2025
Gender-Affirming Surgery for Transgender and Gender Diverse Medicare Beneficiaries
Balkan E, Babbs G, Meyers D, Kelly P, Yee K, Pletta D, Shireman T, Alpert A, Baker K, Hughto J. Gender-Affirming Surgery for Transgender and Gender Diverse Medicare Beneficiaries. JAMA Network Open 2025, 8: e258072. PMID: 40310645, PMCID: PMC12046427, DOI: 10.1001/jamanetworkopen.2025.8072.Peer-Reviewed Original ResearchConceptsGender-affirming surgeryTransgender individualsRates of chronic conditionsTransgenderBeneficiaries' useProportion of residentsRegional differencesDual statusBeneficiariesChronic conditionsDiverse beneficiariesBeneficiary characteristicsMedicare beneficiariesGenderCross-sectional studyMedicare entitlementGender-affirming surgical proceduresPropensity score matchingNational Medicare dataMedicare programMedicaidProportion of Medicare beneficiariesSouthSurgical proceduresDescriptive analysisThe impact of PGT-A on time to live birth in IVF.
Eliner Y, Foley B, Bayer S, Thornton K, Penzias A, Sakkas D, Vaughan D. The impact of PGT-A on time to live birth in IVF. Fertility And Sterility 2025 PMID: 40222699, DOI: 10.1016/j.fertnstert.2025.04.006.Peer-Reviewed Original ResearchPGT-ALive birth rateLive birthsTime to pregnancyOocyte retrievalAge groupsHazard ratioNon-PGT-A groupPre-implantation genetic testingUniversity-affiliated fertility centerPGT-A groupShorter time to pregnancyPositive pregnancy rateSignificant differenceKaplan-Meier curvesBirth rateOne-year periodStatistically significant differencePropensity score matchingMiscarriage rateYounger age groupsNo significant differenceYounger patientsOlder age groupsEgg retrievalClinical Outcomes With Normothermic Pulsatile Organ Perfusion in Heart Transplantation: A Report From the OCS Heart Perfusion Registry
Stehlik J, Farr M, Mehra M, Schroder J, D’Alessandro D, Pal J, Villavicencio M, Gruber P, Couper G, Shudo Y, Patel P, Daneshmand M, Klein L, Shah A, Skipper E, Esmailian F, Goldstein D, Ohira S, Lozonschi L, Kaczorowski D, Takeda K, Malyala R, Haft J, Meyer D, Sun B, Pretorius V, Kilic A, Anyanwu A, Williams C, Pham D, Kai M, Sulemanjee N, Itoh A, Funamoto M, Salerno C, Ikonomidis J, Durham L, Shaffer A, Zhou X, Zafar F, Pinney S, Milano C. Clinical Outcomes With Normothermic Pulsatile Organ Perfusion in Heart Transplantation: A Report From the OCS Heart Perfusion Registry. Circulation 2025, 151: 896-909. PMID: 40052272, DOI: 10.1161/circulationaha.124.071743.Peer-Reviewed Original ResearchHeart transplantationStatic cold storageNormothermic regional perfusionPosttransplantation outcomesDCD donorsConsecutive heart transplantsRecipient characteristicsDBD donorsExtended-criteria donorsThoracoabdominal normothermic regional perfusionOrgan Care SystemPropensity score matchingClinical outcomesThe Impact of Aortic Arch Morphology on Periprocedural Stroke in Transcatheter Aortic Valve Replacement
Voss S, Rusa K, Campanella C, Georgescu T, Vitanova K, Ruge H, Amabile A, Sideris K, Krane M, Burri M. The Impact of Aortic Arch Morphology on Periprocedural Stroke in Transcatheter Aortic Valve Replacement. Journal Of Clinical Medicine 2025, 14: 1045. PMID: 40004577, PMCID: PMC11856225, DOI: 10.3390/jcm14041045.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementMulti-slice computed tomographyAortic valve replacementAortic arch morphologyArch anatomyValve replacementPeriprocedural strokeLeft common carotid arteryTransfemoral transcatheter aortic valve replacementEpi-aortic vesselsIschemic strokeArch morphologyPeriprocedural ischemic strokePropensity-matched case-control studyScore-matched studyCase-control studyCommon carotid arteryOccurrence of ischemic strokeAortic arch geometryEuroSCORE IIPropensity score matchingAortic archComparing patientsCatheter manipulationCarotid arteryAssociation of workforce participation with depression among US older adults: results from NHANES 2005–2018
