulesTumor areaHigh value of SUVmaxF-18 FDG PETPositron emission tomography/computed tomographyF-18 fluorodeoxyglucose uptakeImaging parametersValue of SUVmaxEmission tomography/computed tomographyStandardized uptake valueTissue densityPost-enhanced CTEnhanced CT imagesPreenhancement CTTomography/computed tomographyChest CTLung windowMediastinal windowUptake valueFDG-PET
2020
A Tale of Three Rarities: Secondary Amyloid A (AA) Amyloidosis Caused by Recurrent Sialadenitis and Complicated by Pulmonary Hypertension and Adrenal Insufficiency
Desai P, Mbachi C, Joshi U, Mba B. A Tale of Three Rarities: Secondary Amyloid A (AA) Amyloidosis Caused by Recurrent Sialadenitis and Complicated by Pulmonary Hypertension and Adrenal Insufficiency. Cureus 2020, 12: e7792. PMID: 32455087, PMCID: PMC7243608, DOI: 10.7759/cureus.7792.Peer-Reviewed Original ResearchAmyloid A (AA) amyloidosisRecurrent sialadenitisPulmonary hypertensionAdrenal insufficiencyAcute hypoxic respiratory failureA (AA) amyloidosisElevated gamma gapHypoxic respiratory failureSystemic amyloid A (AA) amyloidosisSystemic AA amyloidosisAlkaline phosphatase elevationConstellation of findingsGamma gapAdrenal involvementRenal dysfunctionRespiratory failureLiver biopsyRare sequelaAmyloid depositionMental statusAA amyloidosisParotid massPulmonary nodulesMicrocytic anemiaHypertension
2019
Imaging Features of Pulmonary Leukemic Infiltration With Comparison of Lymphoid and Myeloid Leukemias
Gosangi B, Hatabu H, Hammer MM. Imaging Features of Pulmonary Leukemic Infiltration With Comparison of Lymphoid and Myeloid Leukemias. Current Problems In Diagnostic Radiology 2019, 50: 164-167. PMID: 31582265, DOI: 10.1067/j.cpradiol.2019.09.007.Peer-Reviewed Original ResearchConceptsBronchovascular bundle thickeningMyeloid leukemiaLeukemic infiltrationLung infiltrationCentrilobular nodulesImaging featuresLymphoid leukemiaPulmonary leukemic infiltrationCommon imaging featuresChronic lymphocytic leukemiaElectronic medical recordsConsolidative opacitiesHilar lymphadenopathyLung involvementSeptal thickeningMediastinal lymphadenopathyPulmonary massCT findingsMedical recordsDifferential diagnosisLymphocytic leukemiaInterstitial abnormalitiesPulmonary nodulesLeukemiaPatientsPulmonary Leiomyomatosis: A Case Report [10L]
Kailasam A, Dubinskaya A, Roland P. Pulmonary Leiomyomatosis: A Case Report [10L]. Obstetrics And Gynecology 2019, 133: 131s-131s. DOI: 10.1097/01.aog/01.aog.0000559244.16502.f5.Peer-Reviewed Original ResearchOvarian massPulmonary symptomsPulmonary nodulesLeft ovarian massSevere chest painFeatures of leiomyomaUnilocular ovarian cystsAnti-hormonal therapyMultidisciplinary tumor boardVATS resectionBilateral oophorectomyTotal hysterectomyCA-125Uterine leiomyomataChest painTransvaginal ultrasoundClinical coursePleural nodulesSurgical managementOvarian cystsSurgical historyCT scanMalignant metastasisTumor boardAnti-estrogen
2018
[18F]Fluorocholine and [18F]Fluoroacetate PET as Imaging Biomarkers to Assess Phosphatidylcholine and Mitochondrial Metabolism in Preclinical Models of TSC and LAM
