2025
BCL2 inhibition for multiple myeloma and AL amyloidosis
Cani L, Gupta V, Kaufman J. BCL2 inhibition for multiple myeloma and AL amyloidosis. British Journal Of Haematology 2025 PMID: 40090369, DOI: 10.1111/bjh.20046.Peer-Reviewed Original ResearchMultiple myelomaAL amyloidosisBCL2 inhibitorsLight-chain (ALTreatment landscape of MMPlasma cell disorderMalignant blood disordersDevelopment of novel treatmentsBCL2 inhibitionTreatment landscapeDose optimizationCell disordersPatient selectionClinical studiesBlood disordersNovel treatmentAmyloidosisBCL2Light chainMyelomaToxicity concernsPatientsInhibitorsDrugTreatmentProceedings of the National Cancer Institute Workshop on combining immunotherapy with radiotherapy: challenges and opportunities for clinical translation
Morris Z, Demaria S, Monjazeb A, Formenti S, Weichselbaum R, Welsh J, Enderling H, Schoenfeld J, Brody J, McGee H, Mondini M, Kent M, Young K, Galluzzi L, Karam S, Theelen W, Chang J, Huynh M, Daib A, Pitroda S, Chung C, Serre R, Grassberger C, Deng J, Sodji Q, Nguyen A, Patel R, Krebs S, Kalbasi A, Kerr C, Vanpouille-Box C, Vick L, Aguilera T, Ong I, Herrera F, Menon H, Smart D, Ahmed J, Gartrell R, Roland C, Fekrmandi F, Chakraborty B, Bent E, Berg T, Hutson A, Khleif S, Sikora A, Fong L. Proceedings of the National Cancer Institute Workshop on combining immunotherapy with radiotherapy: challenges and opportunities for clinical translation. The Lancet Oncology 2025, 26: e152-e170. PMID: 40049206, DOI: 10.1016/s1470-2045(24)00656-9.Peer-Reviewed Original ResearchConceptsAnti-tumor immune responseDelivery of radiotherapyTumor immune recognitionSelection of immunotherapyBiomarker-guided approachesNational Cancer Institute workshopClinical trial dataImmunotherapy combinationsClinical responseImprove patient outcomesPreclinical modelsPatient selectionRadiotherapyImmunotherapyClinical endpointsClinical dataClinical studiesImmune recognitionImmune responseImmune effectsAnimal studiesClinical translationPatient outcomesTrial dataNegative trialsCarotid artery stenting with open versus closed stent cell configurations in the CREST-2 Registry
Lal B, Roubin G, Meschia J, Jones M, Heck D, Sternbergh W, Aronow H, Mena-Hurtado C, Howard G, Mayorga-Carlin M, Sorkin J, Brott T. Carotid artery stenting with open versus closed stent cell configurations in the CREST-2 Registry. Journal Of Vascular Surgery 2025 PMID: 40024381, DOI: 10.1016/j.jvs.2025.02.025.Peer-Reviewed Original ResearchCarotid artery stentingOpen-cell stentClosed-cell stentsFood and Drug Administration-approved deviceArtery stentingEmbolic protectionComparison of clinical outcomesStandardized procedure protocolsSymptomatic patientsPeri-proceduralAntiplatelet therapyPatient selectionClinical outcomesInstitutional experiencePatient characteristicsProcedural detailsCREST-2Lesion characteristicsLesion selectionHigh riskStentVascular anatomyPatient preferencesPatientsProcedure protocolOlaparib in treatment‐refractory isocitrate dehydrogenase 1 (IDH1)– and IDH2‐mutant cholangiocarcinoma: Safety and antitumor activity from the phase 2 National Cancer Institute 10129 trial
Cecchini M, Pilat M, Uboha N, Azad N, Cho M, Davis E, Ahnert J, Tinoco G, Shapiro G, Khagi S, Powers B, Spencer K, Groisberg R, Drappatz J, Chen L, Das B, Bao X, Li J, Narayan A, Vu D, Patel A, Niger M, Doroshow D, Durecki D, Boerner S, Bindra R, Ivy P, Shyr D, Shyr Y, LoRusso P. Olaparib in treatment‐refractory isocitrate dehydrogenase 1 (IDH1)– and IDH2‐mutant cholangiocarcinoma: Safety and antitumor activity from the phase 2 National Cancer Institute 10129 trial. Cancer 2025, 131: e35755. PMID: 39917990, DOI: 10.1002/cncr.35755.Peer-Reviewed Original ResearchConceptsProgression-free survivalHomologous recombination deficiencyClinical benefitNational Cancer InstituteIDH inhibitorsMedian progression-free survivalAccumulation of 2-hydroxyglutaratePhase 2 clinical trialIsocitrate dehydrogenase inhibitorsMedian overall survivalSingle-agent activityNovel combination therapiesEnhance patient selectionSubgroup of patientsOverall survivalOpen-labelCombination therapyIDH mutationsPatient selectionRecombination deficiencySolid tumorsTumor progressionClinical trialsOlaparibCholangiocarcinomaMechanical thrombectomy in elderly stroke patients with low ASPECTS: insights from STAR
