2025
Effect of Diabetes on Clinical Outcomes in Patients with Peripheral Arterial Disease undergoing Lower Extremity Revascularization: A Systematic Review and Meta-Analysis
Edjimbi J, Shah N, Kwaah P, Grimshaw A, Regan C, Nagpal S, Attaran R, Chaar C, Romain G, Smolderen K, Mena-Hurtado C. Effect of Diabetes on Clinical Outcomes in Patients with Peripheral Arterial Disease undergoing Lower Extremity Revascularization: A Systematic Review and Meta-Analysis. Journal Of Vascular Surgery 2025 PMID: 40015609, DOI: 10.1016/j.jvs.2025.02.018.Peer-Reviewed Original ResearchLower extremity revascularizationPeripheral arterial diseaseHospital readmissionRelative riskDiabetes mellitusRandom-effects meta-analysisIncreased riskMeta-analysisAssociation of DMExtremity revascularizationMortality riskWound infectionRisk estimatesAssociated with diabetes mellitusClinical outcomesSystematic reviewArtery diseaseSystematic searchObservational studyWound infection riskReadmissionEffects of diabetesAmputationRiskHospitalAssociation between guideline-directed medical therapy and reintervention risk following peripheral vascular interventions in patients with peripheral artery disease.
Callegari S, Romain G, Capuano I, Cleman J, Scierka L, Smolderen K, Mena-Hurtado C. Association between guideline-directed medical therapy and reintervention risk following peripheral vascular interventions in patients with peripheral artery disease. Vascular Medicine 2025, 1358863x251320347. PMID: 39992181, DOI: 10.1177/1358863x251320347.Peer-Reviewed Original ResearchGuideline-directed medical therapyGuideline-directed medical therapy ratesPeripheral vascular interventionsPeripheral arterial diseaseReintervention outcomesReintervention riskMedical therapyArtery diseaseVascular interventionsAngiotensin receptor blockersCompeting risk analysisScore-matched cohortReceipt of statinsPost-PVIAngiotensin-converting enzymeReceptor blockersReinterventionMedicare outcomesMedication adherencePatientsRegistry dataTherapyOutcomesReceiptRiskLower Extremity Flow Quantification Using Dynamic 82Rb PET: a Preclinical Investigation
Guo L, Thorn S, de Rubio Cruz P, Liu Z, Gallezot J, Liu Q, Moulton E, Carson R, Sinusas A, Liu C. Lower Extremity Flow Quantification Using Dynamic 82Rb PET: a Preclinical Investigation. IEEE Transactions On Radiation And Plasma Medical Sciences 2025, PP: 1-1. DOI: 10.1109/trpms.2025.3542729.Peer-Reviewed Original ResearchHealth Status Improvement After Peripheral Vascular Intervention: Insights From the LIBERTY 360 Study
Mosarla R, Chowdhury M, Smolderen K, Mena-Hurtado C, Spertus J, Yeh R, Secemsky E. Health Status Improvement After Peripheral Vascular Intervention: Insights From the LIBERTY 360 Study. The American Journal Of Cardiology 2025, 243: 22-31. PMID: 39894333, DOI: 10.1016/j.amjcard.2025.01.017.Peer-Reviewed Original ResearchPredictor of health statusHealth statusEQ-VASAssociated with health statusHealth status measuresTarget vessel/lesion revascularizationTotal scoreBaseline health statusAll-cause deathImprove health statusPeripheral endovascular interventionsHealth status improvementChronic limb-threatening ischemiaRepeated measures modelPeripheral arterial disease severitySymptomatic peripheral arterial diseaseStatus measuresPeripheral arterial diseaseLimb-threatening ischemiaLong-term improvementPeripheral vascular interventionsStatus improvementHealthMultivariate regressionClaudicationDevelopment of a Clinical and Ultrasonic Parameter-Based Nomogram Model to Predict Restenosis after Superficial Femoral Artery Stenting
