2025
Dynamic Contrast-enhanced MRI Processing Comparison for Distinguishing True Progression From Pseudoprogression in High-grade Glioma.
Amer A, Ansari S, Krayyem A, Kundu S, Khose S, Pokhylevych H, Calle S, Patel C, Yang Z, Liu H, Johnson J. Dynamic Contrast-enhanced MRI Processing Comparison for Distinguishing True Progression From Pseudoprogression in High-grade Glioma. Journal Of Computer Assisted Tomography 2025 PMID: 39876523, DOI: 10.1097/rct.0000000000001716.Peer-Reviewed Original ResearchHigh-grade gliomasBlood-brain barrierDCE-MRIPeak contrast enhancementQuantify BBB permeabilityTreatment-related changesFollow-up subjectsKtrans mapsTrue progressionTumor progressionClinical dataConventional MRIPseudoprogressionBBB permeabilityCombined pathologyKtransContrast enhancementT1 enhancementStandard processing methodologyStatistically significant resultsClinical data setsPathologyPatientsGliomaSSS technique
2024
Foundational Models for Pathology and Endoscopy Images: Application for Gastric Inflammation
Kerdegari H, Higgins K, Veselkov D, Laponogov I, Polaka I, Coimbra M, Pescino A, Leja M, Dinis-Ribeiro M, Kanonnikoff T, Veselkov K. Foundational Models for Pathology and Endoscopy Images: Application for Gastric Inflammation. Diagnostics 2024, 14: 1912. PMID: 39272697, PMCID: PMC11394237, DOI: 10.3390/diagnostics14171912.Peer-Reviewed Original ResearchUpper gastrointestinal (GI) cancerIntestinal metaplasiaGastric cancerGastrointestinal (GI) cancersImprove patient outcomesAccuracy of endoscopyCancer mortalityGlobal cancer mortalityArtificial intelligencePatient outcomesGC casesChronic inflammationRegular surveillanceGastric inflammationDeep learning modelsClinical practiceIntegration of artificial intelligenceIntegration of multimodal dataLarge-scale dataPathology image analysisEndoscopyCancerEarly detectionMultimodal dataPathologySpatial transcriptomics elucidates medulla niche supporting germinal center response in myasthenia gravis-associated thymoma
Yasumizu Y, Kinoshita M, Zhang M, Motooka D, Suzuki K, Nojima S, Koizumi N, Okuzaki D, Funaki S, Shintani Y, Ohkura N, Morii E, Okuno T, Mochizuki H. Spatial transcriptomics elucidates medulla niche supporting germinal center response in myasthenia gravis-associated thymoma. Cell Reports 2024, 43: 114677. PMID: 39180749, DOI: 10.1016/j.celrep.2024.114677.Peer-Reviewed Original ResearchMyasthenia gravisMedullary thymic epithelial cellsGerminal center responseRegulatory T cellsImmune cell compositionMigratory dendritic cellsThymic epithelial cellsCortico-medullary junctionImmune microenvironmentDendritic cellsT cellsChemokine patternsThymus abnormalitiesHyperplasia samplesThymomaSpatial transcriptomic analysisEpithelial cellsMG pathologyMedullary regionCenter responseMedullaCell compositionCortical regionsPathologyCellsPlacental Vascular Anastamoses and Associated Pathologies in Dichorionic Twin Gestations
Dave E, Bahtiyar M, Campbell W, Morotti R, Kohari K. Placental Vascular Anastamoses and Associated Pathologies in Dichorionic Twin Gestations. Twin Research And Human Genetics 2024, 27: 251-255. PMID: 39508257, DOI: 10.1017/thg.2024.35.Peer-Reviewed Original ResearchTwin-to-twin transfusion syndromeTwin anemia-polycythemia sequenceDichorionic twin gestationsVascular anastamosesTwin gestationsDichorionic twin pregnanciesTwin transfusion syndromePlacental vascular anastomosesDichorionic gestationsMonochorionic pregnanciesPrenatal surveillanceTransfusion syndromeTwin pregnanciesGestationMitigate morbidityVascular anastomosisAssociated pathologyPregnancyAnastamosesPathologyDichorionicityMorbidityPathophysiologySyndromeArtificial intelligence–aided steatosis assessment in donor livers according to the Banff consensus recommendations