Sun Z, Wang Y, Chen X, Qian D. Association of workforce participation with depression among US older adults: results from NHANES 2005–2018. BMC Geriatrics 2025, 25: 77. PMID: 39905307, PMCID: PMC11792604, DOI: 10.1186/s12877-025-05712-3.Peer-Reviewed Original ResearchConceptsNational Health and Nutrition Examination SurveyUS older adultsPHQ-9 scoresOlder adultsDepression riskLogistic regression modelsWorkforce participationPatient Health Questionnaire-9 itemsWork statusHealth and Nutrition Examination SurveyAnalysis of subgroupsRegular daytimeMethodsThis cross-sectional studyNutrition Examination SurveyPrevalence of depressionDecrease depression riskPotential reverse causationRegression modelsCross-sectional studyNon-linear associationInstrumental variablesPHQ-9Propensity score matchingExamination SurveyReverse causationSex differences in in-hospital outcomes and readmission rates after percutaneous coronary intervention
Gomez J, Park D, Eder M, An S, Lowenstern A, Kelsey M, Rymer J, Douglas P, Nanna M. Sex differences in in-hospital outcomes and readmission rates after percutaneous coronary intervention. Baylor University Medical Center Proceedings 2025, 38: 159-169. PMID: 39990004, PMCID: PMC11845020, DOI: 10.1080/08998280.2025.2452113.Peer-Reviewed Original ResearchIn-hospital outcomesIn-hospital mortalitySecondary outcomesReadmission ratesOdds of in-hospital mortalityPercutaneous coronary interventionCalculate odds ratiosInpatient percutaneous coronary interventionHazard of readmissionUnited States National Readmission DatabaseIn-hospital adverse outcomesPropensity score matchingHealth systemHospital characteristicsOdds of cardiac arrestSocioeconomic statusReimbursement implicationsSex differencesYears of ageOdds ratioReadmission riskCox proportional-hazardsLogistic regressionIn-hospital complicationsScore matchingThe Use of Acellular Dermal Matrix May Not Increase 30-Day Complications in Direct-to-Implant Breast Reconstruction: A Multi-institutional Analysis of 10,177 Cases.
Knoedler S, Klimitz F, Friedrich S, Schemet L, Broer P, Cherubino M, Könneker S, Kim B, Pomahac B, Kauke-Navarro M. The Use of Acellular Dermal Matrix May Not Increase 30-Day Complications in Direct-to-Implant Breast Reconstruction: A Multi-institutional Analysis of 10,177 Cases. Annals Of Plastic Surgery 2025 PMID: 39874559, DOI: 10.1097/sap.0000000000004234.Peer-Reviewed Original ResearchDirect-to-implant breast reconstructionDirect-to-implantAcellular dermal matrixBreast reconstructionPropensity score matchingHigher risk of short-term complicationsMedical complicationsAmerican College of Surgeons National Surgical Quality Improvement Program databaseSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseIncreased 30-day complicationsMultivariate analysisRisk of short-term complicationsQuality Improvement Program databaseThirty-day postoperative complicationsSurgical complication rateIncorporation of acellular dermal matrixScore matchingMulti-institutional analysisMulti-institutional databaseShort-term complicationsComplication ratePostoperative complicationsWound dehiscenceNo significant differenceOutcomes in management of locally advanced rectal cancer with total neoadjuvant therapy in an underserved population.
