2025
American Association for the Surgery of Trauma pancreatic organ injury scale: 2024 revision
Notrica D, Tominaga G, Gross J, Southard R, McOmber M, Crandall M, Kozar R, Kaups K, Schuster K, Ball C. American Association for the Surgery of Trauma pancreatic organ injury scale: 2024 revision. Journal Of Trauma And Acute Care Surgery 2025, 98: 442-447. PMID: 39898876, DOI: 10.1097/ta.0000000000004522.Peer-Reviewed Original ResearchConceptsOrgan Injury ScaleDuctal injuryPancreatic headAmerican Association for the Surgery of Trauma-Organ Injury ScaleAmerican Association for the SurgeryAmerican Association for the Surgery of TraumaGrade V injuriesGrade IV injuriesSurgery of TraumaInjury ScaleV injuriesGrade IIIDuctal transectionGrade IIParenchymal injuryIV injuriesPathological findingsPortal veinInterventional gastroenterologyGrading systemIncreasing gradeInjury locationDuctal integrityClinical experienceIncreasing severity
2024
Residual Ultrasound-Enhancing Agents Mimicking Portal Venous Gas
Bitar R, Langdon J, Kaur M, Crandall I, McNamara R, Revzin M. Residual Ultrasound-Enhancing Agents Mimicking Portal Venous Gas. Ultrasound Quarterly 2024, 40: e00694. PMID: 39466239, DOI: 10.1097/ruq.0000000000000694.Peer-Reviewed Original ResearchConceptsUltrasound enhancing agentsPortal venous gasBowel ischemiaAbdominal ultrasoundVenous gasEchogenic fociContrast-enhanced echocardiographyEvaluation of cardiac functionPortal venous systemSeries of casesSonographic detectionCardiac functionDifferential diagnosisPortal veinVenous systemObservational studyLiver parenchymaPortal triadsVascular patencyBowelIschemiaEchocardiographyLiverUltrasoundInvestigation and analysis of the current status of transjugular intrahepatic portosystemic shunt treatment for portal hypertension in China
Guo H, Niu M, Shao H, Han X, Zhao J, Sun J, Fang Z, Xiong B, Zhu X, Ren W, Yuan M, Yu S, Lyu W, Zhang X, Zhang C, Li L, Luo X, Song Y, Ma Y, Dang T, Xiang H, Jin Y, Xue H, Jin G, Li X, Li J, Zhou S, Yu C, He S, Yu L, Zu H, Ma J, Lei Y, Xu K, Qi X. Investigation and analysis of the current status of transjugular intrahepatic portosystemic shunt treatment for portal hypertension in China. Chinese Journal Of Radiology 2024, 58: 437-443. DOI: 10.3760/cma.j.cn112149-20231113-00384.Peer-Reviewed Original ResearchTransjugular intrahepatic portosystemic shuntTransjugular intrahepatic portosystemic shunt treatmentPortal hypertensionPortal pressure gradient measurementCavernous transformationConventional anticoagulationPressure gradient measurementIndications of transjugular intrahepatic portosystemic shuntFollow-upTIPS operationPortal vein cavernous transformationTransjugular intrahepatic portosystemic shunt stentDuration of anticoagulationTreat portal hypertensionPostoperative follow-upIntrahepatic portosystemic shuntPrevention of rebleedingRoutine follow-upEarly-TIPSSurgical indicationsDomestic instrumentsShunt treatmentPortosystemic shuntPortal veinEmbolic materialAtezolizumab and bevacizumab in combination with TACE for patients with BCLC B HCC.
