2025
Optimal approach to performing and reporting computed tomography angiography for suspected acute pulmonary embolism: a clinical consensus statement of the ESC Working Group on Pulmonary Circulation & Right Ventricular Function, the Fleischner Society, the Association for Acute CardioVascular Care (ACVC) and the European Association of Cardiovascular Imaging (EACVI) of the ESC, endorsed by European Respiratory Society (ERS), Asian Society of Thoracic Radiology (ASTR), European Society of Thoracic Imaging (ESTI), and Society of Thoracic Radiology (STR)
Klok F, Barco S, Bertoletti L, Bhalla S, Dubois S, Le Gal G, Haramati L, van Hooidonk E, Humbert M, Konstantinides S, Lang I, Murphy W, Ohno Y, Price S, Prokop M, Pruszczyk P, Rossi A, Thistlethwaite P, West C, Remy-Jardin M. Optimal approach to performing and reporting computed tomography angiography for suspected acute pulmonary embolism: a clinical consensus statement of the ESC Working Group on Pulmonary Circulation & Right Ventricular Function, the Fleischner Society, the Association for Acute CardioVascular Care (ACVC) and the European Association of Cardiovascular Imaging (EACVI) of the ESC, endorsed by European Respiratory Society (ERS), Asian Society of Thoracic Radiology (ASTR), European Society of Thoracic Imaging (ESTI), and Society of Thoracic Radiology (STR). European Heart Journal - Cardiovascular Imaging 2025, 26: 1085-1098. PMID: 40457988, DOI: 10.1093/ehjci/jeaf050.Peer-Reviewed Original ResearchConceptsEuropean Society of CardiologyEuropean Association of Cardiovascular ImagingComputed tomography angiographySociety of Thoracic RadiologyEuropean Society of Thoracic ImagingAcute pulmonary embolismRight ventricular functionPulmonary embolismClinical consensus statementEuropean Respiratory SocietyPE patientsVentricular functionComputed tomography angiography reportsDiagnosing acute pulmonary embolismSuspected acute pulmonary embolismComputed tomography angiography findingsConsensus statementThoracic radiologyCardiovascular imagingEuropean Society of Cardiology Working GroupFleischner SocietyEuropean AssociationCT imaging findingsSociety of CardiologyEuropean SocietyOptimal Approach to Performing and Reporting Computed Tomography Angiography for Suspected Acute Pulmonary Embolism: A Clinical Consensus Statement of the ESC Working Group on Pulmonary Circulation & Right Ventricular Function, the Fleischner Society, the Association for Acute Cardiovascular Care (ACVC) and the European Association of Cardiovascular Imaging (EACVI) of the ESC, Endorsed by European Respiratory Society (ERS), Asian Society of Thoracic Radiology (ASTR), European Society of Thoracic Imaging (ESTI), and Society of Thoracic Radiology (STR).
Klok F, Barco S, Bertoletti L, Bhalla S, Dubois S, Le Gal G, Haramati L, van Hooidonk E, Humbert M, Konstantinides S, Lang I, Murphy W, Ohno Y, Price S, Prokop M, Pruszczyk P, Rossi A, Thistlethwaite P, West C, Remy-Jardin M. Optimal Approach to Performing and Reporting Computed Tomography Angiography for Suspected Acute Pulmonary Embolism: A Clinical Consensus Statement of the ESC Working Group on Pulmonary Circulation & Right Ventricular Function, the Fleischner Society, the Association for Acute Cardiovascular Care (ACVC) and the European Association of Cardiovascular Imaging (EACVI) of the ESC, Endorsed by European Respiratory Society (ERS), Asian Society of Thoracic Radiology (ASTR), European Society of Thoracic Imaging (ESTI), and Society of Thoracic Radiology (STR). Radiology 2025, 315: e243833. PMID: 40459417, DOI: 10.1148/radiol.243833.Peer-Reviewed Original ResearchConceptsEuropean Society of CardiologyEuropean Association of Cardiovascular ImagingSociety of Thoracic RadiologyEuropean Society of Thoracic ImagingAcute pulmonary embolismRight ventricular functionCT angiographyPulmonary embolismClinical consensus statementEuropean Respiratory SocietyPE patientsVentricular functionDiagnosing acute pulmonary embolismSuspected acute pulmonary embolismConsensus statementThoracic radiologyCardiovascular imagingEuropean Society of Cardiology Working GroupFleischner SocietyEuropean AssociationCT angiography findingsCT imaging findingsComputed tomography angiographyCT angiography reportsSociety of CardiologyCT in Pulmonary Embolism
Alis J, Haramati L. CT in Pulmonary Embolism. 2025, 1-22. DOI: 10.1007/978-3-030-70904-4_64-2.Peer-Reviewed Original ResearchRight ventricular/left ventricular diameter ratioEvaluation of acute PEPrognostic value of CTMethods of risk stratificationVentricular diameter ratioCT pulmonary angiographyValue of CTChronic PEPulmonary angiographyAcute PEObstruction scorePrognostic valuePulmonary embolismRisk stratificationClot locationPerfusion mapsDiagnostic studiesRisk Factors for and Prediction of Early Thromboembolic Disease Following Adult Spinal Deformity Surgery
Gallagher D, Bondar K, Hirase T, Harris J, Vemu S, Louie P, Varthi A, Lambert B, Saifi C. Risk Factors for and Prediction of Early Thromboembolic Disease Following Adult Spinal Deformity Surgery. Journal Of Bone And Joint Surgery 2025, 107: 1219-1226. PMID: 40273208, PMCID: PMC12118619, DOI: 10.2106/jbjs.23.01391.Peer-Reviewed Original ResearchConceptsDeep vein thrombosisChronic corticosteroid useAdult spinal deformityPulmonary embolismCorticosteroid useVTE riskRisk factorsCurrent Procedural TerminologyASA classAmerican College of Surgeons National Surgical Quality Improvement Program databaseFactors associated with deep vein thrombosisSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseRisk factors associated with deep vein thrombosisAmerican Society of Anesthesiologists (ASA) classAdult spinal deformity surgeryQuality Improvement Program databaseRisk of deep vein thrombosisRate of deep vein thrombosisPostoperative deep vein thrombosisDescription of levels of evidenceSpinal deformity surgeryAssociated with VTE riskPostoperative VTE riskPreoperative risk assessmentLong-term mortality from imaging-diagnosed pulmonary embolism in women and men
Sosner E, Mathai B, Bordon A, Ye K, Moadel R, Haramati L, Lazarus M. Long-term mortality from imaging-diagnosed pulmonary embolism in women and men. Clinical Imaging 2025, 122: 110469. PMID: 40273669, DOI: 10.1016/j.clinimag.2025.110469.Peer-Reviewed Original ResearchConceptsElectronic health recordsOne-year mortalityIncreased one-year mortalityCox proportional hazards modelsCharlson Comorbidity IndexProportional hazards modelLong-term mortalityUrban academic medical centerNational Death IndexMortality of womenHazards modelAcademic medical centerStudy of adultsHigher hazard ratioHealth recordsDeath IndexHealth statusInclusion of ageImpact of PEHazard ratioRetrospective study of adultsMedical CenterRisk factorsComorbidity indexPulmonary embolismLeveraging Artificial Intelligence in the Diagnosis and Management of Pulmonary Embolism
Mojibian H, Khosla A. Leveraging Artificial Intelligence in the Diagnosis and Management of Pulmonary Embolism. 2025, 1-15. DOI: 10.1007/978-3-030-70904-4_72-1.Peer-Reviewed Original ResearchIsolated subsegmental pulmonary embolism identification based on international classification of diseases (ICD)-10 codes and imaging reports
Rashedi S, Bejjani A, Hunsaker A, Aghayev A, Khairani C, McGonagle B, Lo Y, Mahajan S, Caraballo C, Jimenez J, Krishnathasan D, Zarghami M, Monreal M, Barco S, Secemsky E, Klok F, Muriel A, Hussain M, Appah-Sampong A, Rahaghi F, Sadeghipour P, Lin Z, Mojibian H, Aneja S, Konstantinides S, Goldhaber S, Wang L, Zhou L, Jimenez D, Krumholz H, Piazza G, Bikdeli B, Investigators T. Isolated subsegmental pulmonary embolism identification based on international classification of diseases (ICD)-10 codes and imaging reports. Thrombosis Research 2025, 247: 109271. PMID: 39862754, DOI: 10.1016/j.thromres.2025.109271.Peer-Reviewed Original ResearchInternational Classification of Diseases (ICD)-10 codesICD-10International ClassificationPositive predictive valueDischarge diagnosisAccuracy of ICD-10Radiology reportsPrincipal discharge diagnosisSecondary discharge diagnosisIsolated subsegmental pulmonary embolismMedical records of adult patientsHealth systemRecords of adult patientsPredictive valueBlinded re-evaluationExpert radiologistsSubsegmental pulmonary embolismQuality improvementMedical recordsChart reviewPresence of PEProximal PEPulmonary embolismAdult patientsImaging ReportingBeyond convention: non-compacted myocardium, ventricular tachycardia, and systolic dysfunction in dextrocardia patients: a case series
Nazarenko N, Maliha M, Cerna L, Abittan N, Borkowski P, Csecs I, Garcia M. Beyond convention: non-compacted myocardium, ventricular tachycardia, and systolic dysfunction in dextrocardia patients: a case series. Annals Of Medicine And Surgery 2025, 87: 56-61. PMID: 40109641, PMCID: PMC11918691, DOI: 10.1097/ms9.0000000000002855.Peer-Reviewed Original ResearchLeft ventricleDextrocardia patientsICD placementSeverely reduced ejection fractionHigh risk of sudden cardiac deathRight-sided pleural effusionRisk of sudden cardiac deathAbnormal myocardial developmentYears of follow-upNon-compacted myocardiumTreated with amiodaroneSubsegmental pulmonary embolismTreated with enoxaparinLong-term outcomesSudden cardiac deathSystolic dysfunctionEvent-freeWorsening dyspneaEjection fractionPulmonary embolismAtrial dilatationPleural effusionConduction abnormalitiesMedical therapyCase seriesIntercontinental variations in the presentation and management of venous thromboembolism
Chaar C, Chan S, Lee A, Bikdeli B, Tiberio G, Chopard R, Weinberg I, Yamashita Y, Nikandish R, Monreal M. Intercontinental variations in the presentation and management of venous thromboembolism. JVS-Vascular Insights 2025, 3: 100201. DOI: 10.1016/j.jvsvi.2025.100201.Peer-Reviewed Original ResearchManagement of venous thromboembolismVenous thromboembolismPulmonary embolismLow-risk pulmonary embolismTreatment modalities of patientsOpen pulmonary embolectomyVenous thromboembolism presentationHigh-risk PEIntermediate-risk PELow-molecular-weight heparinLower body mass indexVitamin K antagonistsSystemic thrombolytic therapyProportion of patientsVenous thromboembolism patientsBody mass indexCoronary artery diseaseTreatment of PEPulmonary embolectomyK antagonistsOral anticoagulantsProximal DVTActive cancerOutpatient anticoagulationEndovascular treatment
2024
Novel Mechanical Aspiration Thrombectomy in Patients With Acute Pulmonary Embolism: Results From the Prospective APEX-AV Trial
Ranade M, Foster M, Brady P, Sokol S, Butty S, Klein A, Maholic R, Safar A, Patel T, Zlotnick D, Gans D, Pollak J, Ferrera D, Stegman B, Basra S, Moriarty J, Keeling B, Investigators A. Novel Mechanical Aspiration Thrombectomy in Patients With Acute Pulmonary Embolism: Results From the Prospective APEX-AV Trial. Journal Of The Society For Cardiovascular Angiography & Interventions 2024, 4: 102463. PMID: 40061412, PMCID: PMC11887559, DOI: 10.1016/j.jscai.2024.102463.Peer-Reviewed Original ResearchAcute intermediate-risk PEMechanical aspiration thrombectomyIntermediate-risk PEPulmonary embolismAspiration thrombectomyRV/LV ratioClot burdenAdverse eventsMm HgLow rate of adverse eventsMean pulmonary artery pressureEnd pointsRate of adverse eventsAcute pulmonary embolismPulmonary artery pressureSafety end pointDevice-related deathsTreat pulmonary embolismSingle-arm studyEffectiveness end pointAccess site bleedingStatistically significant reductionCardiac injuryClinical deteriorationArterial pressureThe Incidence and Significance of Iliac Vein Stenosis in Patients with Deep Vein Thrombosis
Ali S, Chan S, Brahmandam A, Xu Y, Deng Y, Elbadawy A, Lee A, Ochoa Chaar C. The Incidence and Significance of Iliac Vein Stenosis in Patients with Deep Vein Thrombosis. Annals Of Vascular Surgery 2024, 111: 310-318. PMID: 39617297, DOI: 10.1016/j.avsg.2024.11.016.Peer-Reviewed Original ResearchIliac vein stenosisIpsilateral DVT recurrenceCross-sectional imagingDVT recurrenceVein stenosisMedical records of consecutive adult patientsRecords of consecutive adult patientsSubgroup analysisPrevention of pulmonary embolismDevelopment of DVTConsecutive adult patientsIncidence of PEDeep vein thrombosisGroup of patientsLower extremity DVTRecurrent DVTPulmonary embolismVein thrombosisBaseline characteristicsRetrospective studyAdult patientsDVTPatientsElectronic medical recordsStatistical significanceSex differences in treatment strategies for pulmonary embolism in older adults: The SERIOUS-PE study of RIETE participants and US Medicare beneficiaries
Bikdeli B, Leyva H, Muriel A, Lin Z, Piazza G, Khairani C, Rosovsky R, Mehdipour G, O’Donoghue M, Madridano O, Lopez-Saez J, Mellado M, Brasero A, Grandone E, Spagnolo P, Lu Y, Bertoletti L, López-Jiménez L, Núñez M, Blanco-Molina Á, Gerhard-Herman M, Goldhaber S, Bates S, Jimenez D, Krumholz H, Monreal M. Sex differences in treatment strategies for pulmonary embolism in older adults: The SERIOUS-PE study of RIETE participants and US Medicare beneficiaries. Vascular Medicine 2024, 30: 58-66. PMID: 39588564, DOI: 10.1177/1358863x241292023.Peer-Reviewed Original ResearchRegistro Informatizado Enfermedad TromboEmbolicaIntermediate-risk PEInferior vena cavaPulmonary embolismFibrinolytic therapyAdvanced therapiesInferior vena cava filter placementUS Medicare beneficiariesSex differencesOlder adultsMedicare beneficiariesAnticoagulation patternsFilter placementVena cavaMale patientsClinical outcomesTreatment strategiesAssess sex differencesPE therapyTherapyRisk factorsStandardized differenceAnticoagulationTherapy utilizationSex disparitiesThrombolytic Therapy for Venous Thromboembolism in the Pediatric Population: A Systematic Review and Meta-Analysis
Kawtharany H, Azzam M, Monagle P, Bercovitz R, Alkhader A, Hamarsha Q, Zeid H, Mansour R, Tabak C, Patel P, Baghdadi S, Betensky M, Bhat R, Biss T, Branchford B, Brandao L, Chan A, Faustino E, Jaffray J, Jones S, Kerlin B, Kucine N, Kumar R, Male C, Pelland-Marcotte M, Raffini L, Raulji C, Sartain S, Takemoto C, Tarango C, Van Ommen H, Velez M, Vesely S, Wiernikowski J, Williams S, Wilson H, Woods G, Zia A, Mustafa R. Thrombolytic Therapy for Venous Thromboembolism in the Pediatric Population: A Systematic Review and Meta-Analysis. Blood 2024, 144: 2633. DOI: 10.1182/blood-2024-212166.Peer-Reviewed Original ResearchRate of thrombus resolutionAbsolute riskRisk of biasCertainty of evidenceMassive PEThrombolytic therapyPediatric patientsOutcome of thrombolysisAC groupPulmonary embolismSystematic reviewThrombus resolutionCovidence systematic review softwareRisk of thrombosis recurrenceThrombolysis groupMeta-analysisConcerns related to riskSystematic review softwareSubmassive pulmonary embolismChronic pulmonary hypertensionManagement of VTERestoring venous patencyRisk of progressionCochrane Central Register of Controlled TrialsCentral Register of Controlled TrialsValidating International Classification of Diseases Code 10th Revision algorithms for accurate identification of pulmonary embolism
Bikdeli B, Khairani C, Bejjani A, Lo Y, Mahajan S, Caraballo C, Jimenez J, Krishnathasan D, Zarghami M, Rashedi S, Jimenez D, Barco S, Secemsky E, Klok F, Hunsaker A, Aghayev A, Muriel A, Hussain M, Appah-Sampong A, Lu Y, Lin Z, Mojibian H, Aneja S, Khera R, Konstantinides S, Goldhaber S, Wang L, Zhou L, Monreal M, Piazza G, Krumholz H, Investigators P. Validating International Classification of Diseases Code 10th Revision algorithms for accurate identification of pulmonary embolism. Journal Of Thrombosis And Haemostasis 2024, 23: 556-564. PMID: 39505153, DOI: 10.1016/j.jtha.2024.10.013.Peer-Reviewed Original ResearchDischarge codesInternational ClassificationICD-10Yale New Haven Health SystemPositive predictive valueMass General Brigham hospitalsAccuracy of ICD-10ICD-10 codesPulmonary embolismHealth systemImage codingElectronic databasesF1 scorePre-specified protocolExcellent positive predictive valueIndependent physiciansHighest F1 scoreIdentification of pulmonary embolismAcute pulmonary embolismSecondary codePE codesScoresIdentified PERevised algorithmA rare case of endoscopic visualization of a metallic coil in a duodenal ulcer after transcatheter arterial embolization
Ameyaw P, Jajja A, Ilagan-Ying Y. A rare case of endoscopic visualization of a metallic coil in a duodenal ulcer after transcatheter arterial embolization. Oxford Medical Case Reports 2024, 2024: omae143. PMID: 39588506, PMCID: PMC11586761, DOI: 10.1093/omcr/omae143.Peer-Reviewed Original ResearchTranscatheter arterial embolizationArtery embolizationEndoscopic hemostatic techniquesHemostatic techniquesIncreased vasopressor requirementMinimally invasive approachRare adverse eventsMetallic coilsVasopressor requirementsRepeat esophagogastroduodenoscopyComplication ratePulmonary embolismBipolar cauteryBowel obstructionInvasive approachRare caseAdverse eventsMultidisciplinary consultationEpinephrine injectionEndoscopic visualizationEmbolizationCulprit vesselUlcer baseCoil migrationDuodenal ulcerHeart lung axis in acute pulmonary embolism: Role of CT in risk stratification
Friedman R, Haramati L, Christian T, Sokol S, Alis J. Heart lung axis in acute pulmonary embolism: Role of CT in risk stratification. Clinical Imaging 2024, 116: 110311. PMID: 39413674, DOI: 10.1016/j.clinimag.2024.110311.Peer-Reviewed Original ResearchPathophysiology of pulmonary embolismRisk stratificationPulmonary embolismComputed tomographyRight ventricular (RV) dysfunctionRisk stratification of acute PEIndicator of RV dysfunctionRV/LV diameter ratioAcute pulmonary embolismLeft atrial volumeReview current guidelinesCause of mortalityRV dysfunctionAcute PEAtrial volumeCT findingsClot burdenCardiopulmonary reserveCurrent guidelinesLung axisClot locationPatient managementPatient populationRadiologist's reportPredictive valueA Rare Case of Acute Bacterial Native Valve Endocarditis Caused by Streptococcus thoraltensis
Abid S, Stolear A, Dulgher M, Sethi S, Zarich S. A Rare Case of Acute Bacterial Native Valve Endocarditis Caused by Streptococcus thoraltensis. Cureus 2024, 16: e70934. PMID: 39502956, PMCID: PMC11537169, DOI: 10.7759/cureus.70934.Peer-Reviewed Original ResearchNative valve endocarditisIntravenous drug useValve endocarditisRare caseHistory of intravenous drug useLost to follow-upTricuspid valve vegetationPartial clinical improvementDrug useIntravenous ceftriaxoneValve vegetationsBlood culturesChest painPulmonary embolismClinical improvementProductive coughRare pathogenAtrial flutterFollow-upClinical evaluationPatient historyExposure to animalsEndocarditisHuman pathogensPatientsHereditary antithrombin deficiency pilot project registry from the American Thrombosis and Hemostasis Network
DeSancho M, Suvar E, Roberts J, Tarantino M, Schwartz J, Callis J, Recht M. Hereditary antithrombin deficiency pilot project registry from the American Thrombosis and Hemostasis Network. Journal Of Thrombosis And Haemostasis 2024, 22: 3183-3190. PMID: 39151704, DOI: 10.1016/j.jtha.2024.07.026.Peer-Reviewed Original ResearchConceptsHereditary antithrombin deficiencyLow-molecular-weight heparinVenous thromboembolismOral anticoagulantsAT concentrateAdverse eventsIncreased risk of venous thromboembolismRisk factorsRisk of venous thromboembolismDirect oral anticoagulantsAmerican ThrombosisSeventy-nine patientsDeep vein thrombosisHemostasis NetworkRecurrent thrombosisConcentrate administrationPulmonary embolismAntithrombin deficiencyThrombotic eventsVein thrombosisProspective studyPredominant manifestationArterial thrombosisGlobal RegistryIncreased riskPulmonary embolism with thrombus in transit across a patent foramen ovale
Iyengar S, Stolear A, Dulgher M, Ahmed A, Shkolnik E, Zarich S. Pulmonary embolism with thrombus in transit across a patent foramen ovale. Oxford Medical Case Reports 2024, 2024: omae091. PMID: 39184868, PMCID: PMC11343825, DOI: 10.1093/omcr/omae091.Peer-Reviewed Original ResearchPatent foramen ovalePatent foramen ovale closureImpending paradoxical embolismPulmonary embolismForamen ovaleCritical left anterior descending coronary artery stenosisObstructive sleep apneaCoronary artery bypass graftingOptimal treatment strategySaddle pulmonary embolusAbsence of standard guidelinesDeep vein thrombosisArtery bypass graftingLife-threatening conditionCoronary artery stenosisSleep apneaTransesophageal echocardiogramPulmonary emboliSurgical thrombectomyVein thrombosisDiagnostic challengeSurgical interventionRight atriumThrombolytic therapyBypass graftingThe Predictive Value of Qanadli and Miller Index Scores in Patients with Intermediate-High–Risk and High-Risk Pulmonary Emboli Undergoing Aspiration Thrombectomy
Fish A, Knight E, Mutonga M, Moulton J, Gathagan R, Andreca M, Sare A, Cornman-Homonoff J. The Predictive Value of Qanadli and Miller Index Scores in Patients with Intermediate-High–Risk and High-Risk Pulmonary Emboli Undergoing Aspiration Thrombectomy. Journal Of Vascular And Interventional Radiology 2024, 35: 1457-1463. PMID: 38969337, DOI: 10.1016/j.jvir.2024.06.031.Peer-Reviewed Original ResearchPulmonary artery pressureIntensive care unitMiller scoreHigh-risk patientsArterial pressureInstitutional review boardPulmonary pressureClot burdenB-type natriuretic peptideIntensive care unit length of stayAssociated with ICU lengthIntensive care unit lengthLength of stayFlowTriever SystemConsecutive patientsEchocardiographic findingsPulmonary emboliCreatinine levelsPulmonary embolismNatriuretic peptideStratify patientsRetrospective studyClinical outcomesAspiration thrombectomyICU length
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