Cunningham C, Hubbard Z, Kasem R, Elawady S, Sowlat M, Matsukawa H, Maier I, Jabbour P, Kim J, Wolfe S, T A, Starke R, Psychogios M, Samaniego E, Goyal N, Yoshimura S, Cuellar H, Howard B, Alawieh A, Alaraj A, Ezzeldin M, Romano D, Tanweer O, Mascitelli J, Fragata I, Polifka A, Siddiqui F, Osbun J, Grandhi R, Crosa R, Matouk C, Park M, Levitt M, Brinjikji W, Moss M, Daglioglu E, Williamson R, Navia P, Kan P, De Leacy R, Chowdhry S, Altschul D, Al Kasab S, Spiotta A. Mechanical thrombectomy in elderly stroke patients with low ASPECTS: insights from STAR. Journal Of NeuroInterventional Surgery 2025, jnis-2024-022677. PMID: 39855673, DOI: 10.1136/jnis-2024-022677.Peer-Reviewed Original ResearchAlberta Stroke Program Early CT ScoreLow Alberta Stroke Program Early CT ScorePropensity score matchingSymptomatic intracranial hemorrhageEndovascular thrombectomyAnterior circulation large vessel occlusion acute ischemic strokeElderly patientsLVO-AISAssociated with 90-day mortalityRate of atrial fibrillationScore matchingLarge vessel occlusion acute ischemic strokeFirst-pass reperfusionAcute ischemic strokeCT scoreIntracranial hemorrhagePatient selectionMRS scoreAtrial fibrillationClinical factorsFavorable outcomeRecanalization ratePrimary outcomeMechanical thrombectomyPatientsAdherence to Recommendations and Yield of Critical Care EEG Monitoring: A Prospective Multicentric Study.
Bellante F, Santos S, Gérard L, Jacquet L, Piagnerelli M, Taccone F, Thooft A, Wittebole X, Legros B, Gaspard N. Adherence to Recommendations and Yield of Critical Care EEG Monitoring: A Prospective Multicentric Study. Journal Of Clinical Neurophysiology 2025 PMID: 39810297, DOI: 10.1097/wnp.0000000000001143.Peer-Reviewed Original ResearchGroup of patientsAcute brain injuryClinical seizuresElectrographic seizuresStatus epilepticusClinical factorsEEG monitoringSociety recommendationsMulticenter prospective observational studySeizure riskAmerican Clinical Neurophysiology SocietyMental statusCritically ill adult patientsRefractory status epilepticusConvulsive status epilepticusProspective multicentre studyDetection of electrographic seizuresIll adult patientsLow-risk groupIntensive care unitTime of dischargeBrain injuryPrimary admission diagnosisPatient selectionAdult patientsState of the Art in Left Atrial Appendage Occlusion
Garg J, Kabra R, Gopinathannair R, Di Biase L, Wang D, Saw J, Hahn R, Freeman J, Ellis C, Lakkireddy D. State of the Art in Left Atrial Appendage Occlusion. JACC Clinical Electrophysiology 2025, 11: 602-641. PMID: 39797854, DOI: 10.1016/j.jacep.2024.10.024.Peer-Reviewed Original ResearchConceptsLeft atrial appendage occlusionAppendage occlusionStroke preventionLeft atrial appendage occlusion devicesNonvalvular atrial fibrillationOptimal patient selectionDevice-related thrombusLeft atrial appendagePericardial effusionPostprocedural complicationsPatient selectionAtrial fibrillationAtrial appendageArrhythmia therapyDevice leakTherapeutic targetClinical needOcclusionPreventionStroke
2024
Machine Learning Models for 3-Month Outcome Prediction Using Radiomics of Intracerebral Hemorrhage and Perihematomal Edema from Admission Head Computed Tomography (CT)
