2025
Evaluating the association between routine pneumococcal vaccination and COVID-19 severity among older adults in the United States: A case control study
Prunas O, Tiu A, Shioda K, Bansal S, Weinberger D. Evaluating the association between routine pneumococcal vaccination and COVID-19 severity among older adults in the United States: A case control study. Vaccine X 2025, 24: 100622. DOI: 10.1016/j.jvacx.2025.100622.Peer-Reviewed Original ResearchCOVID-19 patientsCase-control studyIntensive care unitSevere respiratory symptomsPneumococcal vaccineSevere outcomesRespiratory symptomsOdds of progressionReceipt of pneumococcal vaccinationCOVID-19 severitySevere COVID-19 outcomesLogistic regression modelsSevere acute respiratory syndrome coronavirus 2Streptococcus pneumoniaeAcute respiratory syndrome coronavirus 2Non-severeRespiratory syndrome coronavirus 2Care unitControlled studiesPatientsSyndrome coronavirus 2COVID-19 outcomesSARS-CoV-2VaccineCoronavirus 2Fertility preserving, uterine sparing approach to a uterine extragonadal yolk sac tumor
Greenman M, McNamara B, Ettorre V, Buza N, Azodi M. Fertility preserving, uterine sparing approach to a uterine extragonadal yolk sac tumor. Gynecologic Oncology Reports 2025, 59: 101778. DOI: 10.1016/j.gore.2025.101778.Peer-Reviewed Original ResearchExtragonadal yolk sac tumorYolk sac tumorSac tumorUterine preservationSpontaneously conceived pregnanciesFertility preservation strategiesYoung womenDegenerating fibroidsNegative marginsWedge resectionSurgical approachStaging procedureTreatment optionsTumorCompleted childbearingRecurrencePatientsWomenReproductive goalsObjective treatmentTreatmentHysterectomyFibroidsMyometriumChemotherapyAssociation of clinical manifestations and immune alterations with genetic variants of uncertain significance in patients concerned for inborn errors of immunity
Novotny S, Yoo N, Chen J, Granoth M, Kohli-Pamnani A, Hsu F, Rodenas M, Steele R, Kaman K, Soffer G, Price C, Kuster J, Kang I, Osmani L, Shin J. Association of clinical manifestations and immune alterations with genetic variants of uncertain significance in patients concerned for inborn errors of immunity. Clinical Immunology 2025, 277: 110513. PMID: 40354868, DOI: 10.1016/j.clim.2025.110513.Peer-Reviewed Original ResearchInborn errors of immunityErrors of immunityGenetic variantsInborn errorsAssociation of clinical manifestationsGene clusterGene functionStudy evaluated associationsImmune alterationsDiagnostic challengeClinical manifestationsImmunological profileGenetic testingVUSGenesImmunological characteristicsImmune functionLaboratory dataImmunityVariantsAssociationPatientsAdherence to SVS Abdominal Aortic Aneurysm Guidelines Among Pati ents Detected by AI-Based Algorithm
Wilson E, Yao K, Kostiuk V, Bader J, Loh S, Mojibian H, Fischer U, Ochoa Chaar C, Aboian E. Adherence to SVS Abdominal Aortic Aneurysm Guidelines Among Pati ents Detected by AI-Based Algorithm. Annals Of Vascular Surgery 2025 PMID: 40349830, DOI: 10.1016/j.avsg.2025.05.007.Peer-Reviewed Original ResearchAbdominal aortic aneurysmAdherent patientsSurgical interventionAbdominal aortic aneurysm patientsNon-adherent patientsTertiary care centerFollow-up adherenceFollow-up algorithmSVS guidelinesImaging surveillanceSurgical criteriaAneurysm sizeAortic aneurysmIdentified patientsPati entsSurveillance adherenceVascular providersImaging scansDeceased patientsPatientsPhysician evaluationCare centerPatient outcomesStatistical significanceNo significant age differencesHypersensitivity pneumonitis associated with home mold exposure: A retrospective cohort analysis
Adams T, Redlich C, Glazer C, Gulati M. Hypersensitivity pneumonitis associated with home mold exposure: A retrospective cohort analysis. PLOS ONE 2025, 20: e0323093. PMID: 40338891, PMCID: PMC12061107, DOI: 10.1371/journal.pone.0323093.Peer-Reviewed Original ResearchConceptsDiagnosis of HPHP patientsRetrospective cohort of patientsMold exposureTransplant free survivalCohort of patientsRetrospective cohort analysisMedical chart reviewDevelopment of HPHypersensitivity pneumonitis patientsHome moldFibrotic HPFree survivalAntigen exposureChart reviewConfident diagnosisRetrospective cohortPneumonic patientsInvasive proceduresHypersensitivity pneumonitisCohort analysisCulprit antigenPatientsImprove outcomesCohortValidity of Diagnostic Codes and Laboratory Tests to Identify Cholangiocarcinoma and Its Subtypes
Ferrante N, Hubbard R, Weinfurtner K, Mezina A, Newcomb C, Furth E, Bhattacharya D, Njei B, Taddei T, Singal A, Hoteit M, Park L, Kaplan D, Re V. Validity of Diagnostic Codes and Laboratory Tests to Identify Cholangiocarcinoma and Its Subtypes. Pharmacoepidemiology And Drug Safety 2025, 34: e70154. PMID: 40328444, PMCID: PMC12055315, DOI: 10.1002/pds.70154.Peer-Reviewed Original ResearchConceptsPositive predictive valueVeterans Health AdministrationExtrahepatic cholangiocarcinomaValidity of diagnostic codesInternational Classification of Diseases for OncologyUS Veterans Health AdministrationConfidence intervalsPharmacoepidemiological studiesICD-O-3Days of diagnosisVA dataHealth AdministrationIntrahepatic cholangiocarcinomaDiagnostic codesHistology codesCholangiocarcinomaUnique patientsInclusion criteriaCholangiocarcinoma subtypesTopography codesPredictive valuePatientsEvaluate medicationsSubtypesEvaluate determinantsOn‐scalp magnetoencephalography based on optically pumped magnetometers to investigate temporal lobe epilepsy
Feys O, Wens V, Depondt C, Rikir E, Gaspard N, Van Paesschen W, Aeby A, Bodart O, Carrette E, Holmes N, Brookes M, Ferez M, Corvilain P, De Tiège X. On‐scalp magnetoencephalography based on optically pumped magnetometers to investigate temporal lobe epilepsy. Epilepsia 2025 PMID: 40317508, DOI: 10.1111/epi.18439.Peer-Reviewed Original ResearchInterictal epileptiform dischargesOptically pumped magnetometersTemporal lobe epilepsyOn-scalp magnetoencephalographyLobe epilepsyRefractory temporal lobe epilepsySignal-to-noise ratioInvestigate temporal lobe epilepsySurgical resection cavityExtratemporal lobe epilepsyOn-scalpResection cavityEpileptiform dischargesPatientsEpilepsyTemporal lobeMEG recordingsMagnetoencephalographyMagnetometerAmplitudeOpioid Dose Variation in Cardiac Surgery: A Multicenter Study of Practice
