2025
Network structure of psychotic symptoms and childhood trauma in first-episode versus treatment-resistant schizophrenia
Liu Z, Wang X, Deng H, Huang J, Wang J, Chen W, Yang K, Li W, Chen S, Xie T, Liu R, Tian L, Yang F, Tian B, Li Y, Li C, Tan Y. Network structure of psychotic symptoms and childhood trauma in first-episode versus treatment-resistant schizophrenia. Journal Of Psychiatric Research 2025, 185: 31-39. PMID: 40147152, DOI: 10.1016/j.jpsychires.2025.03.037.Peer-Reviewed Original ResearchTreatment-resistant schizophrenia patientsTreatment-resistant schizophreniaFirst-episode schizophreniaPositive and Negative Syndrome ScaleChildhood traumaPsychotic symptomsInfluences psychotic symptomsNegative Syndrome ScaleChildhood Trauma QuestionnaireChildhood trauma experiencesSyndrome ScaleFirst-episodeTrauma QuestionnaireEmotional neglectTraumatic stressTrauma experiencesSchizophreniaSymptom patternsSexual abuseInfluence symptomsSymptom evolutionPartial correlationSymptomsClinical symptomsChildhoodConnectome-based predictive modeling of early and chronic psychosis symptoms
Foster M, Ye J, Powers A, Dvornek N, Scheinost D. Connectome-based predictive modeling of early and chronic psychosis symptoms. Neuropsychopharmacology 2025, 1-9. PMID: 40016363, DOI: 10.1038/s41386-025-02064-9.Peer-Reviewed Original ResearchConnectome-based predictive modelingPositive and Negative Syndrome ScalePsychosis symptomsSymptom networksSymptom severityBrain networksNeural correlates of CPResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingNegative Syndrome ScaleIdentified group differencesPredicted effect sizeCorrelates of CPGeneral psychopathologyNegative symptomsPositive symptomsSyndrome ScaleFrontoparietal networkNeural correlatesVirtual lesion analysisGroup differencesConnectivity changesEffect sizeLesion analysisLongitudinal studyDeep multimodal representations and classification of first-episode psychosis via live face processing
Singh R, Zhang Y, Bhaskar D, Srihari V, Tek C, Zhang X, Noah J, Krishnaswamy S, Hirsch J. Deep multimodal representations and classification of first-episode psychosis via live face processing. Frontiers In Psychiatry 2025, 16: 1518762. PMID: 40134976, PMCID: PMC11934110, DOI: 10.3389/fpsyt.2025.1518762.Peer-Reviewed Original ResearchFirst-episode psychosisPositive and Negative Syndrome ScaleFunctional near-infrared spectroscopyGlobal Assessment of FunctioningEarly psychosisNeural correlates of social cognitionFirst-episode psychosis individualsNegative Syndrome ScaleBehavior recordsAssessment of FunctioningSevere psychiatric disordersSyndrome ScaleFace processingPsychosis symptomsNeural underpinningsSocial cognitionNeural correlatesPsychiatric disordersBrain activitySocial difficultiesNeurophysiological dysfunctionPsychosisNeural characteristicsMultimodal representationsAcquisition paradigmCELECOXIB ADDED TO RISPERIDONE FOR DEPRESSIVE SYMPTOMS IN FIRST-EPISODE AND DRUG NAÏ VE SCHIZOPHRENIA: PHARMACOGENETIC IMPACT OF BDNF GENE POLYMORPHISMS
Wang *, Chen X, Tian Y, Yu Z, Chen D, Xiu M, Kosten T, Zhang X. CELECOXIB ADDED TO RISPERIDONE FOR DEPRESSIVE SYMPTOMS IN FIRST-EPISODE AND DRUG NAÏ VE SCHIZOPHRENIA: PHARMACOGENETIC IMPACT OF BDNF GENE POLYMORPHISMS. The International Journal Of Neuropsychopharmacology 2025, 28: i158-i159. PMCID: PMC11815116, DOI: 10.1093/ijnp/pyae059.274.Peer-Reviewed Original ResearchHamilton Depression Rating ScaleBrain-derived neurotrophic factorPositive and Negative Syndrome ScaleBrain-derived neurotrophic factor serum levelsBrain-derived neurotrophic