Wang Y, Gao M, Zhao X, Han P, Zhang L, Dardik A. Development of a Clinical and Ultrasonic Parameter-Based Nomogram Model to Predict Restenosis after Superficial Femoral Artery Stenting. Annals Of Vascular Surgery 2025, 113: 175-185. PMID: 39855385, DOI: 10.1016/j.avsg.2024.12.068.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAlloysDecision Support TechniquesEndovascular ProceduresFemaleFemoral ArteryHumansMaleMiddle AgedNomogramsPeripheral Arterial DiseasePredictive Value of TestsRecurrenceReproducibility of ResultsRetrospective StudiesRisk AssessmentRisk FactorsSelf Expandable Metallic StentsStentsTime FactorsTreatment OutcomeConceptsIn-stent restenosisSuperficial femoral arteryDecision curve analysisSuperficial femoral artery stentingLogistic regression analysisPeripheral arterial diseaseReceiver operating characteristicNomogram modelClinical utilityCurve analysisMultivariate logistic regression analysisSelf-expanding bare nitinol stentsTreated with stentingReceiver operating characteristic curveRisk of in-stent restenosisNomogram's clinical utilityBare nitinol stentsPrediction of in-stent restenosisExcellent discriminatory powerRegression analysisFemoral artery stentingArtery flow rateRetrospective studyTraining cohortSFA stenting
2024
Presentation and patterns of reinterventions after revascularization in patients with premature peripheral arterial disease
Sivakumar A, Satam K, Wu Z, Alameddine D, Aboian E, Chaer R, Schermerhorn M, Moreira C, Guzman R, Chaar C. Presentation and patterns of reinterventions after revascularization in patients with premature peripheral arterial disease. European Journal Of Vascular And Endovascular Surgery 2024, 68: e77. DOI: 10.1016/j.ejvs.2024.11.007.Peer-Reviewed Original ResearchNew Horizons in Nuclear Cardiology: Imaging of Peripheral Arterial Disease
Callegari S, Mena-Hurtado C, Smolderen K, Thorn S, Sinusas A. New Horizons in Nuclear Cardiology: Imaging of Peripheral Arterial Disease. Journal Of Nuclear Cardiology 2024, 102079. PMID: 39549830, DOI: 10.1016/j.nuclcard.2024.102079.Peer-Reviewed Original ResearchPeripheral arterial diseaseDiagnostic modalitiesRisk stratificationArtery diseaseEarly diagnosisImprove risk stratificationAssociated with higher ratesLower extremity peripheral arterial diseaseEvaluation of therapyClinically relevant areasPreclinical modelsObstructive atherosclerotic diseaseClinical studiesArtery stenosisMicrovascular diseasePreprocedural assessmentPeripheral vasculaturePET imagingAtherosclerotic diseaseNuclear cardiologyTherapeutic interventionsClinical diseaseDiseaseComplex physiologyPerfusionPatient-specific, multiscale modelling of neointimal hyperplasia in lower-limb vein grafts using readily available clinical data
Ninno F, Chiastra C, Donadoni F, Dardik A, Strosberg D, Aboian E, Tsui J, Balabani S, Díaz-Zuccarini V. Patient-specific, multiscale modelling of neointimal hyperplasia in lower-limb vein grafts using readily available clinical data. Journal Of Biomechanics 2024, 177: 112428. PMID: 39561605, DOI: 10.1016/j.jbiomech.2024.112428.Peer-Reviewed Original ResearchTime-averaged wall shear stressInflow boundary conditionsBoundary conditionsWall shear stressShear stressMultiscale modelWaveform shapePeripheral arterial diseaseNeointimal hyperplasiaVein graftsClinical dataMechanobiological mechanismsGraft responseMultiscale in silico modelSystolic acceleration timeThirty-day outcomes from the Disrupt PAD BTK II study of the Shockwave Intravascular Lithotripsy System for treatment of calcified below-the-knee peripheral arterial disease