Dierksen F, Sommer J, Tran A, Lin H, Haider S, Maier I, Aneja S, Sanelli P, Malhotra A, Qureshi A, Claassen J, Park S, Murthy S, Falcone G, Sheth K, Payabvash S. Machine Learning Models for 3-Month Outcome Prediction Using Radiomics of Intracerebral Hemorrhage and Perihematomal Edema from Admission Head Computed Tomography (CT). Diagnostics 2024, 14: 2827. PMID: 39767188, PMCID: PMC11674633, DOI: 10.3390/diagnostics14242827.Peer-Reviewed Original ResearchIntegrated discrimination indexNet reclassification indexPerihematomal edemaHead computed tomographyIntracerebral hemorrhageComputed tomographyClinical variablesClinical predictors of poor outcomeOutcome predictionAcute supratentorial intracerebral hemorrhageAdmission head computed tomographyRadiomic featuresNon-contrast head computed tomographyPredictors of poor outcomeModified Rankin Scale scoreIntracerebral hemorrhage scoreSupratentorial intracerebral hemorrhageIntracerebral hemorrhage patientsClinical risk factorsRankin Scale scoreReceiver operating characteristic areaOperating characteristics areaSecondary brain injuryHematoma evacuationPatient selectionThe Relationship Between Quantitative Ischemia, Early Revascularization, and Major Adverse Cardiovascular Events A Multicenter Study
Miller R, Bednarski B, Cui Y, Calsavara V, Patel K, Rozanski A, Liang J, Builoff V, Acampa W, Bateman T, Di Carli M, Dorbala S, Einstein A, Fish M, Hauser M, Kaufmann P, Miller E, Ruddy T, Sharir T, Sinusas A, Dey D, Berman D, Slomka P. The Relationship Between Quantitative Ischemia, Early Revascularization, and Major Adverse Cardiovascular Events A Multicenter Study. JACC Advances 2024, 4: 101440. PMID: 39759439, PMCID: PMC11697767, DOI: 10.1016/j.jacadv.2024.101440.Peer-Reviewed Original ResearchMyocardial perfusion imagingEarly revascularizationMyocardial infarctionPerfusion imagingAssociated with reduced riskMedian follow-upImprove patient selectionAssociated with reduced deathSeverity of ischemiaMulticenter registryMale patientsPatient selectionRetrospective analysisFollow-upRandomized trialsRegistry sitesMyocardial ischemiaRevascularizationPatientsIschemiaSurvival analysisAuthors evaluated differencesPropensity scoreRegistryDeathSoutheAsTern eUrope microciRculATION (SATURATION) registry - Design and rationale
Odanovic N, Tsioufis K, Dimitriadis K, Sakalidis A, Papafaklis M, Davlouros P, Ivanov I, Cankovic M, Kalogeropoulos A, Hamilos M, Sideras E, Konigstein M, Zornitzki L, Kovarnik T, Ruzsa Z, Piroth Z, Zdravkovic M, Mehmedbegovic Z, Miovski Z, Jurin H, Kanovsky J, Regev E, Shah S, Ilic I, investigators S. SoutheAsTern eUrope microciRculATION (SATURATION) registry - Design and rationale. Cardiovascular Revascularization Medicine 2024 PMID: 39672766, DOI: 10.1016/j.carrev.2024.11.012.Peer-Reviewed Original ResearchSeattle Angina QuestionnairePatient-centered outcomesEQ-5D-5LQuality of lifeAngina QuestionnaireCoronary function testingInvasive physiologic evaluationMajor adverse cardiovascular eventsStages of coronary artery diseaseCoronary microvascular dysfunctionInvasive coronary physiological assessmentAdverse cardiovascular eventsPotential interventionsSigns of ischemiaCoronary artery diseaseCardiac catheterization labEvaluation of microcirculationDegree of coronary atherosclerosisRegistryCoronary physiology assessmentClinical practiceSymptomatic patientsCardiovascular riskPatient selectionMicrovascular dysfunctionSame Day Discharge after Metabolic and Bariatric Surgery in Adults 65 Years and Older: An Analysis of the 2015 to 2022 MBSAQIP
Hamid S, Graetz E, Esdaille C, Schneider E, Gibbs K. Same Day Discharge after Metabolic and Bariatric Surgery in Adults 65 Years and Older: An Analysis of the 2015 to 2022 MBSAQIP. Obesity Surgery 2024, 35: 25-32. PMID: 39636520, DOI: 10.1007/s11695-024-07611-9.Peer-Reviewed Original ResearchClavien-Dindo complicationsObesity-associated diseasesPostoperative dayBariatric surgeryPrimary sleeve gastrectomyDay dischargeInsulin-dependent diabetesSame-day dischargePOD1 dischargePostoperative morbiditySleeve gastrectomyPatient selectionSafety profileSafety of SDDPatientsSDD protocolCohort of older adultsPOD1Logistic regressionAge groupsSurgeryComplicationsMBSAQIPOlder adultsReadmissionArtificial Intelligence–Driven Patient Selection for Preoperative Portal Vein Embolization for Patients with Colorectal Cancer Liver Metastases
