2025
A Prospective Study of Conventionally Fractionated Dose Constraints for Reirradiation of Primary Brain Tumors in Children
McGovern S, Johnson J, Luo D, Nguyen K, McAleer M, Paulino A, Grosshans D, Baxter P, Zaky W, Thall P, Mahajan A. A Prospective Study of Conventionally Fractionated Dose Constraints for Reirradiation of Primary Brain Tumors in Children. International Journal Of Radiation Oncology • Biology • Physics 2025, 121: e13-e14. DOI: 10.1016/j.ijrobp.2024.11.049.Peer-Reviewed Original ResearchDose-volume constraintsSymptomatic brain necrosisRecurrent brain tumorsBrain tumorsBrain necrosisPrimary endpointDose constraintsProton therapyProspective studyRecurrent pediatric brain tumorsMedian overall survivalMedian prescription doseCourse of radiationResults Median ageTreated with radiationPediatric brain tumorsPrimary brain tumorProgression of diseaseBrain reirradiationDosimetric guidelinesDose escalationPrescription doseOverall survivalMedian intervalProspective trials
2023
Feasibility and Toxicity of Full-Body Volumetric Modulated Arc Therapy Technique for High-Dose Total Body Irradiation
Keit E, Liveringhouse C, Figura N, Weygand J, Sandoval M, Garcia G, Peters J, Nieder M, Faramand R, Khimani F, Kim S, Robinson T, Johnstone P, Penagaricano J, Latifi K. Feasibility and Toxicity of Full-Body Volumetric Modulated Arc Therapy Technique for High-Dose Total Body Irradiation. Technology In Cancer Research & Treatment 2023, 22: 15330338231180779. PMID: 37287260, PMCID: PMC10272663, DOI: 10.1177/15330338231180779.Peer-Reviewed Original ResearchConceptsHigh-dose total body irradiationTotal body irradiationHelical tomotherapyBody irradiationDosimetric outcomesLower lung dosesMucosal sparing techniquesArc therapy (VMAT) techniqueMucosal sparingHead-first positionMyeloablative conditioningDaily fractionsLung dosesAcute leukemiaPrescription doseHT plansDose goalsFFS plansOAR sparingPatientsLow dosesArc therapyUnique protocolDosesVMAT plans
2022
Dosimetric Parameters are Associated with Local Control after SBRT for Colorectal Cancer Lung Metastases
Laird J, Mokhtech M, Johung K, Park H, Jethwa K. Dosimetric Parameters are Associated with Local Control after SBRT for Colorectal Cancer Lung Metastases. International Journal Of Radiation Oncology • Biology • Physics 2022, 114: e431-e432. DOI: 10.1016/j.ijrobp.2022.07.1640.Peer-Reviewed Original ResearchCRC lung metastasesInternal target volumeLung metastasesLocal controlPrescription dosesUnivariate analysisPrescription doseCox proportional hazards regression modelColorectal cancer lung metastasesProportional hazards regression modelsDosimetric parametersRetrospective cohort studyFavorable local controlImproved local controlLocal treatment optionsSingle cancer centerKaplan-Meier methodHazards regression modelsTarget volume dosesMATERIAL/METHODSMetastasis sizePTV D90Dosimetric predictorsMedian doseCohort study
2020
A prototype open-ended multichannel intracavitary-interstitial hybrid applicator for gynecological high-dose-rate brachytherapy
Tien CJ, Chen Z. A prototype open-ended multichannel intracavitary-interstitial hybrid applicator for gynecological high-dose-rate brachytherapy. Radiological Physics And Technology 2020, 13: 187-194. PMID: 32424632, DOI: 10.1007/s12194-020-00567-2.Peer-Reviewed Original ResearchConceptsPrescription doseRate brachytherapyHybrid applicatorPrior patientsRisk doseMinimum doseOAR D2ccMultichannel applicatorCentral tandemDoseTarget coverageInterstitial needlesPatientsApplicator bodyBrachytherapyDistal endOpen distal endsPeripheral needlesPeripheral channelsSilico studiesNeedleBowelBladderD2ccRectum
2017
Incorporating patient-specific CT-based ophthalmic anatomy in modeling iodine-125 eye plaque brachytherapy dose distributions
Tien CJ, Astrahan MA, Kim JM, Materin M, Chen Z, Nath R, Liu W. Incorporating patient-specific CT-based ophthalmic anatomy in modeling iodine-125 eye plaque brachytherapy dose distributions. Brachytherapy 2017, 16: 1057-1064. PMID: 28778599, DOI: 10.1016/j.brachy.2017.06.014.Peer-Reviewed Original ResearchConceptsEye modelDisc distanceDose differenceTumor apexPrescription doseOcular parametersPlaque SimulatorOcular structuresSubstantial dose differencesTarget volumePlaque positionDosimetric parametersPatientsClinical planningDosimetric impactSignificant differencesBrachytherapy planningSeed strengthPlaquesBrachytherapy dose distributionsDose distributionPatient-specific modelsDifferencesTumorsRetina
2016
The impact of cobalt-60 source age on biologically effective dose in high-dose functional Gamma Knife radiosurgery.