Chandra V, Lansky A, Sayfo S, Shammas N, Soukas P, Park J, Siah M, Babaev A, Shields R, West N, Armstrong E. Thirty-day outcomes from the Disrupt PAD BTK II study of the Shockwave Intravascular Lithotripsy System for treatment of calcified below-the-knee peripheral arterial disease. Journal Of Vascular Surgery 2024, 81: 710-719.e2. PMID: 39536842, DOI: 10.1016/j.jvs.2024.11.003.Peer-Reviewed Original ResearchPost-operative deathsII studyPercutaneous transluminal angioplastyProcedural successBTK lesionsResidual stenosisFollow-upIntravascular lithotripsyIndex limbCore labRutherford category 3Treated target lesionsUltrasound core laboratoryInterventional clinical studyAngiographic core labThirty-day outcomesMinimal adverse eventsTarget lesion lengthSevere lesion calcificationIVL systemAdverse limb eventsOptimal standard of careStandard of carePeripheral arterial diseaseVascuQol scoresOpen and endovascular treatment of the common femoral artery in a tertiary care center
Wells N, Hundito A, Tuttle M, Alameddine D, Aboian E, Arhuidese I, Fischer U, Perez Lozada J, Guzman R, Ochoa Chaar C. Open and endovascular treatment of the common femoral artery in a tertiary care center. Journal Of Vascular Surgery 2024, 81: 386-396.e2. PMID: 39442735, PMCID: PMC11748354, DOI: 10.1016/j.jvs.2024.10.027.Peer-Reviewed Original ResearchLower extremity revascularizationTreated with open surgeryPeripheral arterial diseaseCFA endarterectomyEndovascular therapyOpen surgeryEndovascular treatmentEndovascular lower extremity revascularizationTreated with endovascular therapyCompared to open surgeryAssociated with higher perioperative complicationsLower extremity revascularization proceduresPost-operative bleedingFemoral arteryImprove patient selectionKaplan-Meier analysisTertiary care centerTertiary-care centerLong-term outcomesEndovascular treatment of peripheral arterial diseaseLonger hospital lengthMALE-free survivalMultivariate logistic regressionTreatment of peripheral arterial diseaseCommon femoral arteryPrediction of Health Status in Patients Undergoing Lower Extremity Intervention for Claudication
Peri-Okonny P, Romain G, Callegari S, Cleman J, Vashist A, Smolderen K, Mena-Hurtado C. Prediction of Health Status in Patients Undergoing Lower Extremity Intervention for Claudication. Annals Of Vascular Surgery 2024, 110: 314-322. PMID: 39395588, DOI: 10.1016/j.avsg.2024.08.016.Peer-Reviewed Original ResearchHealth statusPeripheral arterial diseaseEQ-5D VASPeripheral vascular interventionsPredictor of future health statusPredictor of health statusDrug-coated balloonLower extremity peripheral arterial diseaseHealth status outcomesFuture health statusEQ-5D-3LHistory of deep venous thrombosisImprove patient outcomesStatus outcomesPrediction of health statusChronic lung diseaseDeep venous thrombosisPlain balloon angioplastyPatient outcomesDisease managementExtremity interventionsApproach to treatmentSD ageVenous thrombosisBaseline characteristicsVariations in Antithrombotic Combinations and Prescription Durations After Lower Extremity Revascularization in Patients With Peripheral Arterial Disease
Wells N, Alameddine D, Dhanda U, Tran L, Silva D, Slade M, Guzman R, Chaar C. Variations in Antithrombotic Combinations and Prescription Durations After Lower Extremity Revascularization in Patients With Peripheral Arterial Disease. Journal Of Vascular Surgery 2024, 80: e135-e136. DOI: 10.1016/j.jvs.2024.07.076.Peer-Reviewed Original ResearchThe Incidence and Impact of Cardiac Function Decline after Lower Extremity Revascularization
