2025
Voxel-Wise Map of Intracerebral Hemorrhage Locations Associated With Worse Outcomes
Karam G, Chen M, Zeevi D, Harms B, Berson E, Torres-Lopez V, Rivier C, Malhotra A, Qureshi A, Falcone G, Sheth K, Payabvash S. Voxel-Wise Map of Intracerebral Hemorrhage Locations Associated With Worse Outcomes. Stroke 2025, 56: 868-877. PMID: 40052269, DOI: 10.1161/strokeaha.124.048453.Peer-Reviewed Original ResearchConceptsImpact of intracerebral hemorrhageAssociated with worse outcomesClinical risk factorsVoxel-wise mapsMapping of brain regionsBaseline hematomaVoxel-wise analysisHematoma volumeICH locationBrain regionsValidation cohortWorse outcomesPresence of intraventricular hemorrhageRisk factorsBaseline hematoma volumeModified Rankin Scale scorePoor scan qualityMulticenter clinical trialRankin Scale scoreDeep white matterLow-risk categoryComprehensive stroke centerIntraventricular hemorrhageConsecutive patientsPatient ageComparative Performance of Machine Learning Models in Reducing Unnecessary Targeted Prostate Biopsies
Chen F, Esmaili R, Khajir G, Zeevi T, Gross M, Leapman M, Sprenkle P, Justice A, Arora S, Weinreb J, Spektor M, Huber S, Humphrey P, Levi A, Staib L, Venkataraman R, Martin D, Onofrey J. Comparative Performance of Machine Learning Models in Reducing Unnecessary Targeted Prostate Biopsies. European Urology Oncology 2025 PMID: 39924390, DOI: 10.1016/j.euo.2025.01.005.Peer-Reviewed Original ResearchProstate cancerPrediction of clinically significant prostate cancerClinical dataProstate-specific antigen levelClinically significant prostate cancerProstate magnetic resonance imagingSeverity of prostate cancerCombination of clinical featuresPrediction of csPCaSignificant prostate cancerProstate Imaging-ReportingCore needle biopsyRetrospective analysis of dataDecision curve analysisReducing unnecessary biopsiesProstate cancer diagnosisReceiver operating characteristic curveArea under the receiver operating characteristic curveFalse-negative rateMagnetic resonance imagingPersonalized risk assessmentAntigen levelsNeedle biopsyPatient ageUnnecessary biopsiesThe Use of Extended-Release Buprenorphine in the Treatment of Adolescent Opioid Use Disorder: A Case Series.
Neptune A, Kaliamurthy S. The Use of Extended-Release Buprenorphine in the Treatment of Adolescent Opioid Use Disorder: A Case Series. Journal Of Addiction Medicine 2025 PMID: 39898524, DOI: 10.1097/adm.0000000000001447.Peer-Reviewed Original ResearchExtended-release buprenorphineOpioid use disorderCase seriesUse disorderOpioid abstinenceMedical recordsTreatment of opioid use disorderChart review periodNo significant complicationsDuration of treatmentOnset of treatmentMedical records of adolescentsRecords of adolescentsExtended-releaseSublingual buprenorphinePatient ageSignificant complicationsSubcutaneous injectionOpioidBuprenorphinePatientsOutpatient settingTreatment approachesElectronic medical recordsTreatment retentionColorectal adenosquamous carcinoma: clinicopathologic analysis of two large cohorts and literature review confirm poor prognosis and reveal prognostic aspects
Gonzalez R, Horton R, Zhang X, Graham R, Longacre T, Mehrotra A, Allende D, McHugh K, Shia J, Westerhoff M, Srivastava A, Chen W, Vazzano J, Swanson P, Chatterjee D, Cheema H, Ma C, Mannan R, Chetty R, Nowak K, Serra S, Agostini‐Vulaj D, Kazemimood R, Henn P, Kakar S, Choi W, Adeyi O, Jenkins S, Nagtegaal I. Colorectal adenosquamous carcinoma: clinicopathologic analysis of two large cohorts and literature review confirm poor prognosis and reveal prognostic aspects. Histopathology 2025 PMID: 39887413, DOI: 10.1111/his.15412.Peer-Reviewed Original ResearchTumor-infiltrating lymphocytesAdenosquamous carcinomaColorectal adenosquamous carcinomaTumor buddingPoor prognosisMedian time to progressionMeta-analysis of cohortLow tumor buddingTime to progressionMale:female ratioReview of casesIndividual case seriesNodal metastasisRecurrent diseaseSquamous componentPatient ageRecurrence rateAcademic medical centreCase seriesImmunohistochemical featuresPrognostic aspectsClinicopathological analysisFemale ratioFollow-upColorectal cancer427. Underlying Medical Conditions and Vaccination Status among U.S. Children Aged ≤17 Years Hospitalized for COVID-19 in COVID-19-Associated Hospitalization Surveillance Network (COVID-NET), January–December 2023
