2025
A positron emission tomography tracer for the imaging of oxidative stress in the central nervous system
Wilde J, Sun Y, Simpson S, Hill E, Fu Z, Bian E, Kinkaid M, Villanueva P, Weybright A, Terrell W, Qureshi Z, Perera S, Sheppard H, Stone J, Kundu B, Kuan C, Neumann K. A positron emission tomography tracer for the imaging of oxidative stress in the central nervous system. Nature Biomedical Engineering 2025, 1-14. PMID: 40044816, DOI: 10.1038/s41551-025-01362-3.Peer-Reviewed Original ResearchCentral nervous systemPositron emission tomographyInjection of sodium nitroprussideOxidative stressNervous systemClinical trials of antioxidantsMiddle cerebral arteryBlood-brain barrierTrials of antioxidantsPositron emission tomography tracersIntrastriatal injectionParametric mappingSodium nitroprussideCerebral arteryLongitudinally in vivoIn vivo quantificationQuantification of oxidative stressEmission tomographyPET imagingAntioxidant edaravoneDynamic PET imagesHuman plasmaNovel F-18-labeled Tracers of Sympathetic Function for Improved Risk Stratification and Clinical Outcomes
Zohora F, Nazari M, Sinusas A. Novel F-18-labeled Tracers of Sympathetic Function for Improved Risk Stratification and Clinical Outcomes. Current Cardiology Reports 2025, 27: 61. PMID: 40009333, DOI: 10.1007/s11886-025-02197-9.Peer-Reviewed Original ResearchConceptsSudden cardiac deathImplantable cardioverter defibrillatorPositron emission tomographyImplantable cardioverter defibrillator placementMyocardial sympathetic denervationRisk stratificationSympathetic denervationIschemic heart diseaseHeart failurePrevention of sudden cardiac deathRisk stratification of patientsHeart diseaseOptimal risk stratificationLow ejection fractionStratification of patientsSympathetic nerve densityImprove risk stratificationHeart failure patientsPositron emission tomography radiotracersPredicting sudden cardiac deathPositron emission tomography tracersPrognostic benefitEjection fractionClinically practical approachNerve densityEffects of lung expansion on global and regional pulmonary blood volume in a sheep model of acute lung injury.
Zang M, Zeng C, Lagier D, Leng N, Grogg K, Motta-Ribeiro G, Laine A, Winkler T, Vidal Melo M. Effects of lung expansion on global and regional pulmonary blood volume in a sheep model of acute lung injury. Anesthesiology 2025 PMID: 39946655, DOI: 10.1097/aln.0000000000005412.Peer-Reviewed Original ResearchPositive end-expiratory pressurePulmonary blood volumeLung expansionBlood volumeLung injurySystemic endotoxemiaMechanical ventilationRespiratory-gated positron emission tomographyVentilator-induced lung injuryModel of acute lung injuryDistribution of blood volumeAcute lung injuryLow-volume mechanical ventilationLung injury modelEnd-expiratory pressureQuantify blood volumePulmonary capillary blood volumeLow blood volumeRegional blood volumePositron emission tomographyVascular blood volumeCapillary blood volumeLung blood volumeCapillary closureEnd-inspirationHow to Use Imaging: Complex Cases of Atherosclerosis, Myocardial Inflammation, and Cardiomyopathy in Cardio-Oncology
Khattab M, Baig M, Zarif T, Barac A, Ferencik M, Henry M, Lopez-Mattei J, Redheuil A, Salem J, Scherrer-Crosbie M, Yang E, Baldassarre L. How to Use Imaging: Complex Cases of Atherosclerosis, Myocardial Inflammation, and Cardiomyopathy in Cardio-Oncology. Circulation Cardiovascular Imaging 2025, 18: e015981. PMID: 39772610, DOI: 10.1161/circimaging.124.015981.Peer-Reviewed Original ResearchConceptsCardio-oncologyCases of atherosclerosisCardiac magnetic resonance imagingCoronary computed tomography angiographySingle-photon emission computed tomographyImmune checkpoint inhibitorsLeft ventricular dysfunctionMultimodality cardiac imagingTyrosine kinase inhibitorsCardiac imaging modalitiesComputed tomography angiographyRisk of cardiovascular diseaseEmission computed tomographyPositron emission tomographyMagnetic resonance imagingCheckpoint inhibitorsVentricular dysfunctionMyocardial inflammationCoronary vasospasmAccelerated atherosclerosisKinase inhibitorsPatient populationDiagnosing such pathologiesCancer therapyCardiac imagingSelective Mu-Opioid Receptor Imaging Using 18F‑Labeled Carfentanils