Kuhn T, Engelhardt W, Kahl V, Alkukhun A, Gross M, Iseke S, Onofrey J, Covey A, Camacho J, Kawaguchi Y, Hasegawa K, Odisio B, Vauthey J, Antoch G, Chapiro J, Madoff D. Artificial Intelligence–Driven Patient Selection for Preoperative Portal Vein Embolization for Patients with Colorectal Cancer Liver Metastases. Journal Of Vascular And Interventional Radiology 2024, 36: 477-488. PMID: 39638087, DOI: 10.1016/j.jvir.2024.11.025.Peer-Reviewed Original ResearchTotal liver volumeMetastatic colorectal cancer patientsPreoperative portal vein embolizationColorectal cancer liver metastasesPortal vein embolizationCancer liver metastasesMulticenter retrospective studyColorectal cancer patientsStudent's t-testBoard-certified radiologistsVein embolizationConsecutive patientsLiver metastasesLiver volumePatient selectionRetrospective studyCancer patientsRadiomic featuresInclusion criteriaPatientsSemi-automatic segmentationLab valuesT-testSDAUCMRI after focal therapy for prostate cancer: what radiologists must know?
Jalilianhasanpour R, Arora S, Mansoori B, Raman S, Greenwood B, Sprenkle P, Schade G, Camacho M, Hosseini N, Westphalen A. MRI after focal therapy for prostate cancer: what radiologists must know? Abdominal Radiology 2024, 1-20. PMID: 39542951, DOI: 10.1007/s00261-024-04670-5.Peer-Reviewed Original ResearchClinical Implementation of fMRI and EEG to Detect Cognitive Motor Dissociation
Bodien Y, Fecchio M, Freeman H, Sanders W, Meydan A, Lawrence P, Kirsch J, Fischer D, Cohen J, Rubin E, He J, Schaefer P, Hochberg L, Rapalino O, Cash S, Young M, Edlow B. Clinical Implementation of fMRI and EEG to Detect Cognitive Motor Dissociation. Neurology Clinical Practice 2024, 15: e200390. PMID: 39473967, PMCID: PMC11515113, DOI: 10.1212/cpj.0000000000200390.Peer-Reviewed Original ResearchCognitive motor dissociationTask-based functional MRIMotor dissociationLanguage functionEvidence-based guidelinesBehavioral evidenceFunctional MRIEEG assessmentClinical careBrain injuryEvidence baseClinical assessmentPatient selectionClinical implementationPatientsReports lessonsEEGFMRIUnited StatesEffective strategyAssessmentEthical implicationsCareBrainCriteriaMapper: establishing the automatic identification of clinical trial cohorts from electronic health records by matching normalized eligibility criteria and patient clinical characteristics
Lee K, Mai Y, Liu Z, Raja K, Jun T, Ma M, Wang T, Ai L, Calay E, Oh W, Schadt E, Wang X. CriteriaMapper: establishing the automatic identification of clinical trial cohorts from electronic health records by matching normalized eligibility criteria and patient clinical characteristics. Scientific Reports 2024, 14: 25387. PMID: 39455879, PMCID: PMC11511882, DOI: 10.1038/s41598-024-77447-x.Peer-Reviewed Original ResearchConceptsElectronic health recordsCell lung cancerEligibility criteriaClinical characteristicsLung cancerHealth recordsNon-small cell lung cancerSmall cell lung cancerPatient clinical characteristicsClinical trial cohortPatients' electronic health recordsIdentification of patientsClinical trial criteriaIdentification of eligible patientsSickle cell anemiaNon-alcoholic steatohepatitisStandardized terminologyProstate cancerMultiple myelomaTrial eligibility criteriaPatient selectionTrial cohortBreast cancerEligible patientsTrial criteriaPtcog International Survey of Practice Patterns and Trends in Utilization of Proton Therapy for Breast Cancer
Choi I, Abeloos C, Lozano A, Kim M, Hanlon A, Vargas C, Maduro J, Bradley J, Offersen B, Haffty B, Pankuch M, Amos R, Kim N, Kirova Y, Mutter R. Ptcog International Survey of Practice Patterns and Trends in Utilization of Proton Therapy for Breast Cancer. International Journal Of Radiation Oncology • Biology • Physics 2024, 120: e742-e743. DOI: 10.1016/j.ijrobp.2024.07.1632.Peer-Reviewed Original ResearchRegional nodal irradiationParticle Therapy Co-Operative GroupBreast cancerBC patientsPractice patternsDose-fractionation regimensHighly-selected patientsProton beam therapyPatient selection criteriaPencil beam scanningFisher's exact testEvolution of practice patternsPatient selection methodsClinical trial enrollmentSurvey of practice patternsImage guidance capabilitiesTreated BC patientsHypofractionated regimensNodal irradiationRecurrent BCBeam therapyPatient selectionProton therapyU.S. centersExact testImpact of Synthetic PET Evaluation prior to PET-Guided Functional Modeling in Optimizing Patient Selection for Biology-Guided Radiotherapy