Jiao J, Tang H, Sun N, Zhang X. Artificial intelligence–aided steatosis assessment in donor livers according to the Banff consensus recommendations. American Journal Of Clinical Pathology 2024, 162: 401-407. PMID: 38716796, DOI: 10.1093/ajcp/aqae053.Peer-Reviewed Original ResearchBanff Working GroupLiver Allograft PathologyBiopsy specimensDonor liversAllograft pathologyAssociated with primary graft dysfunctionMacrovesicular steatosisPrimary graft dysfunctionManual quantificationSteatosis assessmentLiver biopsy specimensSevere macrovesicular steatosisAssessment of liver steatosisGraft dysfunctionPathological evaluationModerate steatosisEvaluate steatosisConsensus recommendationsLiver steatosisSteatosisBanffLiverPathologyAI modelsArtificial intelligenceNeuromarkers in addiction: definitions, development strategies, and recent advances
Harp N, Wager T, Kober H. Neuromarkers in addiction: definitions, development strategies, and recent advances. Journal Of Neural Transmission 2024, 131: 509-523. PMID: 38630190, DOI: 10.1007/s00702-024-02766-2.Peer-Reviewed Original ResearchConceptsSubstance use disordersFeatures of substance use disordersResponse to treatmentNeurobiological basisAddiction neuroscienceIndividual treatment outcomesPsychiatric conditionsDetecting response to treatmentPsychological phenomenaNeuromarkersIndex riskSeverity of pathologyTreatment outcomesAbnormal processingAddictionPutative markerClinical practiceStable indicatorSevere pathologyAssess riskNeurosciencePathologyReview recent advancesDisordersTreatmentReliable Prostate Cancer Risk Mapping From MRI Using Targeted and Systematic Core Needle Biopsy Histopathology
Zeevi T, Leapman M, Sprenkle P, Venkataraman R, Staib L, Onofrey J. Reliable Prostate Cancer Risk Mapping From MRI Using Targeted and Systematic Core Needle Biopsy Histopathology. IEEE Transactions On Biomedical Engineering 2024, 71: 1084-1091. PMID: 37874731, PMCID: PMC10901528, DOI: 10.1109/tbme.2023.3326799.Peer-Reviewed Original ResearchMagnetic resonance imagingIndividual patientsBiopsy locationProstate biopsy dataBiopsy histopathologyHistopathology scoresPathology scoresBiopsy dataMRI biomarkersTreatment planPatientsResonance imagingProstate regionBiomarkersTherapy treatment plansPathologyRepresentative sampleScoresImaging analysisPrevious studiesHistopathologyProstateCancerCliniciansNeutrophils in Physiology and Pathology
Aroca-Crevillén A, Vicanolo T, Ovadia S, Hidalgo A. Neutrophils in Physiology and Pathology. Annual Review Of Pathology Mechanisms Of Disease 2024, 19: 227-259. PMID: 38265879, PMCID: PMC11060889, DOI: 10.1146/annurev-pathmechdis-051222-015009.Peer-Reviewed Original ResearchBrain energy metabolism: A roadmap for future research
Rae C, Baur J, Borges K, Dienel G, Díaz‐García C, Douglass S, Drew K, Duarte J, Duran J, Kann O, Kristian T, Lee‐Liu D, Lindquist B, McNay E, Robinson M, Rothman D, Rowlands B, Ryan T, Scafidi J, Scafidi S, Shuttleworth C, Swanson R, Uruk G, Vardjan N, Zorec R, McKenna M. Brain energy metabolism: A roadmap for future research. Journal Of Neurochemistry 2024, 168: 910-954. PMID: 38183680, PMCID: PMC11102343, DOI: 10.1111/jnc.16032.Peer-Reviewed Original ResearchChapter 6 The eye and the microbiome
Raolji S, Lai J, Watane A, Goodman C, Chipkin B, Galor A. Chapter 6 The eye and the microbiome. 2024, 229-262. DOI: 10.1016/b978-0-323-90144-4.00006-9.Peer-Reviewed Original Research
2023
Distinguishing probable atypical anorexia nervosa from weight loss alone in a national sample of U.S. Military Veterans: Disentangling the roles of weight suppression and cognitive concerns
Neff K, Buta E, Fenn L, Ramsey C, Snow J, Haskell S, Masheb R. Distinguishing probable atypical anorexia nervosa from weight loss alone in a national sample of U.S. Military Veterans: Disentangling the roles of weight suppression and cognitive concerns. International Journal Of Eating Disorders 2023, 57: 827-838. PMID: 38129986, DOI: 10.1002/eat.24116.Peer-Reviewed Original ResearchAtypical anorexia nervosaAtypical ANWeight suppressionAnorexia nervosaClinical entityWeight lossControl groupDietary restraintMental healthDistinct clinical entityPoor mental healthOnly groupU.S. military veteransClinical significanceHigh riskVeteran populationSecondary analysisWeight gainSpecialized interventionsMilitary veteransNervosaDisordersVeteransNational studyPathologyDiencephalic organoids – A key to unraveling development, connectivity, and pathology of the human diencephalon