Ganguly A, Paladiya R, Ingawale S, Giri S, Abbagoni V, Thumar J. Outcomes in management of locally advanced rectal cancer with total neoadjuvant therapy in an underserved population. Journal Of Clinical Oncology 2025, 43: 208-208. DOI: 10.1200/jco.2025.43.4_suppl.208.Peer-Reviewed Original ResearchTNT groupTotal neoadjuvant therapyLocally advanced rectal cancerAdvanced rectal cancerManagement of locally advanced rectal cancerTumor locationNeoadjuvant therapyConventional therapyRectal cancerCT groupPropensity score matchingLow tumorsHigh tumorNo responsePathologic response to treatmentTreating locally advanced rectal cancerResponse ratePartial response ratePathological response rateScore matchingFisher's exact testResponse to treatmentComplete responseAdjuvant treatmentUnderserved populationsMechanical thrombectomy in elderly stroke patients with low ASPECTS: insights from STAR
Cunningham C, Hubbard Z, Kasem R, Elawady S, Sowlat M, Matsukawa H, Maier I, Jabbour P, Kim J, Wolfe S, T A, Starke R, Psychogios M, Samaniego E, Goyal N, Yoshimura S, Cuellar H, Howard B, Alawieh A, Alaraj A, Ezzeldin M, Romano D, Tanweer O, Mascitelli J, Fragata I, Polifka A, Siddiqui F, Osbun J, Grandhi R, Crosa R, Matouk C, Park M, Levitt M, Brinjikji W, Moss M, Daglioglu E, Williamson R, Navia P, Kan P, De Leacy R, Chowdhry S, Altschul D, Al Kasab S, Spiotta A. Mechanical thrombectomy in elderly stroke patients with low ASPECTS: insights from STAR. Journal Of NeuroInterventional Surgery 2025, jnis-2024-022677. PMID: 39855673, DOI: 10.1136/jnis-2024-022677.Peer-Reviewed Original ResearchAlberta Stroke Program Early CT ScoreLow Alberta Stroke Program Early CT ScorePropensity score matchingSymptomatic intracranial hemorrhageEndovascular thrombectomyAnterior circulation large vessel occlusion acute ischemic strokeElderly patientsLVO-AISAssociated with 90-day mortalityRate of atrial fibrillationScore matchingLarge vessel occlusion acute ischemic strokeFirst-pass reperfusionAcute ischemic strokeCT scoreIntracranial hemorrhagePatient selectionMRS scoreAtrial fibrillationClinical factorsFavorable outcomeRecanalization ratePrimary outcomeMechanical thrombectomyPatientsEfficacy and Safety of IV Thrombolysis for Acute Ischemic Stroke Patients With Moyamoya Disease
Chen H, Colasurdo M, Khunte M, Malhotra A, Gandhi D. Efficacy and Safety of IV Thrombolysis for Acute Ischemic Stroke Patients With Moyamoya Disease. Neurology 2025, 104: e210243. PMID: 39772663, DOI: 10.1212/wnl.0000000000210243.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeTreated with IV thrombolysisIn-hospital mortalityMoyamoya disease patientsIV thrombolysisMoyamoya diseasePropensity score matchingIntracranial hemorrhageRisk factors of acute ischemic strokeSelf-careIschemic stroke patientsAcute ischemic stroke patientsStroke patientsTreating acute ischemic strokeNationwide Readmissions DatabaseRisk factorsRate of routine dischargeRoutine dischargeEfficacy outcomesAssociated with different ratesProspective studyBypass surgeryRetrospective analysisEstablished treatmentReadmissions Database
2024
Endovascular arterial embolization versus conservative management with nasal packing alone for severe epistaxis: a nationwide cohort study
