2025
Reassessing Cardiovascular Risk in Patients with Peripheral Artery Disease undergoing Myocardial Perfusion Imaging
Wang K, Sharir T, Hauser M, Dorbala S, Di Carli M, Fish M, Ruddy T, Bateman T, Einstein A, Kaufmann P, Miller E, Sinusas A, Acampa W, Halcox J, Martins M, Liang J, Builoff V, Dey D, Berman D, Miller R, Slomka P. Reassessing Cardiovascular Risk in Patients with Peripheral Artery Disease undergoing Myocardial Perfusion Imaging. Canadian Journal Of Cardiology 2025 PMID: 40368278, DOI: 10.1016/j.cjca.2025.05.002.Peer-Reviewed Original ResearchCoronary artery diseaseMyocardial perfusion abnormalitiesPeripheral arterial diseaseHistory of peripheral arterial diseaseTotal perfusion deficitMyocardial perfusion imagingPerfusion abnormalitiesMACE riskPropensity-score matchingArtery diseaseCoronary revascularizationInitiation of disease-modifying therapyPerfusion imagingAssociated with increased MACE riskSPECT myocardial perfusion imagingConcomitant coronary artery diseaseLate coronary revascularizationMedian follow-upReview of electronic medical recordsMyocardial ischemic burdenRisk of MACEAdverse cardiovascular eventsGroup of patientsBalanced groups of patientsDisease-modifying therapies
2024
Early antiviral use and supplemental oxygen decrease the risk of secondary bacterial infections: a multi-centre, nested, case–control study
Zhu Y, Hu H, Guo X, Zhang H, Li D, Dela Cruz C, Xie W, Xie L, Sharma L, Chang D. Early antiviral use and supplemental oxygen decrease the risk of secondary bacterial infections: a multi-centre, nested, case–control study. Journal Of Hospital Infection 2024, 156: 87-95. PMID: 39701496, DOI: 10.1016/j.jhin.2024.12.005.Peer-Reviewed Original ResearchConceptsRisk of secondary bacterial infectionIncidence of secondary bacterial infectionSecondary bacterial infectionAge-adjusted Charlson Comorbidity IndexCase-control studyPropensity-score matchingBacterial infectionsCOVID-19 patientsParenteral nutritionSupplemental oxygenTreatment strategiesAssociated with significant protectionAssociated with decreased incidenceAssociated with increased incidenceConditional logistic regression analysisSusceptibility to secondary bacterial infectionsAssociated with protectionCharlson Comorbidity IndexLogistic regression analysisAssociated with significant increasesAntiviral useGastric tubeAntibacterial therapyComorbidity indexIntravenous injectionMechanical clot disruption during pulmonary thromboembolectomy is safe: A propensity score-matched analysis
Thomas S, Deshmukh A, Mojibian H, Marino A, Lozada J, Cornman-Homonoff J. Mechanical clot disruption during pulmonary thromboembolectomy is safe: A propensity score-matched analysis. Clinical Imaging 2024, 118: 110381. PMID: 39637758, DOI: 10.1016/j.clinimag.2024.110381.Peer-Reviewed Original ResearchPulmonary thromboembolectomyPulmonary emboliPulmonary arteryRight pulmonary arteryLeft pulmonary arteryPulmonary artery pressureAdministration of anticoagulantsDuration of hospitalizationMechanical clot disruptionPropensity-score matchingSPESI scorePulmonary vasculatureArterial pressureClinical effectsOrganized thrombusThromboembolectomyPropensity-scoreClot disruptionInclusion criteriaPatientsMortality rateRisk categoriesCompare groupsStudy periodArteryVentral hernia repair with permanent mesh for non-Hispanic black versus white patients: access and post-operative outcomes in the era of robotic surgery