Free R, Patel K, Sachdev D, Alden N, Meek J, Ryan P, Falkowski A, D’Heilly P, Smelser C, Engesser K, Bushey S, Moran N, Sutton M, Talbot H, Swain A, Campbell A, Havers F, Openo K. 427. Underlying Medical Conditions and Vaccination Status among U.S. Children Aged ≤17 Years Hospitalized for COVID-19 in COVID-19-Associated Hospitalization Surveillance Network (COVID-NET), January–December 2023. Open Forum Infectious Diseases 2025, 12: ofae631.141. PMCID: PMC11777352, DOI: 10.1093/ofid/ofae631.141.Peer-Reviewed Original ResearchCOVID-19-Associated Hospitalization Surveillance NetworkAge-eligible childrenChildren aged 6Medical conditionsCOVID-19 hospitalizationVaccine doseAcute care hospitalsAged 6Random sample of childrenPositive SARS-CoV-2 test resultSARS-CoV-2 test resultsVaccination statusAssessed patient ageSample of childrenNeurological disordersMaster of ScienceSARS-CoV-2 infectionActive surveillance systemCare hospitalProbability of selectionPediatric COVID-19 vaccineCOVID-19U.S. childrenPatient ageMedical recordsRadiologist, trainee, and logistical factors impacting the timeliness of CTA head and neck reporting in stroke code activations.
Zaree O, Nguyen J, de Oliveira Santo I, Kertam A, Rahmani S, Johnson J, Tu L. Radiologist, trainee, and logistical factors impacting the timeliness of CTA head and neck reporting in stroke code activations. American Journal Of Neuroradiology 2025, ajnr.a8660. PMID: 39832953, DOI: 10.3174/ajnr.a8660.Peer-Reviewed Original ResearchStroke code activationAttending radiologistsTimeliness of reportingEmergency department settingRadiologist characteristicsCare settingsMultivariate regression modelImprove workflow efficiencyDepartment settingStroke codeModifiable factorsDescriptive statisticsSecondary analysisCoding activitiesReport factorsPatient ageObservational studyWorkflow efficiencyShift typeMedian TATMultivariate regressionInterquartile rangeRegression modelsCTA reportsLogistical factorsImpact of patient age on morbidity and mortality in adults with acute traumatic cervical spinal cord injury: An ACS trauma quality programs database study
Elsamadicy A, Serrato P, Belkasim S, Ghanekar S, Khalid S, Lo S, Sciubba D. Impact of patient age on morbidity and mortality in adults with acute traumatic cervical spinal cord injury: An ACS trauma quality programs database study. Clinical Neurology And Neurosurgery 2025, 249: 108740. PMID: 39813756, DOI: 10.1016/j.clineuro.2025.108740.Peer-Reviewed Original ResearchConceptsIn-hospital mortalityAcute CSCI patientsLength of stayCSCI patientsTreatment modalitiesCervical SCIAcute traumatic cervical spinal cord injuryTraumatic cervical spinal cord injuryAssociated with increased morbidityImpact of patient ageAcute cervical SCICervical spinal cord injuryRetrospective cohort studyMultivariate logistic regressionPredictors of AEYears of ageSpinal cord injuryCervicothoracic fusionAssociated with AECervical fusionPatient ageIndependent predictorsInjury typePatient demographicsProgram databasePredicting Elevated Postvoid Residual Urine Volume Following OnabotulinumtoxinA Treatment for Overactive Bladder: A Pilot Study
Franco I, Schwartz M, Cline K, Glazier D, Patel A. Predicting Elevated Postvoid Residual Urine Volume Following OnabotulinumtoxinA Treatment for Overactive Bladder: A Pilot Study. LUTS Lower Urinary Tract Symptoms 2025, 17: e70004. PMID: 39800349, PMCID: PMC11725389, DOI: 10.1111/luts.70004.Peer-Reviewed Original ResearchConceptsOveractive bladderUrine flow rateOnabotulinumtoxinA treatmentPatient ageElevated postvoid residual urine volumeElevated postvoid residual volumePostvoid residual urine volumePeak urine flow rateSymptoms of overactive bladderAverage urine flow ratePostvoid residual volumeIdiopathic overactive bladderResidual urine volumeOveractive bladder treatmentEvaluate potential predictorsLogistic regression analysisMedical chart dataOnabotulinumtoxinA administrationIndex therapyUrinary urgencyRetrospective reviewUrine volumeUrology clinicPVR valuesUrinary condition
2024
After Anterior Cruciate Ligament Surgery, Variables Associated With Returning to the Same Surgeon If a Subsequent Antrior Cruciate Ligament Surgery Is Needed?