Verwer E, Kavanagh T, Mischler W, Feng Y, Takahashi K, Wang S, Shoup T, Neelamegam R, Yang J, Guehl N, Ran C, Massefski W, Cui Y, El-Chemaly S, Sadow P, Oldham W, Kijewski M, Fakhri G, Normandin M, Priolo C. [18F]Fluorocholine and [18F]Fluoroacetate PET as Imaging Biomarkers to Assess Phosphatidylcholine and Mitochondrial Metabolism in Preclinical Models of TSC and LAM. Clinical Cancer Research 2018, 24: 5925-5938. PMID: 30054282, PMCID: PMC6816044, DOI: 10.1158/1078-0432.ccr-17-3693.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnimalsBiomarkersCholineDisease Models, AnimalFemaleFluoroacetatesHeterograftsHumansImage Processing, Computer-AssistedImmunohistochemistryLipid MetabolismLymphangioleiomyomatosisMaleMiceMice, TransgenicMitochondriaOxygen ConsumptionPhosphatidylcholinesPositron-Emission TomographyRatsTuberous SclerosisConceptsTuberous sclerosis complexMetabolic imaging biomarkersPreclinical modelsImaging biomarkersTSC2-deficient cellsStandardized uptake valueTuberous sclerosis complex manifestationsModels of tuberous sclerosis complexAutosomal dominant disorderPotential clinical interestBenign tumorsOvariectomized miceUptake valueSubcutaneous tumorsPreclinical studiesPulmonary nodulesCystic destructionLymphangioleiomyomatosisDominant disorderProliferative lesionsInactivating mutationsTumorMetabolic reprogrammingNeurocognitive impairmentPET imagingPrevalence and variability in reporting of clinically actionable incidental findings on attenuation-correction CT scans in a veteran population
He BJ, Malm BJ, Carino M, Sadeghi MM. Prevalence and variability in reporting of clinically actionable incidental findings on attenuation-correction CT scans in a veteran population. Journal Of Nuclear Cardiology 2018, 26: 1688-1693. PMID: 29492838, DOI: 10.1007/s12350-018-1232-9.Peer-Reviewed Original ResearchConceptsIncidental noncardiac findingsMyocardial perfusion imagingNoncardiac findingsPulmonary nodulesIncidental findingActionable incidental findingsVeteran populationOverall interobserver agreementAttenuation correction CTSpecific guidelinesHiatal herniaExtracardiac massPleural plaquesAortic aneurysmPhysician specialtyPerfusion imagingCommon occurringCardiologistsInterobserver agreementInterreader agreementAttenuation artifactsRadiologistsPrevalenceNodulesVeterans
2017
Safety of coronary CT angiography and functional testing for stable chest pain in the PROMISE trial: A randomized comparison of test complications, incidental findings, and radiation dose
Lu MT, Douglas PS, Udelson JE, Adami E, Ghoshhajra BB, Picard MH, Roberts R, Lee KL, Einstein AJ, Mark DB, Velazquez EJ, Carter W, Ridner M, Al-Khalidi HR, Hoffmann U. Safety of coronary CT angiography and functional testing for stable chest pain in the PROMISE trial: A randomized comparison of test complications, incidental findings, and radiation dose. Journal Of Cardiovascular Computed Tomography 2017, 11: 373-382. PMID: 28838846, PMCID: PMC6201309, DOI: 10.1016/j.jcct.2017.08.005.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngina PectorisComputed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseCoronary StenosisEchocardiography, StressFemaleHumansIncidental FindingsMaleMiddle AgedMultidetector Computed TomographyNorth AmericaPredictive Value of TestsProspective StudiesRadiation DosageRadiation ExposureRadionuclide ImagingRisk AssessmentRisk FactorsConceptsStable chest painMore incidental findingsIncidental findingLow radiation doseChest painPatient characteristicsRadiation doseNuclear stress testingCoronary CT angiographyRadiation dose variesCumulative radiation doseAdvanced CT scannersMinor complicationsPROMISE trialRandomized comparisonTomography angiographyFunctional testingTest choiceFunctional testing strategyCT angiographyNuclear stressPulmonary nodulesSimilar outcomesComplicationsDose
2016
Serum mass profile signature as a biomarker of early lung cancer
