2025
Home‐based family recovery supports: Feasibility, acceptability, and adoption of training home visitors in “Mothering from the Inside Out”
Peacock‐Chambers E, Jurkowski B, Kangas S, DeCoste C, McMahon T, Borelli J, Feinberg E, Byatt N, Zayde A, Lowell A, Friedmann P. Home‐based family recovery supports: Feasibility, acceptability, and adoption of training home visitors in “Mothering from the Inside Out”. Infant Mental Health Journal 2025 PMID: 40318079, DOI: 10.1002/imhj.70019.Peer-Reviewed Original ResearchSubstance use disordersEI providersEarly interventionFamily recoveryEvidence-based parenting interventionsDidactic trainingHome visitation settingRetention of providersTrained home visitorsImplementation outcomesTen providersHome visitorsAssess feasibilityVisit settingIn-personParenting interventionsPostpartum periodWeekly consultationQualitative interviewsProvidersImprove retentionAdequate adoptionDidactic learningAdequate fidelityPilot studyThe effects of hypnosis and music intervention on comfort and anxiety during weaning from mechanical ventilation: A pilot study
Devroey M, Orbegozo Cortes D, Gaspard N, Foucart J, Preiser J, Taccone F. The effects of hypnosis and music intervention on comfort and anxiety during weaning from mechanical ventilation: A pilot study. Journal Of Critical Care 2025, 87: 155044. PMID: 40036993, DOI: 10.1016/j.jcrc.2025.155044.Peer-Reviewed Original ResearchConceptsMusic intervention groupMusic interventionMV weaningIntervention groupVisual analog scaleCalm musicMusicCritically ill patientsAnxiety levelsIll patientsPilot studyMechanical ventilationReduce anxietyCriticismCortisol blood levelsEfficacy of hypnosisDistressing symptomsEffects of hypnosisHypnosis groupInclusion criteriaPrimary outcomeEligible patientsInterventionSpontaneous breathing trialAnalog scalePortal and Hepatic Vein Embolization vs Portal Venous Embolization Alone in Cirrhotic and Non-cirrhotic Swine: A Pilot Study
Tefera J, Kuhn T, Matuschewski N, Meister E, Nguyenová J, Kao T, Mutonga M, Bitar R, Kahl V, Zhang X, Shewarega A, Chapiro J, Madoff D. Portal and Hepatic Vein Embolization vs Portal Venous Embolization Alone in Cirrhotic and Non-cirrhotic Swine: A Pilot Study. Journal Of Vascular And Interventional Radiology 2025 PMID: 40043833, DOI: 10.1016/j.jvir.2025.02.028.Peer-Reviewed Original ResearchPost-embolizationCirrhotic groupPortal venous embolizationHepatic vein embolizationPortal venous phaseNon-cirrhotic groupStudent's t-testFLR hypertrophyFLR increaseVein embolizationVenous phaseEffects of PVELiver volumeCT scanVenous embolizationEmbolizationCirrhotic liverFour-week intervalsWeeksT-testFLRLiverPilot studyYorkshire pigsPVEPilot study evaluating duplex sequencing of urinary DNA as a biomarker for recurrence in non-muscle invasive bladder cancer.