Jamil Y, Huttler J, Alameddine D, Wu Z, Mena-Hurtado C, Velazquez E, Guzman R, Ochoa Chaar C. The Incidence and Impact of Cardiac Function Decline after Lower Extremity Revascularization. Annals Of Vascular Surgery 2024, 110: 414-423. PMID: 39343374, DOI: 10.1016/j.avsg.2024.07.119.Peer-Reviewed Original ResearchCardiac functional declineStable cardiac functionLower extremity revascularizationPeripheral arterial diseaseCardiac functionFollow-upExtremity revascularizationFunctional declineElectronic records of patientsKaplan-Meier analysisRecords of patientsMode of revascularizationAdverse limb eventsLower-extremity revascularizationTransthoracic echocardiogramReintervention rateHeart failureDiabetes mellitusPeriprocedural bleedingPatient characteristicsArtery diseasePatientsLimb eventsIncreased mortalityRevascularizationAssociation of health status and hospitalization risk for peripheral artery disease in the PORTRAIT registry
Cleman J, Romain G, Scierka L, Labrosciano C, Bradley B, Fitridge R, Beltrame J, Shishehbor M, Spertus J, Mena-Hurtado C, Smolderen K. Association of health status and hospitalization risk for peripheral artery disease in the PORTRAIT registry. Vascular Medicine 2024, 29: 664-674. PMID: 39319857, DOI: 10.1177/1358863x241274758.Peer-Reviewed Original ResearchPeripheral Artery QuestionnairePeripheral arterial diseaseED visitsHealth statusHospital admissionHealthcare utilizationPAD-specific health statusEmergency departmentCause-specific hospital admissionsAssociation of health statusPatient-reported outcome measuresPatient's risk of hospitalizationBaseline health statusAll-cause hospital admissionsCox proportional hazards modelsRisk of hospitalizationOverall summary scorePAQ scoresProportional hazards modelSummary scoreOutcome measuresHospitalization riskArtery diseaseVisitsHazards modelAntithrombotic Strategies for Patients With Peripheral Artery Disease JACC Scientific Statement
Bonaca M, Barnes G, Bauersachs R, Bessada Y, Conte M, Dua A, Hess C, Serhal M, Mena-Hurtado C, Weitz J, Beckman J. Antithrombotic Strategies for Patients With Peripheral Artery Disease JACC Scientific Statement. Journal Of The American College Of Cardiology 2024, 84: 936-952. PMID: 39197984, DOI: 10.1016/j.jacc.2024.06.027.Peer-Reviewed Original ResearchConceptsPeripheral arterial diseaseAntithrombotic strategiesArtery diseaseResponse to antithrombotic therapyLimb eventsRisk of bleedingCoronary artery diseaseAdverse limb eventsAntithrombotic therapyMultidisciplinary working groupClinical scenariosPatientsAssessment of benefit-riskBenefit-riskAnticoagulationDiseaseScientific statementPatient-centeredBleedingCompeting risk analysis to estimate amputation incidence and risk in lower-extremity peripheral artery disease
Callegari S, Smolderen K, Cleman J, Mena-Hurtado C, Romain G. Competing risk analysis to estimate amputation incidence and risk in lower-extremity peripheral artery disease. Vascular Medicine 2024, 29: 496-506. PMID: 39219174, PMCID: PMC11575932, DOI: 10.1177/1358863x241268727.Peer-Reviewed Original ResearchChronic limb-threatening ischemiaAmputation riskTime-to-event analysisPeripheral arterial diseaseLower-extremity peripheral arterial diseaseCumulative incidence functionCompeting risk analysisAmputation incidenceAmputation dataMedicare claimsLimb-threatening ischemiaVascular Quality Initiative registryMortality riskOutcomes researchPeripheral vascular interventionsArtery diseaseAmputationVascular outcomesCox regressionRiskMortalityCohortVascular interventionsTime-to-event methodsPatientsTwelve-month health status response after peripheral vascular intervention for femoropopliteal lesions using Zilver PTX databases focusing on the role of preprocedural health status, comorbid risks, and global setting
