2025
Connectome-Based Predictive Modeling of PTSD Development Among Recent Trauma Survivors
Ben-Zion Z, Simon A, Rosenblatt M, Korem N, Duek O, Liberzon I, Shalev A, Hendler T, Levy I, Harpaz-Rotem I, Scheinost D. Connectome-Based Predictive Modeling of PTSD Development Among Recent Trauma Survivors. JAMA Network Open 2025, 8: e250331. PMID: 40063028, PMCID: PMC11894499, DOI: 10.1001/jamanetworkopen.2025.0331.Peer-Reviewed Original ResearchConceptsConnectome-based predictive modelingPosttraumatic stress disorderClinician-Administered PTSD Scale for DSM-5Months post-traumaFunctional magnetic resonance imagingTrauma survivorsDSM-5Post-traumaPosttraumatic stress disorder symptom clustersPosttraumatic stress disorder symptom severityPosttraumatic stress disorder symptom trajectoriesPosttraumatic stress disorder severityTask-based fMRI dataAnterior default modePredictive of symptomsFollow-up assessmentDevelopment of effective personalized treatmentsComprehensive clinical assessmentClinician-AdministeredNeurobiological indicesPosttraumatic psychopathologyHyperarousal symptomsCentral executiveTrauma exposureSalience network
2024
Prevalence, Correlates, and Burden of Subthreshold PTSD in US Veterans.
Fischer I, Na P, Harpaz-Rotem I, Marx B, Pietrzak R. Prevalence, Correlates, and Burden of Subthreshold PTSD in US Veterans. The Journal Of Clinical Psychiatry 2024, 85 PMID: 39480145, DOI: 10.4088/jcp.24m15465.Peer-Reviewed Original ResearchConceptsSubthreshold posttraumatic stress disorderPosttraumatic stress disorderPosttraumatic stress disorder symptom clustersLifetime psychiatric disordersUS veteransUS military veteransSymptom-related distressStress disorderPsychiatric disordersSymptom clustersTreating veteransCriterion AMilitary veteransTraumatic eventsCognitive functionWorking case definitionMental healthCriterion FFunctional impairmentVeteransNationally representative sampleFunctional correlatesDisordersElevated oddsGreater oddsUnraveling PTSD: Symptom Cluster Change During and 1 Year After Veterans’ Residential PTSD Treatment
Gross G, Spiller T, Ben-Zion Z, Rubenstein A, Pietrzak R, Duek O, Hoff R, Harpaz-Rotem I. Unraveling PTSD: Symptom Cluster Change During and 1 Year After Veterans’ Residential PTSD Treatment. Psychological Trauma Theory Research Practice And Policy 2024 PMID: 38990694, DOI: 10.1037/tra0001734.Peer-Reviewed Original ResearchPosttraumatic stress disorderPosttraumatic stress disorder symptom clustersPosttraumatic stress disorder clustersSymptom clustersIntrusive symptomsResidential treatmentTreatment of posttraumatic stress disorderPosttraumatic stress disorder symptomsResidential PTSD treatmentPTSD symptom clustersNovel treatment interventionsDifferential treatment responseReduce symptom severityDifferential patterns of changeAvoidance symptomsPTSD treatmentTreatment gainsStress disorderVeterans AffairsSymptom severityCluster CTreatment interventionsCluster BIndividual symptomsCohort of veteransRandomized controlled trial of two internet-based written therapies for world trade center workers and survivors with persistent PTSD symptoms
Feder A, Kowalchyk M, Brinkman H, Cahn L, Aaronson C, Böttche M, Presseau C, Fred-Torres S, Markowitz J, Litz B, Yehuda R, Knaevelsrud C, Pietrzak R. Randomized controlled trial of two internet-based written therapies for world trade center workers and survivors with persistent PTSD symptoms. Psychiatry Research 2024, 336: 115885. PMID: 38603979, DOI: 10.1016/j.psychres.2024.115885.Peer-Reviewed Original ResearchPosttraumatic stress disorderPosttraumatic stress disorder symptom clustersWTC-related PTSD symptomsMental health-related functioningPTSD symptomsSymptom clustersHealth-related functioningPosttraumatic stress disorder's avoidancePosttraumatic stress disorder symptomsPosttraumatic Stress Disorder ChecklistPresent-centered therapyAssociated with significantly greater reductionsPersistent PTSD symptomsActive control interventionModerate-to-largeQuality of lifeSignificant main effectTreatment-by-time interactionWorld Trade Center survivorDSM-5PCL-5Stress disorderDepressive/anxiety symptomsWorld Trade CenterDepressive symptomsAssociations of Posttraumatic Stress Disorder Symptom Clusters and Pain Interference in Post-9/11 Veterans: Exploring Sleep Impairment and Physical Activity as Underlying Mechanisms
Emrich M, Gnall K, Garnsey C, George J, Park C, Mazure C, Hoff R. Associations of Posttraumatic Stress Disorder Symptom Clusters and Pain Interference in Post-9/11 Veterans: Exploring Sleep Impairment and Physical Activity as Underlying Mechanisms. International Journal Of Behavioral Medicine 2024, 1-14. PMID: 38438749, DOI: 10.1007/s12529-024-10268-4.Peer-Reviewed Original ResearchPost-9/11 veteransPain interferencePhysical activityPTSD symptomsAssociated with pain interferenceModifiable health factorsSleep impairmentSymptom clustersPosttraumatic stress disorder symptom clustersWorsening pain interferencePTSD symptom clustersRe-experiencing symptomsBackgroundPosttraumatic stress disorderHealth factorsSecondary analysisTargeting sleepMethodsThe present studyVeteransHyperarousal symptomsRe-experiencingStress disorderStudy variablesPTSDPainAssociated with changesFunctional correlates of a novel 8-factor model of PTSD in U.S. military veterans: Results from the National Health and Resilience in Veterans Study
Stiltner B, Fischer I, Duek O, Polimanti R, Harpaz-Rotem I, Pietrzak R. Functional correlates of a novel 8-factor model of PTSD in U.S. military veterans: Results from the National Health and Resilience in Veterans Study. Journal Of Psychiatric Research 2024, 171: 69-74. PMID: 38244335, DOI: 10.1016/j.jpsychires.2024.01.017.Peer-Reviewed Original ResearchConceptsModels of posttraumatic stress disorderPosttraumatic stress disorderNational Health and ResilienceU.S. military veteransArousal symptomsSuicidal ideationVeterans StudyCurrent depressionSymptom clustersMilitary veteransPosttraumatic stress disorder symptom clustersPosttraumatic stress disorder symptomsPosttraumatic Stress Disorder ChecklistAnxious arousal symptomsDysphoric arousal symptomsIntrusive symptom clustersOdds of suicidal ideationFunctional correlatesMulti-faceted disorderExternalizing behavioral symptomsAssociated with lower oddsAssociated with higher oddsSymptom structureAvoidance symptomsDSM-5
2010
Posttraumatic Stress Disorder Symptom Structure in Injured Children
KassamAdams N, Marsac M, Cirilli C. Posttraumatic Stress Disorder Symptom Structure in Injured Children. Journal Of The American Academy Of Child & Adolescent Psychiatry 2010, 49: 616-625.e4. DOI: 10.1097/00004583-201006000-00010.Peer-Reviewed Original ResearchPosttraumatic stress disorderStructure of posttraumatic stress disorderSymptom clustersEffort avoidanceSymptom structureDysphoria symptomsDSM-IVPTSD symptomsGeneral distressFactor structureFactor structure of posttraumatic stress disorderFactor structure of PTSD symptomsPTSD symptom categoriesPosttraumatic stress disorder symptom checklistPosttraumatic stress disorder symptom clustersPTSD symptom structureSpecificity of PTSD symptomsStructure of PTSD symptomsDSM-IV modelPTSD-specific symptomsGeneral emotional distressSingle-incident traumaDepressive symptom clustersFunctional impairmentIndicators of functional impairmentPosttraumatic Stress Disorder Symptom Structure in Injured Children: Functional Impairment and Depression Symptoms in a Confirmatory Factor Analysis
Kassam-Adams N, Marsac M, Cirilli C. Posttraumatic Stress Disorder Symptom Structure in Injured Children: Functional Impairment and Depression Symptoms in a Confirmatory Factor Analysis. Journal Of The American Academy Of Child & Adolescent Psychiatry 2010, 49: 616-625.e4. PMID: 20494271, DOI: 10.1016/j.jaac.2010.02.011.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChecklistChildComorbidityDepressive DisorderDisability EvaluationEmergency Service, HospitalFeasibility StudiesFemaleFollow-Up StudiesHospitalizationHumansInterview, PsychologicalMaleMass ScreeningPersonality AssessmentPsychometricsStress Disorders, Post-TraumaticWounds and InjuriesConceptsPosttraumatic stress disorderStructure of posttraumatic stress disorderSymptom clustersEffort avoidanceSymptom structureDysphoria symptomsDSM-IVPTSD symptomsGeneral distressFactor structureDepressive symptomsFactor structure of posttraumatic stress disorderFactor structure of PTSD symptomsPTSD symptom categoriesPosttraumatic stress disorder symptom checklistPosttraumatic stress disorder symptom clustersPTSD symptom structureSpecificity of PTSD symptomsStructure of PTSD symptomsFunctional impairmentDSM-IV modelPTSD-specific symptomsGeneral emotional distressSingle-incident traumaDepressive symptom clusters
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