Chen H, Khunte M, Colasurdo M, Gunawardane S, Malhotra A, Gandhi D. Endovascular arterial embolization versus conservative management with nasal packing alone for severe epistaxis: a nationwide cohort study. Journal Of NeuroInterventional Surgery 2024, jnis-2024-022790. PMID: 39715667, DOI: 10.1136/jnis-2024-022790.Peer-Reviewed Original ResearchEndovascular arterial embolizationNasal packingSevere epistaxisPropensity score matchingNationwide Readmissions DatabaseArtery embolizationIschemic strokeCohort studyRates of patient morbidityHemorrhage risk factorsConservative management groupConservative managementRetrospective cohort studyNationwide cohort studyRate of ischemic strokeBalance patient characteristicsContemporary real-world dataAssociated with lower ratesPatients admitted to hospitalNon-routine dischargeRisk of ischemic strokeRecurrent epistaxisRecurrence ratePatient morbidityPatient characteristicsEffect of cannabis use history on postoperative opioid utilization in lumbar fusion patients: an American retrospective study
Mirpuri P, Khalid S, King P, Roy J, Elsamadicy A, Mehta A, Adogwa O. Effect of cannabis use history on postoperative opioid utilization in lumbar fusion patients: an American retrospective study. Asian Spine Journal 2024, 18: 639-646. PMID: 39434224, PMCID: PMC11538822, DOI: 10.31616/asj.2024.0194.Peer-Reviewed Original ResearchCannabis use historyPostoperative opioid utilizationOpioid utilizationCannabis usersLumbar fusionHistory of cannabis useChronic opioid useNon-cannabis usersDegenerative spine diseaseCannabis use patternsImmediate postoperative periodPostsurgical pain managementLumbar fusion patientsPropensity score matchingUse historyOpioid useSpine surgeryPain medicationFusion patientsRetrospective studySpine diseasePostoperative periodCannabis usePain managementWidespread prescriptionBipolar disorder among individuals with atopic dermatitis: a case–control study in the All of Us Research Program
Wride A, Chen G, Fan R, Leasure A, Jones S, Levey D, Damsky W, Cohen J. Bipolar disorder among individuals with atopic dermatitis: a case–control study in the All of Us Research Program. Clinical And Experimental Dermatology 2024, 50: 760-763. PMID: 39425681, DOI: 10.1093/ced/llae451.Peer-Reviewed Original ResearchSex disparities in outcomes of transcatheter aortic valve implantation- a multi-year propensity-matched nationwide study
Kumar M, Hu J, Ali S, Khlidj Y, Upreti P, Ati L, Kumar S, Shaka H, Zheng S, Bae J, Alraies M, Mba B, Yadav N, Vora A, Davila C. Sex disparities in outcomes of transcatheter aortic valve implantation- a multi-year propensity-matched nationwide study. International Journal Of Cardiology 2024, 418: 132619. PMID: 39370048, DOI: 10.1016/j.ijcard.2024.132619.Peer-Reviewed Original ResearchTranscatheter aortic valve implantationAcute kidney injuryProcedure-related mortalityAcute respiratory failureMechanical circulatory supportTranscatheter aortic valve implantation outcomesSudden cardiac arrestPropensity score matchingAortic stenosisReadmission ratesCardiogenic shockIncidence of acute kidney injuryOutcomes of transcatheter aortic valve implantationManagement of severe aortic stenosisCirculatory supportPost-procedural complication ratesSevere aortic stenosisPost-procedural bleedingSignificant disparitiesPost-procedural outcomesIn-hospital mortalityAortic valve implantationPearson chi-square testNationwide Readmissions DatabaseWomenEndovascular thrombectomy versus medical management for patients with large vessel stroke and infective endocarditis