Stein S, Cheng W, Wiess C, Pollak J, Perez Lozada J, Chapiro J, Madoff D. Atezolizumab and bevacizumab in combination with TACE for patients with BCLC B HCC. Journal Of Clinical Oncology 2024, 42: tps584-tps584. DOI: 10.1200/jco.2024.42.3_suppl.tps584.Peer-Reviewed Original ResearchRates of grade 3Grade 3Child-Pugh A cirrhosisBCLC-B HCCCombination of atezolizumabCurative intent therapyMain portal veinRisk of bleedingDiagnosis of HCCSignificant autoimmune diseaseSingle arm pilot studyB HCCECOG PSEffective regimenOpen-labelOverall survivalGastroesophageal varicesIntent therapyPredicted probabilityAutoimmune diseasesHepatic arteryPortal veinHepatic encephalopathyPatientsImprove outcomes
2023
Diagnosis and classification of vascular liver disorders
González I, Jain D. Diagnosis and classification of vascular liver disorders. Diagnostic Histopathology 2023, 29: 36-51. DOI: 10.1016/j.mpdhp.2022.10.005.Peer-Reviewed Original ResearchLiver vasculatureVascular liver disordersUnderlying liver diseaseNoncirrhotic portal hypertensionAcute liver failureDual blood supplyDiverse clinical presentationsTerminal portal venulesKey histologicPortal hypertensionAtypical presentationLiver biopsyLiver failureClinical featuresClinical presentationHepatic arteryLiver diseaseUnclear diagnosisHepatic veinHistologic findingsPortal veinChallenging disorderLiver disordersBlood supplyHepatic sinusoids
2021
Portal hypertension in cirrhosis: Pathophysiological mechanisms and therapy
Iwakiri Y, Trebicka J. Portal hypertension in cirrhosis: Pathophysiological mechanisms and therapy. JHEP Reports 2021, 3: 100316. PMID: 34337369, PMCID: PMC8318926, DOI: 10.1016/j.jhepr.2021.100316.Peer-Reviewed Original ResearchLiver sinusoidal endothelial cellsHepatic stellate cellsPortal hypertensionChronic liver diseaseIntrahepatic vascular resistanceSinusoidal endothelial cellsExtrahepatic vasculatureVascular resistanceMicrovascular thrombosisHaemodynamic changesLiver diseasePathophysiological mechanismsPortal veinHypertensionPreclinical studiesEffective treatmentStellate cellsPathogenic complexityExtrahepatic mechanismsClinical advancesEffective therapeuticsUnsuccessful translationEndothelial cellsCirrhosisDysregulationLipiodol as an intra-procedural imaging biomarker for liver tumor response to transarterial chemoembolization: Post-hoc analysis of a prospective clinical trial
Letzen BS, Malpani R, Miszczuk M, de Ruiter QMB, Petty CW, Rexha I, Nezami N, Laage-Gaupp F, Lin M, Schlachter TR, Chapiro J. Lipiodol as an intra-procedural imaging biomarker for liver tumor response to transarterial chemoembolization: Post-hoc analysis of a prospective clinical trial. Clinical Imaging 2021, 78: 194-200. PMID: 34022765, PMCID: PMC8364875, DOI: 10.1016/j.clinimag.2021.05.007.Peer-Reviewed Original ResearchConceptsConventional trans-arterial chemoembolizationMedian overall survivalProspective clinical trialsLipiodol depositionTumor responsePredictive biomarkersClinical trialsModified Response Evaluation CriteriaPost-TACE CTResponse Evaluation CriteriaMetastatic liver cancerKaplan-Meier analysisTrans-arterial chemoembolizationTumor response criteriaLiver tumor responsePrediction of survivalSelective drug targetingArterial embolizationLiver metastasesOverall survivalBland-Altman plotsTransarterial chemoembolizationPortal veinTumor respondersHepatocellular carcinoma
2020
Glucagon stimulates gluconeogenesis by INSP3R1-mediated hepatic lipolysis
Perry RJ, Zhang D, Guerra MT, Brill AL, Goedeke L, Nasiri AR, Rabin-Court A, Wang Y, Peng L, Dufour S, Zhang Y, Zhang XM, Butrico GM, Toussaint K, Nozaki Y, Cline GW, Petersen KF, Nathanson MH, Ehrlich BE, Shulman GI. Glucagon stimulates gluconeogenesis by INSP3R1-mediated hepatic lipolysis. Nature 2020, 579: 279-283. PMID: 32132708, PMCID: PMC7101062, DOI: 10.1038/s41586-020-2074-6.Peer-Reviewed Original ResearchConceptsHepatic steatosisType 2Nonalcoholic fatty liver diseaseDiet-induced hepatic steatosisFatty liver diseasePlasma glucagon concentrationsHepatic adipose triglyceride lipaseHepatic acetyl-CoA contentHepatic glucose productionRatio of insulinHepatic glucose metabolismInositol triphosphate receptorAdipose triglyceride lipaseMitochondrial oxidationMitochondrial fat oxidationGlucose intoleranceLiver diseaseGlucagon concentrationsInsulin resistancePortal veinAcetyl-CoA contentHepatic lipolysisGlucagon biologyGlucose metabolismKnockout mice