factor levelsSchizophrenia patientsTreatment of depressionDepressive symptomsPositive symptomsFirst-episodeSCZ patientsHamilton Depression Rating Scale total scoreBrain-derived neurotrophic factor systemComorbid major depressive disorderTreatment response to antidepressantsTotal scoreEarly stages of schizophreniaBrain-derived neurotrophic factor polymorphismsBrain-derived neurotrophic factor genotypePathogenesis of depressive symptomsBrain-derived neurotrophic factor gene polymorphismImprove treatment of depressionBrain-derived neurotrophic factor signalingHealthy controlsAmerican Journal of Psychiatry
2024
Sex-specific associations between 10-year cardiovascular risk, clinical symptoms and cognitive impairments in schizophrenia
Jin X, Lu C, Liu N, Li Y, Dong Y, Wang X, Li S, Li J. Sex-specific associations between 10-year cardiovascular risk, clinical symptoms and cognitive impairments in schizophrenia. Journal Of Neural Transmission 2024, 132: 313-322. PMID: 39387913, DOI: 10.1007/s00702-024-02842-7.Peer-Reviewed Original ResearchPositive and Negative Syndrome ScaleRepeatable Battery for the Assessment of Neuropsychological StatusPsychiatric symptomsNegative symptomsCognitive functionSex differencesAssessment of Neuropsychological StatusPANSS total scoreNegative Syndrome ScaleFramingham risk scoreSignificant sex differencesSyndrome ScalePsychopathology scoresImmediate memoryNeuropsychological statusCardiovascular riskSCZTotal scoreCognitive impairmentCardiovascular diseaseSex-specific associationsFasting venous blood samplesHigher Framingham risk scoreGlycolipid metabolism indexesSymptomsEfficacy and tolerability of antipsychotic polypharmacy for schizophrenia spectrum disorders. A systematic review and meta-analysis of individual patient data
Lochmann van Bennekom M, IntHout J, Gijsman H, Akdede B, Yağcıoğlu A, Barnes T, Galling B, Gueorguieva R, Kasper S, Kreinin A, Nielsen J, Nielsen R, Remington G, Repo-Tiihonen E, Schmidt-Kraepelin C, Shafti S, Xiao L, Correll C, Verkes R. Efficacy and tolerability of antipsychotic polypharmacy for schizophrenia spectrum disorders. A systematic review and meta-analysis of individual patient data. Schizophrenia Research 2024, 272: 1-11. PMID: 39142215, DOI: 10.1016/j.schres.2024.07.035.Peer-Reviewed Original ResearchClinical Global Impression ScaleSchizophrenia spectrum disordersPositive and Negative Syndrome ScaleBaseline PANSS total scoreAntipsychotic polypharmacyPANSS total scoreTotal scorePositive symptomsPsychotic patientsPositive and Negative Syndrome Scale positive symptom subscaleNegative symptom subscale scoreSubgroup of psychotic patientsBaseline positive symptomsExtrapyramidal side effectsNegative Syndrome ScalePositive symptom subscaleSecond-generation antipsychoticsGlobal Impression ScaleModerators of efficacySeverely psychotic patientsStudy-level moderatorsStudy discontinuationSymptom subscale scoresAntipsychotic monotherapySyndrome ScaleDisentangling negative and positive symptoms in schizophrenia and autism spectrum disorder
Corbera S, Wexler B, Bell M, Pittman B, Pelphrey K, Pearlson G, Assaf M. Disentangling negative and positive symptoms in schizophrenia and autism spectrum disorder. Schizophrenia Research 2024, 271: 1-8. PMID: 39002525, PMCID: PMC11384336, DOI: 10.1016/j.schres.2024.07.002.Peer-Reviewed Original ResearchAutism spectrum disorderPositive and Negative Syndrome ScaleAutism Diagnostic Observation Schedule-GenericExperiential negative symptomsPositive symptomsNegative symptomsExploratory factor analysisSpectrum disorderNegative Syndrome ScaleTarget negative symptomsSyndrome ScaleDiscriminant function analysisSZ relativesAssociated with quality of lifeSchizophreniaSocial skillsSocial functioningDiagnostic classificationAutismFactor analysisAssociated with qualityPredictor of diagnosisSymptomsDisordersQuality of lifeRelationship between plasma TNF-α levels and agitation symptoms in first episode patients with schizophrenia
