2025
Collagen Hybridizing Peptide-Based Radiotracers for Molecular Imaging of Collagen Turnover in Pulmonary Fibrosis.
Ahmad A, Ghim M, Kukreja G, Neishabouri A, Zhang Z, Li J, Salarian M, Toczek J, Gona K, Hedayatyanfard K, Morrison T, Zhang J, Huang Y, Liu C, Yu S, Sadeghi M. Collagen Hybridizing Peptide-Based Radiotracers for Molecular Imaging of Collagen Turnover in Pulmonary Fibrosis. Journal Of Nuclear Medicine 2025, 66: 425-433. PMID: 39915119, PMCID: PMC11876730, DOI: 10.2967/jnumed.124.268832.Peer-Reviewed Original ResearchConceptsPulmonary fibrosisTracer uptakeLung uptakeMurine model of pulmonary fibrosisModel of pulmonary fibrosisMice 3 wkEffect of antifibrotic therapyCollagen turnoverInterstitial lung diseaseClinical diagnostic methodsSPECT/CT imagingHybrid tracersLung histologyAntifibrotic therapyControl miceDisease activityMurine modelLung diseaseMice 8Tissue fibrosisPatient managementLiver uptakeSPECT/CTFibrosisSPECT images
2024
Beyond cholangiocarcinoma: imaging features of mimicking pathologies in the biliary tract
Khasawneh H, O’Brien C, Czeyda-Pommersheim F, Qayyum A, Miller F, Arif Tiwari H, Paspulati R, Kierans A. Beyond cholangiocarcinoma: imaging features of mimicking pathologies in the biliary tract. Abdominal Radiology 2024, 1-16. PMID: 39710762, DOI: 10.1007/s00261-024-04749-z.Peer-Reviewed Original ResearchMalignant conditionsOverlap of imaging findingsDiagnosis of cholangiocarcinomaPrimary malignancyDifferentiate cholangiocarcinomaHistopathological confirmationImaging findingsMorphological subtypesDifferential diagnosisBiliary tractHeterogeneous diseaseDiagnostic accuracyPatient managementCholangiocarcinomaAccurate diagnosisHepatobiliary systemImage featuresPeriductal-infiltratingClinical practiceImaging characteristicsDiagnosisHeart lung axis in acute pulmonary embolism: Role of CT in risk stratification
Friedman R, Haramati L, Christian T, Sokol S, Alis J. Heart lung axis in acute pulmonary embolism: Role of CT in risk stratification. Clinical Imaging 2024, 116: 110311. PMID: 39413674, DOI: 10.1016/j.clinimag.2024.110311.Peer-Reviewed Original ResearchPathophysiology of pulmonary embolismRisk stratificationPulmonary embolismComputed tomographyRight ventricular (RV) dysfunctionRisk stratification of acute PEIndicator of RV dysfunctionRV/LV diameter ratioAcute pulmonary embolismLeft atrial volumeReview current guidelinesCause of mortalityRV dysfunctionAcute PEAtrial volumeCT findingsClot burdenCardiopulmonary reserveCurrent guidelinesLung axisClot locationPatient managementPatient populationRadiologist's reportPredictive valueDetection of Gastrointestinal Bleeding With Large Language Models to Aid Quality Improvement and Appropriate Reimbursement
Zheng N, Keloth V, You K, Kats D, Li D, Deshpande O, Sachar H, Xu H, Laine L, Shung D. Detection of Gastrointestinal Bleeding With Large Language Models to Aid Quality Improvement and Appropriate Reimbursement. Gastroenterology 2024, 168: 111-120.e4. PMID: 39304088, DOI: 10.1053/j.gastro.2024.09.014.Peer-Reviewed Original ResearchElectronic health recordsOvert gastrointestinal bleedingGastrointestinal bleedingRecurrent bleedingMachine learning modelsHealth recordsClinically relevant applicationsNursing notesLanguage modelAcute gastrointestinal bleedingQuality improvementLearning modelsDetection of gastrointestinal bleedingReimbursementIdentification of clinical conditionsSeparate hospitalsQuality measuresHospitalBleedingClinical conditionsPatient managementEarly identificationPatientsReimbursement codesCoding algorithmThe COVID-19 thrombus: distinguishing pathological, mechanistic, and phenotypic features and management