Kann BH, Yu JB, Stahl JM, Bond JE, Loiselle C, Chiang VL, Bindra RS, Gerrard JL, Carlson DJ. The impact of cobalt-60 source age on biologically effective dose in high-dose functional Gamma Knife radiosurgery. Journal Of Neurosurgery 2016, 125: 154-159. PMID: 27903196, DOI: 10.3171/2016.6.gks161497.Peer-Reviewed Original ResearchConceptsTrigeminal neuralgiaGKRS treatmentObsessive-compulsive disorderTN managementEffective doseRefractory obsessive-compulsive disorderGamma Knife radiosurgery proceduresStudy of patientsGamma knife radiosurgeryRates of toxicitySingle-fraction dosesStudy of outcomesNerve ablationSerious sequelaePrescription dosesKnife radiosurgeryPrescription doseClinical studiesConclusion UseGKRSDose prescriptionGy/minRepair halftimeTreatment timeAuthors' department
2015
SU‐E‐T‐523: Investigation of Various MR‐Compatible Shielding Materials for Direction Modulated Brachytherapy (DMBT) Tandem Applicator for Cervical Cancer Treatment
Safigholi H, Han D, Soliman A, Meigooni A, Scanderbeg D, Song W. SU‐E‐T‐523: Investigation of Various MR‐Compatible Shielding Materials for Direction Modulated Brachytherapy (DMBT) Tandem Applicator for Cervical Cancer Treatment. Medical Physics 2015, 42: 3455-3455. DOI: 10.1118/1.4924885.Peer-Reviewed Original ResearchDirection modulated brachytherapyShielding materialsPlan qualityLevels of intensity modulationClinical patient plansClinical plan qualityCervical cancer brachytherapyOAR D2ccDose matrixPrescription doseSigmoid D2ccPatient plansMonte Carlo simulationsCancer brachytherapyHRCTV D90Rectum D2ccHDR brachytherapyIntensity modulationD2ccPlanning systemCarlo simulationsAuCervical cancer treatmentHRCTVMR compatibilitySU‐E‐T‐787: Utility of the Two Candidate 192‐Ir and 169‐Yb HDR Sources for Use with a Novel Direction Modulated Brachytherapy Tandem Applicator for Cervical Cancer Treatment
Safigholi H, Han D, Soliman A, Meigooni A, Song W. SU‐E‐T‐787: Utility of the Two Candidate 192‐Ir and 169‐Yb HDR Sources for Use with a Novel Direction Modulated Brachytherapy Tandem Applicator for Cervical Cancer Treatment. Medical Physics 2015, 42: 3518-3518. DOI: 10.1118/1.4925151.Peer-Reviewed Original ResearchDirection modulated brachytherapyHDR sourceYb-169Ir-192Treatment planning programTG-43Dose matrixTungsten alloysConformal plansPrescription doseHR-CTVTandem applicationsHRCTV D90Ring-planeIntensity modulationCervical cancer treatmentGyV100Cancer treatmentClinical casesOARsEvaluate treatmentDirectional beamsD2ccD98SU‐F‐BRA‐05: Utility of the Combined Use of Two Types of HDR Sources with the Direction Modulation Brachytherapy (DMBT) Tandem Applicator for Cervical Cancer Treatment
Safigholi H, Han D, Soliman A, Meigooni A, Scanderbeg D, Song W. SU‐F‐BRA‐05: Utility of the Combined Use of Two Types of HDR Sources with the Direction Modulation Brachytherapy (DMBT) Tandem Applicator for Cervical Cancer Treatment. Medical Physics 2015, 42: 3534-3534. DOI: 10.1118/1.4925216.Peer-Reviewed Original ResearchDirection modulated brachytherapyHDR sourcePlan qualityLevel of dose conformityHDR brachytherapy sourceEvaluate plan qualityClinical patient casesBrachytherapy sourcesDose conformityDose matrixPrescription doseHRCTV D90Tungsten alloy rodsPlanning systemHRCTVDual-sourceTandem applicationsCervical cancer treatmentPeripheral holesMinimal doseCancer treatmentBrachytherapyPatient casesDoseHDR
