2025
PET Mapping of Receptor Occupancy Using Joint Direct Parametric Reconstruction
Marin T, Belov V, Chemli Y, Ouyang J, Najmaoui Y, Fakhri G, Duvvuri S, Iredale P, Guehl N, Normandin M, Petibon Y. PET Mapping of Receptor Occupancy Using Joint Direct Parametric Reconstruction. IEEE Transactions On Biomedical Engineering 2025, 72: 1057-1066. PMID: 39446540, PMCID: PMC11875991, DOI: 10.1109/tbme.2024.3486191.Peer-Reviewed Original ResearchCentral nervous systemReceptor occupancyLow-binding regionsPET scansSimulation resultsPreclinical in vivo experimentsDynamic PET scansPairs of baselineEstimation of receptor occupancyEstimation frameworkPET neuroimagingReconstruction frameworkModulating drugsTime activity curvesParametric reconstructionDevelopment of drugs
2024
An In Vivo High-Resolution Human Brain Atlas of Synaptic Density
Johansen A, Beliveau V, Colliander E, Raval N, Dam V, Gillings N, Aznar S, Svarer C, Plavén-Sigray P, Knudsen G. An In Vivo High-Resolution Human Brain Atlas of Synaptic Density. Journal Of Neuroscience 2024, 44: e1750232024. PMID: 38997157, PMCID: PMC11326867, DOI: 10.1523/jneurosci.1750-23.2024.Peer-Reviewed Original ResearchPathogenesis of brain disordersBrain disordersHuman brainFunctional topographySynaptic densityBrain physiologySynapse densityHigher-order cortical areasSynaptic vesicle glycoprotein 2AHuman brain physiologyHealthy human brainSV2A densityPET neuroimagingComparative neuroscienceNeuroscience researchCortical areasBrainAutoradiography dataDisordersNeuroscienceBrain atlasesHealthy humansSV2APositive associationMRNA patterns
2018
The effect of preclinical Alzheimer's disease on age-related changes in intelligence in cognitively normal older adults
Harrington K, Dang C, Lim Y, Ames D, Laws S, Pietrzak R, Rainey-Smith S, Robertson J, Rowe C, Salvado O, Villemagne V, Masters C, Maruff P, Group F. The effect of preclinical Alzheimer's disease on age-related changes in intelligence in cognitively normal older adults. Intelligence 2018, 70: 22-29. DOI: 10.1016/j.intell.2018.07.004.Peer-Reviewed Original ResearchPreclinical Alzheimer's diseaseAge-related declineAlzheimer's diseaseNormal older adultsOlder adultsRisk of progressionClinical disease progressionRapid age-related declinesEarly Alzheimer's diseaseNormal age-related declineAge-related changesEffect of ageAβ groupProspective studyAβ statusDisease progressionSerial assessmentAbnormal amyloidPET neuroimagingLinear regression analysisNormal agingDiseaseIntellectual functionGreater age-related declineLinear mixed models
2016
Discovery of a Highly Selective Glycogen Synthase Kinase‐3 Inhibitor (PF‐04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging
Liang S, Chen J, Normandin M, Chang J, Chang G, Taylor C, Trapa P, Plummer M, Para K, Conn E, Lopresti‐Morrow L, Lanyon L, Cook J, Richter K, Nolan C, Schachter J, Janat F, Che Y, Shanmugasundaram V, Lefker B, Enerson B, Livni E, Wang L, Guehl N, Patnaik D, Wagner F, Perlis R, Holson E, Haggarty S, Fakhri G, Kurumbail R, Vasdev N. Discovery of a Highly Selective Glycogen Synthase Kinase‐3 Inhibitor (PF‐04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging. Angewandte Chemie International Edition 2016, 55: 9601-9605. PMID: 27355874, PMCID: PMC4983481, DOI: 10.1002/anie.201603797.Peer-Reviewed Original ResearchConceptsGlycogen synthase kinase-3Tau phosphorylationPET neuroimagingPET imaging studiesModulation of tau phosphorylationNon-human primatesRegulate multiple cellular processesModulates tau phosphorylationMultiple cellular processesBrainBrain permeabilityImaging studiesCellular processesDisplaceable bindingKinase-3
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