2025
Unintended Prolonged Opioid Use: Protocol for a Case-Controlled Trial.
Hooten W, Erickson D, Chawarski M, Scholz N, Waljee J, Brummett C, Jeffery M. Unintended Prolonged Opioid Use: Protocol for a Case-Controlled Trial. JMIR Research Protocols 2025, 14: e72032. PMID: 39992690, DOI: 10.2196/72032.Peer-Reviewed Original ResearchConceptsINTERNATIONAL REGISTERED REPORT IDENTIFIERElectronic health record systemsPatient recruitmentPractice environment characteristicsPrescribing opioids to patientsOpioid prescriptionsHealth record systemsPatient characteristicsContinuation of opioid therapyIndividual practice environmentsOpioids to patientsOpioid-naive adultsOpioid-naive patientsProlonged opioid useSelf-report surveyNational administrative claims databaseMisuse of prescription opioidsCOVID-19 pandemicPublic health problemClinician recruitmentCase-control trialShort-term useAdministrative claims databaseMayo Clinic sitesCTSA programCarotid artery stenting with open versus closed stent cell configurations in the CREST-2 Registry
Lal B, Roubin G, Meschia J, Jones M, Heck D, Sternbergh W, Aronow H, Mena-Hurtado C, Howard G, Mayorga-Carlin M, Sorkin J, Brott T. Carotid artery stenting with open versus closed stent cell configurations in the CREST-2 Registry. Journal Of Vascular Surgery 2025 PMID: 40024381, DOI: 10.1016/j.jvs.2025.02.025.Peer-Reviewed Original ResearchCarotid artery stentingOpen-cell stentClosed-cell stentsFood and Drug Administration-approved deviceArtery stentingEmbolic protectionComparison of clinical outcomesStandardized procedure protocolsSymptomatic patientsPeri-proceduralAntiplatelet therapyPatient selectionClinical outcomesInstitutional experiencePatient characteristicsProcedural detailsCREST-2Lesion characteristicsLesion selectionHigh riskStentVascular anatomyPatient preferencesPatientsProcedure protocolAssessment of health conditions from patient electronic health record portals vs self-reported questionnaires: an analysis of the INSPIRE study
Khera R, Sawano M, Warner F, Coppi A, Pedroso A, Spatz E, Yu H, Gottlieb M, Saydah S, Stephens K, Rising K, Elmore J, Hill M, Idris A, Montoy J, O’Laughlin K, Weinstein R, Venkatesh A, Weinstein R, Gottlieb M, Santangelo M, Koo K, Derden A, Gottlieb M, Gatling K, Ahmed Z, Gomez C, Guzman D, Hassaballa M, Jerger R, Kaadan A, Venkatesh A, Spatz E, Kinsman J, Malicki C, Lin Z, Li S, Yu H, Mannan I, Yang Z, Liu M, Venkatesh A, Spatz E, Ulrich A, Kinsman J, Malicki C, Dorney J, Pierce S, Puente X, Salah W, Nichol G, Stephens K, Anderson J, Schiffgens M, Morse D, Adams K, Stober T, Maat Z, O’Laughlin K, Gentile N, Geyer R, Willis M, Zhang Z, Chang G, Lyon V, Klabbers R, Ruiz L, Malone K, Park J, Rising K, Kean E, Chang A, Renzi N, Watts P, Kelly M, Schaeffer K, Grau D, Cheng D, Shutty C, Charlton A, Shughart L, Shughart H, Amadio G, Miao J, Hannikainen P, Elmore J, Wisk L, L’Hommedieu M, Chandler C, Eguchi M, Roldan K, Moreno R, Rodriguez R, Wang R, Montoy J, Kemball R, Chan V, Chavez C, Wong A, Arreguin M, Hill M, Site R, Kane A, Nikonowicz P, Sapp S, Idris A, McDonald S, Gallegos D, Martin K, Saydah S, Plumb I, Hall A, Briggs-Hagen M. Assessment of health conditions from patient electronic health record portals vs self-reported questionnaires: an analysis of the INSPIRE study. Journal Of The American Medical Informatics Association 2025, 32: 784-794. PMID: 40036551, PMCID: PMC12012333, DOI: 10.1093/jamia/ocaf027.Peer-Reviewed Original ResearchElectronic health recordsSelf-report questionnairesSelf-reportHealth conditionsElectronic health record portalsElectronic health record platformsEHR elementsSelf-reported health conditionsElectronic health record dataSelf-reported conditionsAssessment of health conditionEvaluation of health conditionsPrevalence of conditionsPatient portalsTraditional self-reportPrevalence of comorbiditiesHealth recordsEHR dataEHR phenotypesDiagnosis codesHospitalization riskComputable phenotypeNationwide studyCohen's kappaPatient characteristicsSimultaneous Symmetrizing Surgery on the Contralateral Breast in Unilateral Autologous Breast Reconstruction Is Cost-Effective
Zhao K, Kammien A, Graetz E, Moore M, Evans B, Schneider E, Ayyala H. Simultaneous Symmetrizing Surgery on the Contralateral Breast in Unilateral Autologous Breast Reconstruction Is Cost-Effective. Journal Of Reconstructive Microsurgery 2025 PMID: 39821138, DOI: 10.1055/a-2517-0803.Peer-Reviewed Original ResearchFree flap reconstructionSymmetrization surgeryFlap reconstructionBreast reconstructionDelayed reconstructionPatient characteristicsSingle-stage breast reconstructionUnilateral autologous breast reconstructionAutologous breast reconstructionSurgical site infectionThirty-day complicationsContralateral breastUnilateral reconstructionImmediate reconstructionSite infectionWound dehiscenceThirty-dayIncreased complicationsNational administrative dataSurgeryRevision surgeryComplicationsPatientsWilcoxon testChi-squareUptake of Peritoneal Dialysis (PD) by Minoritized Patients: The Role of Modality Education.
Arnaoudova I, Wilson C, Rizzolo K, Shen J, Ehtesham N, Wilson J, Golestaneh L. Uptake of Peritoneal Dialysis (PD) by Minoritized Patients: The Role of Modality Education. Kidney360 2025 PMID: 39899379, DOI: 10.34067/kid.0000000702.Peer-Reviewed Original ResearchModality educationMinoritized patientsQualitative analysis of interviewsPeritoneal dialysisAnalysis of interviewsStructural barriersAssociation of patient characteristicsDialysis modality educationRacial ethnic minoritiesSemi-structured interviewsEducation sessionsMontefiore Medical CenterStudy of individualsCohort of patientsPatients' perceptionsQualitative analysisTailored contentPerception of usefulnessLessen anxietyMedical CenterEducationPatient characteristicsLate-stage kidney diseaseQuality of informationClinical comorbidityInsights into treatment of patients with mycosis fungoides or Sézary syndrome using mogamulizumab
Foss F, Kim Y, Scarisbrick J, Akilov O, Ristuccia R, Dwyer K, Wu W, Bagot M. Insights into treatment of patients with mycosis fungoides or Sézary syndrome using mogamulizumab. Journal Of Dermatological Treatment 2025, 36: 2438794. PMID: 39894454, DOI: 10.1080/09546634.2024.2438794.Peer-Reviewed Original ResearchConceptsMogamulizumab-associated rashConcomitant steroid useSezary syndromeAdvanced diseaseMycosis fungoidesSteroid useResponse to mogamulizumabProportion of patientsPercentage of patientsTreatment of patientsConcomitant steroidsRelapsed/refractory patientsLong-term responseMogamulizumabNext treatmentPatient characteristicsPatientsLymphopeniaVorinostatPatient responseFungoidesPFSMycosisSyndromeTreatmentClinical Effectiveness of Electroconvulsive Therapy for Psychotic vs Nonpsychotic Depression: A Cohort Study.