Smolderen K, Romain G, Cleman J, Callegari S, Peri-Okonny P, Mena-Hurtado C. Twelve-month health status response after peripheral vascular intervention for femoropopliteal lesions using Zilver PTX databases focusing on the role of preprocedural health status, comorbid risks, and global setting. Journal Of Vascular Surgery 2024, 81: 210-220.e7. PMID: 39214426, DOI: 10.1016/j.jvs.2024.08.035.Peer-Reviewed Original ResearchMinimal clinically important differenceEQ-5D indexHealth statusPeripheral vascular interventionsPeripheral arterial diseaseEQ-5DNon-respondersValue-based careEuroQol-5D-3LClinically important differenceSecondary data analysisFemoropopliteal peripheral vascular interventionsStable health statusLogistic regression modelsArtery diseaseSymptomatic peripheral arterial diseaseStatus responseTailored resourcesVascular interventionsSingle-arm studyImportant differenceCarotid artery diseaseComorbidity riskEnrolling centersPatient characteristicsPeripheral Arterial Disease prevalence and risk factors in the Eastern Caribbean Health Outcomes Research Network (ECHORN) cohort
Adams O, Galusha D, Martinez-Brockman J, Morris E, Hassan S, Maharaj R, Nazario C, Nunez M, Nunez-Smith M. Peripheral Arterial Disease prevalence and risk factors in the Eastern Caribbean Health Outcomes Research Network (ECHORN) cohort. PLOS ONE 2024, 19: e0306918. PMID: 39186495, PMCID: PMC11346651, DOI: 10.1371/journal.pone.0306918.Peer-Reviewed Original ResearchConceptsEastern Caribbean Health Outcomes Research NetworkAnkle brachial indexPeripheral arterial disease prevalencePeripheral arterial diseasePotential risk factorsSample of community-dwelling peopleRisk factorsCommunity-dwelling peopleAssociation of potential risk factorsFemale sexLower educational attainmentHistory of heart diseaseRisk factors of peripheral arterial diseaseCohort Study participantsAssociated with peripheral arterial diseaseHigh school educationHeart diseaseBody mass indexMultivariate logistic regressionOscillometric deviceAssociation of increasing ageSmoking statusYears of ageStudy participantsHeart disease historyAssociation of social support and health status outcomes in peripheral artery disease
Callegari S, Romain G, Cleman J, Scierka L, Peri-Okonny P, Spertus J, Labrosciano C, Beltrame J, Abbott J, Fitridge R, Mena-Hurtado C, Smolderen K. Association of social support and health status outcomes in peripheral artery disease. Journal Of Vascular Surgery 2024, 80: 1824-1835.e7. PMID: 39151740, PMCID: PMC11585422, DOI: 10.1016/j.jvs.2024.08.010.Peer-Reviewed Original ResearchENRICHD Social Support InventoryLow social supportLow perceived social supportGeneric health statusHealth status outcomesPeripheral arterial diseaseSocial supportHealth statusBiopsychosocial variablesStatus outcomesAssociation with health status outcomesAssociated with lower health statusDisease-specific health statusBaseline perceived social supportImprove social supportLower health statusSocial Support InventoryImprove health statusPerceived social supportDisease-specificEQ-5D-3LCare of patientsQuality of lifeEQ-5D-3L indexBiopsychosocial factorsAddressing Psychosocial Care Needs in Women with Peripheral Artery Disease
Mubarak E, Cleman J, Romain G, Mena-Hurtado C, Smolderen K. Addressing Psychosocial Care Needs in Women with Peripheral Artery Disease. Current Cardiology Reports 2024, 26: 1085-1095. PMID: 39073508, DOI: 10.1007/s11886-024-02106-6.Peer-Reviewed Original ResearchVascular careIncreased psychosocial riskPsychosocial care needsIntegration of careMental health comorbiditiesBehavioral health careReviewPeripheral artery diseaseManagement of individualsCare integrationIllness perceptionsGender-based factorsCare needsHealthcare accessHealth behaviorsHealth comorbiditiesSubstance use disordersCare strategiesHealth carePeripheral arterial diseasePsychosocial comorbiditiesReimbursement structuresClinician educationCare paradigmUnique sexPsychosocial risks
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply