2025
Experiential avoidance in depression, anxiety, obsessive–compulsive related, and posttraumatic stress disorders: A comprehensive systematic review and meta-analysis
Shahar G. Experiential avoidance in depression, anxiety, obsessive–compulsive related, and posttraumatic stress disorders: A comprehensive systematic review and meta-analysis. Psychoanalytic Psychology 2025, 42: 123-127. DOI: 10.1037/pap0000533.Peer-Reviewed Original ResearchConnectome-Based Predictive Modeling of PTSD Development Among Recent Trauma Survivors
Ben-Zion Z, Simon A, Rosenblatt M, Korem N, Duek O, Liberzon I, Shalev A, Hendler T, Levy I, Harpaz-Rotem I, Scheinost D. Connectome-Based Predictive Modeling of PTSD Development Among Recent Trauma Survivors. JAMA Network Open 2025, 8: e250331. PMID: 40063028, PMCID: PMC11894499, DOI: 10.1001/jamanetworkopen.2025.0331.Peer-Reviewed Original ResearchConceptsConnectome-based predictive modelingPosttraumatic stress disorderClinician-Administered PTSD Scale for DSM-5Months post-traumaFunctional magnetic resonance imagingTrauma survivorsDSM-5Post-traumaPosttraumatic stress disorder symptom clustersPosttraumatic stress disorder symptom severityPosttraumatic stress disorder symptom trajectoriesPosttraumatic stress disorder severityTask-based fMRI dataAnterior default modePredictive of symptomsFollow-up assessmentDevelopment of effective personalized treatmentsComprehensive clinical assessmentClinician-AdministeredNeurobiological indicesPosttraumatic psychopathologyHyperarousal symptomsCentral executiveTrauma exposureSalience networkTrauma and related measures one year after the 2023 earthquakes in Türkiye: post-traumatic stress, post-traumatic growth, spiritual well-being, and self-compassion
Kartol A, Üztemur S, Chen C, Lin C, Gökalp A, Potenza M, Pakpour A. Trauma and related measures one year after the 2023 earthquakes in Türkiye: post-traumatic stress, post-traumatic growth, spiritual well-being, and self-compassion. Current Psychology 2025, 1-11. DOI: 10.1007/s12144-025-07563-y.Peer-Reviewed Original ResearchPosttraumatic stress disorderPromote post-traumatic growthSelf-compassionPost-traumatic growthReducing posttraumatic stress disorderPosttraumatic stress disorder symptomsSpiritual well-beingLevels of self-compassionPosttraumatic stress disorder scoreWell-beingPost-traumatic stressMental health professionalsAdverse effects of traumaEffects of traumaAdverse psychological effectsStress disorderTraumatic eventsEarthquake-related traumaEarthquake survivorsPsychological effectsTraumatic effectsHealth professionalsIndividualsHealthy wayTraumaObservational and Genetic Analyses of Traumatic Experiences and Endometriosis
Koller D, Løkhammer S, Goroshchuk O, Denner V, Stiltner B, Mitjans M, He J, Taylor H, Lawn R, Koenen K, Polimanti R. Observational and Genetic Analyses of Traumatic Experiences and Endometriosis. JAMA Psychiatry 2025, 82 PMID: 39908042, PMCID: PMC11800128, DOI: 10.1001/jamapsychiatry.2024.4694.Peer-Reviewed Original ResearchPolygenic risk scoresLatent class analysisAssociated with increased oddsTraumatic experiencesImpact of childhoodIndividual-level dataCase-control studyStressful eventsGenetic predispositionTrauma-related outcomesUnaffected womenMain OutcomesFinnGen cohortRisk scoreAssociation of endometriosisPosttraumatic stress disorderTrauma eventsMeta-analysisSexual traumaAssociated with endometriosisContact traumaPotential associationStress disorderPsychological traumaPhenotypic associationsPosttraumatic stress disorder and eating disorders: maintaining mechanisms and treatment targets
Mitchell K, Scioli E, Galovski T, Belfer P, Cooper Z. Posttraumatic stress disorder and eating disorders: maintaining mechanisms and treatment targets. 2025, 95-109. DOI: 10.4324/9781003607403-10.Peer-Reviewed Original ResearchPosttraumatic stress disorderStress disorderComorbid posttraumatic stress disorderPosttraumatic stress disorder symptomsExposure to interpersonal traumaCognitive behavioral theoryHistory of eating disordersLow self-worthEvidence-based treatmentsEmotion dysregulationHyperarousal symptomsInterpersonal traumaBinge eatingTrauma exposureED behaviorsLifetime historyEating disordersSelf-criticismSelf-worthEvidence-based therapiesTreatment of EDCoping strategiesBidirectional relationshipTreatment targetDisordersCorrelates of Impaired Sleep Duration Among Adults With Trauma Alone and With Posttraumatic Stress Disorder
Havlik J, Rhee T, Rosenheck R. Correlates of Impaired Sleep Duration Among Adults With Trauma Alone and With Posttraumatic Stress Disorder. Psychological Trauma Theory Research Practice And Policy 2025 PMID: 39836166, DOI: 10.1037/tra0001846.Peer-Reviewed Original ResearchImpaired sleep durationStress disorderSleep durationEffect sizePosttraumatic stress disorderClinically meaningful effect sizesNational Epidemiologic SurveyMeaningful effect sizesPsychiatric multimorbidityPTSDTrauma/PTSDImprove treatment outcomesMedical comorbiditySleep disturbanceImpaired sleepBehavioral variablesTreatment outcomesAllostatic loadNationally representative sampleAdjusted multivariable regressionEpidemiological surveyDisordersBody mass indexRepresentative sampleSleepA genetic exploration of the relationship between posttraumatic stress disorder and cardiovascular diseases
Lukas E, Veeneman R, Smit D, Ahluwalia T, Vermeulen J, Pathak G, Polimanti R, Verweij K, Treur J. A genetic exploration of the relationship between posttraumatic stress disorder and cardiovascular diseases. Translational Psychiatry 2025, 15: 1. PMID: 39755697, PMCID: PMC11700205, DOI: 10.1038/s41398-024-03197-z.Peer-Reviewed Original ResearchPosttraumatic stress disorderMendelian randomizationCardiovascular diseaseCausal pathwaysData of genome-wide association studiesGenetic liabilityMultivariable Mendelian randomizationWaist-to-hip ratioPotential mediatorsWaist-to-hipRisk of cardiovascular diseaseGenome-wide association studiesPotential causal pathwaysPrevent cardiovascular diseaseStress disorderIncreased risk of cardiovascular diseaseGenomic structural equationSignificant genetic correlationsPsychosocial factorsEffects of posttraumatic stress disorderAssociation studiesIncreased riskPosttraumatic stress disorder patientsCausal effectsTraumatic events
2024
MDMA and MDMA-Assisted Therapy
Wolfgang A, Fonzo G, Gray J, Krystal J, Grzenda A, Widge A, Kraguljac N, McDonald W, Rodriguez C, Nemeroff C. MDMA and MDMA-Assisted Therapy. American Journal Of Psychiatry 2024, 182: 79-103. PMID: 39741438, DOI: 10.1176/appi.ajp.20230681.Peer-Reviewed Original ResearchConceptsMDMA-assisted therapyPosttraumatic stress disorderControlled clinical settingRecreational useMDMA administrationNeurobiological mechanismsStress disorderEgo functionsSelf-compassionMDMAEfficacious treatmentPreliminary evidenceHeightened trustTherapeutic settingNonclinical settingsDiagnostic criteriaFood and Drug AdministrationBreakthrough therapiesClinical settingNonmedical settingsConsiderable bodyPsychotherapyPsychedelicsLong-term follow-upDrug AdministrationVoice hearing in young people with posttraumatic stress disorder (PTSD) following multiple trauma exposure
