2025
Protocol for finding genetic variation associated with unmeasured traits through GenomicSEM common-factor GWAS
Johnston K, Signer R, Huckins L. Protocol for finding genetic variation associated with unmeasured traits through GenomicSEM common-factor GWAS. STAR Protocols 2025, 6: 103905. PMID: 40531628, PMCID: PMC12213288, DOI: 10.1016/j.xpro.2025.103905.Peer-Reviewed Original ResearchPredictors of Physical, Chiropractic, and Acupuncture Therapy Utilization in the Three Months Following Newly Diagnosed Low Back Pain.
Seddio A, Dhodapkar M, Halperin S, Jabbouri S, Gouzoulis M, Joo P, Grauer J. Predictors of Physical, Chiropractic, and Acupuncture Therapy Utilization in the Three Months Following Newly Diagnosed Low Back Pain. Clinical Spine Surgery A Spine Publication 2025 PMID: 40521727, DOI: 10.1097/bsd.0000000000001859.Peer-Reviewed Original ResearchLow back painChiropractic therapyAcupuncture therapyBack painDays of low back painNonclinical factorsLow back pain patientsPredictors of CT utilizationTherapy utilizationMultivariate logistic regressionMusculoskeletal problemsPhysical therapyElixhauser Comorbidity IndexIndependent predictorsLogistic regressionCT utilizationUtilization patternsAcupunctureLevel IIIMale sexExclusion criteriaComorbidity indexTherapy typeNational levelPainInterventional Image-Guided Deformity-Correcting Options for Pathological Fractures
Elsamadicy A, Reeves B, Robert S, Latich I, Kolb L, Laurans M, Mendel E. Interventional Image-Guided Deformity-Correcting Options for Pathological Fractures. 2025, 93-111. DOI: 10.1007/978-3-031-87939-5_7.Peer-Reviewed Original ResearchPathological fracturesMechanical back painIdeal surgical candidatesTumor mass effectMinimally invasive interventionsMechanical painSurgical candidatesBack painMetastatic cancerOsteoporosis literatureInvasive interventionsAblative interventionsTreated levelOncology populationPatientsMass effectPainMild deformityPolymethylmethacrylate cementAffected levelCementoplastyOsteoporosisInterventionCancerSpinePsychosocial mechanisms underlying the transition from acute to chronic postsurgical pain in youth following spinal fusion: a 6-month longitudinal study.
Li R, Rogers A, Sujan A, Zhou C, Thiagarajan P, Palermo T, Kain Z, Rabbitts J. Psychosocial mechanisms underlying the transition from acute to chronic postsurgical pain in youth following spinal fusion: a 6-month longitudinal study. Pain 2025 PMID: 40408233, DOI: 10.1097/j.pain.0000000000003631.Peer-Reviewed Original ResearchChronic postsurgical painAcute pain intensityPain intensityPain catastrophizingPsychosocial factorsPostsurgical painSpinal fusionAcute to chronic postsurgical painDevelopment of chronic postsurgical painAcute pain severityHigher pain intensityParental distressCPSP developmentLongitudinal studyCausal mediation analysisPain severityAdolescent psychosocial factorsPain interferenceDays postsurgeryPainPsychological distressPresurgeryPsychosocial changesPostsurgeryPsychosocial mechanismsPharmacological and behavioral pain treatment strategies for patients with opioid use disorder
Ameral V, Hickey T, Reilly E, Patterson J, Sofuoglu M. Pharmacological and behavioral pain treatment strategies for patients with opioid use disorder. Expert Opinion On Pharmacotherapy 2025, 26: 1041-1054. PMID: 40366730, PMCID: PMC12202159, DOI: 10.1080/14656566.2025.2506688.Peer-Reviewed Original ResearchConceptsOpioid agonist treatmentOpioid use disorderChronic painUse disorderCochrane Central Register of Controlled TrialsCentral Register of Controlled TrialsEffective management of painPain treatment strategiesRegister of Controlled TrialsManagement of painCochrane Central RegisterAgonist treatmentPharmacological optionsTreatment strategiesPainOpioidEffective treatmentControlled trialsBehavioral treatmentTreatmentPatientsDisordersMedical careEffective managementEffective medical care505. Understanding the Pleiotropy Contributing to the Comorbidities Among Psychopathology, Chronic Back Pain, and Spinal Degenerative Disease
Qiu D, Friligkou E, He J, Mendoza B, Aslan M, Gupta M, Polimanti R. 505. Understanding the Pleiotropy Contributing to the Comorbidities Among Psychopathology, Chronic Back Pain, and Spinal Degenerative Disease. Biological Psychiatry 2025, 97: s305-s306. DOI: 10.1016/j.biopsych.2025.02.744.Peer-Reviewed Original Research452. Examining the Role of the Kappa Opioid Receptor in Trauma-Related Psychopathology and Chronic Pain Using [11C]EKAP Positron Emission Tomography