Ghali F, Blaha O, Lam H, Kennedy S, Wright J. Pilot study evaluating duplex sequencing of urinary DNA as a biomarker for recurrence in non-muscle invasive bladder cancer. Journal Of Clinical Oncology 2025, 43: 865-865. DOI: 10.1200/jco.2025.43.5_suppl.865.Peer-Reviewed Original ResearchNon-muscle invasive bladder cancerInvasive bladder cancerVariant allele fractionUrinary DNAIntravesical therapyBladder cancerPathogenic variantsTransurethral resection of bladder tumorMedian time to recurrenceResection of bladder tumorNext-generation sequencingDetection of recurrenceTime to recurrenceTime to relapseRecurrence of tumorBiomarkers of recurrencePilot studyTransurethral resectionBladder tumorsMedian ageRecurrenceAllele fractionUrine samplesTumorBiomarkersAdapting and Implementing a Blended Collaborative Care Intervention for Older Adults with Multimorbidity: Quantitative and Qualitative Results from the ESCAPE Pilot Study
Schulze J, Lühmann D, Nagel J, Regner C, Zelenak C, Bersch K, Herrmann-Lingen C, Burg M, Herbeck-Belnap B. Adapting and Implementing a Blended Collaborative Care Intervention for Older Adults with Multimorbidity: Quantitative and Qualitative Results from the ESCAPE Pilot Study. Behavioral Sciences 2025, 15: 79. PMID: 39851883, PMCID: PMC11762138, DOI: 10.3390/bs15010079.Peer-Reviewed Original ResearchPrimary care providersCare managementHealthcare systemPrimary care provider involvementImprove intervention deliveryPhysical-mental multimorbidityCollaborative care interventionPatient's health goalsEuropean healthcare systemsPilot studyRandomised-controlled trialsSemi-structured interviewsEvaluate goal attainmentCollaborative careFragmented careIntervention deliveryIntervention fidelityCare interventionsCare providersPsychosocial supportCare complexityHealth goalsOlder AdultsParticipant satisfactionLifestyle changesPilot study of a comprehensive multidisciplinary inpatient-based approach to smoking cessation in patients with vascular disease
Kim T, Brahmandam A, Alameddine D, Forman R, Hardik A, Fucito L, Mena-Hurtado C, Guzman R, Chaar C. Pilot study of a comprehensive multidisciplinary inpatient-based approach to smoking cessation in patients with vascular disease. JVS-Vascular Insights 2025, 3: 100174. DOI: 10.1016/j.jvsvi.2024.100174.Peer-Reviewed Original ResearchSmoking cessation ratesSmoking cessation programSmoking cessationCessation programsCessation ratesQuit smokingTeachable momentInpatient smoking cessation interventionsPatient-Reported Outcomes Measurement Information System questionnairesFree nicotine replacement therapyPilot studySmoking cessation counselingSmoking cessation interventionsProvider follow-upCarbon monoxide breath testNicotine replacement therapyCare of patientsQuality of lifeCessation counselingCessation interventionsInpatient strategiesVascular surgeryMental healthStop smokingCounseling sessions
2024
Relationships Between Retinal Amyloid Imaging and Amyloid PET in the A4 Trial
Rissman R, Ngolab J, Donohue M, Belsha A, Salazar J, Cohen P, Jaiswal S, Tan V, Aggarwal N, Alber J, Johnson K, Jicha G, van Dyck C, Lah J, Salloway S, Rafii M, Aisen P, Sperling R. Relationships Between Retinal Amyloid Imaging and Amyloid PET in the A4 Trial. Alzheimer's & Dementia 2024, 20: e090880. PMCID: PMC11716286, DOI: 10.1002/alz.090880.Peer-Reviewed Original ResearchA4 trialFeasibility of retinal imagingPositron emission tomographyAmyloid positron emission tomographyLongitudinal Evaluation of Amyloid RiskRetinal spotsCohort of individualsAnti-Amyloid TreatmentAsymptomatic Alzheimer's diseaseRetinal amyloid depositsAlzheimer's diseaseStandardized uptake value ratioAD-diagnosed patientsPilot studyRetinal imaging techniquesLongitudinal evaluationRisk detectionNon-invasive evaluationAmyloid depositsClinically normal individualsAnti-amyloidRetinal amyloid imagingParticipantsPET standardized uptake value ratioRetinal fundus imagesCorrection: Randomized trial of physical activity on quality of life and lung cancer biomarkers in patients with advanced stage lung cancer: a pilot study
