2025
Connectome-Based Predictive Modeling of PTSD Development Among Recent Trauma Survivors
Ben-Zion Z, Simon A, Rosenblatt M, Korem N, Duek O, Liberzon I, Shalev A, Hendler T, Levy I, Harpaz-Rotem I, Scheinost D. Connectome-Based Predictive Modeling of PTSD Development Among Recent Trauma Survivors. JAMA Network Open 2025, 8: e250331. PMID: 40063028, PMCID: PMC11894499, DOI: 10.1001/jamanetworkopen.2025.0331.Peer-Reviewed Original ResearchConceptsConnectome-based predictive modelingPosttraumatic stress disorderClinician-Administered PTSD Scale for DSM-5Months post-traumaFunctional magnetic resonance imagingTrauma survivorsDSM-5Post-traumaPosttraumatic stress disorder symptom clustersPosttraumatic stress disorder symptom severityPosttraumatic stress disorder symptom trajectoriesPosttraumatic stress disorder severityTask-based fMRI dataAnterior default modePredictive of symptomsFollow-up assessmentDevelopment of effective personalized treatmentsComprehensive clinical assessmentClinician-AdministeredNeurobiological indicesPosttraumatic psychopathologyHyperarousal symptomsCentral executiveTrauma exposureSalience network
2024
Longitudinal associations between five factor model and impulsive personality traits and PTSD symptoms: Findings from the AURORA study
Hyatt C, Reddi P, Sharpe B, Michopoulos V, van Rooij S, House S, Beaudoin F, An X, Stevens J, Zeng D, Neylan T, Clifford G, Linnstaedt S, Germine L, Bollen K, Rauch S, Haran J, Lewandowski C, Musey P, Hendry P, Sheikh S, Jones C, Punches B, Kurz M, Swor R, Hudak L, Pascual J, Seamon M, Harris E, Pearson C, Peak D, Merchant R, Domeier R, Rathlev N, Sergot P, Sanchez L, Bruce S, Miller M, Pietrzak R, Joormann J, Pizzagalli D, Sheridan J, Smoller J, Harte S, Elliott J, McLean S, Kessler R, Ressler K, Koenen K, Maples-Keller J. Longitudinal associations between five factor model and impulsive personality traits and PTSD symptoms: Findings from the AURORA study. Journal Of Research In Personality 2024, 112: 104524. DOI: 10.1016/j.jrp.2024.104524.Peer-Reviewed Original ResearchImpulsive personality traitsPTSD symptomsPersonality traitsOne-year post-traumaSevere PTSD symptomsPost-traumaFactor modelNegative urgencyLow agreeablenessLow conscientiousnessTrauma exposurePersonality assessmentPTSD riskProspective linksSymptom TotalPTSDLongitudinal associationsAURORA studyIncremental predictorNeuroticismTime pointsSymptomsTraitsAgreeablenessConscientiousnessBreaking the cycle with trauma-focused mentalization-based treatment: theory and practice of a trauma-focused group intervention
Smits M, de Vos J, Rüfenacht E, Nijssens L, Shaverin L, Nolte T, Luyten P, Fonagy P, Bateman A. Breaking the cycle with trauma-focused mentalization-based treatment: theory and practice of a trauma-focused group intervention. Frontiers In Psychology 2024, 15: 1426092. PMID: 39346509, PMCID: PMC11427379, DOI: 10.3389/fpsyg.2024.1426092.Peer-Reviewed Original ResearchMentalization-based treatmentImpact of traumaAdaptations of MBTGroup interventionBorderline personality pathologyTrauma-focused group interventionAttachment behavioral systemNegative perceptions of selfImpaired mental abilityClinical case examplesEffects of traumaPerceptions of selfPersonality pathologyAttachment traumaMental abilityMental perspectiveComplex traumaAvoidance behaviorEpistemic trustRelational difficultiesDissociative experiencesBehavioral systemsTreatment phaseCase examplePost-traumaDefining the r factor for post-trauma resilience and its neural predictors
van Rooij S, Santos J, Hinojosa C, Ely T, Harnett N, Murty V, Lebois L, Jovanovic T, House S, Bruce S, Beaudoin F, An X, Neylan T, Clifford G, Linnstaedt S, Germine L, Bollen K, Rauch S, Haran J, Storrow A, Lewandowski C, Musey P, Hendry P, Sheikh S, Jones C, Punches B, Swor R, Pascual J, Seamon M, Harris E, Pearson C, Peak D, Merchant R, Domeier R, Rathlev N, O’Neil B, Sanchez L, Joormann J, Pizzagalli D, Sheridan J, Harte S, Kessler R, Koenen K, McLean S, Ressler K, Stevens J. Defining the r factor for post-trauma resilience and its neural predictors. Nature Mental Health 2024, 2: 680-693. DOI: 10.1038/s44220-024-00242-0.Peer-Reviewed Original ResearchDefault mode network activityFunctional magnetic resonance imagingResponse to rewardMode network activityPost-trauma resilienceWeeks post-traumaNeurobiological profilesReward valuationReward processingSpecific psychopathologyTransdiagnostic approachBrain mechanismsCognitive functionResilience factorsWhole-brainComponents of resilienceNeural predictorsAURORA studyRewardPost-traumaMagnetic resonance imagingProcess of recoveryNetwork activityResonance imagingPsychopathology
2017
Preventing intrusive memories after trauma via a brief intervention involving Tetris computer game play in the emergency department: a proof-of-concept randomized controlled trial
Iyadurai L, Blackwell S, Meiser-Stedman R, Watson P, Bonsall M, Geddes J, Nobre A, Holmes E. Preventing intrusive memories after trauma via a brief intervention involving Tetris computer game play in the emergency department: a proof-of-concept randomized controlled trial. Molecular Psychiatry 2017, 23: 674-682. PMID: 28348380, PMCID: PMC5822451, DOI: 10.1038/mp.2017.23.Peer-Reviewed Original ResearchConceptsIntrusive memoriesTrauma memoriesIntrusive trauma memoriesReal-life traumaAttention-placebo controlDisrupt consolidationIntrusive symptomsCognitive neuroscienceVisual memorySymptom clustersRandomized controlled trialsPsychiatric interventionBehavioral interventionsPsychological traumaNeuroscientific insightsEmergency departmentPost-traumaMemoryControl conditionMotor vehicle accidentsInterventionSymptomsTraumaComputer gamesTetris
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