Widlak P, Pietrowska M, Polanska J, Marczyk M, Ros-Mazurczyk M, Dziadziuszko R, Jassem J, Rzyman W. Serum mass profile signature as a biomarker of early lung cancer. Lung Cancer 2016, 99: 46-52. PMID: 27565913, DOI: 10.1016/j.lungcan.2016.06.011.Peer-Reviewed Original ResearchConceptsEarly lung cancerLung cancerNegative predictive valuePredictive valueComputed tomographyEarly-stage lung cancerLow-dose computed tomographyIndeterminate pulmonary nodulesStage lung cancerPotential clinical usefulnessPositive predictive valueValidation cohortHealthy controlsClinical usefulnessDiscovery cohortBlood samplesIndependent cohortWeight serum fractionsPulmonary nodulesIndependent sample setCancerPatientsHealthy participantsMolecular biomarkersCohort
2015
Prediction of Pulmonary Metastasis in Renal Cell Carcinoma Patients with Indeterminate Pulmonary Nodules
Adibi M, Kenney PA, Thomas AZ, Borregales LD, Nogueras-González GM, Wang X, Devine CE, Karam JA, Wood CG. Prediction of Pulmonary Metastasis in Renal Cell Carcinoma Patients with Indeterminate Pulmonary Nodules. European Urology 2015, 69: 352-360. PMID: 26382085, DOI: 10.1016/j.eururo.2015.08.053.Peer-Reviewed Original ResearchConceptsLung metastasis-free survivalIndeterminate pulmonary nodulesRenal cell carcinomaAdvanced renal cell carcinomaPulmonary metastasesCell carcinomaPulmonary nodulesMultivariable Cox regression modelsRenal cell carcinoma patientsRadical nephrectomy patientsCell carcinoma patientsMetastasis-free survivalCox regression modelIndividualized risk stratificationAvailable preoperative imagingKidney cancer patientsSmall lung nodulesThree yrNephrectomy patientsPreoperative chestOverall cohortCarcinoma patientsDistant metastasisPathological variablesRadical nephrectomyPredicting pulmonary metastases among patients with indeterminate pulmonary nodules with renal cell carcinoma.
Adibi M, Kenney P, Thomas A, Devine C, Karam J, Wood C. Predicting pulmonary metastases among patients with indeterminate pulmonary nodules with renal cell carcinoma. Journal Of Clinical Oncology 2015, 33: 505-505. DOI: 10.1200/jco.2015.33.7_suppl.505.Peer-Reviewed Original ResearchIndeterminate pulmonary nodulesPulmonary metastasesChest CTTumor thrombusFat invasionLung metastasesTumor gradePulmonary nodulesRenal cell carcinoma patientsRenal sinus fat invasionRadical nephrectomy patientsRenal tumor diameterCancer-specific mortalityCell carcinoma patientsSinus fat invasionHigh tumor gradeLung metastasis developmentRenal cell carcinomaNephrectomy patientsHilar lymphadenopathyPerformance statusCarcinoma patientsIndependent predictorsSmoking statusTumor diameter
2014
The IASLC/ITMIG Thymic Epithelial Tumors Staging Project: Proposals for the N and M Components for the Forthcoming (8th) Edition of the TNM Classification of Malignant Tumors
Kondo K, Van Schil P, Detterbeck FC, Okumura M, Stratton K, Giroux D, Asamura H, Crowley J, Falkson C, Filosso PL, Giaccone G, Huang J, Kim J, Lucchi M, Marino M, Marom EM, Nicholson AG, Ruffini E, Committee††† O, Boards‡‡‡ M, Domain§§§ P. The IASLC/ITMIG Thymic Epithelial Tumors Staging Project: Proposals for the N and M Components for the Forthcoming (8th) Edition of the TNM Classification of Malignant Tumors. Journal Of Thoracic Oncology 2014, 9: s81-s87. PMID: 25396316, DOI: 10.1097/jto.0000000000000291.Peer-Reviewed Original Research
2009
Pulmonary amyloidosis with calcified nodules and masses - a six-year computed tomography follow-up: a case report