Chao G, Ying L, Huang L, Ma J, Ghiassi S, Gibbs K, Nadzam G, Morton J, Duffy A, Zhou R. Ventral hernia repair with permanent mesh for non-Hispanic black versus white patients: access and post-operative outcomes in the era of robotic surgery. Surgical Endoscopy 2024, 39: 560-567. PMID: 39433584, DOI: 10.1007/s00464-024-11252-5.Peer-Reviewed Original ResearchRobotic surgeryVentral hernia repairBlack patientsHernia repairPermanent meshT-scoreEra of robotic surgeryAbdominal Core Health Quality CollaborativeRate of laparoscopyHigher pain scoresPatient outcomesPost-operative outcomesSurgical site infectionPropensity-score matchingVentral hernia surgeryRecurrence scoreChi-square testPain scoresSite infectionFisher's exactHernia recurrenceOpen approachHernia surgeryWhite patientsSurgeryMechanical versus biological mitral valve replacement: Insights from propensity score matching on survival and reoperation rates
Feirer N, Buchner A, Weber M, Lang M, Dzilic E, Amabile A, Geirsson A, Trenkwalder T, Krane M, Vitanova K. Mechanical versus biological mitral valve replacement: Insights from propensity score matching on survival and reoperation rates. Journal Of Thoracic And Cardiovascular Surgery 2024, 169: 1717-1727. PMID: 39067811, DOI: 10.1016/j.jtcvs.2024.07.038.Peer-Reviewed Original ResearchMitral valve replacementBiological mitral valve replacementPropensity-score matchingValve replacementReoperation rateCumulative incidenceFollow-upMechanical mitral valve replacementMedian follow-up timeCumulative incidence of reoperationSurgical mitral valve replacementSymptomatic mitral valve diseaseIncidence of reoperationThirty-day mortalityHigh-volume centersMitral valve diseaseHistory of neurological disordersPropensity score matchingAnalyzed time pointsConcomitant proceduresPeriprocedural complicationsSingle-centerThirty-dayRetrospective studyReoperationImplementing Formal Mitral Heart Team Improves Multidisciplinary Evaluation Rate and Survival of Patients With Severe Primary Mitral Regurgitation
Waldron C, Mori M, Krane M, Reinhardt S, Ahmad Y, Kaple R, Forrest J, Geirsson A. Implementing Formal Mitral Heart Team Improves Multidisciplinary Evaluation Rate and Survival of Patients With Severe Primary Mitral Regurgitation. Journal Of The American Heart Association 2024, 13: e033324. PMID: 38390804, PMCID: PMC11179864, DOI: 10.1161/jaha.123.033324.Peer-Reviewed Original ResearchSevere primary mitral regurgitationPrimary mitral regurgitationHeart failure symptomsMitral regurgitationMultidisciplinary evaluationPatient survivalHeart teamFailure symptomsSociety of Thoracic Surgeons Predicted Risk of MortalityThoracic Surgeons Predicted Risk of MortalityImprove overall patient survivalCorrection of MRAssociated with lower oddsMultidisciplinary heart teamSurvival of patientsAssociated with higher oddsOverall patient survivalProportion of patientsRetrospective cohort studyCardiac surgery servicesHistory of MIOptimal treatment decisionsPropensity-score matchingRisk of mortalityStructural cardiology
2023
Evaluating Airway Management in Patients With Trisomy 21 in the PICU and Cardiac ICU: A Retrospective Cohort Study
Wilsterman E, Nellis M, Panisello J, Al-Subu A, Breuer R, Kimura D, Krawiec C, Mallory P, Nett S, Owen E, Parsons S, Sanders R, Garcia-Marcinkiewicz A, Napolitano N, Shults J, Nadkarni V, Nishisaki A, Network F. Evaluating Airway Management in Patients With Trisomy 21 in the PICU and Cardiac ICU: A Retrospective Cohort Study. Pediatric Critical Care Medicine 2023, 25: 335-343. PMID: 38059735, PMCID: PMC10994735, DOI: 10.1097/pcc.0000000000003418.Peer-Reviewed Original ResearchTracheal intubationCardiac ICUTrisomy 21Trisomy 21 patientsNational Emergency Airway RegistryCervical spine protectionDifficult airway featuresLower median weightNorth American PICUsPeri-intubation hypoxemiaRetrospective cohort studyUpper airway obstructionRetrospective database studyCohort of childrenCongenital heart diseasePropensity-score matchingAirway RegistryAirway riskAirway obstructionAirway outcomesCohort studyAirway managementMedian weightHeart diseaseIll childrenCT With CTA Versus MRI in Patients Presenting to the Emergency Department With Dizziness: Analysis Using Propensity Score Matching.
