2025
Representation of Women, Older Adults, and Racial and Ethnic Minoritized Patients in Pivotal Trials for US Food and Drug Administration Novel Oncology Therapeutic Approvals, 2012-2021: Bright Spot Trials and Trends Over Time.
Miller J, Pelletiers W, Gross C, Mello M, Ramachandran R, Schwartz J, Suttiratana S, Varma T, Ross J. Representation of Women, Older Adults, and Racial and Ethnic Minoritized Patients in Pivotal Trials for US Food and Drug Administration Novel Oncology Therapeutic Approvals, 2012-2021: Bright Spot Trials and Trends Over Time. JCO Oncology Practice 2025, op2400563. PMID: 40493876, DOI: 10.1200/op-24-00563.Peer-Reviewed Original ResearchFood and Drug AdministrationOncology therapeuticsLatino patientsBlack patientsTherapeutic approvalsOlder adultsRetrospective cross-sectional studyUS Food and Drug AdministrationTrial characteristicsMinoritized patientsUS patient populationSpot trialsPivotal trialsPatient demographicsPatient populationRepresentative patientsTrial enrollmentUS Census dataDrug AdministrationPatientsStudy of trialsTrialsOncologyWomenClinical trial diversityAssociation between patient demographics and smoldering multiple myeloma progression to multiple myeloma: A SEER-Medicare data analysis
Theprungsirikul P, Wang R, Ahmad I, Neparidze N, Ma X, Chang S, Wang S. Association between patient demographics and smoldering multiple myeloma progression to multiple myeloma: A SEER-Medicare data analysis. Clinical Lymphoma Myeloma & Leukemia 2025 DOI: 10.1016/j.clml.2025.06.016.Peer-Reviewed Original ResearchSmoldering multiple myelomaSmoldering multiple myeloma patientsMultiple myelomaPatient demographicsProgression to multiple myelomaSymptomatic multiple myelomaDevelopment of hypercalcemiaCox proportional hazards modelsRisk stratification modelConfidence intervalsNon-cancer controlsEstimate hazard ratiosProportional hazards modelNon-cancer patientsSymptomatic MMRandom sample of Medicare beneficiariesSMM patientsRenal failureAnalyzed SurveillanceSEER-MedicareNatural history modelHazard ratioBone diseasePatientsSample of Medicare beneficiariesClinical outcomes following brachytherapy for endometrial cancer patients with narrow vaginal anatomy
Adefres B, Tien C, Gueble S, Damast S. Clinical outcomes following brachytherapy for endometrial cancer patients with narrow vaginal anatomy. Brachytherapy 2025 PMID: 40447531, DOI: 10.1016/j.brachy.2025.04.002.Peer-Reviewed Original ResearchHigh-dose-rateVaginal brachytherapyVaginal recurrenceEndometrial cancerClinical outcomesStage I-II diseaseClinical outcome of EC patientsHigher surface doseIn-field recurrenceOutcome of EC patientsExcellent local controlIRB-approved databaseKaplan-Meier analysisEndometrial cancer patientsVaginal cylinderUrinary toxicityVaginal stenosisCTCAE v4.0Dose heterogeneityVaginal scarringVaginal anatomyMedian ageRecurrence rateSurface dosePatient demographicsMinimally Invasive Surgery Versus Conventional Neurosurgical Treatments for Patients with Subcortical Supratentorial Intracerebral Hemorrhage: A Nationwide Study of Real-World Data from 2016 to 2022
Chen H, McIntyre M, Khunte M, Malhotra A, Labib M, Colasurdo M, Gandhi D. Minimally Invasive Surgery Versus Conventional Neurosurgical Treatments for Patients with Subcortical Supratentorial Intracerebral Hemorrhage: A Nationwide Study of Real-World Data from 2016 to 2022. Diagnostics 2025, 15: 1308. PMID: 40506881, PMCID: PMC12154345, DOI: 10.3390/diagnostics15111308.Peer-Reviewed Original ResearchMinimally invasive surgery patientsSupratentorial intracerebral hemorrhageIn-hospital mortalityMinimally invasive surgeryConventional craniotomyIntracerebral hemorrhageDecompressive craniectomyExcellent outcomesMultivariable adjustmentNeurosurgical treatmentOdds of excellent outcomeExternal ventricular drainageOptimal treatment modalityRates of in-hospital mortalityRetrospective cohort studyMental status abnormalitiesSurgical evacuationVentricular drainageHematoma sizeDC patientsPatient demographicsRandomized studyTreatment modalitiesVascular risk factorsCC patientsNational Estimates and Outcomes for Supplemental Home Oxygen Therapy Injuries—A Burn Care Quality Platform Analysis
Sheckter C, Stanton E, Klas K, Phillips B, Coffey R, Savetamal A, Wibbenmeyer L. National Estimates and Outcomes for Supplemental Home Oxygen Therapy Injuries—A Burn Care Quality Platform Analysis. Journal Of Burn Care & Research 2025, iraf087. PMID: 40394868, DOI: 10.1093/jbcr/iraf087.Peer-Reviewed Original ResearchTotal body surface areaNational estimatesIncidence rateOdds of discharge homeHome oxygen therapyTargeted prevention strategiesOxygen therapyBurn admissionsInhalation injuryIncidence of admissionPublic health problemTotal body surface area burnHome oxygen usePoisson regressionInjury characteristicsInjury descriptionInpatient mortalityPrevention strategiesBody surface areaInpatient outcomesDischarged homeHealth problemsNational averagePatient demographicsAnnual increaseDoes Stapling Platform Influence Robotic Sleeve Gastrectomy Postoperative Outcomes?