Becker R, Tantry U, Khan M, Gurbel P. The COVID-19 thrombus: distinguishing pathological, mechanistic, and phenotypic features and management. Journal Of Thrombosis And Thrombolysis 2024, 58: 15-49. PMID: 39179952, PMCID: PMC11762605, DOI: 10.1007/s11239-024-03028-4.Peer-Reviewed Original ResearchNeutrophil extracellular trapsMild to moderate illnessHost immunoinflammatory responseOptimal patient managementSARS-CoV-2SARS-CoV-2 infectionEndothelial cell inflammationVascular endothelial cellsSurveillance modalitiesClinical featuresOrgan injuryImmunoinflammatory responseMicrovascular thrombosisInflammatory signatureAtherothrombotic phenotypeCirculating monocytesChronic phasePatient managementVascular eventsAcute phaseExtracellular trapsCritical illnessThrombosisEndothelial cellsMedical literatureTailoring neoadjuvant systemic therapy in breast cancer: “The advent of a personalized approach”—The Breast‐Gynecological and Immuno‐Oncology International Cancer Conference (BGICC) consensus and recommendations
Elghazaly H, Azim H, Rugo H, Cameron D, Swain S, Curigliano G, Harbeck N, Tripathy D, Arun B, Aapro M, Piccart M, Cardoso F, Gligorov J, Elghazawy H, Saghir N, Penault‐Llorca F, Perez E, Poortmans P, Abdelaziz H, El‐Zawahry H, Kassem L, Sabry M, Viale G, Al‐Sukhun S, Gado N, Leung J, Elarab L, Cardoso M, Karim K, Foheidi M, Elmaadawy M, Conte P, Selim A, Kandil A, Kamal R, Paltuev R, Guarneri V, Abulkhair O, Zakaria O, Golshan M, Orecchia R, ElMahdy M, Abdel‐Aziz A, Eldin N. Tailoring neoadjuvant systemic therapy in breast cancer: “The advent of a personalized approach”—The Breast‐Gynecological and Immuno‐Oncology International Cancer Conference (BGICC) consensus and recommendations. Cancer 2024, 130: 3251-3271. PMID: 38985794, DOI: 10.1002/cncr.35389.Peer-Reviewed Original ResearchBreast cancerNeoadjuvant therapyManagement of early breast cancerEarly breast cancerIndividual patient managementDe-escalation strategiesModified Delphi approachBC expertsPostneoadjuvant treatmentSystemic therapyClinical evidencePatient managementConsensus recommendationsClinical situationsTherapyDe-escalationDelphi approachTherapy outcomeTreatment settingsCancerExpert opinionRecommendationsBreastConsensusRenal bleeding: imaging and interventions in patients with tumors
Singer E, Karbasian N, Katz D, Wong V, Abdelsalam M, Stanietzky N, Nguyen T, Shenoy-Bhangle A, Badawy M, Revzin M, Shehata M, Eltaher M, Elsayes K, Korivi B. Renal bleeding: imaging and interventions in patients with tumors. Diagnostic And Interventional Radiology 2024 PMID: 38874163, DOI: 10.4274/dir.2024.242822.Peer-Reviewed Original ResearchRenal bleedingComputed tomographyRenal tumorsSpontaneous renal bleedingMalignant renal tumorsRenal cell carcinomaCross-sectional imaging techniquesFollow-up evaluationEffective patient managementMagnetic resonance imagingAdvanced imaging techniquesCell carcinomaClinical presentationCoagulation disordersImaging techniquesImaging findingsVascular anomaliesUreteral obstructionTreatment optionsEnhancing massBleedingPatient managementTumorResonance imagingPatientsCerebral venous sinus thrombosis associated with cancer: analysis of the ACTION-CVT study
Vedovati M, Shu L, Henninger N, Zubair A, Heldner M, Al Kasab S, Siegler J, Liebeskind D, Antonenko K, Yaghi S, Paciaroni M. Cerebral venous sinus thrombosis associated with cancer: analysis of the ACTION-CVT study. Journal Of Thrombosis And Thrombolysis 2024, 57: 1008-1017. PMID: 38824485, PMCID: PMC11315801, DOI: 10.1007/s11239-024-02997-w.Peer-Reviewed Original ResearchCases of cerebral vein thrombosisVenous thromboembolismRisk of recurrent venous thromboembolismRadiological characteristics of patientsCerebral vein thrombosisRecurrent venous thromboembolismKaplan-Meier methodLog-rank testAbsence of headacheAll-cause-deathLogistic regression analysisCharacteristics of patientsCancer statusCohort studyPropensity score matchingConsecutive patientsAssociated with cancerRadiological characteristicsVein thrombosisStudy outcomesRecanalization rateOlder ageRisk factorsMultivariate analysisPatient managementApplication of Computerized Surgical Planning in Craniosynostosis Surgery