Tu L, Navaratnam D, Melnick E, Forman H, Venkatesh A, Malhotra A, Yaesoubi R, Sureshanand S, Sheth K, Mahajan A. CT With CTA Versus MRI in Patients Presenting to the Emergency Department With Dizziness: Analysis Using Propensity Score Matching. American Journal Of Roentgenology 2023, 221: 836-845. PMID: 37404082, DOI: 10.2214/ajr.23.29617.Peer-Reviewed Original ResearchConceptsSecondary stroke prevention medicationsStroke prevention medicationsEmergency departmentPrevention medicationsEchocardiography evaluationPosterior circulation strokeProportion of patientsGroup of patientsPhysical examination findingsNeuroimaging resultsUse of MRIReview of systemsGreater frequencyPropensity-score matchingExamination findingsRetrospective studyED readmissionMedical historyHead CTClinical impactMRI examinationsBrain MRINeck CTADizzinessPatientsThe role of imaging and sentinel lymph node biopsy in patients with T3b-T4b melanoma with clinically negative disease
Papageorge M, Maina R, King A, Lee V, Baumann R, Pucar D, Ariyan S, Khan S, Weiss S, Clune J, Olino K. The role of imaging and sentinel lymph node biopsy in patients with T3b-T4b melanoma with clinically negative disease. Frontiers In Oncology 2023, 13: 1143354. PMID: 37223678, PMCID: PMC10200883, DOI: 10.3389/fonc.2023.1143354.Peer-Reviewed Original ResearchPre-operative imagingCross-sectional imagingFree survivalLow-risk melanomaHigh-risk melanomaHigh-risk diseaseKaplan-Meier methodRecurrence-free survivalSentinel node biopsyWide local excisionManagement of patientsLog-rank testRole of imagingPropensity-score matchingIncidental cancerT4b diseaseMetastatic diseaseNodal diseaseNode biopsyPerioperative periodMedian ageNegative diseaseSentinel lymphLocal excisionNodular melanomaAnalysis of the impact of eliminating bolus 5-fluorouracil in metastatic colorectal cancer.
Peng C, Saffo S, Shusterman M, Becker D, Berlin J, Oberstein P, Nagar A, Yu S. Analysis of the impact of eliminating bolus 5-fluorouracil in metastatic colorectal cancer. Journal Of Clinical Oncology 2023, 41: 59-59. DOI: 10.1200/jco.2023.41.4_suppl.59.Peer-Reviewed Original ResearchMetastatic colorectal cancerOverall survivalECOG scoreColorectal cancerUnivariable Cox proportional hazards modelsFirst-line treatment regimensCox proportional hazards modelHigh-risk comorbiditiesHigher ECOG scoreRole of bolusMulticenter cohort studyOverall survival benefitRisk of deathLimited functional statusCombination drug regimenProportional hazards modelUse of bolusPropensity-score matchingAdjuvant settingBaseline creatinineFlatiron HealthMedian followCohort studyCreatinine levelsDrug regimen
2022
Comparative Safety and Effectiveness of Biologic Therapy for Crohn’s Disease: A CA-IBD Cohort Study
Singh S, Kim J, Luo J, Paul P, Rudrapatna V, Park S, Zheng K, Syal G, Ha C, Fleshner P, McGovern D, Sauk J, Limketkai B, Dulai P, Boland B, Eisenstein S, Ramamoorthy S, Melmed G, Mahadevan U, Sandborn W, Ohno-Machado L. Comparative Safety and Effectiveness of Biologic Therapy for Crohn’s Disease: A CA-IBD Cohort Study. Clinical Gastroenterology And Hepatology 2022, 21: 2359-2369.e5. PMID: 36343846, PMCID: PMC12145724, DOI: 10.1016/j.cgh.2022.10.029.Peer-Reviewed Original ResearchConceptsTNF-α antagonistsRisk of hospitalizationUstekinumab-treated patientsCrohn's diseaseSerious infectionsLower riskMulticenter cohortInflammatory bowel disease-related surgeryTumor necrosis factor α antagonistsNecrosis factor α antagonistsDisease-related surgeryHigher comorbidity burdenVedolizumab-treated patientsNew biologic agentsPropensity-score matchingComorbidity burdenCause hospitalizationAdult patientsBiologic therapyCohort studyPrior hospitalizationBiologic agentsΑ antagonistsBiologic classesComparative safetyPoorer functional Outcomes in Patients with Multi‐Ligamentous Knee Injury with Concomitant Patellar Tendon Ruptures at 5 years Follow‐Up