2014
Direction-Modulated Brachytherapy for High-Dose-Rate Treatment of Cervical Cancer. I: Theoretical Design
Han D, Webster M, Scanderbeg D, Yashar C, Choi D, Song B, Devic S, Ravi A, Song W. Direction-Modulated Brachytherapy for High-Dose-Rate Treatment of Cervical Cancer. I: Theoretical Design. International Journal Of Radiation Oncology • Biology • Physics 2014, 89: 666-673. PMID: 24751413, DOI: 10.1016/j.ijrobp.2014.02.039.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlgorithmsBrachytherapyColon, SigmoidEquipment DesignFemaleHumansIridium RadioisotopesMagnetic Resonance ImagingMiddle AgedMonte Carlo MethodOrgans at RiskRadiation InjuriesRadiotherapy DosageRadiotherapy Planning, Computer-AssistedRectumTungstenUrinary BladderUterine Cervical NeoplasmsYoung AdultConceptsCervical cancerHigh-risk clinical target volume D90Sizeable patient populationSimilar target coveragePlan qualityTreatment plan qualityPatient populationPrescription doseHigh doseRate brachytherapyImproved organClinical validationAnatomic informationPatient casesTarget coverageCancerBrachytherapyOvoid applicatorsPeripheral holesDose distributionDwell positionsBladderD2ccRectumDose
2013
SU‐E‐J‐207: Dosimetric Effects of Diaphragm Motion On Spine SBRT Treatments
Winey B, Chen H, Daartz J, Gierga D, Shin J, Schwab J, Oh K. SU‐E‐J‐207: Dosimetric Effects of Diaphragm Motion On Spine SBRT Treatments. Medical Physics 2013, 40: 199-199. DOI: 10.1118/1.4814419.Peer-Reviewed Original ResearchSU‐E‐T‐462: Energy Modulated Photon Radiotherapy: A Monte Carlo Investigation
Zhang Y, Feng Y, Ming X, Nath R, Deng J. SU‐E‐T‐462: Energy Modulated Photon Radiotherapy: A Monte Carlo Investigation. Medical Physics 2013, 40: 311-311. DOI: 10.1118/1.4814895.Peer-Reviewed Original ResearchIMRT plansProstate cancer patientsPhoton radiation therapyBeam energyPhoton beamsCancer patientsNeck cancerPrescription doseEclipse treatment planning systemDose reductionRadiation therapyBEAM Monte Carlo codePencil beam dose distributionsDVH analysisTumor sitePhoton radiotherapyDose distributionNormal tissuesPatientsLow-energy photonsPhoton beam intensityBeam dose distributionsTarget coverageOptimal beam energyIntegral dose
2012
Dynamic modulated brachytherapy (DMBT) for rectal cancer
Webster M, Devic S, Vuong T, Han D, Park J, Scanderbeg D, Lawson J, Song B, Watkins W, Pawlicki T, Song W. Dynamic modulated brachytherapy (DMBT) for rectal cancer. Medical Physics 2012, 40: 011718. PMID: 23298088, DOI: 10.1118/1.4769416.Peer-Reviewed Original ResearchConceptsRate brachytherapyDose heterogeneity indexTreatment deliveryAverage clinical target volumeClinical target volumePotential clinical benefitPlan qualityTotal treatment timeTreatment planning simulationClinical treatment plansRectal cancerClinical benefitMean dosePrescription doseTreatment planTumor coverageTarget volumeClinical patient casesBrachytherapyPatient casesDose conformalityDoseRectal cavityCritical structuresHigh-quality plansSU‐E‐T‐630: MCO‐Informed VMAT Planning for Prostate Cancer