Halperin S, Dhodapkar M, McLaughlin W, Santos E, Medvecky M, Grauer J. After Anterior Cruciate Ligament Surgery, Variables Associated With Returning to the Same Surgeon If a Subsequent Antrior Cruciate Ligament Surgery Is Needed? JAAOS Global Research And Reviews 2024, 9: e24.00349. PMID: 39761541, PMCID: PMC11692955, DOI: 10.5435/jaaosglobal-d-24-00349.Peer-Reviewed Original ResearchConceptsCruciate ligament surgeryIndex surgeryAdverse eventsLigament surgeryAnterior cruciate ligament surgeryAssociated with adverse eventsAnterior cruciate ligament reconstructionCruciate ligament reconstructionIpsilateral revisionsRevision ACLRSame surgeonPatient agePearlDiver databaseSurgical factorsACLR patientsSurgeryPatient factorsLigament reconstructionIpsilateral kneePatientsSurgeonsAssess factorsORPearlDiverACLRVariables Affecting 90-Day Overall Reimbursement After Anterior Cruciate Ligament Reconstruction: Analysis of Nearly 250,000 Patients in the United States
Halperin S, Prenner S, Dhodapkar M, Santos E, Medvecky M, Grauer J. Variables Affecting 90-Day Overall Reimbursement After Anterior Cruciate Ligament Reconstruction: Analysis of Nearly 250,000 Patients in the United States. Orthopaedic Journal Of Sports Medicine 2024, 12: 23259671241300500. PMID: 39697605, PMCID: PMC11653448, DOI: 10.1177/23259671241300500.Peer-Reviewed Original ResearchAnterior cruciate ligament reconstructionElixhauser Comorbidity IndexCruciate ligament reconstructionAdverse eventsPatient ageLigament reconstructionHealth care systemAssociated with older agePostoperative adverse eventsMultivariate logistic regressionInsurance typeFactors associated with variabilityOverall reimbursementCare systemPatient cohortSurgery statusOutpatient basisFemale sexMultivariate linear regressionComorbidity indexComorbidity burdenEmergency department visitsPatientsInpatient proceduresOrthopaedic proceduresEmergency Department Use Within 90 Days After Single-Level Posterior Cervical Foraminotomy.
Jayaram R, Oghenesume O, Day W, Kammien A, Grauer J. Emergency Department Use Within 90 Days After Single-Level Posterior Cervical Foraminotomy. Orthopedics 2024, 48: 51-56. PMID: 39699166, DOI: 10.3928/01477447-20241213-04.Peer-Reviewed Original ResearchConceptsSingle-level posterior cervical foraminotomyPosterior cervical foraminotomyElixhauser Comorbidity IndexCervical foraminotomyEmergency departmentPredictive factorsMultivariate analysisED visitsAcute postoperative periodPrimary ED diagnosisPatient agePostoperative periodPatient characteristicsSurgical siteFemale sexComorbidity indexIndications of traumaED diagnosisED useRisk factorsYounger agePatientsMultilevel proceduresForaminotomySurgeryMulticenter Analysis of the Relationship Between Operative Team Familiarity and Safety and Efficiency Outcomes in Cardiac Surgery
Bauer T, Janda A, Wu X, Ling C, Shook D, Querejeta-Roca G, Shann K, Smith T, Mathis M, Kaneko T, Sundt T, Schonberger R, Harrington S, Dias R, Pagani F, Likosky D, Yule S, Caldwell M, Corso J, Louis N, Krein S, Manojlovich M, Stakich-Alpirez K, Sturmer D, Yalamuri S, Lawton J, Abernathy J, Cleveland J, Clendenen N, Justison G, Fried M, Nemeh H, Fitzsimons M, Dickinson T, Stulak J, de la Cruz K. Multicenter Analysis of the Relationship Between Operative Team Familiarity and Safety and Efficiency Outcomes in Cardiac Surgery. Circulation Cardiovascular Quality And Outcomes 2024, 17: e011065. PMID: 39689169, PMCID: PMC11654451, DOI: 10.1161/circoutcomes.124.011065.