Bade B, Gan G, Li F, Lu L, Tanoue L, Silvestri G, Irwin M. Correction: Randomized trial of physical activity on quality of life and lung cancer biomarkers in patients with advanced stage lung cancer: a pilot study. BMC Cancer 2024, 24: 1409. PMID: 39548453, PMCID: PMC11566398, DOI: 10.1186/s12885-024-13183-9.Peer-Reviewed Original ResearchStability and Reliability of Repeated Plasma Pregnenolone Levels After Oral Pregnenolone Dosing in Individuals with Cocaine Use Disorder: Pilot Findings
Gao H, Magin Z, Fogelman N, Sinha R, Angarita G, Milivojevic V. Stability and Reliability of Repeated Plasma Pregnenolone Levels After Oral Pregnenolone Dosing in Individuals with Cocaine Use Disorder: Pilot Findings. Life 2024, 14: 1483. PMID: 39598281, PMCID: PMC11595496, DOI: 10.3390/life14111483.Peer-Reviewed Original ResearchCocaine use disorderSubstance use disordersUse disorderPregnenolone levelsTreatment of cocaine use disorderReduce alcohol cravingTreatment-seeking individualsAssociated across timeAdministration of pregnenoloneEight-week trialSignificant main effectAlcohol cravingPregnenolone administrationNegative health risksDouble-blind clinical trialMain effectPilot findingsLevels of pregnenoloneChronic dosingStudy medication doseMedication dosesDisordersCocainePilot studyStress biologyPediatric critical care nursing empowerment through distance education and simulation in Accra, Ghana
Nader M, Silvers R, Phatak U, White L, Jaeger M, Whitfill T, Owusu-Sekyere F, Boateng G, Lano G, Canarie M, Gross I. Pediatric critical care nursing empowerment through distance education and simulation in Accra, Ghana. Clinical Simulation In Nursing 2024, 96: 101616. DOI: 10.1016/j.ecns.2024.101616.Peer-Reviewed Original ResearchNurse empowermentKorle Bu Teaching HospitalNursing curriculumPediatric intensive care unitClinical Teamwork ScaleSimulation Effectiveness ToolSimulated case scenariosFree-text feedbackPediatric critical careQualitative content analysisTeamwork ScaleNursing staffDistance simulationEducational interventionCritical careTeaching hospitalIntensive care unitContent analysisPilot studyCare unitInternational partnershipsEmpowermentCase scenariosMixing methodEducational contentPilot study of a parent-based intervention for functional somatic symptoms in children
Etkin R, Winograd S, Calhoun A, Silverman W, Lebowitz E, Shapiro E. Pilot study of a parent-based intervention for functional somatic symptoms in children. Journal Of Pediatric Psychology 2024, 49: 900-910. PMID: 39468777, DOI: 10.1093/jpepsy/jsae092.Peer-Reviewed Original ResearchFunctional somatic symptomsParent-based interventionsSomatic symptomsLevels of functional impairmentWeekly group sessionsPilot studyAssociated with significant distressEvidence-based treatmentsBaseline to posttreatmentGroup sessionsSignificant distressClinical outcomesChildren's symptomsPromote better functioningTreatment satisfactionInterventionBetter functionChild's levelChild careFunctional impairmentClinical researchFollow-upChildrenSymptomsParentsA Pilot Study Using Continuous Glucose Monitoring among Patients with a Low 1-Hour Glucose Challenge Test Result versus Controls to Detect Maternal Hypoglycemia
Ding J, Milley L, Son M. A Pilot Study Using Continuous Glucose Monitoring among Patients with a Low 1-Hour Glucose Challenge Test Result versus Controls to Detect Maternal Hypoglycemia. American Journal Of Perinatology 2024, 42: 555-563. PMID: 39413845, DOI: 10.1055/a-2419-8476.Peer-Reviewed Original ResearchContinuous glucose monitoring analysisMaternal hypoglycemiaBlinded continuous glucose monitoringGCT resultsNeonatal morbidityContinuous glucose monitoringGlycemic groupsGCT valuesEligible patientsGCT groupSmall-for-gestational-age birth weightAssociated with neonatal morbidityStudent's <i>t</i>-test anGlucose monitoringAverage glucose valuesPrimary outcome measureGlycemic dataWeeks gestationChi-square testBirth weightPilot studyHypoglycemiaGlycemic valuesPatientsGlucose valuesPre-operative stereotactic radiosurgery and peri-operative dexamethasone for resectable brain metastases: a two-arm pilot study evaluating clinical outcomes and immunological correlates
