2025
Craniosynostosis among children with X-linked hypophosphatemia: A systematic review and meta-analysis
Fisch S, Tudor A, Benchekroun E, Landsberg W, Feldstein N, Lamb M, Carpenter T, Rundle A, Jacobson J, Neugut A, Freedberg D. Craniosynostosis among children with X-linked hypophosphatemia: A systematic review and meta-analysis. Bone 2025, 196: 117488. PMID: 40220947, DOI: 10.1016/j.bone.2025.117488.Peer-Reviewed Original ResearchX-linked hypophosphatemiaPrevalence of craniosynostosisPooled prevalenceSystematic reviewMeta-analysisRandom-effects modelWeb of SciencePediatric populationSkull abnormalitiesCohort studyImpaired phosphate reabsorptionElevated FGF23 levelsPrevalenceFemale predominanceCase seriesFGF23 levelsPhosphate reabsorptionGene variantsChildrenIncreased vigilanceCraniosynostosisAbnormal bone growthGenetic disordersHypophosphatemiaAbnormalitiesLong COVID Incidence Proportion in Adults and Children Between 2020 and 2024: An EHR-Based Study From the RECOVER Initiative
Mandel H, Yoo Y, Allen A, Abedian S, Verzani Z, Karlson E, Kleinman L, Mudumbi P, Oliveira C, Muszynski J, Gross R, Carton T, Kim C, Taylor E, Park H, Divers J, Kelly J, Arnold J, Geary C, Zang C, Tantisira K, Rhee K, Koropsak M, Mohandas S, Vasey A, Mosa A, Haendel M, Chute C, Murphy S, O'Brien L, Szmuszkovicz J, Guthe N, Santana J, De A, Bogie A, Halabi K, Mohanraj L, Kinser P, Packard S, Tuttle K, Hirabayashi K, Kaushal R, Pfaff E, Weiner M, Thorpe L, Moffitt R. Long COVID Incidence Proportion in Adults and Children Between 2020 and 2024: An EHR-Based Study From the RECOVER Initiative. Clinical Infectious Diseases 2025, ciaf046. PMID: 39907495, DOI: 10.1093/cid/ciaf046.Peer-Reviewed Original ResearchElectronic health recordsIncidence proportionIncidence estimatesComputable phenotypeEHR-based studiesLong COVIDPublic health priorityPost-acute sequelae of SARS-CoV-2 infectionHealth recordsSequelae of SARS-CoV-2 infectionHealth priorityProportion of individualsRetrospective cohort studyHarmonized definitionExcess incidenceCohort studyImprove preventionSARS-CoV-2 infectionResearch NetworkRisk factorsAdultsCOVID-19Control groupAcute SARS-CoV-2 infectionPediatric populationIncidence of Surgery for Pediatric Wrist Ganglion Cysts.
Rancu A, Kammien A, Katsnelson B, Diatta F, Lewis K, Grauer J, Colen D. Incidence of Surgery for Pediatric Wrist Ganglion Cysts. Hand 2025, 15589447251314142. PMID: 39891524, PMCID: PMC11787722, DOI: 10.1177/15589447251314142.Peer-Reviewed Original ResearchWrist ganglion cystsGanglion cystYears of follow-upIncidence of surgeryPercentage of patientsNationwide analysisStatistically significant differenceMagnetic resonance imagingNonoperative managementSurgical managementPearlDiver databaseDiagnosis of ganglion cystPediatric populationFollow-upSurgical planningPatient counselingSurgeryPatientsExclusion criteriaResonance imagingFirst diagnosisCystsSignificant differenceDiagnosis codesDiagnosis
2024
Anticoagulation Therapy for Venous Thromboembolism in the Pediatric Population: A Systematic Review and Meta-Analysis