Wang X, Chen W, Gou M, Li W, Li N, Tong J, Zhou Y, Xie T, Yu T, Feng W, Li Y, Chen S, Tian B, Tan S, Wang Z, Pan S, Luo X, Zhang P, Huang J, Tian L, Li C, Tan Y. Relationship between plasma TNF-α levels and agitation symptoms in first episode patients with schizophrenia. BMC Psychiatry 2024, 24: 480. PMID: 38956509, PMCID: PMC11218378, DOI: 10.1186/s12888-024-05796-y.Peer-Reviewed Original ResearchConceptsPositive and Negative Syndrome ScalePlasma TNF-a levelsAgitation symptomsPANSS-ECEpisode patientsTNF-a levelsPositive and Negative Syndrome Scale total scorePANSS-EC scoreNegative Syndrome ScaleSymptoms of schizophreniaPathophysiology of schizophreniaEnzyme-linked immunosorbent assayTNF-aR1 levelSyndrome ScalePlasma levels of tumor necrosis factor-alphaLevels of tumor necrosis factor-alphaSchizophreniaTotal scoreTumor necrosis factor-alphaNecrosis factor-alphaPlasma TNF-aHealthy controlsFEPImmune abnormalitiesShort-term antipsychotic treatment reduces functional connectivity of the striatum in first-episode drug-naïve early-onset schizophrenia
Hu W, Ran X, Wu Z, Zhu H, Kou Y, Zhang S, Yang G, Li W, Yang Y, Lv L, Zhang Y. Short-term antipsychotic treatment reduces functional connectivity of the striatum in first-episode drug-naïve early-onset schizophrenia. Schizophrenia Research 2024, 270: 281-288. PMID: 38944974, DOI: 10.1016/j.schres.2024.06.016.Peer-Reviewed Original ResearchPositive and Negative Syndrome ScaleEarly-onset schizophreniaEarly-onset schizophrenia patientsDorsal caudal putamenStriatal FCFunctional connectivityAntipsychotic treatmentStriatal subregionsFrontal gyrusPositive and Negative Syndrome Scale negative scoresResting-state functional magnetic resonance imaging scansShort-term antipsychotic treatmentFunctional magnetic resonance imaging scansWeeks of treatmentEarly stages of schizophreniaHealthy controlsLeft supplementary motor areaNegative Syndrome ScaleInferior frontal gyrusStages of schizophreniaMiddle frontal gyrusInferior parietal lobuleMeasure psychiatric symptomsAbnormal functional connectivityRight postcentral gyrusSex differences in correlates of suicide attempts in Chinese Han first‐episode and drug‐naïve major depressive disorder with comorbid subclinical hypothyroidism: A cross‐sectional study
Tian X, Liu X, Bai F, Li M, Qiu Y, Jiao Q, Li J, Zhang X. Sex differences in correlates of suicide attempts in Chinese Han first‐episode and drug‐naïve major depressive disorder with comorbid subclinical hypothyroidism: A cross‐sectional study. Brain And Behavior 2024, 14: e3578. PMID: 38844426, PMCID: PMC11156525, DOI: 10.1002/brb3.3578.Peer-Reviewed Original ResearchConceptsPositive and Negative Syndrome ScaleHamilton Depression ScaleHamilton Anxiety ScaleFEDN MDD patientsMDD patientsSuicide attemptsSex differencesDepressive disorderFirst-episodeFactors associated with suicide attemptsRisk of suicide attemptNegative Syndrome ScaleMajor depressive disorderHamilton Depression Scale scoresHamilton Anxiety Scale scoresThyroid peroxidase antibodySubclinical hypothyroidismIncreased suicide attemptsInvestigate sex differencesSignificant sex differencesSyndrome ScalePositive subscaleIncreased riskAnxiety ScaleFEDNBelief Updating, Childhood Maltreatment, and Paranoia in Schizophrenia-Spectrum Disorders