Parikh N, Aral A, Lewis K, Alperovich M. Application of Computerized Surgical Planning in Craniosynostosis Surgery. Seminars In Plastic Surgery 2024, 38: 214-223. PMID: 39118860, PMCID: PMC11305832, DOI: 10.1055/s-0044-1786803.Peer-Reviewed Original ResearchComputerized surgical planningSurgical planningMultiple cranial suturesComputed tomography scanTreatment of craniosynostosisSurgical guide designPreoperative imagingIntraoperative timeSurgical correctionCraniofacial surgeryCraniosynostosis surgeryTomography scanTreatment modalitiesCraniosynostosis casesIntraoperative implementationPatient managementPremature fusionPreoperative planningMedical trainee educationCraniosynostosisCranial suturesResidency trainingMedical conditionsSurgeryPatient educationReevaluating the Role of T2/FLAIR Mismatch Sign: Improving Diagnostic Accuracy With Qualitative MRI Features?
Willms K, von Reppert M, Lost J, Tillmanns N, Merkaj S, Huttner A, Schrickel E, Memon F, Aboian M. Reevaluating the Role of T2/FLAIR Mismatch Sign: Improving Diagnostic Accuracy With Qualitative MRI Features? Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2024 DOI: 10.58530/2024/3586.Peer-Reviewed Original ResearchT2/FLAIR mismatch signIDH-mutant gliomasT2/FLAIR-mismatchVASARI featuresDiagnostic accuracyAccurate preoperative diagnosisIDH-mutant astrocytomasAccurate patient managementQualitative MRI featuresImproving diagnostic accuracyPreoperative diagnosisIDH-mutantImproved diagnostic toolsMRI featuresEnhanced diagnostic methodMismatch signGlioma subtypesPatient managementGlioma cohortGliomaNoninvasive methodDiagnostic precisionDiagnostic methodsDiagnostic toolAstrocytomaArtificial intelligence in liver cancer — new tools for research and patient management
Calderaro J, Žigutytė L, Truhn D, Jaffe A, Kather J. Artificial intelligence in liver cancer — new tools for research and patient management. Nature Reviews Gastroenterology & Hepatology 2024, 21: 585-599. PMID: 38627537, DOI: 10.1038/s41575-024-00919-y.Peer-Reviewed Original ResearchLiver cancer managementLiver cancerCancer managementCancer careArtificial intelligenceClinically approved productsInterdisciplinary trainingTumor typesClinical dataClinical trialsPatient managementClinical useCancerPotential of AILiverHidden informationNatural languageIncorporation of AIAI approachesAI systemsPatientsConsensus and controversy in the management of paediatric and adult patients with ovarian immature teratoma: the Malignant Germ Cell International Consortium perspective
Pashankar F, Murray M, Gell J, MacDonald N, Shamash J, Billmire D, Klosterkemper L, Olson T, Hirsch M, Lockley M, Stoneham S, Frazier A. Consensus and controversy in the management of paediatric and adult patients with ovarian immature teratoma: the Malignant Germ Cell International Consortium perspective. EClinicalMedicine 2024, 69: 102453. PMID: 38544795, PMCID: PMC10965411, DOI: 10.1016/j.eclinm.2024.102453.Peer-Reviewed Original ResearchOvarian immature teratomaImmature teratomaElevated serum alpha-fetoproteinSurgery-only approachSerum alpha-fetoproteinOvarian ITStage IAAdjuvant chemotherapyRare neoplasmsOvarian cancerAdult patientsAlpha-fetoproteinLack of published dataPathologic interpretationPatient managementLow-gradeGrade 1Multiple subspecialtiesPatientsTeratomaYoung femalesAdult practiceNational advisory panelPaediatric teamGCTThe Critical Challenge of Neonatal Airway Management: An Overview
Johnston L, Sawyer T. The Critical Challenge of Neonatal Airway Management: An Overview. 2024, 3-10. DOI: 10.1007/978-3-031-71946-2_1.Peer-Reviewed Original ResearchNeonatal airway managementAirway managementNeonatal intensive care unitAirway management techniquesIntensive care unitLaryngeal mask airwayAirway management proceduresDelivery roomPatient managementCare unitVideo laryngoscopyAirwayNeonatesSystemic factorsHypoxemiaBradycardiaPatientsInfantsLaryngoscopyPremedication
2023
Saudi consensus guidance for the management of inflammatory bowel disease during pregnancy.