Azzam M, Kawtharany H, Monagle P, Bercovitz R, Hamarsha Q, Alkhader A, Abou Zeid H, Mansour R, Patel P, Tabak C, Baghdadi S, Betensky M, Bhat R, Biss T, Branchford B, Brandao L, Chan A, Faustino E, Jaffray J, Jones S, Kerlin B, Kucine N, Kumar R, Male C, Pelland-Marcotte M, Raffini L, Raulji C, Sartain S, Takemoto C, Tarango C, Van Ommen H, Velez-Yanguas M, Vesely S, Wiernikowski J, Williams S, Wilson H, Woods G, Zia A, Mustafa R. Anticoagulation Therapy for Venous Thromboembolism in the Pediatric Population: A Systematic Review and Meta-Analysis. Blood 2024, 144: 1257-1257. DOI: 10.1182/blood-2024-212150.Peer-Reviewed Original ResearchRisk of biasCertainty of evidenceVenous thromboembolismPediatric patientsThrombus resolutionAll-cause mortalityThrombus recurrenceAC therapyAnticoagulant therapyAbsolute effectEvents of all-cause mortalityPediatric populationSystematic reviewNon-randomized Studies of InterventionsManagement of venous thromboembolismMeta-analysisStudies of interventionsConcerns related to riskNon-randomized observational studyNon-randomized studiesRecommendations AssessmentThrombus progressionBleeding eventsBleeding riskPortal hypertensionPractice patterns of cardiovascular magnetic resonance use in the diagnosis of pediatric myocarditis: A survey-based study
Jacobs H, Soslow J, Cornicelli M, Merves S, Garg R, Patel M, Agarwal A, Misra N, DiLorenzo M, Campbell M, Steele J, Co-Vu J, Robinson J, Lee S, Johnson J. Practice patterns of cardiovascular magnetic resonance use in the diagnosis of pediatric myocarditis: A survey-based study. Journal Of Cardiovascular Magnetic Resonance 2024, 26: 101091. PMID: 39270799, PMCID: PMC11647491, DOI: 10.1016/j.jocmr.2024.101091.Peer-Reviewed Original ResearchLake Louise criteriaDiagnosis of myocarditisCardiovascular magnetic resonancePractice patternsEvaluate clinical practice patternsCardiovascular magnetic resonance evaluationClinical cardiovascular magnetic resonanceNon-invasive cardiac imagingSuspicion of myocarditisParametric mappingPediatric normative dataMagnetic resonance evaluationSpecificity of diagnosisClinical practice patternsDiagnosing myocarditisPediatric myocarditisNormative dataResearch Electronic Data CapturePediatric centersPediatric populationMyocardial diseaseMyocarditisElectronic Data CaptureCMR imagesDiagnostic uncertaintyAssociation Between High-Sensitivity Troponin (hs-cTnT) and Diagnosis of Myocarditis in Previously Healthy Pediatric Patients
Degen M, Leviter J, Bradley A, Karnik R, Ferdman D, McCollum S, Faherty E. Association Between High-Sensitivity Troponin (hs-cTnT) and Diagnosis of Myocarditis in Previously Healthy Pediatric Patients. Pediatric Cardiology 2024, 1-7. PMID: 39126513, DOI: 10.1007/s00246-024-03621-7.Peer-Reviewed Original ResearchDiagnosis of myocarditisPediatric patientsHs-cTnTTroponin levelsCardiac diagnosisHigh-sensitivity troponin THealthy pediatric patientsHigh-sensitivity troponinHs-cTnT groupMedian peak levelSensitivity troponin levelsElevated hs-cTnTCut-off valueInitial troponin levelMyocarditis diagnosisAcute myocarditisTroponin valuesCardiac troponinPediatric populationTroponin TMyocarditisPatientsPeak levelsDiagnosisMyocardial tissueA Protocol for Using Point-of-Care Ultrasound as an Adjunct in Pediatric Cardiac Arrest
Leviter J, Feick M, Riera A, White L. A Protocol for Using Point-of-Care Ultrasound as an Adjunct in Pediatric Cardiac Arrest. Pediatric Emergency Care 2024, 40: 835-838. PMID: 39043130, DOI: 10.1097/pec.0000000000003239.Peer-Reviewed Original ResearchPoint-of-care ultrasoundPediatric cardiac arrestCardiac arrestPoint-of-care ultrasound useLocation of chest compressionHealth care providersAdult cardiac arrestCare providersChest compressionsPoint-of-careStandard-of-care measuresInadequate compressionPediatricPediatric populationPediatric ultrasoundTime-critical eventsProvidersHealthDirect managementInitiation of Buprenorphine Treatment of Opioid Use Disorder in Pediatric Emergency Departments.