Sloan A, Kittleson A, Torregrossa L, Feola B, Rossi-Goldthorpe R, Corlett P, Sheffield J. Belief Updating, Childhood Maltreatment, and Paranoia in Schizophrenia-Spectrum Disorders. Schizophrenia Bulletin 2024, sbae057. PMID: 38701234, DOI: 10.1093/schbul/sbae057.Peer-Reviewed Original ResearchSchizophrenia spectrum disordersExposure to childhood maltreatmentPositive and Negative Syndrome ScaleChildhood Trauma QuestionnaireChildhood maltreatmentHierarchical Gaussian FilterBelief updatingProbabilistic reversal learningNegative Syndrome ScaleSyndrome ScaleNonpsychiatric controlsReversal learningSchizophrenia spectrumCumulative maltreatmentTrauma QuestionnaireDeprivation exposureGreen et al.ParanoiaConferring riskMaltreatmentPrior expectationsDisordersIndirect effectsChildhoodBeliefsThe influence of gender-specific factors influencing severe anxiety in psychotic major depression: role of thyroid hormones and depression severity
Luo G, Jing Y, Yang J, Wang S, Xuekelaiti Z, Yao C, Gao Y, Chen H, Sun D, Li J, Zhang X. The influence of gender-specific factors influencing severe anxiety in psychotic major depression: role of thyroid hormones and depression severity. Journal Of Neural Transmission 2024, 131: 833-845. PMID: 38693463, DOI: 10.1007/s00702-024-02781-3.Peer-Reviewed Original ResearchHamilton Depression Rating ScalePositive and Negative Syndrome ScaleHamilton Depression Rating Scale scoresClinical Global Impressions-SeverityHamilton Anxiety Rating ScaleDepression severitySevere anxietyMDD patientsMajor depressionPMD patientsNon-psychotic MDD patientsRating ScaleThyroid-stimulating hormoneNegative Syndrome ScalePsychotic major depressionDepression Rating ScaleThyroid-stimulating hormone levelsAnxiety Rating ScaleIncreased depression severityAssociated with anxietyNo significant gender differencesSyndrome ScalePrevalence of severe anxietyPsychotic symptomsDepressive disorderRight superior frontal gyrus: A potential neuroimaging biomarker for predicting short-term efficacy in schizophrenia
Yang Y, Jin X, Xue Y, Li X, Chen Y, Kang N, Yan W, Li P, Guo X, Luo B, Zhang Y, Liu Q, Shi H, Zhang L, Su X, Liu B, Lu L, Lv L, Li W. Right superior frontal gyrus: A potential neuroimaging biomarker for predicting short-term efficacy in schizophrenia. NeuroImage Clinical 2024, 42: 103603. PMID: 38588618, PMCID: PMC11015154, DOI: 10.1016/j.nicl.2024.103603.Peer-Reviewed Original ResearchSuperior frontal gyrusPositive and Negative Syndrome ScaleMATRICS Consensus Cognitive BatteryRight superior frontal gyrusAntipsychotic drug treatmentStructural magnetic resonance imagingInferior temporal gyrusSZ patientsFunctional connectivityWM densityFrontal gyrusEffect of antipsychotic drug treatmentTarget of antipsychotic drugsSecond-generation antipsychotic treatmentRight medial superior frontal gyrusMedial superior frontal gyrusRight inferior temporal gyrusConsensus Cognitive BatteryNegative Syndrome ScaleResting-state functional MRIRight anterior cingulateMeasure psychiatric symptomsRegional gray matterAssociated with treatment outcomeRight cingulate gyrusEfficacy, safety, and tolerability of xanomeline for schizophrenia spectrum disorders: a systematic review