Lofthouse K, Beeson E, Dalgleish T, Danese A, Hodgekins J, Mahoney-Davies G, Smith P, Stallard P, Wilson J, Meiser-Stedman R. Voice hearing in young people with posttraumatic stress disorder (PTSD) following multiple trauma exposure. European Journal Of Psychotraumatology 2024, 15: 2435790. PMID: 39691055, PMCID: PMC11656750, DOI: 10.1080/20008066.2024.2435790.Peer-Reviewed Original ResearchConceptsNegative post-traumatic cognitionsPosttraumatic stress disorderPost-traumatic cognitionsPosttraumatic stress disorder symptom severityHearing groupPrevalence of sexual traumaVoice hearingPanic symptomsSymptom severitySexual traumaSecondary analysisExposure to multiple traumatic eventsCognitive phenotype of childrenHearing voicesExposure to multiple traumasPosttraumatic stress disorder diagnosisTrauma memory qualityMental health difficultiesMethods:</b> ParticipantsMultiple traumatic eventsMultiple trauma exposuresExploratory secondary analysisCognitive-behavioral factorsPhenotype of childrenHealth difficultiesIdentifying transdiagnostic traumatic stress reactions in U.S. military veterans: A nationally representative study
Pugach C, Adams S, Wisco B, Pietrzak R. Identifying transdiagnostic traumatic stress reactions in U.S. military veterans: A nationally representative study. Journal Of Traumatic Stress 2024 PMID: 39682069, DOI: 10.1002/jts.23119.Peer-Reviewed Original ResearchPosttraumatic stress disorderTraumatic stress reactionsU.S. military veteransDysphoric arousalMilitary veteransSelf-reported posttraumatic stress disorderPosttraumatic stress disorder symptomsNational Health and ResilienceStress reactionsComorbid psychopathologyPsychopathological symptomsGeneralized anxietyStress disorderDiagnostic subtypesVeterans StudyDepressive symptomsLatent class analysisTrauma historySymptom differencesU.S. veteransPsychopathologyMental functioningPsychosocial correlatesArousalFunctional impairmentMental Health Service Referral and Treatment Following Screening and Assessment in Juvenile Detention.
Tedeschi F, Horwitz S, Surko M, Weinberger E, Bart A, Baetz C, Guo F, Alexander A, Havens J. Mental Health Service Referral and Treatment Following Screening and Assessment in Juvenile Detention. The Journal Of The American Academy Of Psychiatry And The Law 2024, 52: 460-469. PMID: 39393913, DOI: 10.29158/jaapl.240082-24.Peer-Reviewed Original ResearchAttention-deficit/hyperactivity disorderDSM-5 diagnosisMental health screeningDSM-5Prevalence of attention-deficit/hyperactivity disorderRates of mental health disordersPosttraumatic stress disorderProblematic substance useMental health disordersMental health service referralJuvenile detention facilitiesStress disorderAttention-deficit/hyperactivityDetained youthSubstance useNeurodevelopmental disordersHealth disordersJuvenile detentionDetention facilitiesEvaluate youthHealth screeningDisordersEmotional concernsAvailability of servicesService referralsSex-stratified Genomic Structural Equation Models of Posttraumatic Stress Inform PTSD Etiology: L'utilisation de la modélisation génomique par équations structurelles stratifiée par sexe du stress post-traumatique pour expliquer l'étiologie du TSPT
Moo-Choy A, Stein M, Gelernter J, Wendt F. Sex-stratified Genomic Structural Equation Models of Posttraumatic Stress Inform PTSD Etiology: L'utilisation de la modélisation génomique par équations structurelles stratifiée par sexe du stress post-traumatique pour expliquer l'étiologie du TSPT. The Canadian Journal Of Psychiatry 2024, 70: 117-126. PMID: 39654303, PMCID: PMC11629358, DOI: 10.1177/07067437241301016.Peer-Reviewed Original ResearchGenome-wide association studiesGenome-wide significant lociSignificant lociMultivariate genome-wide association studyIndividuals of European ancestryPosttraumatic stress disorderGenomic structural equation modelingPosttraumatic stressUK Biobank (UKBAssociation studiesGenetic basisSymptom combinationsEtiological differencesSex-specific patternsEuropean ancestryAssociation dataPosttraumatic stress disorder diagnosisPosttraumatic stress disorder symptomsSex differencesLociInvestigation of sex differencesGeneticsSymptom etiologyModel of maleTraumatic eventsEating Disorders, Co‐Morbid Disorders and Early Risk Factors Amongst Post‐9/11 Veteran Men and Women