Azzam N, Almutairdi A, Almudaiheem H, AlAmeel T, Bakkari S, Alharbi O, Alenzi K, AlMolaiki M, Al-Omari B, Albarakati R, Al-Jedai A, Saadah O, Almadi M, Al-Bawardy B, Mosli M. Saudi consensus guidance for the management of inflammatory bowel disease during pregnancy. Saudi Journal Of Gastroenterology 2023, 30 PMID: 38099556, PMCID: PMC11379253, DOI: 10.4103/sjg.sjg_318_23.Peer-Reviewed Original ResearchInflammatory bowel diseaseManagement of IBDPregnant womenBowel diseaseClear evidence-based recommendationsSubset of patientsClinical care pathwayExpert opinion recommendationsOptimal patient managementEvidence-based recommendationsMultidisciplinary working groupCare pathwayClinical pharmacologyPatient managementPatient basisConsensus guidanceMultidisciplinary teamSaudi MinistryWomenPatientsDiseaseConcise guidelinesWorking GroupLiterature reviewManagementRole of POCUS in Assessing an Acute Aortic Thrombus
Boivin Z, Mensel E, She T. Role of POCUS in Assessing an Acute Aortic Thrombus. POCUS Journal 2023, 8: 129-131. PMID: 38099158, PMCID: PMC10721302, DOI: 10.24908/pocus.v8i2.16480.Peer-Reviewed Original ResearchAortic thrombusComputed tomographyEnd-organ ischemiaRole of POCUSProximal abdominal aortaParoxysmal atrial fibrillationUrgent surgical consultationMajor arterial branchesAbdominal painMobile thrombusFemale patientsAtrial fibrillationSurgical consultationFilling defectRecent diagnosisAbdominal aortaPatient managementArterial branchesCare ultrasoundThrombusNovel casePatientsPOCUSPainIschemiaClinical Data Do Not Reliably Predict Duodenal Histology at Follow-up in Celiac Disease
Patel N, Leffler D, Al-Toma A, Mulder C, Elli L, Gan G, Patil P, Atsawarungruangkit A, Kuijpers K, Del Gobbo A, Goldsmith J, Hintze Z, Pacheco M, Vieth M, Melcher B, Salomao M, Pai R, Hart J, Olivas A, Naini B, Meyerson C, Choi W, Kakar S, Westerhoff M, Cheng J, Gopal P, Hammer S, Prats M, Bronner M, Robert M. Clinical Data Do Not Reliably Predict Duodenal Histology at Follow-up in Celiac Disease. The American Journal Of Surgical Pathology 2023, 48: 212-220. PMID: 37994653, DOI: 10.1097/pas.0000000000002150.Peer-Reviewed Original ResearchIntraepithelial lymphocytesCeliac diseaseClinical dataMarsh scoreMucosal recoveryVillous bluntingDuodenal biopsiesMucosal injuryDiet adherenceGluten-free diet adherenceComplete histologic remissionPersistent mucosal injuryMinority of patientsCeliac disease patientsDuodenal histologyHistologic remissionPathologists' awarenessMucosal statusMucosal healingGastrointestinal pathologistsDisease patientsFollow-upPatient managementEligibility criteriaPatientsImpact and Implications of Neurocognitive Dysfunction in the Management of Ischemic Heart Failure
Tirziu D, Kołodziejczak M, Grubman D, Carrión C, Driskell L, Ahmad Y, Petrie M, Omerovic E, Redfors B, Fremes S, Browndyke J, Lansky A. Impact and Implications of Neurocognitive Dysfunction in the Management of Ischemic Heart Failure. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 101198. PMID: 39131066, PMCID: PMC11308118, DOI: 10.1016/j.jscai.2023.101198.Peer-Reviewed Original ResearchIschemic heart failureHeart failureNeurocognitive dysfunctionCognitive impairmentCoronary Artery Bypass GraftingArtery Bypass GraftingChronic cerebral hypoperfusionCoronary artery bypassPercutaneous coronary interventionPoor cognitive functionArtery bypassBypass GraftingCardiovascular outcomesCerebral hypoperfusionCoronary revascularizationCerebral hypoxiaCoronary interventionNeurologic injuryCardiac outputWorse outcomesBrain damageBrain injuryPatient outcomesInvasive approachPatient managementFrom bench to bedside – current clinical and translational challenges in fibula free flap reconstruction