Fisher C, Janda A, Zhao X, Deng Y, Bardia A, Yanez N, Burns M, Aziz M, Treggiari M, Mathis M, Lin H, Schonberger R. Opioid Dose Variation in Cardiac Surgery: A Multicenter Study of Practice. Anesthesia & Analgesia 2025, 140: 1016-1027. PMID: 39167548, PMCID: PMC11842693, DOI: 10.1213/ane.0000000000007128.Peer-Reviewed Original ResearchCardiac surgeryOpioid doseDose variationIntraoperative opioid administrationIntraoperative opioid doseHigh-dose opioidsAdult cardiac surgerySurgical differencesOpioid-freeOpioid administrationOpioid useMultimodal analgesiaAnalgesic techniquesCardiopulmonary bypassMulticenter studyFentanyl equivalentsSufentanil infusionSurgical patientsOpioidSurgeryAnesthetic techniqueCardiac casesAttending anesthesiologistPatientsDoseSmoking Status of the US Cancer Population and a New Perspective From the National Cancer Database
Caturegli G, Zhu X, Palis B, Mullett T, Resio B, Boffa D. Smoking Status of the US Cancer Population and a New Perspective From the National Cancer Database. JAMA Oncology 2025, 11: 564-566. PMID: 40146125, PMCID: PMC11950973, DOI: 10.1001/jamaoncol.2025.0247.Peer-Reviewed Original ResearchPlain language summary of publication to understand the ROSALIA study: a new biosimilar denosumab for bone health
Eastell R, Jeka S, Lustberg M, Edgerton C, Żuchowski P, Vogg B. Plain language summary of publication to understand the ROSALIA study: a new biosimilar denosumab for bone health. Therapeutic Advances In Musculoskeletal Disease 2025, 17: 1759720x251335147. PMID: 40322084, PMCID: PMC12046156, DOI: 10.1177/1759720x251335147.Peer-Reviewed Original ResearchPostmenopausal osteoporosisBone densityAnti-drug antibodiesRisk of fractureIncreased bone densityNon-clinical studiesResults of switchingDenosumabAdverse eventsBone healthClinical studiesImmune systemMineral ResearchOsteoporosisTreatment groupsJournal of BoneChange treatmentPatient advocacy groupsBoneTreatmentPatientsAntibodiesWomenCommon Cryoneurolysis Targets in Pain Management: Indications, Critical Anatomy, and Potential Complications
Sailer A, Latich I, Levey A. Common Cryoneurolysis Targets in Pain Management: Indications, Critical Anatomy, and Potential Complications. Seminars In Interventional Radiology 2025, 42: 205-212. PMCID: PMC12077947, DOI: 10.1055/s-0045-1804492.Peer-Reviewed Original ResearchQuality of lifePain managementCombination of therapiesImprove quality of lifeIncreased healthcare costsOpioid consumptionAdjunctive therapyHealthcare costsPatient's painUncontrolled painPhysical sufferingPainPotential complicationsAnatomical considerationsCryoneurolysisAbstract PainImprove qualityPatient outcomesPatientsClinical settingPerson's abilityCritical anatomyPatient pathologyTherapyPersonsRecent Survival Gains in Stage IV NSCLC by Sociodemographic Strata
Ayoade O, Canavan M, Zolfaghari E, Caturegli G, Kim S, Boffa D. Recent Survival Gains in Stage IV NSCLC by Sociodemographic Strata. JTO Clinical And Research Reports 2025, 6: 100798. DOI: 10.1016/j.jtocrr.2025.100798.Peer-Reviewed Original ResearchNon-small cell lung cancerStage IV non-small cell lung cancerIV non-small cell lung cancerStage IV NSCLC patientsIV NSCLC patientsCell lung cancerMedian survivalNSCLC patientsLung cancerNon-small cell lung cancer patientsNational Cancer DatabaseKaplan Meier methodTwo-year survivalStratified Cox analysisAdjusted mortality riskMeier methodCancer DatabaseCox analysisEra 1NSCLC treatmentSurvival gainChemotherapy administrationNon-Hispanic blacksPatientsHispanic patientsPost-vasectomy semen analysis: what is the best protocol?