Kelkar R, Liu G, Goodman M, Al-Hashemi A, Rhee T, Blumberger D, Kaster T. Clinical Effectiveness of Electroconvulsive Therapy for Psychotic vs Nonpsychotic Depression: A Cohort Study. The Journal Of Clinical Psychiatry 2025, 86 PMID: 39898922, DOI: 10.4088/jcp.24m15399.Peer-Reviewed Original ResearchConceptsAdverse cognitive effectsMD-PCognitive effectsElectroconvulsive therapyPsychotic symptomsPsychotic featuresAcute course of ECTClinical Global Impression ImprovementTreatment responseClinical effects of electroconvulsive therapyCourse of ECTEffects of electroconvulsive therapyFactors associated with treatment responseElectroconvulsive therapy treatmentsPatient characteristicsNonpsychotic depressionCognitive Functioning ScaleRate of responseAssociated with responseAcute courseRetrospective cohort studyFunctional scalesDepressionAdult inpatientsSymptomsRegional anesthesia in the patient receiving antithrombotic or thrombolytic therapy: American Society of Regional Anesthesia and Pain Medicine Evidence-Based Guidelines (fifth edition)
Kopp S, Vandermeulen E, McBane R, Perlas A, Leffert L, Horlocker T. Regional anesthesia in the patient receiving antithrombotic or thrombolytic therapy: American Society of Regional Anesthesia and Pain Medicine Evidence-Based Guidelines (fifth edition). Regional Anesthesia & Pain Medicine 2025, rapm-2024-105766. PMID: 39880411, DOI: 10.1136/rapm-2024-105766.Peer-Reviewed Original ResearchAmerican Society of Regional AnesthesiaDeep venous thrombosisEvidence-based guidelinesRegional anesthesiaThrombolytic therapyComplications associated with regional anesthesiaRecurrent deep venous thrombosisAmerican SocietyRandomized controlled trialsAnticoagulant doseNeural blockadeVenous thrombosisCase seriesCatastrophic complicationPatient characteristicsClinical trialsHigh dosesPatientsPublished guidelinesControlled trialsPainAnesthesiaPatient safetyTherapyDosePredicting Mortality in Patients Hospitalized With Acute Myocardial Infarction: From the National Cardiovascular Data Registry
Faridi K, Wang Y, Minges K, Smilowitz N, McNamara R, Kontos M, Wang T, Connors A, Clary J, Osborne A, Pereira L, Curtis J, Blankinship K, Mayfield J, Abbott J. Predicting Mortality in Patients Hospitalized With Acute Myocardial Infarction: From the National Cardiovascular Data Registry. Circulation Cardiovascular Quality And Outcomes 2025, 18: e011259. PMID: 39801472, PMCID: PMC11919567, DOI: 10.1161/circoutcomes.124.011259.Peer-Reviewed Original ResearchConceptsNational Cardiovascular Data Registry Chest Pain-MI RegistryIn-hospital mortalityAcute myocardial infarctionChest Pain-MI RegistryOut-of-hospital cardiac arrestRisk scoreRisk-standardized modelsNational Cardiovascular Data RegistryAcute MI hospitalizationsPatient characteristicsMyocardial infarctionContemporary risk modelsIn-hospital mortality rateMI hospitalizationST-segment elevation MIIndependent predictor of mortalityMortality risk predictionSystolic blood pressureMortality riskPredictors of mortalityHospital volumePatient prognosticationData RegistryRisk modelSimplified risk score
2024
Endovascular arterial embolization versus conservative management with nasal packing alone for severe epistaxis: a nationwide cohort study
Chen H, Khunte M, Colasurdo M, Gunawardane S, Malhotra A, Gandhi D. Endovascular arterial embolization versus conservative management with nasal packing alone for severe epistaxis: a nationwide cohort study. Journal Of NeuroInterventional Surgery 2024, jnis-2024-022790. PMID: 39715667, DOI: 10.1136/jnis-2024-022790.Peer-Reviewed Original ResearchEndovascular arterial embolizationNasal packingSevere epistaxisPropensity score matchingNationwide Readmissions DatabaseArtery embolizationIschemic strokeCohort studyRates of patient morbidityHemorrhage risk factorsConservative management groupConservative managementRetrospective cohort studyNationwide cohort studyRate of ischemic strokeBalance patient characteristicsContemporary real-world dataAssociated with lower ratesPatients admitted to hospitalNon-routine dischargeRisk of ischemic strokeRecurrent epistaxisRecurrence ratePatient morbidityPatient characteristicsEmergency Department Use Within 90 Days After Single-Level Posterior Cervical Foraminotomy.
