2025
Computationally derived parent-child interaction patterns and oxytocin in children with and without OCD
Mora-Jensen A, Thoustrup C, Lebowitz E, Hagstrøm J, Pretzmann L, Korsbjerg N, Thorsen E, Uhre V, Christensen S, Uhre C, Ritter M, Plessen K, Pagsberg A, Clemmensen L, Lønfeldt N. Computationally derived parent-child interaction patterns and oxytocin in children with and without OCD. Journal Of Anxiety Disorders 2025, 111: 102996. PMID: 40117840, DOI: 10.1016/j.janxdis.2025.102996.Peer-Reviewed Original ResearchParent-child interaction behaviorsPediatric OCDMother-childParent-child interaction processMother-child interaction patternsParent-child interaction patternsParent-child behaviorsSalivary oxytocin levelsParent-child interactionsFather-child interactionsAssociated with oxytocinFather-child pairsFamily engagementEnzyme-linked immunosorbent assayFrustration taskInteraction patternsOCDInteraction behaviorOxytocin levelsConflictual interactionsBiological mechanismsPositive associationArchetypal analysisFathering behaviorMachine learning techniquesA systematic review of variables associated with snakebite risk in spatial and temporal analyses
Collinson S, Lamb T, Cardoso I, Diggle P, Lalloo D. A systematic review of variables associated with snakebite risk in spatial and temporal analyses. Transactions Of The Royal Society Of Tropical Medicine And Hygiene 2025, trae131. PMID: 39817354, DOI: 10.1093/trstmh/trae131.Peer-Reviewed Original ResearchSystematic reviewJoanna Briggs Institute toolHealth facility reportingRisk estimation accuracyWeb of ScienceNarrative synthesisFacility reportsStudy qualityAd hoc surveyResearch availabilityHigh-risk regionsIncidence dataSub-Saharan AfricaUrban residentsGlobal healthPositive associationSnakebite riskInstitutional toolsRisk variationStatistical associationNegative associationSub-SaharanCase incidenceAssociationRiskPositive associations between mean ambient temperature and involuntary admissions to psychiatric facilities
Joore N, van der Horst M, Noorthoorn E, Strous J, Vruwink F, Guloksuz S, Siegmund P, Luykx J. Positive associations between mean ambient temperature and involuntary admissions to psychiatric facilities. European Psychiatry 2025, 68: e2. PMID: 39791337, PMCID: PMC11795429, DOI: 10.1192/j.eurpsy.2024.1800.Peer-Reviewed Original ResearchConceptsInvoluntary psychiatric admissionsContext of climate changeInvoluntary admissionMean ambient temperatureThin plate regression splinesWeather stationsMeteorological variablesMeteorological dataPsychiatric admissionsClimate changeGeneralized additive modelModeling studiesMental health outcomesPositive associationAir Pollution and Cognitive Impairment Among the Chinese Elderly Population: An Analysis of the Chinese Longitudinal Healthy Longevity Survey (CLHLS)
Zhu Q, Lyu Y, Huang K, Zhou J, Wang W, Steenland K, Chang H, Ebelt S, Shi X, Liu Y. Air Pollution and Cognitive Impairment Among the Chinese Elderly Population: An Analysis of the Chinese Longitudinal Healthy Longevity Survey (CLHLS). GeoHealth 2025, 9: e2024gh001023. PMID: 39776607, PMCID: PMC11705411, DOI: 10.1029/2024gh001023.Peer-Reviewed Original ResearchChinese Longitudinal Health Longevity SurveyWarm-season O<sub>3</sub>Chinese elderly populationAssociated with cognitive impairmentLongevity SurveyCognitive impairmentLinear mixed-effects modelsChinese Longitudinal Healthy Longevity SurveyAir pollutionAssociation of air pollutionMixed-effects modelsAverage NO<sub>2</sub>Average PM<sub>2.5</sub>Elderly populationSingle-pollutant modelsMulti-pollutant modelsLogistic regression modelsCMMSE scoresControl Action PlanAir pollution preventionStudy participantsGaseous air pollutantsFollow-up visitRandom interceptPositive associationAssessing Links Between Alcohol Exposure and Firearm Violence: A Scoping Review Update