Lee S, Pearson T, Dhaynaut M, MacDonagh A, Wey H, Wilks M, Roth B, Hooker J, Normandin M. Selective Mu-Opioid Receptor Imaging Using 18F‑Labeled Carfentanils. Journal Of Medicinal Chemistry 2025, 68: 1632-1644. PMID: 39772615, DOI: 10.1021/acs.jmedchem.4c02287.Peer-Reviewed Original ResearchConceptsMu-opioid receptorsPositron emission tomographyIn vivo PET scansCarbon-11Neurobiological studiesCopper-mediated radiofluorinationMu-opioidReceptor imagingPET scansBrain uptakeFavorable pharmacokineticsImaging evaluationHigh molar activityMass doseEmission tomographyHalf-life of fluorine-18Synthetic opioidsFluorine-18Half-lifeIn vitro binding assaysBinding assaysClinical research useMolar activityCarfentanilResearch useQuantifying VMAT2 target occupancy at effective valbenazine doses and comparing to a novel VMAT2 inhibitor: a translational PET study
Terry-Lorenzo R, Albrecht D, Crouch S, Wong R, Loewen G, Giri N, Skor H, Lin K, Sandiego C, Pajonas M, Rabiner E, Gunn R, Russell D, Haubenberger D. Quantifying VMAT2 target occupancy at effective valbenazine doses and comparing to a novel VMAT2 inhibitor: a translational PET study. Neuropsychopharmacology 2025, 1-9. PMID: 39757283, DOI: 10.1038/s41386-024-02046-3.Peer-Reviewed Original ResearchVesicular monoamine transporter type 2Treatment of tardive dyskinesiaPositron emission tomographyVesicular monoamine transporter type 2 inhibitorsTarget occupancyTreatment of chorea associated with Huntington's diseaseTreatment of TDChorea associated with Huntington's diseaseCentral nervous systemTardive dyskinesiaVMAT2 inhibitorsValbenazineClinical developmentEffect sizeAssociated with efficacyPET studiesEmission tomographyGold standard biomarkerDosing regimensClinical benefitDaily doseHuntington's diseaseActive metabolitePlasma concentrationsAcceptable dosePositron Emission Tomography Brain Imaging Methodologies
Hillmer A, Cosgrove K, Carson R. Positron Emission Tomography Brain Imaging Methodologies. 2025, 107-120. DOI: 10.1093/med/9780197640654.003.0009.Peer-Reviewed Original ResearchPositron emission tomographyBrain imaging studiesStudy of mental illnessDrug occupancyGroup differencesBinding potentialMental illnessSynaptic densityPET imaging dataBrain imagingPositron emission tomography imagingAbstract Positron emission tomographyMethodological considerationsNeurotransmitter synthesisEmission tomographyImaging studiesNeurotransmitter releaseVolume of distributionOutcome measuresClinical researchBPNDNeurotransmitterBrainIllnessImage dataGross tumor volume confidence maps prediction for soft tissue sarcomas from multi-modality medical images using a diffusion model
Dong Y, Marin T, Zhuo Y, Najem E, Moteabbed M, Xing F, Beddok A, Lahoud R, Rozenblum L, Ding Z, Liu X, Grogg K, Woo J, Chen Y, Lim R, Ma C, Fakhri G. Gross tumor volume confidence maps prediction for soft tissue sarcomas from multi-modality medical images using a diffusion model. Physics And Imaging In Radiation Oncology 2025, 33: 100734. PMID: 40123775, PMCID: PMC11926426, DOI: 10.1016/j.phro.2025.100734.Peer-Reviewed Original ResearchGross tumor volumeSoft tissue sarcomasTissue sarcomasGross tumor volume delineationManual GTV delineationsMagnetic resonance imagingComputed tomographyFluorodeoxyglucose positron emission tomographyGTV delineationT1-weighted magnetic resonance imagingSingle-modePositron emission tomographyMulti-modal medical imagesTumor volumeIntra-reader variabilityFDG-PETTreatment planningSarcomaEmission tomographyImaging modalitiesResonance imagingDiffusion modelDice indexReader variabilityPatientsValidación experimental de la gravedad de la estenosis coronaria y el desarrollo de miocardio isquémico