Kumar P, Kaliamurthy S, Thomas J. Initiation of Buprenorphine Treatment of Opioid Use Disorder in Pediatric Emergency Departments. Pediatrics 2024, 154 PMID: 38966873, DOI: 10.1542/peds.2024-066226.Peer-Reviewed Original ResearchOpioid use disorderTreatment of opioid use disorderPediatric emergency departmentEmergency departmentOpioid withdrawalUse disorderTreatment of opioid withdrawalBuprenorphine treatment of opioid use disorderCases of adolescent patientsED settingPartial opioid agonistSevere opioid use disorderOutpatient addiction clinicInitiation of buprenorphineImprove patient complianceOutpatient follow-upInitiation of medicationFood and DrugOpioid agonistsPediatric patientsCase seriesWithdrawal symptomsAdolescent patientsBuprenorphine initiationPediatric populationA dual-acting DNASE1/DNASE1L3 biologic prevents autoimmunity and death in genetic and induced lupus models
Stabach P, Sims D, Gomez-Bañuelos E, Zehentmeier S, Dammen-Brower K, Bernhisel A, Kujawski S, Lopez S, Petri M, Goldman D, Lester E, Le Q, Ishaq T, Kim H, Srivastava S, Kumar D, Pereira J, Yarema K, Koumpouras F, Andrade F, Braddock D. A dual-acting DNASE1/DNASE1L3 biologic prevents autoimmunity and death in genetic and induced lupus models. JCI Insight 2024, 9: e177003. PMID: 38888971, PMCID: PMC11383374, DOI: 10.1172/jci.insight.177003.Peer-Reviewed Original ResearchSystemic lupus erythematosusDNASE1L3 deficiencySporadic systemic lupus erythematosusAssociated with systemic lupus erythematosusChromatin degradationDNA accumulationDevelopment of lupusPristane-induced lupusSelf-DNACell free DNAHuman isoformsSystemic lupus erythematosus plasmasDouble knockout miceDNASE1L3Pathogenic effectsFree DNALupus modelEnzymeInducible lupus modelAdult patientsLupus erythematosusKnockout micePediatric populationAutoimmune diseasesDNAManagement of the refractory nocturnal enuresis patient to desmopressin in a pediatric population: Desmopressin + oxybutynin vs. desmopressin + imipramine
Shain S, Gitlin J, Pantazis A, Fine R, Horowitz M, Friedman S, Zelkovic P, Dyer L, Schlussel R, Freyle J, Fang A, Sommer J, Franco I. Management of the refractory nocturnal enuresis patient to desmopressin in a pediatric population: Desmopressin + oxybutynin vs. desmopressin + imipramine. Journal Of Pediatric Urology 2024, 20: 603.e1-603.e8. PMID: 38871547, DOI: 10.1016/j.jpurol.2024.05.024.Peer-Reviewed Original ResearchVancouver Symptom ScoreInternational Children's Continence SocietyWet nightsDesmopressin treatmentCombination therapyResponse rateIntent-to-treat response rateCombination therapy of desmopressinFirst-line medical therapyEfficacy of adjunctive therapyGroup IMPComplete response rateTreated with desmopressinCohort of patientsContinence successPrescribed desmopressinEnuresis patientsMedical therapyNighttime drynessChart reviewAdjunctive therapyConclusion A combinationDesmopressinOxybutyninPediatric populationDominant, Lesional Pediatric-Onset Hemispheric Epilepsy
Knight V, Herlopian A. Dominant, Lesional Pediatric-Onset Hemispheric Epilepsy. 2024, 533-562. DOI: 10.1007/978-3-031-23828-4_22.Peer-Reviewed Original ResearchRasmussen encephalitisCerebrospinal fluid analysis findingsIctal rhythmic dischargesFocal cortical dysplasiaEpilepsia partialis continuaIctal nystagmusPediatric patientsCortical dysplasiaSurgical considerationsStatus epilepticusSurgical interventionPediatric populationCortical myoclonusRhythmic dischargesDevice placementProgressive epilepsyPatientsQuantitative electroencephalographyEncephalitisTechnical considerationsEpilepticusNystagmusA Cross-Sectional Analysis of Pediatric Necrotizing Soft Tissue Infection Cases and Racial Disparities From the 2016 to 2020 National Inpatient Sample