Ying L, Rutledge R, Butensky S, Lugo D, Morton J, Ringold F. Does Stapling Platform Influence Robotic Sleeve Gastrectomy Postoperative Outcomes? Obesity Surgery 2025, 35: 1838-1844. PMID: 40227538, PMCID: PMC12065732, DOI: 10.1007/s11695-025-07855-z.Peer-Reviewed Original ResearchConceptsGastroesophageal reflux diseasePostoperative outcomesNo significant differenceSleeve gastrectomyRate of de novo GERDStapler useOverall side effect profileRetrospective single-surgeon studyLinear staplerPostoperative refluxOperative timePostoperative length of stayBackgroundLaparoscopic sleeve gastrectomyPostoperative gastroesophageal reflux diseaseRate of postoperative refluxSingle-surgeon studySide effect profileSignificant differenceWeight lossWeight loss surgeryRobotic-assisted sleeve gastrectomyLength of stayPostoperative lengthPatient demographicsEffect profile296 Associated Risk Factors for Extended Length of Stay following Pediatric Tethered Cord Release: An Analysis of 2012 – 2021 NSQIP-Pediatric Database
Hengartner A, Sayeed S, Serrato P, Belkasim S, Sadeghzadeh S, Kundishora A, DiLuna M, Elsamadicy A. 296 Associated Risk Factors for Extended Length of Stay following Pediatric Tethered Cord Release: An Analysis of 2012 – 2021 NSQIP-Pediatric Database. Neurosurgery 2025, 71: 73-73. DOI: 10.1227/neu.0000000000003360_296.Peer-Reviewed Original ResearchNSQIP-Pediatric databaseTethered cord releaseSpinal cordRisk factorsCord releasePediatric patientsSurgical releaseACS NSQIP-Pediatric databaseFactors associated with prolonged hospitalizationMultivariate logistic regression analysisPostoperative hospital LOSTethered spinal cordCardiac risk factorsRetrospective cohort studyHealthcare resource utilizationAssociated risk factorsMultivariate logistic regressionICD-9/10 codesLogistic regression analysisReoperation ratePerioperative complicationsImprove patient outcomesASA classificationPatient demographicsProlonged hospitalization295 Risk Factors Associated With Postoperative Infection following Pediatric Tethered Cord Release: An Analysis of 2012 – 2021 NSQIP-Pediatric Database
Hengartner A, Serrato P, Sayeed S, Belkasim S, Sadeghzadeh S, DiLuna M, Elsamadicy A. 295 Risk Factors Associated With Postoperative Infection following Pediatric Tethered Cord Release: An Analysis of 2012 – 2021 NSQIP-Pediatric Database. Neurosurgery 2025, 71: 73-73. DOI: 10.1227/neu.0000000000003360_295.Peer-Reviewed Original ResearchSurgical site infectionTethered spinal-cord releaseNSQIP-Pediatric databaseCord releaseAdverse eventsPostoperative infectionFactors associated with surgical site infectionACS NSQIP-Pediatric databaseRisk factors associated with postoperative infectionASA classification 3Multivariate logistic regression analysisTethered cord releaseRetrospective cohort analysisStructural CNS abnormalitiesICD-9/10 codesLogistic regression analysisReduce infection ratesPostoperative complicationsASA scoreCNS abnormalitiesImprove patient outcomesPediatric patientsSite infectionPatient demographicsClinical outcomes1369 Use of Distal Embolic Protection Devices as a Bailout Strategy for Suboptimal Flow Reversal During Transcarotid Artery Revascularization