Cooper Z, Smith B, Kehle‐Forbes S, Dorset J, Mitchell K. Eating Disorders, Co‐Morbid Disorders and Early Risk Factors Amongst Post‐9/11 Veteran Men and Women. Journal Of Clinical Psychology 2024, 81: 133-144. PMID: 39648640, PMCID: PMC11802485, DOI: 10.1002/jclp.23756.Peer-Reviewed Original ResearchCo-occurring psychiatric disordersRates of eating disordersPosttraumatic stress disorderPsychiatric disordersEating disordersMilitary risk factorsStress disorderLevels of posttraumatic stress disorderCo-morbid psychiatric disordersCo-morbid psychiatric diagnosesDSM-5 eating disorder diagnosesComorbid psychiatric disordersBinge eating disorderCo-morbid disordersEating disorder diagnosisDocumented risk factorsLongitudinal studyEvidence-based treatmentsNon-veteransRisk factorsEarly risk factorsDSM-5Case statusDisorder onsetPsychiatric diagnosisPsychometric properties, factor structure, and functional correlates of the PTSD checklist for DSM-5 in a U.S. national sample of older veterans
Cook J, Bovin M, Günak M, Lawrence K, Pietrzak R. Psychometric properties, factor structure, and functional correlates of the PTSD checklist for DSM-5 in a U.S. national sample of older veterans. International Psychogeriatrics 2024, 37: 100027. PMID: 40086904, DOI: 10.1016/j.inpsyc.2024.100027.Peer-Reviewed Original ResearchPosttraumatic stress disorderPosttraumatic Stress Disorder ChecklistDSM-5PCL-5Psychometric propertiesOlder veteransSymptoms of posttraumatic stress disorderSubthreshold posttraumatic stress disorderAdult trauma exposurePCL-5 scoresMeasure PTSD symptomsSample of older veteransExcellent internal consistencyRates of childhoodNationally representative web-based surveyU.S. national sampleAssociated with measuresDysphoric symptomsPTSD symptomsStress disorderTrauma exposureFactor structureCommunity-dwelling older veteransAssessment measuresInternal consistencySuicide Risk Among Veterans Who Receive Evidence-Based Therapy for Posttraumatic Stress Disorder
Saulnier K, Brabbs S, Szymanski B, Harpaz-Rotem I, McCarthy J, Sripada R. Suicide Risk Among Veterans Who Receive Evidence-Based Therapy for Posttraumatic Stress Disorder. JAMA Network Open 2024, 7: e2452144. PMID: 39724372, PMCID: PMC11672158, DOI: 10.1001/jamanetworkopen.2024.52144.Peer-Reviewed Original ResearchConceptsVeterans Health AdministrationPosttraumatic stress disorder diagnosisVeterans Health Administration carePosttraumatic stress disorderSuicide riskStress disorderAdequate courseDeath certificate dataAssociated with lower suicide riskCohort study of veteransMortality Data RepositoryPopulation-based sampleStudy of veteransLower suicide riskReceipt of evidence-based treatmentsEvidence-based psychotherapiesMultivariable proportional hazards regressionProportional hazards regressionEvidence-based treatmentsAssociated with suicideEvidence-based therapiesCertificate dataSuicide mortalityHealth AdministrationMain OutcomesPsilocybin Therapy for Clinicians With Symptoms of Depression From Frontline Care During the COVID-19 Pandemic
Back A, Freeman-Young T, Morgan L, Sethi T, Baker K, Myers S, McGregor B, Harvey K, Tai M, Kollefrath A, Thomas B, Sorta D, Kaelen M, Kelmendi B, Gooley T. Psilocybin Therapy for Clinicians With Symptoms of Depression From Frontline Care During the COVID-19 Pandemic. JAMA Network Open 2024, 7: e2449026. PMID: 39636638, PMCID: PMC11621983, DOI: 10.1001/jamanetworkopen.2024.49026.Peer-Reviewed Original ResearchConceptsAdvanced practice practitionersSymptoms of depressionMontgomery-Asberg Depression Rating ScalePosttraumatic stress disorderSymptoms of burnoutMontgomery-Asberg Depression Rating Scale scoreSymptoms of posttraumatic stress disorderFrontline carePsilocybin therapyRandomized clinical trialsSevere symptoms of depressionMental health diagnosesScore changesImprove symptoms of depressionCOVID-19 pandemicPCL-5Intention-to-treat principleMedication sessionsDepression Rating ScalePCL-5 scoresPsychological morbidityHealth diagnosisMain OutcomesPractice practitionersUS cliniciansPosttraumatic Stress Disorder, Obesity, and Accelerated Epigenetic Aging Among US Military Veterans