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnesthesiologistsCardiac Surgical ProceduresCardiopulmonary BypassClinical CompetenceCooperative BehaviorFemaleHealth Knowledge, Attitudes, PracticeHumansInterdisciplinary CommunicationMaleMiddle AgedOperative TimeOutcome and Process Assessment, Health CarePatient Care TeamPatient SafetyPostoperative ComplicationsQuality Indicators, Health CareRegistriesRetrospective StudiesRisk AssessmentRisk FactorsSurgeonsTime FactorsTreatment OutcomeUnited StatesConceptsSociety of Thoracic SurgeonsCardiopulmonary bypass durationTeam familiarityBypass durationElectronic health record dataHealth record dataEffective team dynamicsSociety of Thoracic Surgeons morbidityCardiac Surgery RegistryComposite major morbidityCardiac surgical proceduresMortality measuresLinear regression modelsCrude analysisQuaternary hospitalRecord dataRisk adjustmentPrimary outcomePatient outcomesProcedural efficiencyMajor morbidityCardiac surgeryCardiac operationsMulticenter analysisPatient agePatient Views and Values Placed on the Uterus
Chang O, Huynh A, Ringel N, Hudson P, Halder G, Winkleman W, Ton J, Davidson E, Meriwether K. Patient Views and Values Placed on the Uterus. O&G Open 2024, 1: 048. DOI: 10.1097/og9.0000000000000048.Peer-Reviewed Original ResearchGynecologic conditionsHysterectomy proceduresBenign gynecologic conditionsPelvic organ prolapseProspective cohort studyTreatment of gynecological disordersUterine preservationPelvic painOrgan prolapseMedian agePatient ageUrinary incontinenceChart reviewGynecological disordersCohort studyUterusPatient questionnaireWhite racePatientsMedical CenterHysterectomyPerson-centered careMulticenterGrounded theory approachPhysiological rolePatients on Antidepressants Are at an Increased Risk of Adverse Events following Total Knee Arthroplasty.
Ratnasamy P, Diatta F, Oghenesume O, Sanchez J, Gouzoulis M, Grauer J. Patients on Antidepressants Are at an Increased Risk of Adverse Events following Total Knee Arthroplasty. Journal Of The American Academy Of Orthopaedic Surgeons 2024 PMID: 39637418, DOI: 10.5435/jaaos-d-24-00743.Peer-Reviewed Original ResearchTime of surgeryTotal knee arthroplasty patientsAdverse eventsRevision surgeryTotal knee arthroplastyPatient ageIncreased risk of adverse eventsRisk of adverse eventsElixhauser Comorbidity Index scorePostoperative adverse eventsInferior perioperative outcomesComorbidity Index scoreKnee arthroplastyPerioperative outcomesElixhauser Comorbidity IndexPostoperative outcomesAntidepressant medicationAntidepressantsComorbidity indexMultivariate analysisPatient populationSurgeryIncreased riskLevel IIIPatientsMedicare Local Coverage Determinations: Evidence Quality Is Stronger For Covered Indications
Moneer O, Mooghali M, Moosa K, Ramachandran R, Ross J, Dhruva S. Medicare Local Coverage Determinations: Evidence Quality Is Stronger For Covered Indications. Health Affairs 2024, 43: 1712-1718. PMID: 39626147, DOI: 10.1377/hlthaff.2024.00182.Peer-Reviewed Original ResearchConceptsCentury Cures ActLocal coverage determinationsCures ActQuality of evidenceHigh-risk devicesCoverage decisionsPatient ageClinical evidenceClinical studiesCoverage determinationMedical literatureTherapeutic drugsSixty-fiveCoverage databaseEvidence strengthEvidence qualityEvidence summaryActMedicare coverage decisionsMedicare beneficiary populationUlcerative Colitis Patients are at Increased Risk for Adverse Events Following Total Hip Arthroplasty
Oghenesume O, Gouzoulis M, Ratnasamy P, Dhodapkar M, Grauer J, Rubin L. Ulcerative Colitis Patients are at Increased Risk for Adverse Events Following Total Hip Arthroplasty. The Journal Of Arthroplasty 2024 PMID: 39515400, DOI: 10.1016/j.arth.2024.10.134.Peer-Reviewed Original ResearchPostoperative adverse eventsAdverse eventsClasses of medicationsElixhauser Comorbidity IndexUlcerative colitisPatient ageTotal hip arthroplastyTotal hip arthroplasty patientsFive-year survivalUlcerative colitis patientsArthroplasty patientsPatient's medication regimenHip arthroplasty patientsDisease ulcerative colitisUC patientsColitis patientsComorbidity indexCorticosteroidsPerioperative periodIncreased riskHip arthroplastyPatientsMedication regimenDisease processMatched groupReal-World Analysis of Insurer Rejection Rates for Specialty Oral Anticancer Prescriptions in a Nationwide Sample of Patients with Blood Cancer