Koo A, Amllay A, Kanzler M, Stogniy S, Renedo D, Sujijantarat N, Antonios J, Hebert R, Matouk C. 1369 Use of Distal Embolic Protection Devices as a Bailout Strategy for Suboptimal Flow Reversal During Transcarotid Artery Revascularization. Neurosurgery 2025, 71: 231-231. DOI: 10.1227/neu.0000000000003360_1369.Peer-Reviewed Original ResearchTranscarotid artery revascularizationCarotid flow reversalSymptomatic carotid diseaseAdjunctive useCarotid stenosisCross-clampingArtery revascularizationDatabase of consecutive adult patientsHigh-gradeCarotid diseaseEffective surgical optionConsecutive adult patientsAverage procedure timePost-operative variablesTranscarotid artery revascularization procedureSymptomatic carotid stenosisDistal embolic protection devicesPerioperative stroke rateEmbolic protection devicesRetrospective reviewPeriprocedural complicationsPatient demographicsSurgical optionsAccess-relatedAngiographic evidenceDeucravacitinib in Psoriasis Patients with a History of Malignancy: Follow-up after 4 Years of Deucravacitinib Treatment in the POETYK PSO Program
Lebwohl M, Korman N, Gooderham M, Gottlieb A, Foley P, Eyerich K, Romanelli M, Strober B, Morita A, Li L, Daamen C, Vaile J, Badaka R, Alió A, Puig L. Deucravacitinib in Psoriasis Patients with a History of Malignancy: Follow-up after 4 Years of Deucravacitinib Treatment in the POETYK PSO Program. SKIN The Journal Of Cutaneous Medicine 2025, 9: s538. DOI: 10.25251/skin.10.supp.538.Peer-Reviewed Original ResearchHistory of malignancyOccurrence of malignancyPsoriasis patientsFollow-upDuration of follow-upBaseline patient demographicsTyrosine kinase 2 inhibitorLong-term extensionYear prior to enrollmentTreatment discontinuationClinical characteristicsPatient demographicsPatient withdrawalAdverse eventsDeucravacitinibMalignancyPatient populationMalignant eventsPatientsPsoriasisPooled populationNMSCTrialsBaselineTreatmentIncreasing Omission of Race and Ethnicity in a National Surgical Database.
Hu K, Ihnat J, Zhao K, Oh S, Goss J, Parikh N, Kammien A, Fereydooni S, Butler P, Alperovich M. Increasing Omission of Race and Ethnicity in a National Surgical Database. Journal Of The American College Of Surgeons 2025 PMID: 40035446, DOI: 10.1097/xcs.0000000000001372.Peer-Reviewed Original ResearchBM patientsNSQIP-PHospital lengths-of-stayNational surgical databaseLengths-of-stayNon-BM patientsEthnicity dataCochran-Armitage testOdds of readmissionSurgical databaseSurgical outcomesPatient demographicsSurgery typeNSQIP-P.Multivariate analysisIncreased omissionsPatientsSurgical disparitiesCochran-ArmitageMissing raceSurgical careLinear mixed-effects modelsAccurate data collectionComplicationsMixed-effects modelsEndovascular Embolization versus Observation of Congenital Renal Arteriovenous Malformations: A Retrospective Study
Hufnagle J, Fish A, Schlachter T. Endovascular Embolization versus Observation of Congenital Renal Arteriovenous Malformations: A Retrospective Study. Journal Of Vascular And Interventional Radiology 2025, 36: 988-993.e1. PMID: 39938714, DOI: 10.1016/j.jvir.2025.02.001.Peer-Reviewed Original ResearchCongenital renal arteriovenous malformationRenal arteriovenous malformationType I AVMArteriovenous malformationsEndovascular embolizationAdverse eventsImaging review of patientsReview of patientsArteriovenous malformation ruptureFollow-up dataYakes classificationTransarterial embolizationEmbolization groupPresenting symptomsPatient demographicsRetrospective studyProcedural imagingImaging reviewEmbolizationPatientsObservation groupMalformationsComplicationsVessel sizeNephrectomyAlemtuzumab and thrombotic thrombocytopenic purpura: Analysis of an international surveillance database and systematic literature review