2019
Transhepatic portal stent placement and jejunal varix embolization for management of treatment-limiting gastrointestinal bleeding in a patient with unresectable recurrent intrahepatic cholangiocarcinoma
Cornman-Homonoff J, Bassik N, Madoff DC. Transhepatic portal stent placement and jejunal varix embolization for management of treatment-limiting gastrointestinal bleeding in a patient with unresectable recurrent intrahepatic cholangiocarcinoma. Clinical Imaging 2019, 59: 188-191. PMID: 31837541, DOI: 10.1016/j.clinimag.2019.09.012.Peer-Reviewed Case Reports and Technical NotesConceptsRecurrent cholangiocarcinomaOnly potential cureRecurrent intrahepatic cholangiocarcinomaPoor patient outcomesUnresectable diseaseGastrointestinal bleedingChemotherapy administrationMyelosuppressive effectsTherapeutic mainstayDismal prognosisIntrahepatic cholangiocarcinomaVariceal embolizationStent placementPortal veinPatient outcomesPotential cureCholangiocarcinomaEmbolizationCytopeniasBleedingRegimenChemotherapyPatientsSurgeryPrognosisEndoscopic Ultrasound for the Diagnosis and Staging of Liver Tumors
Lange A, Muniraj T, Aslanian HR. Endoscopic Ultrasound for the Diagnosis and Staging of Liver Tumors. Gastrointestinal Endoscopy Clinics Of North America 2019, 29: 339-350. PMID: 30846157, DOI: 10.1016/j.giec.2018.12.005.Peer-Reviewed Original ResearchConceptsEndoscopic ultrasound examinationUltrasound examinationFine-needle aspirationPortal veinNeedle aspirationLiver lesionsCross-sectional imagingIndeterminate liver lesionsFocal liver lesionsLocoregional nodesLymph nodesLiver malignanciesCancer stagingEndoscopic ultrasoundLiver tumorsTechnologic improvementsLesionsExaminationStagingDiagnosisVeinAspirationMalignancyTumorsLiver
2017
Management of Portal Hypertension
Garcia‐Tsao G, Abraldes J. Management of Portal Hypertension. 2017, 304-335. DOI: 10.1002/9781119251316.ch12.Peer-Reviewed Educational MaterialsComplications of cirrhosisPortal hypertensionVariceal hemorrhagePortal pressure gradientInferior vena cavaObjective of treatmentGastroesophageal varicesPortal pressurePathological increaseVena cavaPortal veinCommon causeCirrhosisHypertensionComplicationsHemorrhageMost studiesVaricesDecompensationCavaSpontaneous Translocation of a Gut Pathobiont Drives Autoimmunity that is Preventable by Intramuscular Vaccination
Vieira S, Hiltensperger M, Kumar V, Dehner C, Zegarra-Ruiz D, Ruff W, Khan N, Goodman A, Kriegel M. Spontaneous Translocation of a Gut Pathobiont Drives Autoimmunity that is Preventable by Intramuscular Vaccination. The Journal Of Immunology 2017, 198: 199.20-199.20. DOI: 10.4049/jimmunol.198.supp.199.20.Peer-Reviewed Original ResearchMesenteric lymph nodesGut microbiotaE. gallinarumGerm-free (GF) C57BL/6 miceAutoimmune hepatitis patientsInduction of autoantibodiesPathogenesis of autoimmunityNovel therapeutic avenuesTfh cellsDietary antigensIntramuscular vaccineIntramuscular vaccinationHepatitis patientsLymph nodesGut barrierHost-microbiota interactionsOral gavageC57BL/6 miceSystemic autoimmunityPortal veinTherapeutic avenuesAutoimmunitySingle antibioticLiver tissueMiceCongenital Extrahepatic Portosystemic Shunt (Abernethy Malformation Type Ib) With Associated Hepatocellular Carcinoma