Hamid S, Graetz E, Schneider E, Gibbs K. A Cross-Sectional Analysis of Pediatric Necrotizing Soft Tissue Infection Cases and Racial Disparities From the 2016 to 2020 National Inpatient Sample. Journal Of Surgical Research 2024, 297: 136-143. PMID: 38518580, DOI: 10.1016/j.jss.2024.02.009.Peer-Reviewed Original ResearchConceptsBlack patientsNecrotizing fasciitisOutcomes of necrotizing soft tissue infectionsPediatric populationSoft-tissue infection casesWhite patientsRacial disparitiesDiagnosis of necrotizing fasciitisNSTI casesSoft tissue infectionsProportion of black patientsNational Inpatient SamplePostoperative complicationsTissue infectionsFournier's gangreneSurgical proceduresCross-sectional analysisInfection overallPatientsHispanic patientsInpatient SampleNSTIMortality rateSubcutaneous tissueFasciitisGuidance for prevention and management of COVID-19 in children and adolescents: A consensus statement from the Pediatric Infectious Diseases Society Pediatric COVID-19 Therapies Taskforce
Willis Z, Oliveira C, Abzug M, Anosike B, Ardura M, Bio L, Boguniewicz J, Chiotos K, Downes K, Grapentine S, Hersh A, Heston S, Hijano D, Huskins W, James S, Jones S, Lockowitz C, Lloyd E, MacBrayne C, Maron G, McDonough M, Miller C, Morton T, Olivero R, Orscheln R, Schwenk H, Singh P, Soma V, Sue P, Vora S, Nakamura M, Wolf J. Guidance for prevention and management of COVID-19 in children and adolescents: A consensus statement from the Pediatric Infectious Diseases Society Pediatric COVID-19 Therapies Taskforce. Journal Of The Pediatric Infectious Diseases Society 2024, 13: 159-185. PMID: 38339996, PMCID: PMC11494238, DOI: 10.1093/jpids/piad116.Peer-Reviewed Original ResearchConceptsRisk factorsRisk stratificationPediatric intensive care medicineEffects of therapyNon-hospitalized childrenPediatric infectious diseasesSevere COVID-19Cases of infectionMeta-analysis of dataIntensive care medicineClinical characteristicsPreventive therapyPediatric populationManagement of COVID-19Fatal infectionConsensus statementSevere illnessTherapyMeta-analysisTherapeutic interventionsSARS-CoV-2Expert consensusCare medicineRe-convenedGuidance statementsBiomarkers vs Machines: The Race to Predict Acute Kidney Injury
Ghazi L, Farhat K, Hoenig M, Durant T, El-Khoury J. Biomarkers vs Machines: The Race to Predict Acute Kidney Injury. Clinical Chemistry 2024, 70: 805-819. PMID: 38299927, DOI: 10.1093/clinchem/hvad217.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsAcute kidney injuryEarly diagnosisInsulin-like growth factor-binding protein 7Prediction of acute kidney injuryGrowth factor-binding protein 7Detect acute kidney injuryNeutrophil gelatinase-associated lipocalinAcute kidney injury detectionClinical practiceIrreversible kidney damageClinical outcome studiesImminent AKISerum creatinineKidney injuryInjury markersPediatric populationCystatin CTissue inhibitorHospitalized patientsClinical useKidney damageRegulatory approvalProtein 7BiomarkersOutcome studies
2023
Lyme Carditis in the Pediatric Population
Beach C, Vinocur J. Lyme Carditis in the Pediatric Population. 2023, 111-119. DOI: 10.1007/978-3-031-41169-4_11.Peer-Reviewed Original ResearchHigh-grade AV blockTemporary transvenous pacingPediatricPediatric patientsLyme carditisHemodynamic instabilityAntibiotic therapyPediatric populationPR prolongationTransvenous pacingAV blockCommon manifestationConduction abnormalitiesTimely administrationCarditisFull recoveryPatientsDiseaseGreat majorityAccompanying increaseTherapyPacingAbnormalitiesSuspicionAdministrationProlongationGenetic variants in the vitamin D pathway and their association with vitamin D metabolite levels: Detailed studies of an inner-city pediatric population suggest a modest but significant effect in early childhood