Fischer I, Na P, Nagamatsu S, Jeste D, Cabrera-Mendoza B, Montalvo-Ortiz J, Krystal J, Polimanti R, Gelernter J, Pietrzak R. Posttraumatic Stress Disorder, Obesity, and Accelerated Epigenetic Aging Among US Military Veterans. JAMA Psychiatry 2024, 81: 1276-1277. PMID: 39476130, PMCID: PMC11581715, DOI: 10.1001/jamapsychiatry.2024.3403.Peer-Reviewed Original ResearchTraumatic Brain Injury in U.S. Veterans: Prevalence and Associations with Physical, Mental, and Cognitive Health
Karr J, Rippey C, Hubert T, Stein M, Adams T, Pietrzak R. Traumatic Brain Injury in U.S. Veterans: Prevalence and Associations with Physical, Mental, and Cognitive Health. Archives Of Physical Medicine And Rehabilitation 2024 PMID: 39613218, DOI: 10.1016/j.apmr.2024.11.010.Peer-Reviewed Original ResearchPosttraumatic stress disorderAlcohol use disorderDrug use disordersTraumatic brain injuryActivities of daily livingInstrumental activities of daily livingU.S. veteransAnxiety disordersSuicidal ideationUse disorderHealth conditionsPrevalence of traumatic brain injuryU.S. military veteransBrain injuryActivities of daily living disabilitySelf-reported health professional diagnosisOdds of mild cognitive impairmentU.S. veteran populationMental health conditionsMild cognitive impairmentPhysical health conditionsDepressive disorderStress disorderAssociated with higher oddsSuicide attemptsNovel Pharmacologic and Other Somatic Treatment Approaches for Posttraumatic Stress Disorder in Adults: State of the Evidence
Sippel L, Hamblen J, Kelmendi B, Alpert J, Carpenter L, Grzenda A, Kraguljac N, McDonald W, Rodriguez C, Widge A, Nemeroff C, Schnurr P, Holtzheimer P, Biomarkers and Treatments T. Novel Pharmacologic and Other Somatic Treatment Approaches for Posttraumatic Stress Disorder in Adults: State of the Evidence. American Journal Of Psychiatry 2024, 181: 1045-1058. PMID: 39616450, DOI: 10.1176/appi.ajp.20230950.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderStress disorderPathophysiology of posttraumatic stress disorderNon-trauma-focused psychotherapyTrauma-focused psychotherapySomatic treatment approachesEvidence-based treatmentsAntidepressant medicationSomatic treatmentsPsychiatric disordersSomatic interventionsTranscranial magnetic stimulationPsychotherapyMagnetic stimulationTreatment approachesDisordersRecommended first-line treatmentAdultsFirst-line treatmentMedicationMechanism of actionMonotherapy strategySalienceSpecific treatmentEvidenceGender Differences in “Making Weight” Behaviors Among U.S. Iraq and Afghan War Veterans: Implications for Future Health
Cary A, Neff K, Buta E, Fenn L, Ramsey C, Snow J, Haskell S, Masheb R. Gender Differences in “Making Weight” Behaviors Among U.S. Iraq and Afghan War Veterans: Implications for Future Health. Journal Of Women's Health 2024, 34: 314-321. PMID: 39510825, DOI: 10.1089/jwh.2024.0246.Peer-Reviewed Original ResearchFemale service membersEating pathologyMental healthAfghanistan war era veteransLevels of dietary restraintMeasures of eating behaviorPosttraumatic stress disorderService membersGender differencesWeight behaviorPotential gender differencesRates of obesityAssociated with female genderStress disorderFood addictionProportion of womenDietary restraintEmotional eatingEra veteransU.S.-IraqWar veteransExcessive exerciseFuture healthMilitary populationVeterans
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