Cahill E, Rabil M, Rotker K, Honig S. Post-vasectomy semen analysis: what is the best protocol? International Journal Of Impotence Research 2025, 1-5. PMID: 40155486, DOI: 10.1038/s41443-025-01052-3.Peer-Reviewed Original ResearchPost-vasectomy semen analysisAmerican Urological AssociationNon-motile spermSemen analysisPatient complianceAmerican Urological Association guidelinesFactors associated with complianceInitial clearance rateUrological AssociationPermanent sterilizationPatientsClearance ratePatient embarrassmentPatient preferencesVasectomyAzoospermiaAt-home testingClearanceIncrease complianceAlternative optionEffective formComplianceContraceptionReducing clinical trial eligibility barriers for patients with MDS: an icMDS position statement
Borate U, Pugh K, Waller A, Welkie R, Huang Y, Bewersdorf J, Stahl M, DeZern A, Platzbecker U, Sekeres M, Wei A, Buckstein R, Roboz G, Savona M, Loghavi S, Hasserjian R, Fenaux P, Sallman D, Hourigan C, Della Porta M, Nimer S, Little R, Santini V, Efficace F, Taylor J, Garcia-Manero G, Odenike O, Kim T, Halene S, Komrokji R, Griffiths E, Greenberg P, Xu M, Xie Z, Bejar R, Sanz G, Patnaik M, Figueroa M, Carraway H, Abdel-Wahab O, Starczynowski D, Padron E, Boultwood J, Gore S, Daver N, Churpek J, Majeti R, Bennett J, List A, Brunner A, Zeidan A. Reducing clinical trial eligibility barriers for patients with MDS: an icMDS position statement. Blood 2025, 145: 1369-1381. PMID: 40146152, DOI: 10.1182/blood.2023023717.Peer-Reviewed Original ResearchConceptsBarriers to clinical trial enrollmentPhase 3 trialClinical trial eligibilityClinical trial enrollmentClinical trialsEligibility criteriaTrial eligibilitySafety signalsTrial enrollmentExclusion criteriaEarly-phase trialsReal-world populationPhase of trialPatientsDrug safety signalsPosition statementRates of anxiety disorders, mood disorders, and substance use disorders in federally qualified health centers, 2019-2022
Tsai J, Witte L, Schick V. Rates of anxiety disorders, mood disorders, and substance use disorders in federally qualified health centers, 2019-2022. Psychiatry Research 2025, 348: 116457. PMID: 40147089, DOI: 10.1016/j.psychres.2025.116457.Peer-Reviewed Original ResearchSubstance use disordersDrug use disordersMood disordersDiagnosis of mental healthAlcohol-related disordersFederally Qualified Health CentersUse disorderMental healthRates of anxiety disordersCOVID-19 pandemicTrauma-related disordersDiagnosis of anxietyU.S. statesAnxiety disordersHealth centersComprehensive health care servicesHealth care servicesPatient populationQualified Health CentersUniform Data SystemDisordersCOVID-19PatientsMoodNational dataIncidence of Dysphagia and Comorbidities in Patients with Cervical Dystonia, Analyzed by Botulinum Neurotoxin Treatment Exposure
Barbano R, Jabbari B, Sadeghi M, Ukah A, Yue E, Ifantides K, Huang N, Swope D. Incidence of Dysphagia and Comorbidities in Patients with Cervical Dystonia, Analyzed by Botulinum Neurotoxin Treatment Exposure. Toxins 2025, 17: 148. PMID: 40137921, PMCID: PMC11945862, DOI: 10.3390/toxins17030148.Peer-Reviewed Original ResearchConceptsIncidence of dysphagiaCervical dystoniaComorbid conditionsContinuous health plan enrollmentCohort entry dateRate of dysphagiaRetrospective cohort studyPre-existing dysphagiaHealth plan enrollmentRisk factors of dysphagiaFactors of dysphagiaReal-world studyPotential adverse eventsPotential risk factorsPatient-level dataReal-world analysisAdverse eventsCD patientsCohort studyComorbid neurological conditionsLongitudinal patient-level dataCD diagnosisDysphagiaDysphagia riskPatientsBCL2 inhibition for multiple myeloma and AL amyloidosis