Benedict M, Rodriguez-Davalos M, Emre S, Walther Z, Morotti R. Congenital Extrahepatic Portosystemic Shunt (Abernethy Malformation Type Ib) With Associated Hepatocellular Carcinoma. Pediatric And Developmental Pathology 2017, 20: 354-362. PMID: 28727971, DOI: 10.1177/1093526616686458.Peer-Reviewed Case Reports and Technical NotesConceptsAbernethy malformationCongenital portosystemic shuntsHepatocellular carcinomaPortosystemic shuntPortal veinVena cavaCongenital absenceCongenital extrahepatic portosystemic shuntAssociated Hepatocellular CarcinomaSplanchnic venous systemNodular regenerative hyperplasiaExtrahepatic portosystemic shuntSmall hepatocellular carcinomaFocal nodular hyperplasiaRegenerative hyperplasiaClinical manifestationsImmunohistochemical characteristicsIntrahepatic shuntsLiver adenomasTypical presentationPortal bloodNodular hyperplasiaVenous systemComplete diversionResult of malformation
2016
Ventilation-Based Decellularization System of the Lung
Tsuchiya T, Mendez J, Calle EA, Hatachi G, Doi R, Zhao L, Suematsu T, Nagayasu T, Niklason LE. Ventilation-Based Decellularization System of the Lung. BioResearch Open Access 2016, 5: 118-126. PMID: 27186445, PMCID: PMC4860652, DOI: 10.1089/biores.2016.0012.Peer-Reviewed Original ResearchAirway groupPulmonary arteryDecellularized groupVessel groupPositive end-expiratory pressureEnd-expiratory pressureMHC class IWestern blot analysisRed blood cellsOrgan recipientsImmunohistochemical findingsNative lungPortal veinAdministration routeAlveolar wallsRat lungLungBlood leakageOrgan donationBlood cellsClass IDonated organsExtracellular matrixAirwayArteryCongenital Extrahepatic Portosystemic Shunt (Abernethy Malformation Type Ib) with Associated Hepatocellular Carcinoma: Case report and Literature Review
Benedict M, Rodriguez-Davalos M, Emre S, Walther Z, Morotti R. Congenital Extrahepatic Portosystemic Shunt (Abernethy Malformation Type Ib) with Associated Hepatocellular Carcinoma: Case report and Literature Review. Pediatric And Developmental Pathology 2016 DOI: 10.2350/16-01-1761-cr.1.Peer-Reviewed Case Reports and Technical NotesAbernethy malformationCongenital portosystemic shuntsHepatocellular carcinomaPortosystemic shuntPortal veinVena cavaCongenital absenceCongenital extrahepatic portosystemic shuntAssociated Hepatocellular CarcinomaSplanchnic venous systemNodular regenerative hyperplasiaExtrahepatic portosystemic shuntMonth old maleSmall hepatocellular carcinomaFocal nodular hyperplasiaRegenerative hyperplasiaClinical manifestationsIntrahepatic shuntsLiver adenomasCase reportImmunohistochemical characteristicsPortal bloodTypical presentationVenous systemNodular hyperplasia
2013
Percutaneous Intraportal Application of Adipose Tissue–derived Mesenchymal Stem Cells Using a Balloon Occlusion Catheter in a Porcine Model of Liver Fibrosis
Avritscher R, Abdelsalam ME, Javadi S, Ensor J, Wallace MJ, Alt E, Madoff DC, Vykoukal JV. Percutaneous Intraportal Application of Adipose Tissue–derived Mesenchymal Stem Cells Using a Balloon Occlusion Catheter in a Porcine Model of Liver Fibrosis. Journal Of Vascular And Interventional Radiology 2013, 24: 1871-1878. PMID: 24144538, DOI: 10.1016/j.jvir.2013.08.022.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAnimalsBalloon OcclusionBiomarkersBiopsyCell TrackingCells, CulturedEndovascular ProceduresEquipment DesignEthanolEthiodized OilGreen Fluorescent ProteinsHepatic VeinsLiverLiver Cirrhosis, ExperimentalMaleMesenchymal Stem Cell TransplantationMesenchymal Stem CellsSus scrofaTime FactorsTransfectionVascular Access DevicesVenous PressureConceptsHepatic venous pressure gradientBalloon occlusion catheterOcclusion catheterMesenchymal stem cellsLiver fibrosisLarge animal modelIntraportal applicationEndovascular approachPortal veinAdipose tissueAnimal modelsExperimental animalsPercutaneous endovascular approachVenous pressure gradientTranscatheter arterial embolizationNovel endovascular approachStem cellsPortal hypertensionVascular complicationsArterial embolizationLiver injuryLiver damageBiopsy specimensSham injectionBalloon inflation
2012
Pulsatile Portal Vein Insulin Delivery Enhances Hepatic Insulin Action and Signaling