Jayaram R, Oghenesume O, Day W, Kammien A, Grauer J. Emergency Department Use Within 90 Days After Single-Level Posterior Cervical Foraminotomy. Orthopedics 2024, 48: 51-56. PMID: 39699166, DOI: 10.3928/01477447-20241213-04.Peer-Reviewed Original ResearchConceptsSingle-level posterior cervical foraminotomyPosterior cervical foraminotomyElixhauser Comorbidity IndexCervical foraminotomyEmergency departmentPredictive factorsMultivariate analysisED visitsAcute postoperative periodPrimary ED diagnosisPatient agePostoperative periodPatient characteristicsSurgical siteFemale sexComorbidity indexIndications of traumaED diagnosisED useRisk factorsYounger agePatientsMultilevel proceduresForaminotomySurgeryAssociations Between Patient Characteristics and Progression to Multiple Myeloma Among Patients With Monoclonal Gammopathy of Undetermined Significance: A Systematic Review
Li Y, Hsu S, Wang R, Theprungsirikul P, Neparidze N, Chang S, Wang S. Associations Between Patient Characteristics and Progression to Multiple Myeloma Among Patients With Monoclonal Gammopathy of Undetermined Significance: A Systematic Review. Clinical Lymphoma Myeloma & Leukemia 2024, 25: e222-e231. PMID: 39730300, PMCID: PMC11911095, DOI: 10.1016/j.clml.2024.12.006.Peer-Reviewed Original ResearchProgression to MMMultiple myelomaNewcastle-Ottawa ScaleMonoclonal gammopathyRisk of progression to MMIncreased riskProgression to multiple myelomaRisk estimatesHigher body mass indexPre-malignant conditionBody mass indexRandom-effects modelMass indexCohort studyPatient characteristicsFemale sexMale genderMethodological qualityNewcastle-OttawaBlack raceRisk ratioMGUSRisk factorsPublication biasSystematic reviewRegional differences in baseline demographic and clinical characteristics from the evoke and evoke+ trials of semaglutide for early Alzheimer’s disease
van der Flier W, Scheltens P, Feldman H, Hansson O, Sano M, Bardtrum L, Johannsen P, Jeppesen R, Hansen C, Leon T, Cummings J. Regional differences in baseline demographic and clinical characteristics from the evoke and evoke+ trials of semaglutide for early Alzheimer’s disease. Alzheimer's & Dementia 2024, 20: e088793. PMCID: PMC11713752, DOI: 10.1002/alz.088793.Peer-Reviewed Original ResearchMini-Mental State Examination scoreBaseline dataCognitive scoresClinical Dementia Rating-SumAlzheimer's diseaseApolipoprotein E4 carrier statusClinical Dementia Rating-Sum of Boxes scoresInclusion of participantsMild cognitive impairmentScreening failure rateProportion of individualsMild dementiaGeographic regionsType 2 diabetesBox scoresAD medicationsClinical characteristicsInclusion criteriaCarrier statusNorth AmericaExamination scoresClinical trial populationsPatient characteristicsCognitive impairmentSmall vessel pathologyTreatment Effect Heterogeneity in Acute Kidney Injury Incidence Following Intravenous Antihypertensive Administration for Severe Blood Pressure Elevation During Hospitalization
Ghazi L, Chen X, Harhay M, Hu L, Biswas A, Peixoto A, Li F, Wilson F. Treatment Effect Heterogeneity in Acute Kidney Injury Incidence Following Intravenous Antihypertensive Administration for Severe Blood Pressure Elevation During Hospitalization. American Journal Of Kidney Diseases 2024, 85: 442-453. PMID: 39580068, DOI: 10.1053/j.ajkd.2024.09.011.Peer-Reviewed Original ResearchAcute kidney injuryAcute kidney injury incidenceSevere hypertensionIV antihypertensivesAntihypertensive treatmentBlood pressureRisk of acute kidney injuryAbstractText Label="SETTINGS &Blood pressure elevationSevere blood pressure elevationSystolic blood pressureIdentifying treatment optionsAntihypertensive administrationKidney injuryAbstractText Label="RATIONALETreatment optionsAntihypertensive effectBP elevationPressure elevationPatient characteristicsDiastolic BPPatientsKidney failureAntihypertensivesHospital admissionInfluence of patient characteristics on Helicobacter pylori eradication with Vonoprazan: A subgroup analysis of the pHalcon‐HP trial
Chey W, Mégraud F, Laine L, Smith N, Leifke E, Hunt B, Howden C. Influence of patient characteristics on Helicobacter pylori eradication with Vonoprazan: A subgroup analysis of the pHalcon‐HP trial. JGH Open 2024, 8: e70044. PMID: 39554983, PMCID: PMC11567116, DOI: 10.1002/jgh3.70044.Peer-Reviewed Original ResearchExperiences and barriers with home bladder manometry in the pediatric neurogenic bladder population: A qualitative study