Baecher H, Hoch C, Knoedler S, Maheta B, Kauke-Navarro M, Safi A, Alfertshofer M, Knoedler L. From bench to bedside – current clinical and translational challenges in fibula free flap reconstruction. Frontiers In Medicine 2023, 10: 1246690. PMID: 37886365, PMCID: PMC10598714, DOI: 10.3389/fmed.2023.1246690.Peer-Reviewed Original ResearchFibula free flapFibula free flap reconstructionAdequate bone lengthPostoperative patient managementMinimal donor site morbidityDual blood supplyFree flap reconstructionClinical research effortsDonor site morbidityTranslational challengesVirtual surgical planningPatient outcomesPreoperative phaseFlap reconstructionPatient managementBlood supplyPaucity of studiesMicrosurgical techniquesFree flapReconstructive scenariosSite morbiditySurgical templateMandible reconstructionNovel flapMaxillary defectsExtrauterine epithelioid trophoblastic tumour and its somatic carcinoma mimics: short tandem repeat genotyping meets the diagnostic challenges
Niu N, Ordulu Z, Burak Z, Buza N, Hui P. Extrauterine epithelioid trophoblastic tumour and its somatic carcinoma mimics: short tandem repeat genotyping meets the diagnostic challenges. Histopathology 2023, 84: 325-335. PMID: 37743102, DOI: 10.1111/his.15054.Peer-Reviewed Original ResearchConceptsEpithelioid trophoblastic tumorGestational trophoblastic tumorsTrophoblastic tumorExtrauterine sitesSomatic carcinomasDifferential diagnosisDiagnosis of ETTExtrauterine epithelioid trophoblastic tumorsTriple-negative breast carcinomaTrophoblastic differentiationMetastatic triple-negative breast carcinomaPrimary lung carcinomaMain differential diagnosisMajor differential diagnosisEctopic gestationImmunohistochemical featuresDiagnostic challengeMetastatic tumorsLung carcinomaBreast carcinomaPatient managementEpithelioid malignanciesImmunohistochemical levelCarcinomaTumor tissueCRP Versus SAA for Identification of Inflammatory Hepatic Adenomas
Soon G, Yasir S, Jain D, Kakar S, Wu T, Yeh M, Torbenson M, Chen Z. CRP Versus SAA for Identification of Inflammatory Hepatic Adenomas. Applied Immunohistochemistry & Molecular Morphology 2023, 31: 590-595. PMID: 37698958, DOI: 10.1097/pai.0000000000001155.Peer-Reviewed Original ResearchConceptsC-reactive proteinFocal nodular hyperplasiaHepatic adenomaInflammatory hepatic adenomaInflammatory adenomasNodular hyperplasiaH-scorePositive C-reactive proteinBeta-catenin activationProportion of casesInflammatory hepatocellular adenomaGlutamine synthetase stainingComplication riskRetrospective studyResection specimensPatient managementHepatocellular adenomaImmunohistochemical stainingSerum amyloidPositive stainingControl groupAdenomasIntense stainingMolecular classificationCRP staining
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