Kiral F, Choe M, Park I. Diencephalic organoids – A key to unraveling development, connectivity, and pathology of the human diencephalon. Frontiers In Cellular Neuroscience 2023, 17: 1308479. PMID: 38130869, PMCID: PMC10733522, DOI: 10.3389/fncel.2023.1308479.Peer-Reviewed Original ResearchHuman diencephalonBrain organoidsNeurodevelopmental disordersDevelopmental brain disordersHuman brain tissueThalamocortical connectionsBrain disordersDiencephalic developmentBrain tissueDiencephalic structuresOrganoid modelsHuman-specific aspectsSensory processingDiencephalonDisordersTelencephalic fatePathologyStem cellsStem cell technologyOrganoidsDevelopment and interobserver reliability of a rating scale for lung ultrasound pathology in lower respiratory tract infection
Baloescu C, Chen A, Schnittke N, Hicks B, Zhu M, Kaili M, Shupp J, Chan D, Malia L, Coneybeare D, Gregory K, Kessler D, Raju B, Moore C. Development and interobserver reliability of a rating scale for lung ultrasound pathology in lower respiratory tract infection. WFUMB Ultrasound Open 2023, 1: 100006. DOI: 10.1016/j.wfumbo.2023.100006.Peer-Reviewed Original ResearchLower respiratory tract infectionsRespiratory tract infectionsIntraclass correlation coefficientTract infectionsUltrasound pathologiesRating ScaleSonographic findingsInter-rater reliabilityExpert consensusPleural line abnormalitiesGood inter-rater reliabilityAverage intraclass correlation coefficientSeverity Rating ScalePleural effusionLung aerationSeverity ScaleFourth subsetInterobserver reliabilityCine clipsInfectionUltrasound expertsScanning protocolPathologyB-linesCOVID-19Evaluation and management of hypotensive patients in the emergency department.
Srica N, Strunk C. Evaluation and management of hypotensive patients in the emergency department. Emergency Medicine Practice 2023, 25: 1-28. PMID: 37976547.Peer-Reviewed Original ResearchConceptsDisease courseSignificant underlying pathologyPatient's disease courseTreatment of hypotensionPhysical examination findingsHypotensive patientsOrgan injuryExamination findingsEmergency departmentUnderlying pathologyBedside evaluationSerial reassessmentPatient's conditionHypotensionDiagnostic testsRapid initiationPatientsEtiologyTreatmentInjuryPathologyEvaluationNeuroimaging to monitor worsening of multiple sclerosis: advances supported by the grant for multiple sclerosis innovation
Oh J, Airas L, Harrison D, Järvinen E, Livingston T, Lanker S, Malik R, Okuda D, Villoslada P, de Vries H. Neuroimaging to monitor worsening of multiple sclerosis: advances supported by the grant for multiple sclerosis innovation. Frontiers In Neurology 2023, 14: 1319869. PMID: 38107636, PMCID: PMC10722910, DOI: 10.3389/fneur.2023.1319869.Peer-Reviewed Original ResearchMultiple sclerosisClinical trialsMonitoring of MSMagnetic resonance imagingPositron emission tomographyDisability worseningKey unmetCentral pathologyEarly pathologyTreatment responseNew therapiesOcular imagingUnmet needResonance imagingEmission tomographyDisease pathologyNew therapeuticsPathologyNeuroimaging measuresTrialsLongitudinal studySclerosisClinicWorseningBiomarkersNanoscale imaging of pT217-tau in aged rhesus macaque: Trans-synaptic propagation and seeding of tau pathology in entorhinal cortex
Datta D, Arnsten A. Nanoscale imaging of pT217-tau in aged rhesus macaque: Trans-synaptic propagation and seeding of tau pathology in entorhinal cortex. Journal Of The Neurological Sciences 2023, 455: 122501. DOI: 10.1016/j.jns.2023.122501.Peer-Reviewed Original ResearchNCCN Guidelines® Insights: Cervical Cancer, Version 1.2024.