Hicks D, Chen H, Kim J, Tressel L, Wallington D, Becht K, Johung K, Young M, Feghali K, de Jong D, Chen Z, Carlson D, Park H. Impact of Synthetic PET Evaluation prior to PET-Guided Functional Modeling in Optimizing Patient Selection for Biology-Guided Radiotherapy. International Journal Of Radiation Oncology • Biology • Physics 2024, 120: s162-s163. DOI: 10.1016/j.ijrobp.2024.07.2188.Peer-Reviewed Original ResearchPlanning target volumeInternal target volumeBiology-guided radiotherapyStereotactic body radiotherapyGross tumor volumeTarget volumeCT simulationOptimal patient selectionPET evaluationStereotactic body radiotherapy planLung target volumesPatient selectionPTV edgesLung casesBgRTPET-CTTumor sizeTumor volumeRadiotherapyCase 2PET dataLungActivity concentrationsPatientsConsistent with resultsClinical Genetic Testing in Nephrology: Core Curriculum 2024
Aron A, Dahl N. Clinical Genetic Testing in Nephrology: Core Curriculum 2024. American Journal Of Kidney Diseases 2024, 84: 632-645. PMID: 39340488, DOI: 10.1053/j.ajkd.2024.05.011.Peer-Reviewed Original ResearchClinical genetic testingGenetic testingRoutine diagnostic workup of patientsKidney diseaseDiagnostic workup of patientsDiagnostic yield of testingRoutine diagnostic workupWorkup of patientsRoutine nephrology careYield of testingGenetic resultsImprove careCore curriculumReduce barriersDiagnostic odysseyExtrarenal manifestationsDiagnostic yieldMonogenic etiologyPatient selectionReduce anxietyPatient populationNephrology careTreatment planningFamily planningSecondary findingsBladder-sparing Therapy for Bacillus Calmette-Guérin–unresponsive Non–muscle-invasive Bladder Cancer: International Bladder Cancer Group Recommendations for Optimal Sequencing and Patient Selection
Li R, Hensley P, Gupta S, Al-Ahmadie H, Babjuk M, Black P, Brausi M, Bree K, Fernández M, Guo C, Horowitz A, Lamm D, Lerner S, Lotan Y, Mariappan P, McConkey D, Mertens L, Mir C, Ross J, O'Donnell M, Palou J, Pohar K, Steinberg G, Soloway M, Spiess P, Svatek R, Tan W, Taoka R, Buckley R, Kamat A. Bladder-sparing Therapy for Bacillus Calmette-Guérin–unresponsive Non–muscle-invasive Bladder Cancer: International Bladder Cancer Group Recommendations for Optimal Sequencing and Patient Selection. European Urology 2024, 86: 516-527. PMID: 39183090, DOI: 10.1016/j.eururo.2024.08.001.Peer-Reviewed Original ResearchNon-muscle-invasive bladder cancerInternational Bladder Cancer GroupBladder-sparing treatmentCarcinoma in situNadofaragene firadenovecRadical cystectomyBladder cancerOptimal selection of patientsAbsence of randomized trialsBladder-sparing therapySingle-agent chemotherapyBladder cancer groupSelection of patientsDevelopment of agentsPatient selectionSystemic toxicityCancer groupUnapproved agentsClinical trial participationPatient characteristicsRandomized trialsMitomycin CTumor attributesConsensus recommendationsCancer expertsEvolution of Vascularized Composite Allotransplantation
Huelsboemer L, Pomahac B. Evolution of Vascularized Composite Allotransplantation. 2024, 15-27. DOI: 10.1007/978-3-031-57132-9_3.Peer-Reviewed Original ResearchVascularized composite allotransplantationSolid organ transplantationProlongation of ischemia timeReconstruction of complex tissue defectsContext of vascularized composite allotransplantationDevelopment of non-toxicTolerogenic strategiesChronic rejectionImmunosuppressive medicationsTolerance inductionComplex tissue defectsPatient selectionIschemia time
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