Weiss E, Hart-Derrick V, Freeman D, Miller R, Hillmer A, Wagner A, Matuskey D, Esterlis I, Davis M. 452. Examining the Role of the Kappa Opioid Receptor in Trauma-Related Psychopathology and Chronic Pain Using [11C]EKAP Positron Emission Tomography. Biological Psychiatry 2025, 97: s283. DOI: 10.1016/j.biopsych.2025.02.690.Peer-Reviewed Original ResearchIntervention for hospitalized people with chronic pain and elevated risk for opioid‐related harm: A pilot randomized controlled trial
Weimer M, Buonora M, Hajduk A, Ackerman A, Daggula K, Becker W, Chaudhry S, Fiellin D. Intervention for hospitalized people with chronic pain and elevated risk for opioid‐related harm: A pilot randomized controlled trial. Journal Of Hospital Medicine 2025 PMID: 40271961, DOI: 10.1002/jhm.70066.Peer-Reviewed Original ResearchOpioid-related harmsGuideline-concordant carePain interventionsCase identification toolElevated riskChronic painOpioid stewardshipHospitalized peopleEMR-based toolOpioid stewardship programsPain-related careRandomized controlled trialsUsual carePotential participantsCareManagement of analgesiaExploratory outcomesControlled trialsPrimary outcomeHospitalized adultsInterventionHarmPainNo significant differenceRiskThe story of pain in people with dementia: a rationale for digital measures
Patrascu M, Berge L, Vahia I, Marty B, Achterberg W, Allore H, Fletcher R, Husebo B. The story of pain in people with dementia: a rationale for digital measures. BMC Medicine 2025, 23: 227. PMID: 40247335, PMCID: PMC12004839, DOI: 10.1186/s12916-025-04057-3.Peer-Reviewed Original ResearchConceptsPain treatmentPain assessmentEffects of pain treatmentMonitor health behaviorsAging-related challengesLevel of painUser involvementAssessment of painDementia careHealth behaviorsCare dependencyOlder adultsPain intensityImproved pain reliefDementiaReduced qualityNeuropsychiatric symptomsPain reliefPainAround-the-clockCareDigital phenotypingTransdisciplinary collaborationPatterns of sleepPain behaviorComorbid Chronic Pain and Posttraumatic Stress Disorder Among Veterans: Approaches to Care
Pratt A, Van Tiem J, Lund B, Johnson N, Steffensmeier K, Ball D, Thomas E, Mengeling M, Norman S, Driscoll M, Garvin L, Hart K, Hadlandsmyth K. Comorbid Chronic Pain and Posttraumatic Stress Disorder Among Veterans: Approaches to Care. Military Medicine 2025, usaf118. PMID: 40215123, DOI: 10.1093/milmed/usaf118.Peer-Reviewed Original ResearchComorbid chronic painChronic painMental health service linesVeterans AdministrationQualitative interviewsOptimize care coordinationVA administrative dataService linesClinical settingAdministrative data analysisQualitative interview participantsCare coordinationIdentified barriersCombined careHealth careMental healthInterview participantsAdministrative dataPosttraumatic stress disorderVeteransCareVisitsParticipantsStress disorderPainFrom breaking point to potential transformation: temporal sequencing of mental health crisis
Roennfeldt H, Wyder M, Roper C, Hill N, Byrne L, Hamilton B. From breaking point to potential transformation: temporal sequencing of mental health crisis. International Journal Of Mental Health 2025, ahead-of-print: 1-16. DOI: 10.1080/00207411.2025.2488184.Peer-Reviewed Original ResearchMental health crisisExperience of crisisHealth crisisReflexive thematic approachGerald CaplanHermeneutic phenomenological studyCrisis careThematic approachPhenomenological studyEmotional painReturn of homeostasisAlchemical spacesEmotional instabilityTemporal sequenceCrisis experienceLiminal phaseCareDistressStorytelling patternsStage of crisisHero’s journeyInterviewsPainCommon Cryoneurolysis Targets in Pain Management: Indications, Critical Anatomy, and Potential Complications
Sailer A, Latich I, Levey A. Common Cryoneurolysis Targets in Pain Management: Indications, Critical Anatomy, and Potential Complications. Seminars In Interventional Radiology 2025, 42: 205-212. PMID: 40376212, PMCID: PMC12077947, DOI: 10.1055/s-0045-1804492.Peer-Reviewed Original ResearchQuality of lifePain managementCombination of therapiesImprove quality of lifeIncreased healthcare costsOpioid consumptionAdjunctive therapyHealthcare costsPatient's painUncontrolled painPhysical sufferingPainPotential complicationsAnatomical considerationsCryoneurolysisAbstract PainImprove qualityPatient outcomesPatientsClinical settingPerson's abilityCritical anatomyPatient pathologyTherapyPersonsThe inflammatory and genetic mechanisms underlying the cumulative effect of co-occurring pain conditions on depression