Lee J, Lee S, Kwon W, Kim H, Hong D, Kim H, Cho S, Shin D, Ki S, Kim J, Moon J, Song H, Lee S, Ha D, Jang J, Ahn Y, Jeong M, Ki H, Park T, Yang J, Bin Song Y, Hahn J, Choi S, Gwon H, Hong Y. Validación experimental de la gravedad de la estenosis coronaria y el desarrollo de miocardio isquémico. Revista Española De Cardiología 2025 DOI: 10.1016/j.recesp.2024.10.006.Peer-Reviewed Original ResearchStress perfusion defectsFractional flow reservePositron emission tomographyLeft anterior descending arteryHemodynamically significant stenosisAnterior descending arteryPerfusion defectsVascular occluderNecrotic myocardiumSignificant stenosisDescending arteryTTC stainingSignificantly higher areaMedian diameter stenosisExperimental animal modelsCoronary artery stenosisHyperemic stenosis resistanceOccluder implantationArtery stenosisDiameter stenosisFlow reserveAnimal modelsStenosisCoronary stenosisOcclusion severity
2024
Plasma Aβ42/Aβ40 is sensitive to early cerebral amyloid accumulation and predicts risk of cognitive decline across the Alzheimer's disease spectrum
Trelle A, Young C, Vossler H, Benitez J, Cody K, Mendiola J, Swarovski M, Le Guen Y, Feinstein I, Butler R, Channappa D, Romero A, Park J, Shahid‐Besanti M, Corso N, Chau K, Smith A, Skylar‐Scott I, Yutsis M, Fredericks C, Tian L, Younes K, Kerchner G, Deutsch G, Davidzon G, Sha S, Henderson V, Longo F, Greicius M, Wyss‐Coray T, Andreasson K, Poston K, Wagner A, Mormino E, Wilson E. Plasma Aβ42/Aβ40 is sensitive to early cerebral amyloid accumulation and predicts risk of cognitive decline across the Alzheimer's disease spectrum. Alzheimer's & Dementia 2024, 21: e14442. PMID: 39713875, PMCID: PMC11848181, DOI: 10.1002/alz.14442.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseCognitive declinePositron emission tomographyAmyloid-betaTau accumulationAmyloid positivityHippocampal-dependent memoryAlzheimer's disease spectrumAmyloidAmyloid accumulationTau burdenAb accumulationRisk of cognitive declineSensitive to memoryTau positron emission tomographyAlzheimer's Disease Research CenterPredicting cognitive declineAlzheimerTauScalable biomarkersAD continuumCerebral amyloid accumulationCross-sectional associationsCI individualsAccumulationPositron emission tomography an imaging biomarker in pulmonary fibrosis: from therapeutic mechanism to treatment monitoring
Cho S, Herzog E, Thorn S, Sinusas A. Positron emission tomography an imaging biomarker in pulmonary fibrosis: from therapeutic mechanism to treatment monitoring. EBioMedicine 2024, 111: 105519. PMID: 39700895, PMCID: PMC11718319, DOI: 10.1016/j.ebiom.2024.105519.Peer-Reviewed Original ResearchPositron emission tomographyPulmonary fibrosisTreatment monitoringImaging biomarkersEmission tomographyConsistent evidence that brain serotonin 2A receptor binding is positively associated with personality-based risk markers of depression
Høgsted E, Beliveau V, Ozenne B, Madsen M, Svarer C, Dam V, Johansen A, Fisher P, Knudsen G, Frokjaer V, Sankar A. Consistent evidence that brain serotonin 2A receptor binding is positively associated with personality-based risk markers of depression. The British Journal Of Psychiatry 2024, 226: 137-143. PMID: 39632615, DOI: 10.1192/bjp.2024.143.Peer-Reviewed Original ResearchFacets of neuroticismCortisol awakening responseHPA axis functionR bindingReduce neuroticismAxis functionPositron emission tomographyNEO Personality InventoryNEO-PI-RAssessment of neuroticismSerotonin 2A receptorMarkers of depressionTreatment of depressionPersonality InventoryMood symptomsAwakening responseNeuroticismPositive associationLatent variable modelsSelf-consciousnessDepressionReceptor bindingNovel interventionsPsilocybinFindings prompt considerationRelationships Between Retinal Amyloid Imaging and Amyloid PET in the A4 Trial