Chen H, Craft D, Gierga D. SU‐E‐T‐630: MCO‐Informed VMAT Planning for Prostate Cancer. Medical Physics 2012, 39: 3851-3851. PMID: 28517507, DOI: 10.1118/1.4735719.Peer-Reviewed Original ResearchHomogeneity indexAnterior rectumSimultaneous integrated boost techniqueVMAT plansProstate cancer patientsAverage homogeneity indexFinal plan qualityVMAT plan qualityPlan qualityCancer patientsProstate PTVPrescription doseProstate cancerOAR sparingDVH parametersBoost techniqueDose homogeneityVMAT planningPatientsVMATProstate patientsClinical objectivesIMRT plansSeminal vesiclesV70
2011
Intensity-Modulated Radiotherapy for Pancreatic Adenocarcinoma
Abelson JA, Murphy JD, Minn AY, Chung M, Fisher GA, Ford JM, Kunz P, Norton JA, Visser BC, Poultsides GA, Koong AC, Chang DT. Intensity-Modulated Radiotherapy for Pancreatic Adenocarcinoma. International Journal Of Radiation Oncology • Biology • Physics 2011, 82: e595-e601. PMID: 22197234, DOI: 10.1016/j.ijrobp.2011.09.035.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAgedAged, 80 and overAntimetabolites, AntineoplasticChemotherapy, AdjuvantDeoxycytidineDisease-Free SurvivalFemaleFluorouracilGemcitabineHumansMaleMiddle AgedNeoplasm Recurrence, LocalPancreatic NeoplasmsRadiotherapy DosageRadiotherapy, Intensity-ModulatedRetrospective StudiesSurvival RateConceptsIntensity-modulated radiotherapyLocal-regional control ratesPancreatic adenocarcinomaAdjuvant patientsDefinitive patientsControl rateSurvival rateGrade 3 late toxicityRecurrence-free survival ratesThree-dimensional conformal radiotherapyOverall survival rateProspective clinical trialsRecurrence-free survivalDurable disease controlPlanning target volumeGreater acute toxicityAcute toxicityLate toxicityOverall survivalSystemic therapyMedian agePancreatic cancerClinical trialsPrescription doseGrade 3
2010
Robotic Brachytherapy and Sublobar Resection for T1 Non-Small Cell Lung Cancer in High-Risk Patients
Blasberg JD, Belsley SJ, Schwartz GS, Evans A, Wernick I, Ashton RC, Bhora FY, Connery CP. Robotic Brachytherapy and Sublobar Resection for T1 Non-Small Cell Lung Cancer in High-Risk Patients. The Annals Of Thoracic Surgery 2010, 89: 360-367. PMID: 20103299, DOI: 10.1016/j.athoracsur.2009.09.052.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAgedAged, 80 and overBrachytherapyCombined Modality TherapyComorbidityDisease ProgressionFemaleFollow-Up StudiesHealth Status IndicatorsHumansImage Processing, Computer-AssistedIodine RadioisotopesLung NeoplasmsMaleMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingPneumonectomyPositron-Emission TomographyPostoperative ComplicationsRadiometryRadiotherapy DosageRadiotherapy Planning, Computer-AssistedRadiotherapy, AdjuvantRoboticsTomography, X-Ray ComputedConceptsNon-small cell lung cancerHigh-risk patientsCell lung cancerPlanning target volumeSublobar resectionLung cancerPrescription doseStage IA non-small cell lung cancerTarget volumeT1 non-small cell lung cancerSublobar lung resectionPatients 5 yearsSite of recurrenceIncidence of recurrenceComputed tomography scanBrachytherapy seed placementDa Vinci systemConventional lobectomyPerioperative mortalityLocoregional recurrenceLung resectionSelect patientsLimited resectionResection marginsTumor size
2007