Matthay E, Gobaud A, Branas C, Keyes K, Roy B, Cerdá M. Assessing Links Between Alcohol Exposure and Firearm Violence: A Scoping Review Update. Alcohol Research 2025, 45: 01. PMID: 39830985, PMCID: PMC11737877, DOI: 10.35946/arcr.v45.1.01.Peer-Reviewed Original ResearchConceptsEffect measure modificationFirearm violenceViolence-related outcomesAlcohol control policiesAlcohol use disorderAlcohol useStudy designFirearm homicideFirearm accessMeasure modificationFirearm suicidesPrevention effortsQuasi-experimental study designSystematic reviewStructured data collection instrumentCross-sectional study designAlcohol exposureComprehensive search of published studiesMeta-Analyses ExtensionDensity of alcohol outletsPositive associationSearch of published studiesModifiable risk factorsFull-text screeningPreferred Reporting Items
2024
Exposure to per- and poly-fluoroalkyl substances and lung, head and neck, and thyroid cancer: A systematic review and meta-analysis
Sassano M, Seyyedsalehi M, Kappil E, Zhang S, Zheng T, Boffetta P. Exposure to per- and poly-fluoroalkyl substances and lung, head and neck, and thyroid cancer: A systematic review and meta-analysis. Environmental Research 2024, 266: 120606. PMID: 39672496, DOI: 10.1016/j.envres.2024.120606.Peer-Reviewed Original ResearchPooled relative riskRelative riskHead and neckEstimate pooled relative risksConfidence intervalsExposure to per-Evidence of publication biasNatural log-unit increaseThyroid cancerCase-control studyPolyfluoroalkyl substances exposuresAssociated with lungPublication biasSystematic reviewPositive associationMeasured serum levelsMeta-analysisSerum PFAS levelsTesticular cancerProspective studyAssociationSerum levelsPFAS exposureExposure assessmentLung cancerConsistent evidence that brain serotonin 2A receptor binding is positively associated with personality-based risk markers of depression
Høgsted E, Beliveau V, Ozenne B, Madsen M, Svarer C, Dam V, Johansen A, Fisher P, Knudsen G, Frokjaer V, Sankar A. Consistent evidence that brain serotonin 2A receptor binding is positively associated with personality-based risk markers of depression. The British Journal Of Psychiatry 2024, 226: 137-143. PMID: 39632615, DOI: 10.1192/bjp.2024.143.Peer-Reviewed Original ResearchFacets of neuroticismCortisol awakening responseHPA axis functionR bindingReduce neuroticismAxis functionPositron emission tomographyNEO Personality InventoryNEO-PI-RAssessment of neuroticismSerotonin 2A receptorMarkers of depressionTreatment of depressionPersonality InventoryMood symptomsAwakening responseNeuroticismPositive associationLatent variable modelsSelf-consciousnessDepressionReceptor bindingNovel interventionsPsilocybinFindings prompt considerationThe unusual suspects: A systematic search for the molecular and cellular correlates of human aggression
Paiva T, Buades-Rotger M, Baskin-Sommers A, Brazil I. The unusual suspects: A systematic search for the molecular and cellular correlates of human aggression. Aggression And Violent Behavior 2024, 79: 102002. DOI: 10.1016/j.avb.2024.102002.Peer-Reviewed Original ResearchClinician Staffing and Quality of Care in US Health Centers
Sun Q, Forman H, Stern L, Oldfield B. Clinician Staffing and Quality of Care in US Health Centers. JAMA Network Open 2024, 7: e2440140. PMID: 39436649, PMCID: PMC11581487, DOI: 10.1001/jamanetworkopen.2024.40140.Peer-Reviewed Original ResearchConceptsAdvanced practice registered nursesUniform Data SystemQuality of careUS health centersHealth centersCancer screeningCross-sectional studyStaffing modelsBody mass indexAssociated with higher performanceHIV testingAssociated with quality of carePrimary care safety netHealth Resources and Services Administration's Uniform Data SystemQuality-of-care metricsPreventive health assessmentsPractice registered nursesBreast cancer screeningClinical quality metricsCommunity-specific needsCervical cancer screeningPositive associationNonlinear positive associationAssociated with qualityFull-time equivalentShort-term effects of wildfire-specific fine particulate matter and its carbonaceous components on perinatal outcomes: A multicentre cohort study in New South Wales, Australia
