2025
American Association for the Surgery of Trauma pancreatic organ injury scale: 2024 revision
Notrica D, Tominaga G, Gross J, Southard R, McOmber M, Crandall M, Kozar R, Kaups K, Schuster K, Ball C. American Association for the Surgery of Trauma pancreatic organ injury scale: 2024 revision. Journal Of Trauma And Acute Care Surgery 2025, 98: 442-447. PMID: 39898876, DOI: 10.1097/ta.0000000000004522.Peer-Reviewed Original ResearchConceptsOrgan Injury ScaleDuctal injuryPancreatic headAmerican Association for the Surgery of Trauma-Organ Injury ScaleAmerican Association for the SurgeryAmerican Association for the Surgery of TraumaGrade V injuriesGrade IV injuriesSurgery of TraumaInjury ScaleV injuriesGrade IIIDuctal transectionGrade IIParenchymal injuryIV injuriesPathological findingsPortal veinInterventional gastroenterologyGrading systemIncreasing gradeInjury locationDuctal integrityClinical experienceIncreasing severity
2024
Lupus erythematosus and dermatomyositis
Ramachandran S, Little A, Gehlhausen J. Lupus erythematosus and dermatomyositis. Clinics In Dermatology 2024 PMID: 39694200, DOI: 10.1016/j.clindermatol.2024.12.009.Peer-Reviewed Original ResearchLupus erythematosusSystemic diseaseTraining of dermatologistsManifestation of systemic diseaseSymptoms of systemic lupus erythematosusCutaneous manifestations of systemic diseaseAutoimmune connective tissue diseaseSystemic lupus erythematosusConnective tissue diseaseSigns of systemic diseasePatient carePhysical examination findingsInternal medicineCutaneous manifestationsYoung dermatologistsTissue diseaseClinicopathologic correlationPathological findingsExamination findingsSkin signsSystem pathologyField of dermatologyClinical signsObservation skillsDiscordances Between Radiology and Pathology
Harigopal M, Verma A, Andrejeva L, Lewin J. Discordances Between Radiology and Pathology. 2024, 375-391. DOI: 10.1007/978-3-031-65711-5_14.Peer-Reviewed Original ResearchPathological findingsImaging characteristicsMRI-guided biopsyFalse-negative diagnosesRadiology-pathology correlationH&E levelsPreoperative biopsyStereotactic biopsySurgical excisionPercutaneous biopsyDiscordant casesSonographic guidanceBreast biopsyAncillary stainsHistopathological findingsBiopsyMammographic lesionsLesionsIndividual pathologistsPathologistsPotential causesUltrasoundWeekly conferencesImage featuresDiscordanceConventional and Contrast-enhanced US of the Lung: From Performance to Diagnosis.
Jiménez-Serrano S, Páez-Carpio A, Doménech-Ximenos B, Cornellas L, Sánchez M, Revzin M, Vollmer I. Conventional and Contrast-enhanced US of the Lung: From Performance to Diagnosis. RadioGraphics 2024, 44: e230171. PMID: 38935548, DOI: 10.1148/rg.230171.Peer-Reviewed Original ResearchConceptsPeripheral lung diseaseContrast-enhanced USDiagnosis of peripheral lung diseasePercutaneous biopsyLung USEnhancement patternLung diseaseImage-guided percutaneous biopsyAccurate differential diagnosisDiagnostic chest imagingLung biopsySubpleural lesionsConventional USDifferential diagnosisPathological findingsPulmonary physiologyChest imagingArterial supplyBiopsyLungDiagnostic testsDiagnosisSoft tissueDiseaseImaging time
2022
P11.54.A Factors effecting early diagnosis in neurolymphomatosis
Egert A, Karschnia P, Huttner A, Baehring J, Kaulen L. P11.54.A Factors effecting early diagnosis in neurolymphomatosis. Neuro-Oncology 2022, 24: ii70-ii70. PMCID: PMC9443184, DOI: 10.1093/neuonc/noac174.243.Peer-Reviewed Original ResearchNon-Hodgkin lymphomaEarly diagnosisSymptom onsetPathological findingsDiffuse large B-cell lymphomaCase of neurolymphomatosisDiagnosis of neurolymphomatosisYale Cancer CenterTertiary referral centerFDG-PET imagingPeripheral nervous systemB-cell lymphomaImaging gold standardSPSS version 27Painful polyneuropathyPainless polyneuropathySecondary neurolymphomatosisAutonomic neuropathyCranial neuropathiesMedian intervalReferral centerAutonomic nervesClinical suspicionFDG-PETCancer CenterCellular and Molecular Pathology in Tourette Syndrome