Abu-Rustum N, Yashar C, Arend R, Barber E, Bradley K, Brooks R, Campos S, Chino J, Chon H, Crispens M, Damast S, Fisher C, Frederick P, Gaffney D, Gaillard S, Giuntoli R, Glaser S, Holmes J, Howitt B, Lea J, Mantia-Smaldone G, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Podoll M, Rodabaugh K, Salani R, Schorge J, Siedel J, Sisodia R, Soliman P, Ueda S, Urban R, Wyse E, McMillian N, Aggarwal S, Espinosa S. NCCN Guidelines® Insights: Cervical Cancer, Version 1.2024. Journal Of The National Comprehensive Cancer Network 2023, 21: 1224-1233. PMID: 38081139, DOI: 10.6004/jnccn.2023.0062.Peer-Reviewed Original ResearchConceptsCervical cancerNCCN guidelinesNCCN Guidelines InsightsSystemic therapy recommendationsAdvanced cervical cancerMetastatic diseaseTreatment landscapeClinical outcomesDiagnostic workupHistopathologic classificationTherapy recommendationsCancerMolecular profileAspects of managementRecent updatesDiagnostic featuresGuidelinesWorkupStagingDiseaseRecurrentPathologyLocalization of PDE4D, HCN1 channels, and mGluR3 in rhesus macaque entorhinal cortex may confer vulnerability in Alzheimer’s disease
Datta D, Perone I, Morozov Y, Arellano J, Duque A, Rakic P, van Dyck C, Arnsten A. Localization of PDE4D, HCN1 channels, and mGluR3 in rhesus macaque entorhinal cortex may confer vulnerability in Alzheimer’s disease. Cerebral Cortex 2023, 33: 11501-11516. PMID: 37874022, PMCID: PMC10724870, DOI: 10.1093/cercor/bhad382.Peer-Reviewed Original ResearchConceptsHCN1 channelsTau pathologyGlutamate synapsesEntorhinal cortexCalcium actionInternal calcium releaseEntorhinal cortex stellate cellsDorsolateral prefrontal cortexSusceptible neuronsInitial pathologySelective vulnerabilityEtiological factorsTau phosphorylationStellate cellsAlzheimer's diseaseSpecific neuronsCalcium releasePrefrontal cortexCortexSynapse strengthPathologyCalcium signalingCalbindinDiseaseNeuronsMicrofluidic Immuno‐Serolomic Assay Reveals Systems Level Association with COVID‐19 Pathology and Vaccine Protection (Small Methods 10/2023)
Kim D, Biancon G, Bai Z, VanOudenhove J, Liu Y, Kothari S, Gowda L, Kwan J, Buitrago‐Pocasangre N, Lele N, Asashima H, Racke M, Wilson J, Givens T, Tomayko M, Schulz W, Longbrake E, Hafler D, Halene S, Fan R. Microfluidic Immuno‐Serolomic Assay Reveals Systems Level Association with COVID‐19 Pathology and Vaccine Protection (Small Methods 10/2023). Small Methods 2023, 7 DOI: 10.1002/smtd.202370057.Peer-Reviewed Original ResearchA multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia
Sri S, Greenstein A, Granata A, Collcutt A, Jochems A, McColl B, Castro B, Webber C, Reyes C, Hall C, Lawrence C, Hawkes C, Pegasiou-Davies C, Gibson C, Crawford C, Smith C, Vivien D, McLean F, Wiseman F, Brezzo G, Lalli G, Pritchard H, Markus H, Bravo-Ferrer I, Taylor J, Leiper J, Berwick J, Gan J, Gallacher J, Moss J, Goense J, McMullan L, Work L, Evans L, Stringer M, Ashford M, Abulfadl M, Conlon N, Malhotra P, Bath P, Canter R, Brown R, Ince S, Anderle S, Young S, Quick S, Szymkowiak S, Hill S, Allan S, Wang T, Quinn T, Procter T, Farr T, Zhao X, Yang Z, Hainsworth A, Wardlaw J. A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia. Cerebral Circulation - Cognition And Behavior 2023, 5: 100189. PMID: 37941765, PMCID: PMC10628644, DOI: 10.1016/j.cccb.2023.100189.Peer-Reviewed Original ResearchVascular cognitive impairmentAlzheimer's diseaseAD brain pathologySmall vessel diseaseClinical featuresMixed pathologyMost dementiasVascular dementiaVessel diseaseVascular contributionsBrain pathologyCognitive impairmentDementiaPreclinical researchOlder peopleDiseasePathologyCommon typeDementia researchHuman pathologiesVCI modelPathogenesisEtiologyImpairment
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