Rissman R, Ngolab J, Donohue M, Belsha A, Salazar J, Cohen P, Jaiswal S, Tan V, Aggarwal N, Alber J, Johnson K, Jicha G, van Dyck C, Lah J, Salloway S, Rafii M, Aisen P, Sperling R. Relationships Between Retinal Amyloid Imaging and Amyloid PET in the A4 Trial. Alzheimer's & Dementia 2024, 20: e090880. PMCID: PMC11716286, DOI: 10.1002/alz.090880.Peer-Reviewed Original ResearchA4 trialFeasibility of retinal imagingPositron emission tomographyAmyloid positron emission tomographyLongitudinal Evaluation of Amyloid RiskRetinal spotsCohort of individualsAnti-Amyloid TreatmentAsymptomatic Alzheimer's diseaseRetinal amyloid depositsAlzheimer's diseaseStandardized uptake value ratioAD-diagnosed patientsPilot studyRetinal imaging techniquesLongitudinal evaluationRisk detectionNon-invasive evaluationAmyloid depositsClinically normal individualsAnti-amyloidRetinal amyloid imagingParticipantsPET standardized uptake value ratioRetinal fundus imagesComparison of eligibility criteria and baseline characteristics between the patient populations of evoke and evoke+, Clarity AD, and TRAILBLAZER‐ALZ‐2
Feldman H, Scheltens P, Hansson O, Sano M, van der Flier W, Bardtrum L, Johannsen P, Jeppesen R, Leon T, Hansen C, Cummings J. Comparison of eligibility criteria and baseline characteristics between the patient populations of evoke and evoke+, Clarity AD, and TRAILBLAZER‐ALZ‐2. Alzheimer's & Dementia 2024, 20: e083684. PMCID: PMC11713343, DOI: 10.1002/alz.083684.Peer-Reviewed Original ResearchClinical Dementia RatingNon-white participantsPositron emission tomographyEarly-stage AD patientsAlzheimer's diseaseMini-Mental State ExaminationMild AD dementiaMild cognitive impairmentTau positron emission tomographyEpisodic memoryGlucagon-like peptide-1 receptor agonist semaglutidePlacebo-controlled trialInclusion criteriaTau pathologyCDR sumCognitive impairmentMini-MentalState ExaminationDementia RatingImpaired patientsAD patientsGlobal scoreAmyloid positivityTrial populationDisease-modifying therapiesExamining early cerebral amyloid beta and tau accumulation in association with cognition in a predominantly middle‐aged cohort
Gonzales M, O’Donnell A, Ghosh S, Thibault E, Tanner J, Satizabal C, Decarli C, Fakhri G, Johnson K, Beiser A, Seshadri S, Pase M. Examining early cerebral amyloid beta and tau accumulation in association with cognition in a predominantly middle‐aged cohort. Alzheimer's & Dementia 2024, 20: e087431. PMCID: PMC11716433, DOI: 10.1002/alz.087431.Peer-Reviewed Original ResearchStratified analysisPoorer visuospatial functionFramingham Heart StudyTau positron emission tomographyPositron emission tomographyMiddle-aged cohortApolipoprotein E4 statusCommunity-based cohortTau accumulationAssociated with cognitive declineVisuospatial functionLow cognitive reserveAssociated with cognitionAmyloid-betaHeart StudyOlder adultsE4 statusLinear regression modelsCerebral amyloid-betaPoor cognitionMeasures of ABCognitive AssessmentCollege degreeCognitive reserveMidlifeAn In Vivo Examination of the Relationship Between Metabotropic Glutamate 5 Receptor and Suicide Attempts in People With Borderline Personality Disorder
Davis M, Asch R, Weiss E, Wagner A, Fineberg S, Nabulsi N, Matuskey D, Carson R, Esterlis I. An In Vivo Examination of the Relationship Between Metabotropic Glutamate 5 Receptor and Suicide Attempts in People With Borderline Personality Disorder. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2024, 10: 324-332. PMID: 39613160, DOI: 10.1016/j.bpsc.2024.11.014.Peer-Reviewed Original ResearchBorderline personality disorderPathophysiology of borderline personality disorderSuicide attemptsPersonality disorderPositron emission tomographyAssociated with history of suicide attemptBorderline personality disorder symptomsBPD pathophysiologyPositron emission tomography outcomes measurementsHistory of suicide attemptsMetabotropic glutamate receptor type 5Metabotropic glutamate receptor 5Glutamate receptor 5Comprehensive clinical assessmentFrontolimbic circuitsMDD groupDepressive disorderEmotion regulationPsychiatric conditionsCognitive functionMGlu5Comparison controlsMDDSuicideAssociated with historyPresynaptic terminal integrity is associated with glucose metabolism in Parkinson’s disease