On the Need to Compensate for Edema-Induced Dose Reductions in Preplanned 131Cs Prostate Brachytherapy
Chen ZJ, Deng J, Roberts K, Nath R. On the Need to Compensate for Edema-Induced Dose Reductions in Preplanned 131Cs Prostate Brachytherapy. International Journal Of Radiation Oncology • Biology • Physics 2007, 70: 303-310. PMID: 17980500, PMCID: PMC2289996, DOI: 10.1016/j.ijrobp.2007.09.007.Peer-Reviewed Original ResearchConceptsDose reductionProstate brachytherapyDose compensationLarge edemaBiochemical recurrence-free survivalRecurrence-free survivalSignificant dose reductionEffects of edemaSublethal damage repairAdditional irradiationPrescription doseProstate cancerIndividual patientsEdemaEdema evolutionPrescribed doseProstate edemaEffective doseRadiobiologic effectsBrachytherapyDoseProstate implantsDose responseImplants
2005
SU‐FF‐T‐91: Unusually Large Fluctuation of Monitor Unit (MU) Efficiency in Large‐Field IMRT Plans Using Sliding‐Window Technique
Song H, Chen Z, Fan Y, Deng J, Ahmad M, Nath R. SU‐FF‐T‐91: Unusually Large Fluctuation of Monitor Unit (MU) Efficiency in Large‐Field IMRT Plans Using Sliding‐Window Technique. Medical Physics 2005, 32: 1970-1970. DOI: 10.1118/1.1997762.Peer-Reviewed Original ResearchStep-and-shootStep-and-shoot techniqueMU efficiencyWhole-body doseMonitor unitsIMRT plansEclipse treatment planning systemMV photon beamsTreatment planning systemTreatment monitor unitsSliding-window techniqueProstate plansIMRT deliveryMultileaf collimatorPhoton beamsLinear acceleratorPrescription doseIMRTPlanning systemDoseMultileafFluctuationsX-rayNeutronCollimator
2004
Optimization of dose distributions for bifurcated coronary vessels treated with catheter‐based photon and beta emitters using the simulated annealing algorithm
Yue N, Roberts KB, Son H, Khosravi S, Pfau SE, Nath R. Optimization of dose distributions for bifurcated coronary vessels treated with catheter‐based photon and beta emitters using the simulated annealing algorithm. Medical Physics 2004, 31: 2610-2622. PMID: 15487744, DOI: 10.1118/1.1783533.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAnimalsBeta ParticlesBlood Vessel ProsthesisBrachytherapyCatheterizationCatheters, IndwellingComputer SimulationCoronary RestenosisHumansModels, CardiovascularPhotonsRadiometryRadiotherapy DosageRadiotherapy Planning, Computer-AssistedRelative Biological EffectivenessReproducibility of ResultsSensitivity and SpecificityConceptsTreatment schemeCatheter-based delivery systemBetter dose distributionDose distributionDwell positionsPrescription doseCoronary vesselsBranch vesselsBranch treatmentBifurcation angleSatisfactory dose distributionMultiple dwell positionsVesselsOverdosingDelivery systemGeometry of bifurcations
2003
Biologically effective dose (BED) for interstitial seed implants containing a mixture of radionuclides with different half-lives
Chen Z, Nath R. Biologically effective dose (BED) for interstitial seed implants containing a mixture of radionuclides with different half-lives. International Journal Of Radiation Oncology • Biology • Physics 2003, 55: 825-834. PMID: 12573770, DOI: 10.1016/s0360-3016(02)04282-7.Peer-Reviewed Original Research
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