Chen H, Colasurdo M, Khunte M, Malhotra A, Gandhi D. Endovascular thrombectomy versus medical management for patients with large vessel stroke and infective endocarditis. Journal Of NeuroInterventional Surgery 2024, jnis-2024-022374. PMID: 39317440, DOI: 10.1136/jnis-2024-022374.Peer-Reviewed Original ResearchEfficacy of endovascular thrombectomyLarge vessel occlusionInfective endocarditisPropensity score matchingIntracerebral hemorrhageSubarachnoid hemorrhageMedical managementMultivariable adjustmentOdds of intracerebral hemorrhageEndovascular thrombectomyHome dischargeRate of intracerebral hemorrhageFavorable hospital outcomesRate of in-hospital deathAssociated with significantly higher oddsLarge vessel occlusion strokeIn-hospital mortalityRoutine home dischargeIn-hospital deathRate of subarachnoid hemorrhageRate of home dischargeSignificantly higher oddsRate of routine dischargePrimary outcomeSecondary outcomesImproved technical outcomes with converting thrombectomy techniques after failed first pass recanalization
Matsukawa H, Matouk C, Uchida K, Al Kasab S, Sowlat M, Elawady S, Maier I, Jabbour P, Kim J, Wolfe S, T A, Starke R, Psychogios M, Samaniego E, Arthur A, Cuellar H, Howard B, Romano D, Tanweer O, Mascitelli J, Fragata I, Polifka A, Osbun J, Crosa R, Park M, Levitt M, Brinjikji W, Moss M, Williamson R, Navia P, Kan P, De Leacy R, Chowdhry S, Ezzeldin M, Spiotta A, Yoshimura S, Alawieh A. Improved technical outcomes with converting thrombectomy techniques after failed first pass recanalization. Journal Of NeuroInterventional Surgery 2024, jnis-2024-022071. PMID: 39304195, DOI: 10.1136/jnis-2024-022071.Peer-Reviewed Original ResearchEfficacy of endovascular thrombectomyFirst-pass recanalizationLarge vessel occlusionModified Rankin scoreClinical outcomesMatched cohortMatched cohort of patientsAcute ischemic stroke secondary to large vessel occlusionFirst-passIschemic stroke secondary to large vessel occlusionAnterior circulation large vessel occlusionRisk of symptomatic hemorrhagePropensity score matched cohortMulticenter international studyCohort of patientsScore-matched cohortAssociated with higher oddsPropensity score matchingMRS 0Symptomatic hemorrhagePostprocedural hemorrhageTechnical successRecanalization attemptsRankin scorePrimary outcomeThe effect of intravenous thrombolysis in stroke patients with unsuccessful thrombectomy.
Elawady S, Kasem R, Matsukawa H, Cunningham C, Sowlat M, Nawabi N, Orscelik A, Venegas J, Isidor J, Loulida H, Maier I, Jabbour P, Kim J, Wolfe S, Rai A, Starke R, Psychogios M, Samaniego E, Goyal N, Yoshimura S, Cuellar H, Howard B, Alawieh A, Alaraj A, Ezzeldin M, Romano D, Tanweer O, Mascitelli J, Fragata I, Polifka A, Siddiqui F, Osbun J, Grandhi R, Crosa R, Matouk C, Park M, Levitt M, Brinjikji W, Moss M, Daglioglu E, Williamson R, Navia P, Kan P, De Leacy R, Chowdhry S, Altschul D, Spiotta A, Al Kasab S. The effect of intravenous thrombolysis in stroke patients with unsuccessful thrombectomy. Interventional Neuroradiology 2024, 15910199241279009. PMID: 39262342, PMCID: PMC11559907, DOI: 10.1177/15910199241279009.Peer-Reviewed Original ResearchAcute ischemic stroke patientsLarge vessel occlusionAcute ischemic strokeIntracranial hemorrhageBenefit of intravenous thrombolysisMechanical thrombectomyIntravenous thrombolysisMT alone groupAlone groupMT groupSecondary outcomesAnterior circulation large vessel occlusionSymptomatic intracranial hemorrhageEffect of intravenous thrombolysisIVT + MTIntravenous thrombolysis prior to MTPropensity score matchingMedian ageSymptomatic ICHMTICI scoreFailed recanalizationPrimary outcomeFunctional outcomesPatientsVessel occlusionPersonalized embryo transfer guided by rsERT with hourly precision improves pregnancy outcomes in patients with a receptive window of implantation: a pilot study