Wang W, Wang Y, Xu L, Liu X, Hu Y, Li J, Huang Q, Ren S, Huang Y, Guan Y, Li Y, Hua F, Ye Q, Xie F. Presynaptic terminal integrity is associated with glucose metabolism in Parkinson’s disease. European Journal Of Nuclear Medicine And Molecular Imaging 2024, 52: 1510-1519. PMID: 39572432, DOI: 10.1007/s00259-024-06993-3.Peer-Reviewed Original ResearchPositron emission tomographyDopamine transporterSynaptic densityGlucose metabolismDopamine transporter availabilityPD patientsPost-commissural caudateParkinson's diseaseReduced synaptic densityAssociated with glucose metabolismDopaminergic transporterMethodsA totalHealthy controlsSynaptic vesicle protein 2PatientsEmission tomographyCaudatePD groupMetabolic patternsTerminal integrityProtein 2DiseaseNC groupCaudate regionsMetabolismCT-Less Whole-Body Bone Segmentation of PET Images Using a Multimodal Deep Learning Network
Bao N, Zhang J, Li Z, Wei S, Zhang J, Greenwald S, Onofrey J, Lu Y, Xu L. CT-Less Whole-Body Bone Segmentation of PET Images Using a Multimodal Deep Learning Network. IEEE Journal Of Biomedical And Health Informatics 2024, 29: 1151-1164. PMID: 40030243, DOI: 10.1109/jbhi.2024.3501386.Peer-Reviewed Original ResearchPositron emission tomographyMultimodal fusion modulePositron emission tomography imagingMultimodal fusion networkAttenuation mapDice similarity coefficientFusion moduleFusion networkEncoder RepresentationsEncoder branchesCT imagesTraining dataComputed tomographyTumor analysisTracer activityModality imagesMultimodal deep learning networkPET imagingBone segmentsSqueeze-and-excitationBone cancerPositron emission tomography informationCT-based approachDeep learning networkImprove segmentation performanceAdvanced Imaging Modalities in Cardiotoxicity: The Roles of Cardiac CT, MRI, and PET in Cardio-oncology
Arbune A, Khattab M, Henry M, Baldassarre L. Advanced Imaging Modalities in Cardiotoxicity: The Roles of Cardiac CT, MRI, and PET in Cardio-oncology. Current Treatment Options In Cardiovascular Medicine 2024, 27: 5. DOI: 10.1007/s11936-024-01061-3.Peer-Reviewed Original ResearchImmune checkpoint inhibitorsBaseline risk stratificationCardiac computed tomographyCardiac magnetic resonanceAdvanced cardiac imaging modalitiesPositron emission tomographyCardiac imaging modalitiesCoronary artery calciumRisk stratificationCardio-oncologyImaging modalitiesCardiac massEvaluate immune checkpoint inhibitorsImmune checkpoint inhibitor myocarditisImmune checkpoint inhibitor therapyAdvanced cardiac imaging techniquesCardiac positron emission tomographyDiagnosis of cardiotoxicityNoninvasive diagnostic testCardiac imaging techniquesRisk stratification toolCardio-oncology patientsAdvanced imaging modalitiesCoronary flow reserveImaging techniquesPET motion correction using subspace-based real-time MR imaging in simultaneous PET/MR
Mounime I, Marin T, Han P, Ouyang J, Gori P, Angelini E, Fakhri G, Ma C. PET motion correction using subspace-based real-time MR imaging in simultaneous PET/MR. 2024, 00: 1-1. DOI: 10.1109/nss/mic/rtsd57108.2024.10657647.Peer-Reviewed Original ResearchOrdered-subset expectation maximizationMotion correctionGated reconstructionsMotion-corrected PET reconstructionsPET eventsCardiac motion phasesMotion correction methodCardiac motionMotion phaseReconstructed dynamic imagesPET reconstructionReal-time MR imagingSimultaneous PET/MRPatient motionSoft tissue contrastDynamic MR image reconstructionReference phaseMitigate artifactsLow-rank propertyMR image reconstructionPositron emission tomographyManifold learning frameworkSpatial resolutionBlurring artifactsImage reconstruction
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