Jiang R, Geha P, Rosenblatt M, Wang Y, Fu Z, Foster M, Dai W, Calhoun V, Sui J, Spann M, Scheinost D. The inflammatory and genetic mechanisms underlying the cumulative effect of co-occurring pain conditions on depression. Science Advances 2025, 11: eadt1083. PMID: 40173244, PMCID: PMC11964001, DOI: 10.1126/sciadv.adt1083.Peer-Reviewed Original ResearchConceptsDepression riskChronic pain conditionsPain conditionsPrevalence of comorbid depressionPain scoresUK Biobank participantsPain-free individualsComposite pain scoresHigh-risk individualsPain screeningMendelian randomizationBiobank participantsPain sitesDepression incidenceComorbid depressionIncreased riskBody sitesDepressionC-reactive proteinPainCausal inferenceFollow-upScoresRiskInflammatory markers522 The Bidirectional Relationship Between Pain and Tobacco Use: Insights From The Population Assessment of Tobacco and Health Study
Costa G, Nunes J, Suh R, Sofuoglu M, De Aquino J. 522 The Bidirectional Relationship Between Pain and Tobacco Use: Insights From The Population Assessment of Tobacco and Health Study. Journal Of Pain 2025, 29: 105320. DOI: 10.1016/j.jpain.2025.105320.Peer-Reviewed Original ResearchShedding more light on the management of intraoperative pain during cesarean delivery: a review of the American Society of Anesthesiologists statements
Gonzalez-Fiol A, Fardelmann K, Landau R. Shedding more light on the management of intraoperative pain during cesarean delivery: a review of the American Society of Anesthesiologists statements. International Journal Of Obstetric Anesthesia 2025, 62: 104360. PMID: 40199022, DOI: 10.1016/j.ijoa.2025.104360.Peer-Reviewed Original ResearchPain During Cesarean Delivery: We Can and Must Do Better
Zakowski M, Fardelmann K, Hofkamp M. Pain During Cesarean Delivery: We Can and Must Do Better. Obstetric Anesthesia Digest 2025, 45: 5-5. DOI: 10.1097/01.aoa.0001097496.37736.42.Peer-Reviewed Original ResearchRepetitive Transcranial Magnetic Stimulation for Substance Use Disorders and Chronic Pain: a Review of the Evidence and Call for Increased Mechanistic Understanding
Michel A, Kang D, Fillingim R, Balderston N, Bond D, Steele V. Repetitive Transcranial Magnetic Stimulation for Substance Use Disorders and Chronic Pain: a Review of the Evidence and Call for Increased Mechanistic Understanding. Current Addiction Reports 2025, 12: 14. DOI: 10.1007/s40429-025-00620-3.Peer-Reviewed Original ResearchSubstance use disordersChronic painRepetitive transcranial magnetic stimulationTranscranial magnetic stimulationDiverse chronic pain conditionsChronic pain conditionsCo-occurring diseasesRTMS interventionMagnetic stimulationMagnetic resonance imagingEffective interventionsPain fieldPain conditionsSubstance use disorders fieldRepetitive transcranial magnetic stimulation applicationPainEffective treatmentUse disorderNarrative reviewClinical populationsSubstance useResonance imagingInterventionEvaluate relative efficacyClinical samplesPOCUS the Pelvis: A Case Series of Timely Diagnoses in Pediatric Patients With Abdominal Pain.
Leviter J, Shah R, Constantine E, Riera A. POCUS the Pelvis: A Case Series of Timely Diagnoses in Pediatric Patients With Abdominal Pain. Pediatric Emergency Care 2025 PMID: 39895170, DOI: 10.1097/pec.0000000000003348.Peer-Reviewed Original ResearchT75 Is Once Daily Enough? Assessing the Impact of Timing of Methadone Dose on Pain Sensitivity via Quantitative Sensory Testing in Persons With Opioid Use Disorder
Ra J, Meyerovich J, Pittman B, De Aquino J, De Aquino J. T75 Is Once Daily Enough? Assessing the Impact of Timing of Methadone Dose on Pain Sensitivity via Quantitative Sensory Testing in Persons With Opioid Use Disorder. Drug And Alcohol Dependence 2025, 267: 111843. DOI: 10.1016/j.drugalcdep.2024.111843.Peer-Reviewed Original ResearchPain Management in the Older Adults A Narrative Review
Rajput K, Ng J, Zwolinski N, Chow R. Pain Management in the Older Adults A Narrative Review. Clinics In Geriatric Medicine 2025, 41: 131-151. PMID: 39551538, DOI: 10.1016/j.cger.2024.03.011.Peer-Reviewed Original ResearchConceptsPain managementOlder adult populationOlder adult patientsOlder adultsAdult populationMultiple medicationsLife expectancyClinical practiceAdult patientsMedical managementPreexisting comorbiditiesPainUnited StatesDegenerative processPracticeNonagenariansMedicationAdultsComorbiditiesReviewManagementOctogenariansPatients
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