Macaraeg A, Alshehabi S, Huen K, Davis-Dao C, Williamson S, Boswell T, Chalmers C, Stephany H, Chuang K, Wehbi E, Kain Z, Kaplan S, Khoury A. Experiences and barriers with home bladder manometry in the pediatric neurogenic bladder population: A qualitative study. Journal Of Pediatric Urology 2024, 21: 173-180. PMID: 39532597, DOI: 10.1016/j.jpurol.2024.10.017.Peer-Reviewed Original ResearchHealthcare providersNursing staffQualitative studyPerceptions of caregiversGrounded theory methodFocus group discussionsSemi-structured interviewsNursesCaregiversHands-on practiceInterview participantsAnalyzed transcriptsBladder manometryStudy designGroup discussionsProvidersHealthcarePatient-specific characteristicsNeurogenic bladder patientsHome environmentPatient characteristicsHomeClean intermittent catheterizationStaffNeurogenic bladder populationImpact of Atopic Dermatitis (Eczema) and Its Treatment on the Risk of Adverse Events Following Total Knee Arthroplasty
Smith-Voudouris J, Dhodapkar M, Halperin S, Cohen J, Grauer J. Impact of Atopic Dermatitis (Eczema) and Its Treatment on the Risk of Adverse Events Following Total Knee Arthroplasty. JAAOS Global Research And Reviews 2024, 8: e23.00267. PMID: 39436712, PMCID: PMC11498930, DOI: 10.5435/jaaosglobal-d-23-00267.Peer-Reviewed Original ResearchConceptsAtopic dermatitisAdverse eventsOdds of pneumoniaTotal knee arthroplastyPerioperative outcomes of patientsModerate-to-severe diseaseIncreased oddsEmergency departmentUrinary tract infectionChronic inflammatory skin conditionOutcomes of patientsLog-rank testRisk of adverse eventsInflammatory skin conditionIncreased odds of pneumoniaKnee arthroplastyTotal knee arthroplasty patientsPerioperative outcomesImmunosuppressive medicationsTract infectionsAggregate adverse eventsAdult patientsImpact of atopic dermatitisPatient characteristicsMultivariate analysisPersistent bloodstream infection in children: examining the role for repeat blood cultures
Puthawala C, Feinn R, Rivera-Viñas J, Lee H, Murray T, Peaper D. Persistent bloodstream infection in children: examining the role for repeat blood cultures. Journal Of Clinical Microbiology 2024, 62: e00998-24. PMID: 39365070, PMCID: PMC11559050, DOI: 10.1128/jcm.00998-24.Peer-Reviewed Original ResearchPositive blood culturesPersistent bloodstream infectionBlood culturesBloodstream infectionsCentral venous catheterPositive culturesVenous cathetersIndex blood cultureCross-sectional study of childrenRepeated blood culturesTime of blood drawElevated inflammatory markersAssociated with persistenceGt;48 hoursIndex cultureCross-sectional studyPersistent bacteremiaImmune dysfunctionPediatric patientsInflammatory markersDiagnostic stewardshipStudy of childrenPatient characteristicsClinical valueBlood drawFactors Underlying Reduced Hospitalizations for Myocardial Infarction During the COVID-19 Pandemic
Wilcock A, Zubizarreta J, Wadhera R, Yeh R, Zachrison K, Schwamm L, Mehrotra A. Factors Underlying Reduced Hospitalizations for Myocardial Infarction During the COVID-19 Pandemic. JAMA Cardiology 2024, 9: 914-920. PMID: 39083317, PMCID: PMC11292572, DOI: 10.1001/jamacardio.2024.2031.Peer-Reviewed Original ResearchHospital encountersAcute myocardial infarctionCare avoidanceShort-term acute careAcute myocardial infarction incidenceAcute myocardial infarction ratesTemporal trendsCOVID-19 pandemicPatient characteristicsTraditional Medicare claimsCross-sectional studyPandemic-related changesAMI incidenceCOVID-19 death ratesAcute careMyocardial infarctionMedicare claimsMain OutcomesExcess deathsExcess mortalityStudy samplePrepandemic levelsTraditional MedicareUnited StatesCOVID-19The Incidence and Impact of Cardiac Function Decline after Lower Extremity Revascularization
Jamil Y, Huttler J, Alameddine D, Wu Z, Mena-Hurtado C, Velazquez E, Guzman R, Ochoa Chaar C. The Incidence and Impact of Cardiac Function Decline after Lower Extremity Revascularization. Annals Of Vascular Surgery 2024, 110: 414-423. PMID: 39343374, DOI: 10.1016/j.avsg.2024.07.119.Peer-Reviewed Original ResearchCardiac functional declineStable cardiac functionLower extremity revascularizationPeripheral arterial diseaseCardiac functionFollow-upExtremity revascularizationFunctional declineElectronic records of patientsKaplan-Meier analysisRecords of patientsMode of revascularizationAdverse limb eventsLower-extremity revascularizationTransthoracic echocardiogramReintervention rateHeart failureDiabetes mellitusPeriprocedural bleedingPatient characteristicsArtery diseasePatientsLimb eventsIncreased mortalityRevascularization
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