Nyadanu S, Foo D, Pereira G, Mickley L, Feng X, Bell M. Short-term effects of wildfire-specific fine particulate matter and its carbonaceous components on perinatal outcomes: A multicentre cohort study in New South Wales, Australia. Environment International 2024, 191: 109007. PMID: 39278048, DOI: 10.1016/j.envint.2024.109007.Peer-Reviewed Original ResearchConceptsAdjusted hazard ratiosLow 5-min Apgar scoreCarbonaceous componentsPerinatal outcomesOrganic carbonNew South WalesNonvertex presentationCaesarean sectionPositive associationApgar scorePreterm birthBlack carbon componentsShort-term effectsLow socioeconomic statusSouth WalesAdverse perinatal outcomesMulticentre cohort studyWildfire seasonBenefit public healthCox regression modelsIntensive care unitSingleton birthsBlack carbonSocioeconomic statusGestational weeksAssociations of Plasma Tau with Amyloid and Tau PET: Results from the Community-Based Framingham Heart Study
Ramos-Cejudo J, Scott M, Tanner J, Pase M, McGrath E, Ghosh S, Osorio R, Thibault E, Fakhri G, Johnson K, Beiser A, Seshadri S. Associations of Plasma Tau with Amyloid and Tau PET: Results from the Community-Based Framingham Heart Study. Journal Of Alzheimer's Disease 2024, 100: 487-494. PMID: 38875034, DOI: 10.3233/jad-231320.Peer-Reviewed Original ResearchConceptsCommunity-based Framingham Heart StudyFramingham Heart StudyHeart StudyCross-sectional associationsPlasma total tauMiddle-aged participantsRisk of ADCognitively healthy individualsCommunity-basedCompound B (PiB)-PETMiddle-agedPositive associationPlasma tauParticipantsTau-PETAssociationTotal tau levelsAD brain pathologyTotal-tauHealthy individualsAPOEe4Tau levelsBurdenRhinal cortexPrecuneus regionsAn In Vivo High-Resolution Human Brain Atlas of Synaptic Density
Johansen A, Beliveau V, Colliander E, Raval N, Dam V, Gillings N, Aznar S, Svarer C, Plavén-Sigray P, Knudsen G. An In Vivo High-Resolution Human Brain Atlas of Synaptic Density. Journal Of Neuroscience 2024, 44: e1750232024. PMID: 38997157, PMCID: PMC11326867, DOI: 10.1523/jneurosci.1750-23.2024.Peer-Reviewed Original ResearchPathogenesis of brain disordersBrain disordersHuman brainFunctional topographySynaptic densityBrain physiologySynapse densityHigher-order cortical areasSynaptic vesicle glycoprotein 2AHuman brain physiologyHealthy human brainSV2A densityPET neuroimagingComparative neuroscienceNeuroscience researchCortical areasBrainAutoradiography dataDisordersNeuroscienceBrain atlasesHealthy humansSV2APositive associationMRNA patternsAssociations of Serum Per- and Polyfluoroalkyl Substances with Hyperuricemia in Adults: A Nationwide Cross-Sectional Study
Zheng X, Pan Y, Qu Y, Ji S, Wang J, Li Z, Zhao F, Wu B, Xie L, Li Y, Song H, Hu X, Qiu Y, Zhang Z, Zhang W, Yang Y, Cai J, Zhu Y, Zhu Y, Cao Z, Ji J, Lv Y, Dai J, Shi X. Associations of Serum Per- and Polyfluoroalkyl Substances with Hyperuricemia in Adults: A Nationwide Cross-Sectional Study. Environmental Science And Technology 2024, 58: 12875-12887. PMID: 38980177, DOI: 10.1021/acs.est.3c11095.Peer-Reviewed Original ResearchNationwide cross-sectional studyPublic health planningCross-sectional studyOdds of hyperuricemiaChinese adultsHealth plansJoint effectsElevated oddsGeneral populationNationwide studyNonmonotonic dose responsePositive associationRisk factorsAdultsHealthEffects of polyfluoroalkyl substancesHealth hazardsParticipantsSerum polyfluoroalkyl substancesJoint effects of PFAS mixtureMeasured serum concentrationsFish consumptionSerum concentrations of uric acidAssociationHyperuricemiaAdolescent Sleep as a Transdiagnostic Factor: Associations Between Actigraphy-Derived Night-to-Night Sleep Metrics and Adolescent Psychopathology