Jansen C, Pagadala M, Cardenas M, Prabhu R, Goyal S, Zhou C, Chappa P, Vo B, Ye C, Hopkins B, Zhong J, Klie A, Daniels T, Admassu M, Green I, Pfister N, Neill S, Switchenko J, Prokhnevska N, Hoang K, Torres M, Logan S, Olson J, Nduom E, del Balzo L, Patel K, Burri S, Asher A, Wilkinson S, Lake R, Kesarwala A, Higgins K, Patel P, Dhere V, Sowalsky A, Carter H, Khan M, Kissick H, Buchwald Z. Pre-operative stereotactic radiosurgery and peri-operative dexamethasone for resectable brain metastases: a two-arm pilot study evaluating clinical outcomes and immunological correlates. Nature Communications 2024, 15: 8854. PMID: 39402027, PMCID: PMC11473782, DOI: 10.1038/s41467-024-53034-6.Peer-Reviewed Original ResearchConceptsPre-operative stereotactic radiosurgeryCD8 T cellsEffector-like cellsT cellsStereotactic radiosurgeryBrain metastasesCD8 T cell responsesEndpoint of overall survivalDistant brain failureResected brain metastasesEfficacy of immunotherapyT cell responsesAntigen presenting cellsSecondary clinical endpointsLocal recurrenceLeptomeningeal diseaseOverall survivalImmune compositionProspective trialsImmune nichePrimary endpointImmunological correlatesPresenting cellsClinical outcomesPilot studyBuilding Frontline Capability for Shared Decision-Making (SDM) in a Major Academic Oncology Center Caring for People With Non–Small Cell Lung Cancer: Performance Outcomes of a SDM Simulation Training Program
Alexander C, Hakim H, Rudell E, Ingram M, Agrawal T, Peterson P, Davies M, Adelson K, Oliver B. Building Frontline Capability for Shared Decision-Making (SDM) in a Major Academic Oncology Center Caring for People With Non–Small Cell Lung Cancer: Performance Outcomes of a SDM Simulation Training Program. The Permanente Journal 2024, 28: 200-211. PMID: 39269220, PMCID: PMC11404653, DOI: 10.7812/tpp/23.160.Peer-Reviewed Original ResearchConceptsShared decision-makingPractice settingsImplementation of shared decision-makingSDM trainingTraining programSimulation training programMultidisciplinary cliniciansCentered carePatient goalsPost-trainingClinician experienceFocus groupsClinical careSelf-efficacyParticipants' understandingClinician awarenessPostinterventionPilot studyActive participationParticipantsProgram designCareCliniciansBody of evidenceGrowing body of evidencePersonalized embryo transfer guided by rsERT with hourly precision improves pregnancy outcomes in patients with a receptive window of implantation: a pilot study
Yang T, Hou Z, Zhang Q, Zhao J, Liu N, Liu D, Li Y, Wang Y, Xu B, Zou Y, Wan C, Li Y. Personalized embryo transfer guided by rsERT with hourly precision improves pregnancy outcomes in patients with a receptive window of implantation: a pilot study. Journal Of Assisted Reproduction And Genetics 2024, 41: 2657-2665. PMID: 39254797, PMCID: PMC11534956, DOI: 10.1007/s10815-024-03246-y.Peer-Reviewed Original ResearchIntrauterine pregnancy ratePersonalized embryo transferWindow of implantationEmbryo transferPropensity score matchingImplantation rateET groupCenter for Reproductive MedicineResultsBefore propensity score matchingImplant failure rateGroup compared to controlsRetrospective pilot studyConventional embryo transferMultiple-pregnancy ratesEndometrial receptivity testCentral South UniversityPregnancy outcomesTransferred embryosPilot studyPregnancy ratePatientsSouth UniversityReproductive medicineScore matchingConfounding factorsA Pilot Study to Test the Feasibility of a Randomized Controlled Trial of E-cigarettes as Harm Reduction Tools Among People Who Smoke and Previously Failed to Quit With Pharmacotherapy