Fasching L, Brady M, Vaccarino F. Cellular and Molecular Pathology in Tourette Syndrome. 2022, 171-183. DOI: 10.1093/med/9780197543214.003.0012.ChaptersTourette syndromeBasal gangliaAminobutyric acid-ergic interneuronsActive cholinergic interneuronsPathophysiology of TSCholinergic interneuronsPathological findingsMicroglial cellsTic disordersCaudate nucleusCortical hemispherePathogenic mechanismsInterneuronsSyndromeMolecular pathologyGangliaProminent increaseAvailable literatureInflammationPathophysiologyPutamenFindingsPathology
2021
Liver Pathology, Including MOC31 Immunohistochemistry, in Congenital Tufting Enteropathy
Chen S, Goldsmith J, Fawaz R, Al-Ibraheemi A, Perez-Atayde A, Vargas S. Liver Pathology, Including MOC31 Immunohistochemistry, in Congenital Tufting Enteropathy. The American Journal Of Surgical Pathology 2021, 45: 1091-1097. PMID: 33756496, DOI: 10.1097/pas.0000000000001710.Peer-Reviewed Original ResearchConceptsCTE patientsCongenital tufting enteropathyParenteral nutritionBiliary epitheliumDuctular reactionLiver pathologyChronic hepatitis CHepatitis C patientsEpithelial cell adhesion moleculeLiver core biopsyIntestinal villous atrophyNormal brush borderClinicopathologic materialEpCAM-deficientCore biopsyTufting enteropathyC patientsEpCAM mutationsCell adhesion moleculesHepatitis CLiver biopsyMOC31Affected patientsLobular inflammationPathological findings
2020
Neutrophils interact with cholangiocytes to cause cholestatic changes in alcoholic hepatitis
Takeuchi M, Vidigal PT, Guerra MT, Hundt MA, Robert ME, Olave-Martinez M, Aoki S, Khamphaya T, Kersten R, Kruglov E, de la Rosa Rodriguez R, Banales JM, Nathanson MH, Weerachayaphorn J. Neutrophils interact with cholangiocytes to cause cholestatic changes in alcoholic hepatitis. Gut 2020, 70: 342-356. PMID: 33214166, PMCID: PMC7906004, DOI: 10.1136/gutjnl-2020-322540.Peer-Reviewed Original ResearchConceptsBile ductCholestatic changesLimited treatment optionsPresence of cholestasisAbility of neutrophilsLife-threatening diseaseNew therapeutic targetsHuman bile ductIntracellular calcium channelsAlcoholic hepatitisLiver biopsyControl neutrophilsPathological findingsHepatocellular damageHistological findingsTreatment optionsCell adhesion moleculeHistological parametersDisease altersITPR3 expressionTherapeutic targetAnimal modelsCalcium channelsNeutrophilsPatientsStem Cell Therapy for Thromboangiitis Obliterans (Buerger’s Disease)
Dash B, Peyvandi H, Duan K, Richardson E, Ndon S, Gabrick K, Faz A, Persing J, Dardik A, Hsia H. Stem Cell Therapy for Thromboangiitis Obliterans (Buerger’s Disease). Processes 2020, 8: 1408. DOI: 10.3390/pr8111408.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsThromboangiitis obliteransYoung male smokersBuerger's diseaseImmunomodulatory approachesMale smokersSurgical bypassPathological findingsTreatment modalitiesVascular diseaseDefinitive cureLower extremitiesMedium arteriesLesion treatmentTherapeutic modalitiesTAO treatmentTherapeutic angiogenesisCell therapyDiseaseObliteransStem cellsCurrent knowledgeModalitiesTreatmentPotential optionVasculitisOral lymphangiectasia and gastrointestinal Crohn disease
Lenskaya V, Panji P, de Moll E, Christian K, Phelps R. Oral lymphangiectasia and gastrointestinal Crohn disease. Journal Of Cutaneous Pathology 2020, 47: 1080-1084. PMID: 32761835, DOI: 10.1111/cup.13834.Peer-Reviewed Original ResearchConceptsMelkersson-Rosenthal syndromeCrohn's diseaseCheilitis granulomatosaTreated with systemic steroidsNon-caseating granulomasClinical contextIntralymphatic granulomasLip edemaSystemic steroidsLip swellingOral symptomsPathological evaluationDiagnosing GCHistopathological findingsGastrointestinal symptomsLymphatic obstructionPathological findingsEarly recognitionEarly diagnosisWork-upSymptoms of CDLymphangiectasiaGranulomaYoung womenGastrointestinal diseasesMouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling
Israelow B, Song E, Mao T, Lu P, Meir A, Liu F, Alfajaro MM, Wei J, Dong H, Homer RJ, Ring A, Wilen CB, Iwasaki A. Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling. Journal Of Experimental Medicine 2020, 217: e20201241. PMID: 32750141, PMCID: PMC7401025, DOI: 10.1084/jem.20201241.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin-Converting Enzyme 2AnimalsBetacoronavirusCell Line, TumorCoronavirus InfectionsCOVID-19DependovirusDisease Models, AnimalFemaleHumansInflammationInterferon Type ILungMaleMiceMice, Inbred C57BLMice, TransgenicPandemicsParvoviridae InfectionsPeptidyl-Dipeptidase APneumonia, ViralSARS-CoV-2Signal TransductionVirus ReplicationConceptsSARS-CoV-2Type I interferonMouse modelI interferonRobust SARS-CoV-2 infectionSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2SARS-CoV-2 infectionRespiratory syndrome coronavirus 2SARS-CoV-2 replicationCOVID-19 patientsSyndrome coronavirus 2Patient-derived virusesSignificant fatality ratePathological findingsInflammatory rolePathological responseEnzyme 2Receptor angiotensinFatality rateVaccine developmentGenetic backgroundViral replicationCoronavirus diseaseMice
2018
PE35 Pathologic findings and MRI concordance at salvage RARP for local recurrence following high-intensity focused ultrasound (HIFU) therapy: High rate of adverse prognostic features and poor sensitivity of MRI
Thompson J, Sridhar A, Tan W, Khetrapal P, Mazzon G, Shaw G, Rajan P, Alkadhi O, Di G, Briggs T, Nathan S, Sooriakumaran P, Kelly J. PE35 Pathologic findings and MRI concordance at salvage RARP for local recurrence following high-intensity focused ultrasound (HIFU) therapy: High rate of adverse prognostic features and poor sensitivity of MRI. European Urology Open Science 2018, 17: e2296. DOI: 10.1016/s1569-9056(18)32698-8.Peer-Reviewed Original ResearchVIDEO: Rethinking "Mural Thickening:" Vasculitis or Aortic Dissection?
Harrington C, Brescia A, Tieu B, Fuss C. VIDEO: Rethinking "Mural Thickening:" Vasculitis or Aortic Dissection? American Journal Of Roentgenology 2018, 210: w240-w241. PMID: 29683349, DOI: 10.2214/ajr.17.19090.Peer-Reviewed Original Research
2017
Congenital Cystic Lung Lesions
Hardee S, Tuzovic L, Silva CT, Cowles RA, Copel J, Morotti RA. Congenital Cystic Lung Lesions. Pediatric And Developmental Pathology 2017, 20: 403-410. PMID: 28812458, DOI: 10.1177/1093526617698604.Peer-Reviewed Original ResearchConceptsCongenital cystic lung lesionsCongenital pulmonary airway malformationCystic lung lesionsBronchopulmonary sequestrationLung lesionsPrenatal ultrasoundSingle tertiary care centerPulmonary airway malformationTertiary care centerFinal pathologic diagnosisCorrelate imagingCPAM lesionsAirway malformationExcellent prognosisPostnatal imagingRetrospective reviewPathological findingsPathology databaseRare pathologySurgical interventionBronchial atresiaPrenatal coursePathologic diagnosisPathology examinationCare centerCo-expression of tissue factor and IL-6 in immature endothelial cells of cerebral cavernous malformations
Noshiro S, Mikami T, Kataoka-Sasaki Y, Sasaki M, Ohnishi H, Ohtaki S, Wanibuchi M, Mikuni N, Kocsis JD, Honmou O. Co-expression of tissue factor and IL-6 in immature endothelial cells of cerebral cavernous malformations. Journal Of Clinical Neuroscience 2017, 37: 83-90. PMID: 28087183, DOI: 10.1016/j.jocn.2016.12.023.Peer-Reviewed Original ResearchConceptsCerebral cavernous malformationsInterleukin-6Immature endothelial cellsTissue factorMRNA expression levelsEndothelial cellsCavernous malformationsSporadic cerebral cavernous malformationDistribution of TFExpression levelsNormal endothelial cellsClinical factorsPrognostic rolePathological findingsUnderlying pathologyOperative specimensMRNA expressionAssociation of TFAbnormal clustersMalformationsProgressive eventsMessenger RNACellsExpressionAssociationOvarian Sertoli-Leydig cell tumors: a single institution experience and review of the literature.