Leber A, Ramachandra R, Ceban F, Kwan A, Rhee T, Wu J, Cao B, Jawad M, Teopiz K, Ho R, Le G, Ramachandra D, McIntyre R. Efficacy, safety, and tolerability of xanomeline for schizophrenia spectrum disorders: a systematic review. Expert Opinion On Pharmacotherapy 2024, 25: 467-476. PMID: 38515004, DOI: 10.1080/14656566.2024.2334424.Peer-Reviewed Original ResearchPositive and Negative Syndrome ScalePANSS total score changeTotal score changeBaseline to week 5Randomized controlled trialsNegative Syndrome ScaleSchizophrenia spectrum disordersPlacebo groupScore changesSyndrome ScaleTreatment of adultsSpectrum disorderSchizophreniaXanomelineWeek 5Dry mouthClinical Trials RegistryTreatment avenuesPlaceboSide effectsPreclinical trialsTrials RegistryControlled trialsPRISMA guidelinesSystematic reviewCorrelation of allostatic load and perceived stress with clinical features in first-episode schizophrenia
Zhou Y, Wang L, Yang K, Huang J, Li Y, Li W, Zhang P, Fan F, Yin Y, Yu T, Chen S, Luo X, Tan S, Wang Z, Feng W, Tian B, Tian L, Li C, Tan Y. Correlation of allostatic load and perceived stress with clinical features in first-episode schizophrenia. Journal Of Psychiatric Research 2024, 172: 156-163. PMID: 38382239, DOI: 10.1016/j.jpsychires.2024.02.025.Peer-Reviewed Original ResearchFirst-episode schizophreniaCalgary Depression Scale for SchizophreniaPositive and Negative Syndrome ScalePerceived stressPositive symptomsAllostatic loadPSS scoresSeverity of positive symptomsClinical features of schizophreniaNegative Syndrome ScaleFeatures of schizophreniaChronic physiological stressAssociated with depressive symptomsEtiology of schizophreniaAssess subjective stressOccurrence of schizophreniaHealthy controlsPerceived Stress Scale-14Clinical featuresCDSS scoresSyndrome ScaleDepressive symptomsSchizophreniaSubjective stressStressor typeDimensions and predictors of clinical and personal recovery in first‐episode psychoses: Results from a cross‐sectional study
Ferrara M, Zaffarami G, Simonelli G, Domenicano I, Vecchioni L, Toffanin T, Folesani F, Zotos S, Scrignoli C, Bertelli R, Carozza P, Grassi L. Dimensions and predictors of clinical and personal recovery in first‐episode psychoses: Results from a cross‐sectional study. Early Intervention In Psychiatry 2024, 18: 455-470. PMID: 38318707, DOI: 10.1111/eip.13513.Peer-Reviewed Original ResearchPersonal recoveryFirst-episode psychosisInvestigate predictors of recoveryRecovery Assessment ScaleDimensions of recoveryNation Outcome ScalesAdjusted logistic regressionCross-sectional studyPositive and Negative Syndrome ScalePredictors of recoveryLong-acting antipsychoticsPromotion interventionsUsual careNegative Syndrome ScalePsychiatric careAssessment ScaleSeverity of symptomatologyPsychiatric hospitalFEP servicesOral antipsychoticsBivariate analysisRecovery dimensionsLogistic regressionCareMale sex
2023
Prevalence, risk factors and clinical correlates of glucose disturbances in a large sample of Han Chinese patients with first-episode drug-naïve major depressive disorder
Chen S, Wu Y, Li S, Li J, Lang X, Zhang X. Prevalence, risk factors and clinical correlates of glucose disturbances in a large sample of Han Chinese patients with first-episode drug-naïve major depressive disorder. European Archives Of Psychiatry And Clinical Neuroscience 2023, 274: 549-557. PMID: 36884047, DOI: 10.1007/s00406-023-01581-2.Peer-Reviewed Original ResearchConceptsFirst-episode drug-naiveFirst-episode drug-naive MDD patientsMajor depressive disorderMajor depressive disorder patientsHamilton Anxiety Rating ScalePositive and Negative Syndrome ScaleMDD patientsPsychotic symptomsDepressive disorderSuicide attemptsHAMD scoresComorbidity of major depressive disorderHamilton Anxiety Rating Scale scoresSample of Han Chinese patientsNegative Syndrome ScalePositive symptom subscaleAnxiety Rating ScaleAssociated with HAMD scoreSevere depressive symptomsBody mass indexHigher suicide attemptsGlucose disturbancesFEDN patientsSyndrome ScaleAcute early phase