Matveyenko A, Liuwantara D, Gurlo T, Kirakossian D, Man C, Cobelli C, White M, Copps K, Volpi E, Fujita S, Butler P. Pulsatile Portal Vein Insulin Delivery Enhances Hepatic Insulin Action and Signaling. Diabetes 2012, 61: 2269-2279. PMID: 22688333, PMCID: PMC3425431, DOI: 10.2337/db11-1462.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood GlucoseDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2DogsForkhead Transcription FactorsGlucokinaseInsulinInsulin Receptor Substrate ProteinsInsulin ResistanceInsulin SecretionLiverMaleNerve Tissue ProteinsPortal VeinProto-Oncogene Proteins c-aktRatsRats, Sprague-DawleySignal TransductionConceptsPulsatile insulin secretionHepatic insulin actionInsulin secretionHepatic insulinPortal veinInsulin deliveryPulsatile patternInsulin actionDiscrete insulin secretory burstsHepatic insulin receptor substrateImpaired activationType 2 diabetes mellitusSequential liver biopsiesIntraportal insulin infusionInsulin secretory burstsHepatic insulin resistanceHepatic portal veinExpression of glucokinaseGlycemic controlDiabetes mellitusLiver biopsyInsulin resistanceInsulin infusionSecretory burstsRat modelPercutaneous Portal Vein Access and Transhepatic Tract Hemostasis
Saad W, Madoff D. Percutaneous Portal Vein Access and Transhepatic Tract Hemostasis. Seminars In Interventional Radiology 2012, 29: 071-080. PMID: 23729976, PMCID: PMC3444873, DOI: 10.1055/s-0032-1312567.Peer-Reviewed Original ResearchPortal vein accessVein accessPostprocedural bleedingPortal venous systemVein interventionsVenous proceduresThrombolytic therapyTranshepatic routeVein proceduresHepatic veinPortal veinVenous systemTract closureHemostatic methodsMeticulous techniqueInvasive accessPortal accessBleedingOverall safetyHemostasisVeinSubsequent closureRiskClosurePatients
2011
Endothelial dysfunction in the regulation of cirrhosis and portal hypertension
Iwakiri Y. Endothelial dysfunction in the regulation of cirrhosis and portal hypertension. Liver International 2011, 32: 199-213. PMID: 21745318, PMCID: PMC3676636, DOI: 10.1111/j.1478-3231.2011.02579.x.BooksConceptsLiver sinusoidal endothelial cellsPortal hypertensionEndothelial dysfunctionArterial vasodilationPortosystemic collateral vesselsProduction of vasodilatorsDevelopment of cirrhosisCollateral vessel formationPathological vascular eventsSinusoidal endothelial cellsExtrahepatic circulationIntrahepatic resistanceOesophageal varicesVascular eventsVascular resistanceVasodilator moleculeCollateral vesselsSinusoidal microcirculationPortal veinHypertensionSystemic circulationBlood flowCirrhosisDysfunctionNitric oxide
2010
Techniques and results of portal vein/superior mesenteric vein reconstruction using femoral and saphenous vein during pancreaticoduodenectomy
Lee D, Mitchell E, Jones M, Landry G, Liem T, Sheppard B, Billingsley K, Moneta G. Techniques and results of portal vein/superior mesenteric vein reconstruction using femoral and saphenous vein during pancreaticoduodenectomy. Journal Of Vascular Surgery 2010, 51: 662-666. PMID: 20080375, DOI: 10.1016/j.jvs.2009.09.025.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaEdemaEndosonographyFemoral VeinGraft Occlusion, VascularHumansKaplan-Meier EstimateMesenteric VeinsMiddle AgedNeoplasm InvasivenessPancreatic NeoplasmsPancreaticoduodenectomyPortal VeinRegistriesReoperationSaphenous VeinTime FactorsTissue and Organ HarvestingTomography, X-Ray ComputedTreatment OutcomeUltrasonography, Doppler, DuplexVascular PatencyVascular Surgical ProceduresConceptsPV/SMV reconstructionLower extremity edemaLower extremity veinsPostoperative wound problemsLate mortalityExtremity edemaFemoral veinExtremity veinsSaphenous veinWound problemsPreoperative imagingPortal veinPV/SMV invasionSuperior mesenteric vein invasionPreoperative computed tomography (CT) imagingPV/SMVVein harvest siteLower extremity complicationsKaplan-Meier analysisGreat saphenous veinMinor operative proceduresEndoscopic ultrasound scanSuperior mesenteric vein reconstructionComputed tomography (CT) imagingPatent reconstruction
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