Smith T, Ferreira A, Wahlquist A, Cummings K, Rojewski A, McClure E, Toll B, Carpenter M. A Pilot Study to Test the Feasibility of a Randomized Controlled Trial of E-cigarettes as Harm Reduction Tools Among People Who Smoke and Previously Failed to Quit With Pharmacotherapy. Nicotine & Tobacco Research 2024, 27: 553-557. PMID: 39233579, DOI: 10.1093/ntr/ntae212.Peer-Reviewed Original ResearchRandomized controlled trialsE-cigarette groupE-cigarettesNRT groupPilot studyPoint prevalence abstinenceNicotine replacement therapyHarm reduction interventionsHarm reduction toolCombination nicotine replacement therapyTraditional pharmacotherapyTrial of e-cigarettesMean cigarettesReduction interventionsPrevalence abstinencePowered trialsControlled trialsEffect sizeNon-whiteElectronic diaryCigarette smokersReplacement therapyParticipantsStandard pharmacotherapyDaily diariesDiagnostic performance of central vein sign versus oligoclonal bands for multiple sclerosis
Toljan K, Daboul L, Raza P, Martin M, Cao Q, O’Donnell C, Rodrigues P, Derbyshire J, Azevedo C, Bar-Or A, Caverzasi E, Calabresi P, Cree B, Freeman L, Henry R, Longbrake E, Oh J, Papinutto N, Pelletier D, Samudralwar R, Schindler M, Sotirchos E, Sicotte N, Solomon A, Shinohara R, Reich D, Sati P, Ontaneda D. Diagnostic performance of central vein sign versus oligoclonal bands for multiple sclerosis. Multiple Sclerosis Journal 2024, 30: 1268-1277. PMID: 39234802, PMCID: PMC11421977, DOI: 10.1177/13524585241271988.Peer-Reviewed Original ResearchConceptsCentral vein signPositive predictive valueOligoclonal bandsDiagnostic performanceMS diagnosisCerebrospinal fluidMultiple sclerosisPredictive valueNegative predictive valueCerebrospinal fluid testingRadiological suspicionDiagnostic accuracyImaging biomarkersDiagnosisDiagnostic biomarkersMonthsSclerosisBiomarkersPilot studyBaselineSelection 3An affordable and open-source tool for mouse behavioral studiespyControl in an undergraduate research setting
Coller A, Alpern E, Clinton K, Estrada M, Emmons E. An affordable and open-source tool for mouse behavioral studiespyControl in an undergraduate research setting. BIOS 2024, 95: 176-182. DOI: 10.1893/bios-d-23-00018.Peer-Reviewed Original ResearchThe Effectiveness and Safety of Stellate Ganglion Block in the Treatment of Symptoms from Long COVID-19: A Pilot Study.
Levey A, Chen G, Ngyuen A, Ostrosky-Zeichner L, Hasoon J, Saroukhani S, Lin M. The Effectiveness and Safety of Stellate Ganglion Block in the Treatment of Symptoms from Long COVID-19: A Pilot Study. Psychopharmacology Bulletin 2024, 54: 8-17. PMID: 39263197, PMCID: PMC11385263.Peer-Reviewed Original ResearchConceptsStellate ganglion blockGanglion blockTreatment of symptomsFatigue severity scoresCOMPASS-31Degree of symptomatic improvementEffect of stellate ganglion blockSafety of stellate ganglion blockNo significant differenceSymptomatic improvementPost-procedureAdjunctive treatmentPre-procedurePilot studyLong COVID-19Severity scoreLow riskPatientsGAD-7 scoresFSS scoresEffective procedureSignificant differenceHeart ratePost-intervention surveysCOVID infectionFeasibility of In-Hospital Administration of a Tool to Predict Persistent Post-ICU Functional Impairment Among Older ICU Survivors A Pilot Study
Stevenson J, Murphy T, Tessier-Sherman B, Pisani M, Gill T, Ferrante L. Feasibility of In-Hospital Administration of a Tool to Predict Persistent Post-ICU Functional Impairment Among Older ICU Survivors A Pilot Study. CHEST Critical Care 2024, 2: 100093. PMID: 39822381, PMCID: PMC11737545, DOI: 10.1016/j.chstcc.2024.100093.Peer-Reviewed Original ResearchRisk prediction toolsICU survivorsIn-hospital administrationOlder adultsFunctional impairmentPilot studyIn-hospital mobilityOlder ICU survivorsDevelopment of risk prediction modelsHospital-related factorsIn-hospital factorsPresence of deliriumRisk prediction modelModel discriminationPersistent functional impairmentStatistical significanceHospital settingStudy designFeasibility thresholdDaily activitiesIncreased riskInternational Consensus ConferenceConsensus conferenceSurvivorsCritical illness
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