Jacobs J, Binns T, Schlafer D, Woo J, Booth G, Adkins B. Alemtuzumab and thrombotic thrombocytopenic purpura: Analysis of an international surveillance database and systematic literature review. Transfusion And Apheresis Science 2025, 64: 104081. PMID: 39883995, DOI: 10.1016/j.transci.2025.104081.Peer-Reviewed Original ResearchConceptsThrombotic thrombocytopenic purpuraSecondary thrombotic thrombocytopenic purpuraFood and Drug Administration Adverse Event Reporting SystemAssociated with alemtuzumabThrombocytopenic purpuraMultiple sclerosisReport of thrombotic thrombocytopenic purpuraImmune-mediated thrombotic thrombocytopenic purpuraCongenital thrombotic thrombocytopenic purpuraHematopoietic stem cell transplantationFAERS databaseAnd Drug Administration Adverse Event Reporting SystemStem cell transplantationUnited States Food and Drug Administration Adverse Event Reporting SystemAdverse Event Reporting SystemADAMTS13 deficiencyAlemtuzumab administrationCell transplantationADAMTS13 geneEvent Reporting SystemPatient demographicsAlemtuzumabCase reportTherapy indicationsCross-sectional analysis
2024
Acute Promyelocytic Leukemia in the Real World: Understanding Outcome Differences and How We Can Improve Them
Bidikian A, Bewersdorf J, Kewan T, Stahl M, Zeidan A. Acute Promyelocytic Leukemia in the Real World: Understanding Outcome Differences and How We Can Improve Them. Cancers 2024, 16: 4092. PMID: 39682277, PMCID: PMC11640703, DOI: 10.3390/cancers16234092.Peer-Reviewed Original ResearchAcute promyelocytic leukemiaAdvent of all-trans retinoic acidEarly mortalityLong-term treatment toxicitiesArsenic trioxidePromyelocytic leukemiaClinical practiceIncidence of acute promyelocytic leukemiaRates of remissionLong-term outcomesTreatment of acute promyelocytic leukemiaLong-term survivalComprehensive patient evaluationResource-limited settingsTreatment toxicityAll-trans retinoic acidDelayed diagnosisPatient demographicsSignificant comorbiditiesTreatment initiationOlder patientsExpert centersClinical trialsTreatment outcomesReal-world settingsSystem-level Variability in Trauma Center Utilization for Seriously Injured Older Adults
Ordoobadi A, Castillo-Angeles M, Tabata-Kelly M, Jenkins P, Hwang U, Cooper Z, Jarman M. System-level Variability in Trauma Center Utilization for Seriously Injured Older Adults. Journal Of Surgical Research 2024, 305: 10-18. PMID: 39616785, PMCID: PMC11779583, DOI: 10.1016/j.jss.2024.10.047.Peer-Reviewed Original ResearchInjured older adultsTrauma service areasSystem-level factorsOlder adultsMultivariable hierarchical logistic regressionHierarchical logistic regressionTrauma centerLogistic regressionRate of undertriageLevel IRetrospective cross-sectional studyCross-sectional studyUnited States countiesHospital destinationInjury characteristicsTrauma center utilizationMedicare dataSystem-level variablesPatient demographicsRandom interceptStates countiesUndertriagePrimary outcomeRural regionsCenter utilizationFactors associated with elective surgical case cancellation at a tertiary hospital in Malawi
Serrato P, Msosa V, Kondwani J, Nkhumbwah M, Mowafi H, Smith J, Mulima G, Sion M. Factors associated with elective surgical case cancellation at a tertiary hospital in Malawi. World Journal Of Surgery 2024, 48: 2990-3000. PMID: 39558490, DOI: 10.1002/wjs.12404.Peer-Reviewed Original ResearchKamuzu Central HospitalFactors associated with lower oddsLower oddsFactors associated with cancellationTertiary hospitalProcess-related factorsAssociated with lower oddsPublic tertiary hospitalCase cancellationsElective surgical case cancellationCancellation of elective surgeriesCross-sectional studyMedian waiting timeReturn for surgerySurgery completion rateMultivariate regression modelHigher cancellation rateSurgical case cancellationCancellation of surgeryCompletion ratesPatient outcomesPatient demographicsOddsElective surgeryRegression modelsComparative analysis of negative pressure wound therapy (PICO) and standard dressing application after arterial vascular reconstructions.