Phillips E, Goldberg E, Brock R, Hamburger E, Nelson J, Mason W, Espy K, Nelson T. Adolescent Sleep as a Transdiagnostic Factor: Associations Between Actigraphy-Derived Night-to-Night Sleep Metrics and Adolescent Psychopathology. JAACAP Open 2024 DOI: 10.1016/j.jaacop.2024.06.001.Peer-Reviewed Original ResearchMultilevel structural equation modelingBifactor S-1 modelIntraindividual variabilityModels of psychopathologySleep metricsSleep durationTransdiagnostic factorAdolescent psychopathologyEmotion dysregulationPsychopathologyStructural equation modelingGeneral factorPsychiatric problemsLatent meansAdolescent sleepNight sleep durationSocioeconomic riskResults ResultsEquation modelingAdolescentsSociodemographic variablesSleepPositive associationDysregulationBifactorPositive Associations of Perfluoroalkyl and Polyfluoroalkyl Substances With Hypertension May Be Attenuated by Endogenous Sex Hormones: A Nationally Representative Cross-Sectional Study
Wu B, Sheng N, Li Z, Wang J, Ji S, Zhao F, Pan Y, Qu Y, Wei Y, Xie L, Li Y, Hu X, Wu C, Zhang Z, Qiu Y, Zheng X, Zhang W, Hu X, Song H, Cai J, Cao Z, Ji J, Lv Y, Dai J, Shi X. Positive Associations of Perfluoroalkyl and Polyfluoroalkyl Substances With Hypertension May Be Attenuated by Endogenous Sex Hormones: A Nationally Representative Cross-Sectional Study. Hypertension 2024, 81: 1799-1810. PMID: 38853753, DOI: 10.1161/hypertensionaha.123.22127.Peer-Reviewed Original ResearchDiastolic blood pressureSystolic blood pressureEndogenous sex hormonesBlood pressureNationally representative cross-sectional studyPositive associationPerfluoroheptane sulfonic acidWeighted multiple logistic regressionSex hormonesLevels of endogenous sex hormonesPrevalence of hypertensionCross-sectional studyMultiple logistic regressionAssociations of polyfluoroalkyl substancesPFAS mixtureJoint effects of PFAS mixtureAssociated with hypertensionProgression of hypertensionChinese adultsSynergy indexOdds ratioG-computationQuantile-based g-computationRisk ratioLogistic regressionIntratumoral T-cell infiltration and response to nivolumab plus ipilimumab in patients with metastatic clear cell renal cell carcinoma from the CheckMate-214 trial.
Matar S, Jegede O, Denize T, Ghandour F, Nabil Laimon Y, El Ahmar N, Bagheri Sheshdeh A, Savla V, Mohanna R, Catalano P, Braun D, Sun M, Gupta S, Vemula S, Freeman G, Motzer R, Atkins M, McDermott D, CHOUEIRI T, Signoretti S. Intratumoral T-cell infiltration and response to nivolumab plus ipilimumab in patients with metastatic clear cell renal cell carcinoma from the CheckMate-214 trial. Journal Of Clinical Oncology 2024, 42: 4536-4536. DOI: 10.1200/jco.2024.42.16_suppl.4536.Peer-Reviewed Original ResearchProgression-free survivalAssociated with progression-free survivalMultiplex immunofluorescenceClinical trialsClinical outcomesMetastatic clear cell renal cell carcinomaIntratumoral T cell infiltrationTreated with nivolumab monotherapyMetastatic clear cell RCCClear cell renal cell carcinomaResponse to nivolumabT cell infiltrationCell renal cell carcinomaPoor-risk patientsRenal cell carcinomaClear cell RCCFormalin fixed paraffinContinuous variablesNivolumab monotherapyCox proportional hazardsAntigen-experiencedCell RCCCell carcinomaLogistic regression modelsPositive associationPrenatal per- and polyfluoroalkyl substances (PFAS) and maternal oxidative stress: Evidence from the LIFECODES study