Yang T, Hou Z, Zhang Q, Zhao J, Liu N, Liu D, Li Y, Wang Y, Xu B, Zou Y, Wan C, Li Y. Personalized embryo transfer guided by rsERT with hourly precision improves pregnancy outcomes in patients with a receptive window of implantation: a pilot study. Journal Of Assisted Reproduction And Genetics 2024, 41: 2657-2665. PMID: 39254797, PMCID: PMC11534956, DOI: 10.1007/s10815-024-03246-y.Peer-Reviewed Original ResearchIntrauterine pregnancy ratePersonalized embryo transferWindow of implantationEmbryo transferPropensity score matchingImplantation rateET groupCenter for Reproductive MedicineResultsBefore propensity score matchingImplant failure rateGroup compared to controlsRetrospective pilot studyConventional embryo transferMultiple-pregnancy ratesEndometrial receptivity testCentral South UniversityPregnancy outcomesTransferred embryosPilot studyPregnancy ratePatientsSouth UniversityReproductive medicineScore matchingConfounding factorsImpact of induction regimens intensity and allogeneic stem cell transplantation on survival of patients with Philadelphia chromosome‐positive acute lymphoblastic leukemia: A multi‐institutional study
Badar T, Narra R, Mims A, Heckman M, Shallis R, Fahad S, Hunter C, Kota V, Othman T, Jonas B, Desai S, de Camargo Correia G, Patel A, DuVall A, Palmisiano N, Curran E, Omer Z, Advani A, Atallah E, Litzow M. Impact of induction regimens intensity and allogeneic stem cell transplantation on survival of patients with Philadelphia chromosome‐positive acute lymphoblastic leukemia: A multi‐institutional study. American Journal Of Hematology 2024, 99: 2388-2391. PMID: 39253997, DOI: 10.1002/ajh.27475.Peer-Reviewed Original ResearchIntensive chemotherapyPhiladelphia chromosome-positive acute lymphoblastic leukemiaAllogeneic stem cell transplantationFirst-generation TKIsStem cell transplantationSurvival of patientsAcute lymphoblastic leukemiaMulti-institutional studyAllo-HCTPropensity score matchingRegimen intensityCell transplantationLymphoblastic leukemiaMultivariate analysisHealthcare Utilization and Costs Among Patients with Acute Myeloid Leukemia Receiving Oral Azacitidine Maintenance Therapy Versus No Maintenance: A US Claims Database Study
Borate U, Seiter K, Potluri R, Mazumder D, Chevli M, Prebet T, Gaugler L, Strocchia M, Vasconcelos A, Sieluk J. Healthcare Utilization and Costs Among Patients with Acute Myeloid Leukemia Receiving Oral Azacitidine Maintenance Therapy Versus No Maintenance: A US Claims Database Study. Advances In Therapy 2024, 41: 4049-4064. PMID: 39240504, PMCID: PMC11480148, DOI: 10.1007/s12325-024-02947-1.Peer-Reviewed Original ResearchAcute myeloid leukemiaHealthcare resource utilizationOral-AZAPropensity score matchingMyeloid leukemiaReal-world healthcare resource utilizationClinical practiceHematopoietic stem cell transplantationLower healthcare resource utilizationResultsAfter propensity score matchingStem cell transplantationContinuous insurance enrollmentClaims database studyOutpatient visitsOral azacitidinePost-remissionMaintenance therapyProlonged remissionCell transplantationDisease remissionDelayed relapseBaseline characteristicsTreatment patternsPatientsDatabase study
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