Doshi J, Li P, Geng Z, Lei X, Pettit A, Armstrong K, Huntington S, Lin J. Real-World Analysis of Insurer Rejection Rates for Specialty Oral Anticancer Prescriptions in a Nationwide Sample of Patients with Blood Cancer. Blood 2024, 144: 786-786. DOI: 10.1182/blood-2024-203410.Peer-Reviewed Original ResearchInsurance typeBlood cancerMedicare patientsCommercial insuranceStep therapyFormulary coverageNationwide sample of patientsPrior authorizationTreatment plan changesDelayed treatment initiationMonths pre-indexOdds of rejectionLonger treatment durationLife-extending therapyReal-world studyOral anticancer medicationsSample of patientsBlood cancer patientsPatient ageClinical characteristicsTreatment initiationReal-world analysisBrand-nameRetrospective analysisPre-indexTen-year follow-up after face transplantation—A single-center retrospective cohort study
Huelsboemer L, Kauke-Navarro M, Boroumand S, Parikh N, Hosseini H, Yu C, Stögner V, Ko C, Perry B, Formica R, Hung P, Mahajan A, Azzi J, Murphy G, Pomahac B. Ten-year follow-up after face transplantation—A single-center retrospective cohort study. American Journal Of Transplantation 2024, 25: 611-622. PMID: 39413877, DOI: 10.1016/j.ajt.2024.10.007.Peer-Reviewed Original ResearchChronic rejectionFace transplantationFollow-upSingle center retrospective cohort studyFunctional outcomesSensory returnAnalysis of functional outcomesMedian follow-upIncidence of malignancyMetabolic side effectsGraft rejection episodesComputed tomography angiogramRetrospective cohort studyEvidence of vasculopathyFollow-up periodLong-term outcomesYear follow-upFacial motor functionRejection episodesInfectious complicationsTransplant recipientsPatient ageGraft retentionMedical complicationsCohort studyUtility of Risk Analysis Index for Assessing Morbidity in Patients Undergoing Posterior Spinal Fusion for Adult Spinal Deformity
Elsamadicy A, Sadeghzadeh S, Serrato P, Sayeed S, Hengartner A, Belkasim S, Khalid S, Lo S, Sciubba D. Utility of Risk Analysis Index for Assessing Morbidity in Patients Undergoing Posterior Spinal Fusion for Adult Spinal Deformity. World Neurosurgery 2024, 192: e292-e305. PMID: 39321916, DOI: 10.1016/j.wneu.2024.09.089.Peer-Reviewed Original ResearchPosterior spinal fusionAdult spinal deformityRisk Analysis IndexLength of stayMFI-5Spinal fusionReceiver operating characteristicSpinal deformityFrail patientsMultivariate analysisModified 5-item frailty indexACS NSQIP databasePreoperative surgical planningRetrospective cohort studyNSQIP databasePatient ageAssess morbidityComplication riskPredicting 30-day readmissionCohort studySurgical planningNormal patientsAdvanced ageComplicationsPatientsRisk of Postoperative Complications After Total Hip and Total Knee Arthroplasty in Behcet Syndrome Patients
Ratnasamy P, Diatta F, Allam O, Kauke-Navarro M, Grauer J. Risk of Postoperative Complications After Total Hip and Total Knee Arthroplasty in Behcet Syndrome Patients. JAAOS Global Research And Reviews 2024, 8: e24.00040. PMID: 39392934, PMCID: PMC11469891, DOI: 10.5435/jaaosglobal-d-24-00040.Peer-Reviewed Original ResearchConceptsBehcet's syndromeAdverse eventsTotal knee arthroplastyMultivariate analysisRevision surgeryRisk of postoperative complicationsRisk of perioperative adverse eventsTotal hip arthroplastyLog-rank testElixhauser Comorbidity Index scoreRetrospective cohort studyMultisystem autoimmune disorderPostoperative adverse eventsPerioperative adverse eventsComorbidity Index scoreNational administrative databaseKnee arthroplastyTotal knee arthroplasty patientsPostoperative complicationsNo significant differencePatient ageAutoimmune disordersPerioperative managementSyndrome patientsCohort study
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