Cani L, Gupta V, Kaufman J. BCL2 inhibition for multiple myeloma and AL amyloidosis. British Journal Of Haematology 2025 PMID: 40090369, DOI: 10.1111/bjh.20046.Peer-Reviewed Original ResearchMultiple myelomaAL amyloidosisBCL2 inhibitorsLight-chain (ALTreatment landscape of MMPlasma cell disorderMalignant blood disordersDevelopment of novel treatmentsBCL2 inhibitionTreatment landscapeDose optimizationCell disordersPatient selectionClinical studiesBlood disordersNovel treatmentAmyloidosisBCL2Light chainMyelomaToxicity concernsPatientsInhibitorsDrugTreatmentCorticosteroid use to mitigate transaminitis-associated decline in FVIII levels following valoctocogene roxaparvovec gene therapy: clinical practice guidance
Konkle B, Peyvandi F, Foster G, Hermans C, La Mura V, Leavitt A, Lillicrap D, Mahlangu J, Ozelo M, Pipe S, Recht M, Srivastava A, Young G, Miesbach W. Corticosteroid use to mitigate transaminitis-associated decline in FVIII levels following valoctocogene roxaparvovec gene therapy: clinical practice guidance. Journal Of Thrombosis And Haemostasis 2025 PMID: 40090623, DOI: 10.1016/j.jtha.2025.02.042.Peer-Reviewed Original ResearchSevere hemophilia AValoctocogene roxaparvovecFactor VIIIGene therapyHemophilia AMarkers of hepatocyte injuryFactor VIII activity levelsCourse of corticosteroidsFactor VIII levelsElevated alanine transaminaseReduced FVIII levelsClinical practice guidanceFVIII levelsCorticosteroid useAdverse eventsClinical dataClinical trialsCorticosteroidsHepatocyte injuryAlanine transaminaseTherapyPatientsActivity levelsExpert opinionAdultsEffect of digital adherence technologies on treatment outcomes in people with drug-susceptible tuberculosis: four pragmatic, cluster-randomised trials
Jerene D, van Kalmthout K, Levy J, Alacapa J, Deyanova N, Dube T, Mganga A, Tasca B, Bogdanov A, Efo E, Gamazina K, Garfin A, Kochanov V, Leung A, Madden N, Maraba N, McQuaid C, Mleoh L, Onjare B, Powers R, Terleiva Y, van Rest J, Gebhard A, Fielding K, Charalambous S. Effect of digital adherence technologies on treatment outcomes in people with drug-susceptible tuberculosis: four pragmatic, cluster-randomised trials. The Lancet 2025 PMID: 40086457, DOI: 10.1016/s0140-6736(24)02847-2.Peer-Reviewed Original ResearchDrug-susceptible tuberculosisTreatment outcomesPoor treatment outcomesPrimary outcomeDigital adherence technologiesIntervention armCluster randomised trialIntention-to-treat populationStandard of care armTuberculosis treatment outcomesDocumented treatment failureLoss to follow-upStandard of careAdherence technologiesTreatment failureTreatment startAdult patientsFollow-upPatientsTreatment statusPatient outcomesCare armTuberculosisMedicationTrialsCannabis legalization and increasing cannabis use in the United States: Data from urine toxicology testing in emergency room patients
Fink D, Samples H, Malte C, Olfson M, Wall M, Alschuler D, Simpson T, Mannes Z, Saxon A, Hasin D. Cannabis legalization and increasing cannabis use in the United States: Data from urine toxicology testing in emergency room patients. International Journal Of Drug Policy 2025, 138: 104765. PMID: 40058102, PMCID: PMC11967342, DOI: 10.1016/j.drugpo.2025.104765.Peer-Reviewed Original ResearchConceptsUrine drug screensCannabis use disorderMedical cannabis lawsVeterans Health AdministrationCannabis useRecreational cannabis lawsRates of cannabis use disordersCannabis lawsEmergency departmentIndicators of cannabis useUrine toxicology testsIncreased cannabis useDifference-in-differences analysisLegalized cannabis useEmergency room patientsSelf-reported dataBinomial regression modelsED visitsED patientsHealth AdministrationCannabis involvementPatient samplesPatientsUse disorderCannabis
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