Siwakoti R, Park S, Ferguson K, Hao W, Cantonwine D, Mukherjee B, McElrath T, Meeker J. Prenatal per- and polyfluoroalkyl substances (PFAS) and maternal oxidative stress: Evidence from the LIFECODES study. Chemosphere 2024, 360: 142363. PMID: 38768789, PMCID: PMC11487489, DOI: 10.1016/j.chemosphere.2024.142363.Peer-Reviewed Original ResearchFetal sexMaternal raceEffect modificationOS biomarkersOxidative stressPre-pregnancy BMIAdverse pregnancy outcomesNo significant effect modificationMaternal oxidative stressPlasma PFASsSignificant effect modificationInterquartile range increasePositive associationExposure to OSPre-pregnancyPregnancy outcomesMaternal ageMultivariate linear regressionSex-specific effectsLinear mixed-effects modelsPotential confoundersInsurance statusRange increaseEndocrine functionEducation levelCross-Sectional Associations between Prenatal Per- and Poly-Fluoroalkyl Substances and Bioactive Lipids in Three Environmental Influences on Child Health Outcomes (ECHO) Cohorts
Suthar H, Manea T, Pak D, Woodbury M, Eick S, Cathey A, Watkins D, Strakovsky R, Ryva B, Pennathur S, Zeng L, Weller D, Park J, Smith S, DeMicco E, Padula A, Fry R, Mukherjee B, Aguiar A, Geiger S, Ng S, Huerta-Montanez G, Vélez-Vega C, Rosario Z, Cordero J, Zimmerman E, Woodruff T, Morello-Frosch R, Schantz S, Meeker J, Alshawabkeh A, Aung M, Outcomes O. Cross-Sectional Associations between Prenatal Per- and Poly-Fluoroalkyl Substances and Bioactive Lipids in Three Environmental Influences on Child Health Outcomes (ECHO) Cohorts. Environmental Science And Technology 2024, 58: 8264-8277. PMID: 38691655, PMCID: PMC11097396, DOI: 10.1021/acs.est.4c00094.Peer-Reviewed Original ResearchConceptsPFAS mixtureLinear mixed modelsBioactive lipidsChild health outcomesCross-sectional associationsPrenatal PFAS exposureBioactive lipid levelsPoly-fluoroalkyl substancesQuantile g-computationMixed modelsGestational outcomesHealth outcomesPregnancy outcomesPregnant womenCombined cohortG-computationCohort analysisProgram cohortQuartile increaseLipid levelsCohortPositive associationMeta-analysisEnvironmental influencesPFAS exposureRelationship between neuroimaging and cognition in frontotemporal dementia: An FDG‐PET and structural MRI study
Cayir S, Volpi T, Toyonaga T, Gallezot J, Yang Y, Sadabad F, Mulnix T, Mecca A, Fesharaki‐Zadeh A, Matuskey D. Relationship between neuroimaging and cognition in frontotemporal dementia: An FDG‐PET and structural MRI study. Journal Of Neuroimaging 2024, 34: 627-634. PMID: 38676301, PMCID: PMC11511789, DOI: 10.1111/jon.13206.Peer-Reviewed Original ResearchMoCA scoresFDG-PETAssociation of cognitionStandardized uptake value ratioMontreal Cognitive AssessmentSignificant positive associationFrontotemporal dementiaPrimary outcome measurePosterior cingulate cortexDecline of cognitive functionYears of ageGM volumeFrontal cortexOutcome measuresCognitive dysfunctionGray matterCognitive AssessmentMoCAAssociated with cognitive dysfunctionFluorodeoxyglucose (FDG)-PETPositive associationMagnetic resonance imagingPartial volume correctionCognitive functionDementiaNetwork analysis of smoking-related sleep characteristics in Chinese adults
Xie Y, Sun P, Huang H, Wu J, Ba Y, Zhou G, Yu F, Zhang D, Zhang Y, Qie R, Hu Z, Zou K, Zhang Y. Network analysis of smoking-related sleep characteristics in Chinese adults. Annals Of Medicine 2024, 56: 2332424. PMID: 38527416, PMCID: PMC10964831, DOI: 10.1080/07853890.2024.2332424.Peer-Reviewed Original ResearchConceptsLate bedtimeMultiple sleep characteristicsChinese adultsCancer-related risk factorsPotential core domainsSleep characteristicsSleep health promotionLogistic regression modelsShort sleep durationHealth promotionTobacco preventionCurrent smokingSmoking cessationSmoking intensitySmoking behaviorHeavy smokingSleep durationNap timeSmokingPositive associationRisk factorsRegression modelsYoung adultsAdultsAssociation
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