Fu L, Wong B, Li Z, Horst R, Williams R, Lee B, Miller J, Carpenter T, Cole D. Genetic variants in the vitamin D pathway and their association with vitamin D metabolite levels: Detailed studies of an inner-city pediatric population suggest a modest but significant effect in early childhood. The Journal Of Steroid Biochemistry And Molecular Biology 2023, 233: 106369. PMID: 37490983, DOI: 10.1016/j.jsbmb.2023.106369.Peer-Reviewed Original ResearchConceptsVitamin D pathwayD binding proteinPediatric populationInner-city pediatric populationVitamin D metabolite levelsVitamin D insufficiencyRisk pediatric populationsVitamin D metabolismVitamin D binding proteinVitamin D metabolitesD pathwayMonths of ageSanger sequencing confirmationD insufficiencyHealthy infantsD metabolismD levelsD metabolitesMultivariate regression modelLarge cohortMetabolite levelsRelevant associationsPotential roleEarly childhoodInter-individual differencesThe association of epigenetic age acceleration and depressive and anxiety symptom severity among children recently exposed to substantiated maltreatment
Zhang Z, Moeckel C, Mustafa M, Pham H, Olson A, Mehta D, Dorn L, Engeland C, Shenk C. The association of epigenetic age acceleration and depressive and anxiety symptom severity among children recently exposed to substantiated maltreatment. Journal Of Psychiatric Research 2023, 165: 7-13. PMID: 37441927, PMCID: PMC10529086, DOI: 10.1016/j.jpsychires.2023.07.007.Peer-Reviewed Original ResearchConceptsEpigenetic age accelerationSymptom severityAnxiety symptom severitySevere depressiveGreater riskAnxiety disordersStress-sensitive biomarkersAnxiety symptomsMajor risk factorAge accelerationYears of ageMultiple psychiatric disordersChild maltreatmentHorvath clockPediatric populationRisk factorsSubstantiated child maltreatmentPsychiatric disordersPromising biomarkerPredictive valueDiagnostic thresholdDepressiveChildren 8Transitory symptomsSymptomsNational Trends in Pediatric Deaths From Fentanyl, 1999-2021
Gaither J. National Trends in Pediatric Deaths From Fentanyl, 1999-2021. JAMA Pediatrics 2023, 177: 733-735. PMID: 37155161, PMCID: PMC10167597, DOI: 10.1001/jamapediatrics.2023.0793.Peer-Reviewed Original ResearchVariation in the Guidelines for the Acute Management of Anaphylaxis in Pediatric Patients
Athanasopoulou S, Leeds S, Auerbach M. Variation in the Guidelines for the Acute Management of Anaphylaxis in Pediatric Patients. Pediatric Emergency Care 2023, 40: 233-238. PMID: 37358800, DOI: 10.1097/pec.0000000000003003.Peer-Reviewed Original ResearchConceptsPatient harmManagement of anaphylaxisMitigate patient harmEmergency medicine organizationsPediatric patientsNarrative reviewCare of pediatric patientsEvidence-based guidelinesReview of guidelinesNational health organizationsAcute managementGrey literature reviewClinical pathwayReview guidelinesResuscitation CouncilConsensus-based approachMedicine organizationsPrevent errorsHarmonization of guidelinesRate of infusionHealth OrganizationClinical practiceDosing recommendationsPeer reviewPediatric population1100-P: Real-World Use of GLP-1 Agonists in Youth with Type 2 Diabetes Is Associated with Improvements in Hemoglobin A1c—A Multicenter Analysis
SAMUELS S, CHAJECKI A, HU P, KAYSER M, WEYMAN K, PAN B, BROWN E, VAN NAME M, WOLF R. 1100-P: Real-World Use of GLP-1 Agonists in Youth with Type 2 Diabetes Is Associated with Improvements in Hemoglobin A1c—A Multicenter Analysis. Diabetes 2023, 72 DOI: 10.2337/db23-1100-p.Peer-Reviewed Original ResearchGlucagon-like-peptide-1 agonistsFollow-upAmerican Diabetes AssociationType 2 diabetesManagement of T2DDiverse cohort of youthReduced doses of insulinMonths of follow-upMulticenter retrospective analysisGlucagon-like-peptide-1High risk of diabetic complicationsGLP-1 agonistsRisk of diabetic complicationsDoses of insulinPediatric diabetes centersBaseline to follow-upAssociated with improvementsMetformin usePharmacological optionsReduced dosePediatric populationPrandial insulinPrescribed metforminRetrospective analysisNational Institutes of Health
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