Mojica ES, Bi AS, Vasavada K, Moran J, Buzin S, Kahan J, Alaia EF, Jazrawi LM, Medvecky MJ, Alaia MJ. Poorer functional Outcomes in Patients with Multi‐Ligamentous Knee Injury with Concomitant Patellar Tendon Ruptures at 5 years Follow‐Up. Knee Surgery, Sports Traumatology, Arthroscopy 2022, 31: 325-331. PMID: 36048200, DOI: 10.1007/s00167-022-07110-3.Peer-Reviewed Original ResearchConceptsMulti-ligamentous knee injuriesPatellar tendon ruptureTendon ruptureBody mass indexKnee injuriesFunctional outcomeInternational Knee Documentation Committee Subjective Knee FormPoorer Functional OutcomesWorse functional outcomeExtensor mechanism injuriesSubjective Knee FormHigh-energy injuriesPatient-reported outcomesPatellar tendon injuryPropensity-score matchingSchenck classificationTegner scoreLysholm scoreMulticenter cohortClinical outcomesMechanism injuriesRare presentationSurgical repairKnee FormMass indexEffectiveness and Safety of Biologic Therapy in Hispanic Vs Non-Hispanic Patients With Inflammatory Bowel Diseases: A CA-IBD Cohort Study
Nguyen N, Luo J, Paul P, Kim J, Syal G, Ha C, Rudrapatna V, Park S, Parekh N, Zheng K, Sauk J, Limketkai B, Fleshner P, Eisenstein S, Ramamoorthy S, Melmed G, Dulai P, Boland B, Mahadevan U, Sandborn W, Ohno-Machado L, McGovern D, Singh S. Effectiveness and Safety of Biologic Therapy in Hispanic Vs Non-Hispanic Patients With Inflammatory Bowel Diseases: A CA-IBD Cohort Study. Clinical Gastroenterology And Hepatology 2022, 21: 173-181.e5. PMID: 35644340, PMCID: PMC9701245, DOI: 10.1016/j.cgh.2022.05.008.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseNon-Hispanic patientsBiologic-treated patientsHispanic patientsSerious infectionsBiologic therapyBowel diseasePropensity score-matched cohortBurden of inflammationRisk of hospitalizationHigh ratePropensity-score matchingCause hospitalizationAdult patientsBiologic initiationCohort studyBiologic agentsMedication useHigh burdenHigh riskHospitalizationPatientsSurvival analysisSurgeryAbstractTextRates of In-Hospital Decongestion and Association with Mortality and Cardiovascular Outcomes Among Patients Admitted for Acute Heart Failure
McCallum W, Tighiouart H, Testani JM, Griffin M, Konstam MA, Udelson JE, Sarnak MJ. Rates of In-Hospital Decongestion and Association with Mortality and Cardiovascular Outcomes Among Patients Admitted for Acute Heart Failure. The American Journal Of Medicine 2022, 135: e337-e352. PMID: 35472391, PMCID: PMC10767835, DOI: 10.1016/j.amjmed.2022.04.003.Peer-Reviewed Original ResearchConceptsB-type natriuretic peptideAcute heart failureHeart failure hospitalizationComposite outcomeHeart failureFailure hospitalizationCardiovascular outcomesCardiovascular mortalityNatriuretic peptideN-terminal pro-B-type natriuretic peptidePro-B-type natriuretic peptideHeart Failure Outcome StudyMultivariable Cox regression modelsResistant heart failureLower hazardCox regression modelRisk of mortalityPropensity-score matchingTolvaptan (EVEREST) trialCause mortalityCardiovascular benefitsVasopressin AntagonismVolume overloadReduced riskOutcome studiesUsing probabilistic record linkage and propensity‐score matching to identify a community‐based comparison population
Holland ML, Taylor RM, Condon E, Rinne GR, Bleicher S, Li C, Seldin M, Sadler L. Using probabilistic record linkage and propensity‐score matching to identify a community‐based comparison population. Research In Nursing & Health 2022, 45: 390-400. PMID: 35388528, PMCID: PMC9064948, DOI: 10.1002/nur.22226.Peer-Reviewed Original ResearchConceptsBirth certificate dataInterpregnancy intervalComparison groupRecord linkageProbabilistic record linkageRetrospective cohort studyCommunity-based comparison groupFirst-time mothersPropensity-score matchingCohort studyBirth outcomesLarge comparison groupCertificate dataComparison populationHV programsMultiple comparison groupsBirth certificatesGeneral Versus Neuraxial Anesthesia in Revision Surgery for Periprosthetic Joint Infection
Serino J, Galivanche AR, Grauer JN, Haynes M, Karas V, Della Valle CJ. General Versus Neuraxial Anesthesia in Revision Surgery for Periprosthetic Joint Infection. The Journal Of Arthroplasty 2022, 37: s971-s976. PMID: 35017049, DOI: 10.1016/j.arth.2022.01.002.Peer-Reviewed Original ResearchConceptsPeriprosthetic joint infectionNeuraxial anesthesiaAdverse eventsGeneral anesthesiaRevision surgeryJoint infectionLower riskNational Surgical Quality Improvement Program databaseSurgeons National Surgical Quality Improvement Program databaseQuality Improvement Program databaseMinor adverse eventsSerious adverse eventsThirty-day outcomesImprovement Program databasePropensity-score matchingIntraspinal abscessProgram databaseRevision arthroplastyAmerican CollegeAnesthesiaMultivariate analysisProcedural variablesSurgeryPatientsInfection