2022
Metabolic parameters and thyroid hormones in relation to suicide attempts in patients with first-episode and drug-naive major depressive disorder with comorbid glucose disturbances: a large cross-sectional study
Chen S, Li X, Lang X, Li J, Zhang X. Metabolic parameters and thyroid hormones in relation to suicide attempts in patients with first-episode and drug-naive major depressive disorder with comorbid glucose disturbances: a large cross-sectional study. European Archives Of Psychiatry And Clinical Neuroscience 2022, 273: 199-207. PMID: 36127506, DOI: 10.1007/s00406-022-01490-w.Peer-Reviewed Original ResearchConceptsPositive and Negative Syndrome ScaleFirst-episode drug-naiveHamilton Depression ScaleHamilton Anxiety ScaleMDD patientsNon-suicide attemptersHamilton Depression Scale scoresSuicide attemptsDepressive disorderPANSS positive symptomsFirst-episode drug-naive MDD patientsThyroid peroxidase antibodyFactors associated with suicide attemptsNegative Syndrome ScaleRisk factors of suicide attemptsIncidence of suicide attemptsPositive symptom scoresMajor depressive disorderHamilton Anxiety Scale scoresFactors of suicide attemptsSuicide attempt rateThyroid-stimulating hormoneGlucose disturbancesThyroid hormone levelsClinically relevant factors
2012
Psychopathology, rehospitalization and quality of life among patients with schizophrenia under home care case management in Taiwan
Chang L, Lin Y, Chang H, Chen Y, Huang W, Liu C, Liu C, Hwu H. Psychopathology, rehospitalization and quality of life among patients with schizophrenia under home care case management in Taiwan. Journal Of The Formosan Medical Association 2012, 112: 208-215. PMID: 23537867, DOI: 10.1016/j.jfma.2012.01.018.Peer-Reviewed Original ResearchConceptsNegative symptom subscale scoreSymptom subscale scoresAssociated with higher positive symptomsPositive and Negative Syndrome ScaleSubscale scoresGeneral psychopathology scoreNegative Syndrome ScaleSocio-occupational dysfunctionAssessment of FunctioningDuration of rehospitalizationPANSS scoresPositive symptomsSyndrome ScalePatients' psychopathologyPsychopathology scoresPsychopathologySchizophreniaLength of inpatient stayQuality of lifeCase managementNon-ICMDecrease rehospitalizationCase management programGAFRehospitalization rates
2010
Patient subgroups of schizophrenia based on the Positive and Negative Syndrome Scale: composition and transition between acute and subsided disease states
Huang G, Tsai H, Hwu H, Chen C, Liu C, Hua M, Chen W. Patient subgroups of schizophrenia based on the Positive and Negative Syndrome Scale: composition and transition between acute and subsided disease states. Comprehensive Psychiatry 2010, 52: 469-478. PMID: 21193177, DOI: 10.1016/j.comppsych.2010.10.012.Peer-Reviewed Original ResearchConceptsPositive and Negative Syndrome ScaleNegative Syndrome ScaleNegative symptomsSyndrome ScaleWhole syndromeFlorid symptomsNeurobiological studies of schizophreniaPartial syndromesSubgroup of schizophreniaStudies of schizophreniaReality distortionAcute schizophreniaNeurocognitive variablesLatent class analysisNeurobiological studiesSchizophreniaSymptom patternsPatient subgroupsAcute stateClass analysisSociodemographic variablesPAN dataSymptomsHostilityRegression extension
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