Kostiuk V, Fereydooni S, Setia O, Loh S, Strosberg D, Tonnessen B, Ochoa Chaar C, Aboian E. Comparative analysis of negative pressure wound therapy (PICO) and standard dressing application after arterial vascular reconstructions. Vascular 2024, 17085381241296606. PMID: 39460535, DOI: 10.1177/17085381241296606.Peer-Reviewed Original ResearchGroin wound complicationsWound complicationsNegative pressure wound therapyNegative pressure therapyVascular reconstructionGroin dissectionPressure therapyPICO dressingIncidence of groin wound complicationsProcedure indicationArterial reconstructionWound therapyIncidence of wound complicationsReduction of wound complicationsMultivariate logistic regression analysisAssociated with lower riskSurgical site infectionAntibiotics post-operativelyFemoral artery dissectionOpen vascular reconstructionLogistic regression analysisSzilagyi classificationGroin surgerySite infectionPatient demographicsDevelopment of a Uniform Apheresis Case Report Form for Standardized Collection of Apheresis Data
Johnson A, Szczepiorkowski Z, Balogun R, Karam O, Nellis M, Schneiderman J, Schwartz J, Winters J, Wu Y, Armendariz T, Burgstaler E, Collins L, Geile K, Pavenski K, Sanchez A, Witt V, Muthusamy A, Pederson T, Ramesh V, Thao M, Chlebeck T, Zantek N. Development of a Uniform Apheresis Case Report Form for Standardized Collection of Apheresis Data. Journal Of Clinical Apheresis 2024, 39: e22146. PMID: 39420527, PMCID: PMC11523286, DOI: 10.1002/jca.22146.Peer-Reviewed Original ResearchConceptsElectronic case report formsCase report formsReport formsData elementsConsensus panelImprove patient careRelevant data elementsOnline survey toolPatient careSurvey toolQuality InitiativeBlood cell collectionLaboratory parametersPatient demographicsDraft documentTool's abilityStandardized collectionApheresisCell collectionDatabase developmentVascular accessTherapeutic apheresisOnline conferencingUsabilitySubject eligibilityComplications and Radiographic Outcomes of Tibial Tubercle Osteotomy at Minimum 5-Year Follow-up
Yalcin S, Seals K, Joo P, Fulkerson J, Farrow L. Complications and Radiographic Outcomes of Tibial Tubercle Osteotomy at Minimum 5-Year Follow-up. Orthopaedic Journal Of Sports Medicine 2024, 12: 23259671241278722. PMID: 39430114, PMCID: PMC11489970, DOI: 10.1177/23259671241278722.Peer-Reviewed Original ResearchMidterm follow-upTibial tubercle osteotomyComplication rateFollow-upLogistic regression analysisRadiographic outcomesYears of clinical follow-up dataClinical follow-up dataRisk factorsUnivariate logistic regression analysisMultivariate logistic regression analysisGrades 3 to 4Tubercle osteotomyTreatment of patellofemoral instabilityHistory of smokingCase series studyFollow-up periodRate of patientsLong-term outcomesFollow-up dataLevel of evidenceRegression analysisPatient demographicsCase seriesPatellofemoral instabilityOutcomes Following In-Office Peroneal Needle Tendoscopy: A Retrospective Review
Butler J, Randall G, Wingo T, Gianakos A, Kennedy J. Outcomes Following In-Office Peroneal Needle Tendoscopy: A Retrospective Review. Foot & Ankle Orthopaedics 2024, 9: 2473011424s00398. PMCID: PMC11686665, DOI: 10.1177/2473011424s00398.Peer-Reviewed Original ResearchReturn to sportPre-operative MRIVisual analog scaleFollow-upIn-officeTendon dysfunctionRetrospective reviewAmerican Orthopaedic Foot and Ankle Society (AOFAS) ankle-hindfoot scoreAnkle-hindfoot scorePeroneal tendon disordersPeroneal tearsComplication rateRadiological outcomesPatient demographicsAnalog scaleRetrospective studyEffective modalityPathological characteristicsTreatment characteristicsTendon disordersTEN casesPatientsTendoscopyOperating suiteDysfunction
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