2021
COVID-positive ankle fracture patients are at increased odds of perioperative surgical complications following open reduction internal fixation surgery
Mercier MR, Galivanche AR, Brand JP, Pathak N, Medvecky MJ, Varthi AG, Rubin LE, Grauer JN. COVID-positive ankle fracture patients are at increased odds of perioperative surgical complications following open reduction internal fixation surgery. PLOS ONE 2021, 16: e0262115. PMID: 34972190, PMCID: PMC8719674, DOI: 10.1371/journal.pone.0262115.Peer-Reviewed Original ResearchConceptsCOVID-positive patientsAnkle fracture surgeryPerioperative adverse eventsAdverse eventsAnkle fracture patientsFracture surgeryFracture patientsOperative interventionAnkle fracturesPropensity matchingCOVID statusOpen reduction internal fixation surgeryPerioperative adverse outcomesPerioperative surgical complicationsMinor adverse eventsPostoperative adverse eventsSerious adverse eventsChronic kidney diseaseCOVID-19 Research DatabaseLong-term outcomesInternal fixation surgeryBasis of agePropensity-score matchingPostoperative complicationsNegative patientsEffects of preoperative nutritional status on complications and readmissions after posterior lumbar decompression and fusion for spondylolisthesis: A propensity-score analysis
Elsamadicy AA, Havlik J, Reeves BC, Koo AB, Sherman J, Lo SL, Shin JH, Sciubba DM. Effects of preoperative nutritional status on complications and readmissions after posterior lumbar decompression and fusion for spondylolisthesis: A propensity-score analysis. Clinical Neurology And Neurosurgery 2021, 211: 107017. PMID: 34781222, DOI: 10.1016/j.clineuro.2021.107017.Peer-Reviewed Original ResearchConceptsUnplanned readmissionAdverse eventsSpine surgerySurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseOccurrence of AEsPreoperative serum albumin levelQuality Improvement Program databaseMultivariate logistic regression analysisPosterior lumbar decompressionPreoperative nutritional statusHigh rateImprovement Program databaseRetrospective cohort studySerum albumin levelSignificant independent predictorsEffects of malnutritionLogistic regression analysisPropensity score analysisPropensity-score matchingMalnourished cohortMalnourished patientsPerioperative complicationsPostoperative complicationsLumbar decompressionPost-operative radiation therapy for non-small cell lung cancer: A comparison of radiation therapy techniques
Jairam V, Pasha S, Soulos PR, Gross CP, Yu JB, Park HS, Decker RH. Post-operative radiation therapy for non-small cell lung cancer: A comparison of radiation therapy techniques. Lung Cancer 2021, 161: 171-179. PMID: 34607209, DOI: 10.1016/j.lungcan.2021.09.010.Peer-Reviewed Original ResearchConceptsPost-operative radiation therapyNon-small cell lung cancerCell lung cancerRadiation therapyPropensity-score matchingLA-NSCLCCardiac toxicityLung cancerAdvanced non-small cell lung cancerClinical risk factorsProportion of patientsMultivariable logistic regressionPrior treatment historyPredictors of receiptUse of IMRTConformal radiation therapyLong-term toxicityChi-squared testRadiation therapy techniquesRadiotherapy treatment techniquesUpfront surgeryElderly patientsTreatment toxicityMean ageMedicare databaseImpact of Racial Disparities on All-Cause Mortality in Patients With Tumors of the Spinal Cord or Spinal Meninges: A Propensity-Score Analysis
Elsamadicy AA, Freedman I, Koo AB, David WB, Reeves BC, Hengartner A, Pennington Z, Laurans M, Kolb L, Shin JH, Sciubba D. Impact of Racial Disparities on All-Cause Mortality in Patients With Tumors of the Spinal Cord or Spinal Meninges: A Propensity-Score Analysis. Global Spine Journal 2021, 13: 1365-1373. PMID: 34318727, PMCID: PMC10416582, DOI: 10.1177/21925682211033827.Peer-Reviewed Original ResearchSpinal cordCause mortalitySpinal meningesNonmalignant tumorsCox proportional hazards regression analysisProportional hazards regression analysisIntradural spine tumorsReceipt of RTOutcomes of patientsRetrospective cohort studyEnd Results registryKaplan-Meier methodOverall survival estimatesSpinal cord tumorsAssociation of survivalLog-rank testAfrican American patientsPopulation-based estimatesPropensity score analysisPropensity-score matchingCohort studyCord tumorsSpine tumorsWhite patientsAnalysis age
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