Gressel G, Buza N, Pal L. Ovarian Sertoli-Leydig cell tumors: a single institution experience and review of the literature. European Journal Of Gynaecological Oncology 2017, 38: 214-220. PMID: 29953783.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsChemotherapy, AdjuvantDisease-Free SurvivalFemaleHumansHyperandrogenismHysterectomyMiddle AgedNeoadjuvant TherapyNeoplasm GradingOvarian NeoplasmsOvariectomyPostmenopauseRetrospective StudiesSalpingectomySertoli-Leydig Cell TumorConceptsSertoli-Leydig cell tumorOvarian Sertoli-Leydig cell tumorPresent patient populationDisease-free survivalSingle institution experienceTertiary care institutionTime of diagnosisOnset of menopauseRisk of recurrenceSeries of casesAdjuvant chemotherapyMedian followPostmenopausal bleedingPostmenopausal patientsMedian ageMedian intervalClinical presentationDefinitive managementPathological findingsRetrospective reviewInstitution experiencePatient populationTreatment modalitiesCell tumorsTumor grade
2016
Biological relevance of tissue factor and IL-6 in arteriovenous malformations
Noshiro S, Mikami T, Kataoka-Sasaki Y, Sasaki M, Hashi K, Ohtaki S, Wanibuchi M, Mikuni N, Kocsis JD, Honmou O. Biological relevance of tissue factor and IL-6 in arteriovenous malformations. Neurosurgical Review 2016, 40: 359-367. PMID: 27542852, DOI: 10.1007/s10143-016-0780-1.Peer-Reviewed Original ResearchConceptsInterleukin-6Vascular endothelial growth factor receptor 2Arteriovenous malformationsTissue factorControl tissuesMRNA expressionEndothelial cellsAbnormal endothelial cellsPlatelet-derived growth factor receptor betaGrowth factor receptor 2Growth factor receptor betaEndothelial growth factor receptor 2Factor receptor 2Distribution of TFSporadic arteriovenous malformationsNormal endothelial cellsMessenger RNAAsymptomatic groupSymptomatic groupClinical factorsPrognostic rolePathological findingsShunt bloodUnderlying pathologyOperative specimensCONGENITAL CYSTIC LUNG LESIONS: EVOLUTION FROM IN-UTERO TO PATHOLOGY DIAGNOSIS - A MULTIDISCIPLINARY APPROACH
Hardee S, Tuzovic L, Silva C, Cowles R, Copel J, Morotti R. CONGENITAL CYSTIC LUNG LESIONS: EVOLUTION FROM IN-UTERO TO PATHOLOGY DIAGNOSIS - A MULTIDISCIPLINARY APPROACH. Pediatric And Developmental Pathology 2016 DOI: 10.2350/16-05-1815-oa.1.Peer-Reviewed Original ResearchCongenital cystic lung lesionsCongenital pulmonary airway malformationBronchopulmonary sequestrationPrenatal ultrasoundSingle tertiary care centerCystic lung lesionsPulmonary airway malformationTertiary care centerFinal pathologic diagnosisCorrelate imagingCPAM lesionsAirway malformationExcellent prognosisPathological findingsPostnatal imagingRetrospective reviewPathology databaseSurgical interventionRare pathologyBronchial atresiaLung lesionsPathologic diagnosisPrenatal coursePathology examinationCare centerVaried autopsy findings in five treated patients with Gaucher disease and parkinsonism include the absence of Gaucher cells
Monestime G, Borger DK, Kim J, Lopez G, Allgaeuer M, Jain D, Vortmeyer A, Wang HW, Sidransky E. Varied autopsy findings in five treated patients with Gaucher disease and parkinsonism include the absence of Gaucher cells. Molecular Genetics And Metabolism 2016, 118: 55-59. PMID: 26992326, DOI: 10.1016/j.ymgme.2016.02.008.Peer-Reviewed Original ResearchConceptsAutopsy findingsGaucher diseaseDose/durationEnzyme replacement therapySpleen statusPathological findingsReplacement therapyDisease burdenPathological studiesGaucher cellsPatientsHematological symptomsExtensive involvementTherapyParkinsonismDiseaseMultiple tissuesComplete absenceFindingsAutopsiesSymptomsPathologyBiomarkersCareChange in a 17-gene genomic prostate score over time in men with low- and intermediate-risk prostate cancer managed with active surveillance.
Leapman M, Cowan J, Nguyen H, Cooperberg M, Carroll P. Change in a 17-gene genomic prostate score over time in men with low- and intermediate-risk prostate cancer managed with active surveillance. Journal Of Clinical Oncology 2016, 34: 124-124. DOI: 10.1200/jco.2016.34.2_suppl.124.Peer-Reviewed Original ResearchGenomic Prostate ScoreAdverse pathological findingsActive surveillanceProstate cancerRadical prostatectomyPathological findingsFavorable-risk prostate cancerIntermediate-risk prostate cancerIntermediate clinical riskNCCN risk classificationSerial prostate biopsyRisk prostate cancerSubsequent clinical outcomesTime of surgeryRT-PCR assaysPT3a diseaseDefinitive therapyIntermediate riskOncologic outcomesClinical outcomesAdverse pathologySerial biopsiesProstate biopsyMedian changeSerial changes
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