Vieira I, Marchiori E, Zanetti G, Cabral R, Takayassu T, Spilberg G, Batista R. Pulmonary amyloidosis with calcified nodules and masses - a six-year computed tomography follow-up: a case report. Cases Journal 2009, 2: 6540. PMID: 19918529, PMCID: PMC2769299, DOI: 10.4076/1757-1626-2-6540.Peer-Reviewed Original ResearchPulmonary amyloidosisPulmonary nodulesOpen lung biopsyMultiple pulmonary nodulesPrimary pulmonary amyloidosisLung biopsyCase presentationWeUncommon diseaseNodular amyloidosisCase reportDifferential diagnosisChest radiographsFibrillary proteinExtracellular depositionAmyloidosisCalcified nodulesSix yearsNodulesTomographyReportDyspneaHemoptysisLong-term observationsCoughPulmonaryComputer-aided detection for the identification of pulmonary nodules in pediatric oncology patients: initial experience
Helm EJ, Silva CT, Roberts HC, Manson D, Seed MT, Amaral JG, Babyn PS. Computer-aided detection for the identification of pulmonary nodules in pediatric oncology patients: initial experience. Pediatric Radiology 2009, 39: 685-693. PMID: 19418048, DOI: 10.1007/s00247-009-1259-9.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAlgorithmsArtificial IntelligenceChildChild, PreschoolFemaleHumansLung NeoplasmsMaleObserver VariationPattern Recognition, AutomatedPilot ProjectsRadiographic Image EnhancementRadiographic Image Interpretation, Computer-AssistedReproducibility of ResultsSensitivity and SpecificitySolitary Pulmonary NoduleTomography, X-Ray ComputedConceptsPediatric oncology patientsPulmonary nodulesSensitivity of CADOncology patientsPediatric patientsPrimary tumorIRB approvalPediatric radiologistsMethodsCT scansInitial experiencePatientsLung nodulesNodule sizeNodulesAvailable CAD systemPerformance of CADRadiologistsComputer-aided detectionInitial findingsLow numberRadiologists' sensitivityObjectiveToTumorsSensitivity
2007
Beliefs among Physicians in the Diagnostic and Therapeutic Approach to Non-small Cell Lung Cancer
Stinchcombe TE, Detterbeck FC, Lin L, Rivera MP, Socinski MA. Beliefs among Physicians in the Diagnostic and Therapeutic Approach to Non-small Cell Lung Cancer. Journal Of Thoracic Oncology 2007, 2: 819-826. PMID: 17805059, DOI: 10.1097/jto.0b013e31811f478a.Peer-Reviewed Original ResearchMeSH KeywordsCarcinoma, Non-Small-Cell LungClinical CompetenceCombined Modality TherapyFemaleHumansLung NeoplasmsMaleNeoplasm StagingOutcome Assessment, Health CarePractice Guidelines as TopicQuality of LifeRetrospective StudiesSeverity of Illness IndexSurveys and QuestionnairesSurvival RateUnited StatesConceptsEvidence-based guidelinesStage IV diseaseSolitary pulmonary nodulesLung cancerPhysicians' beliefsPractice beliefsPulmonary nodulesNon-small cell lung cancerRole of chemotherapyStage III diseaseMediastinal lymph nodesPostoperative radiation therapyCell lung cancerTreatment of patientsMajority of physiciansQuality of lifePositron emission tomographyReminder e-mailsAdjuvant chemotherapyOperable patientsSurvival benefitChest PhysiciansLymph nodesPractice patternsRadiation therapy
2006
Massive cavitary pulmonary rheumatoid nodules in a patient with HIV
Khazeni N, Homer RJ, Rubinowitz AN, Chupp GL. Massive cavitary pulmonary rheumatoid nodules in a patient with HIV. European Respiratory Journal 2006, 28: 872-874. PMID: 17012633, DOI: 10.1183/09031936.06.00144105.Peer-Reviewed Original ResearchConceptsRheumatoid nodulesRheumatoid arthritisCavitary pulmonary nodulesPulmonary rheumatoid nodulesWarrants further investigationLung biopsyHIV infectionDiagnostic bronchoscopyPathological analysisPulmonary nodulesArthritisHIVFurther investigationNodulesBronchoscopyBiopsyPatientsHistiocytesPrognosisNecrobiosisInfection
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