2025
Computational Nuclear Oncology Toward Precision Radiopharmaceutical Therapies: Current Tools, Techniques, and Uncharted Territories.
Yusufaly T, Roncali E, Brosch-Lenz J, Uribe C, Jha A, Currie G, Dutta J, El-Fakhri G, McMeekin H, Pandit-Taskar N, Schwartz J, Shi K, Strigari L, Zaidi H, Saboury B, Rahmim A. Computational Nuclear Oncology Toward Precision Radiopharmaceutical Therapies: Current Tools, Techniques, and Uncharted Territories. Journal Of Nuclear Medicine 2025, jnumed.124.267927. PMID: 39947910, DOI: 10.2967/jnumed.124.267927.Peer-Reviewed Original ResearchRadiopharmaceutical therapyImage-based dosimetryPrediction of doseInternal dosimetryPersonalized treatment plansMetastatic diseaseDosimetryNuclear oncologyClinical outcomesNuclear medicineClinical endpointsTreatment planningOncology communityDose responseEtiological mechanismsTargeted deliveryRadiobiologyRadiotherapyMalignancyRadiationLong-termTherapyPharmacotherapyDoseRadiopharmacokinetics
2023
Artificial Intelligence in Clinical Oncology: From Data to Digital Pathology and Treatment.
Senthil Kumar K, Miskovic V, Blasiak A, Sundar R, Pedrocchi A, Pearson A, Prelaj A, Ho D. Artificial Intelligence in Clinical Oncology: From Data to Digital Pathology and Treatment. American Society Of Clinical Oncology Educational Book 2023, 43: e390084. PMID: 37235822, DOI: 10.1200/edbk_390084.Peer-Reviewed Educational MaterialsConceptsDigital pathologyClinical oncology communityArtificial intelligence (AI)-based applicationsClinical oncologyDeployment of AIDomain of digital pathologyTreatment selectionOncology communityBiomarker developmentArtificial intelligenceImprove patient outcomesAI innovationRegimen optimizationModulating dosesStandard histologyPatient outcomes
2022
Associations between interpersonal violence and cancer risk factors for transgender and cisgender people.
Alpert A, Sayegh S, Strawderman M, Cunliffe S, Cupertino A, Griggs J, Cerulli C. Associations between interpersonal violence and cancer risk factors for transgender and cisgender people. Journal Of Clinical Oncology 2022, 40: 6516-6516. DOI: 10.1200/jco.2022.40.16_suppl.6516.Peer-Reviewed Original ResearchCancer risk factorsRates of smokingCisgender peopleRisk factorsTransgender peopleRobust Poisson regression modelsDecrease socioeconomic disparitiesCancer prevention researchPoisson regression modelsRisk of cancerInterpersonal violenceFollow-up timeSocioeconomic disparitiesPrevalence ratiosPrevention researchRates of interpersonal violenceExperiences of violenceLife courseSmokingSignificantly higher ratesBMIExposure to interpersonal violenceRegression modelsOncology communityStatistically significant differenceMaking National Cancer Institute–Designated Comprehensive Cancer Center Knowledge Accessible to Community Oncologists via an Online Tumor Board: Longitudinal Observational Study
Kalra M, Henry E, McCann K, Karuturi MS, Bustamante Alvarez JG, Parkes A, Wesolowski R, Wei M, Mougalian SS, Durm G, Qin A, Schonewolf C, Trivedi M, Armaghani AJ, Wilson FH, Iams WT, Turk AA, Vikas P, Cecchini M, Lubner S, Pathak P, Spencer K, Koshkin VS, Labriola MK, Marshall CH, Beckermann KE, , Sharifi MN, Bejjani AC, Hotchandani V, Housri S, Housri N. Making National Cancer Institute–Designated Comprehensive Cancer Center Knowledge Accessible to Community Oncologists via an Online Tumor Board: Longitudinal Observational Study. JMIR Cancer 2022, 8: e33859. PMID: 35588361, PMCID: PMC9164098, DOI: 10.2196/33859.Peer-Reviewed Original Research
2021
The Ethical Imperative of Equity in Oncology: Lessons Learned From 2020 and a Path Forward.
Marron J, Charlot M, Gaddy J, Rosenberg A. The Ethical Imperative of Equity in Oncology: Lessons Learned From 2020 and a Path Forward. American Society Of Clinical Oncology Educational Book 2021, 41: e13-e19. PMID: 34061560, DOI: 10.1200/edbk_100029.Peer-Reviewed Original ResearchConceptsU.S. health careOncology communityProfessional medical organizationsCancer careRacial/ethnic disparitiesOncology workforceHealth careStructural racismMedical organizationsOncologyClinical practiceEthical principlesEthical responsibilityPracticing oncologistsEthical imperativesCareCOVID-19 pandemicOptimize equityUnited StatesCOVID-19CommunityDisparitiesWork—andInequalityWorkforce
2016
Promoting the Appropriate Use of Advanced Radiation Technologies in Oncology: Summary of a National Cancer Policy Forum Workshop
Smith G, Ganz P, Bekelman J, Chmura S, Dignam J, Efstathiou J, Jagsi R, Johnstone P, Steinberg M, Williams S, Yu J, Zietman A, Weichselbaum R, Shih Y. Promoting the Appropriate Use of Advanced Radiation Technologies in Oncology: Summary of a National Cancer Policy Forum Workshop. International Journal Of Radiation Oncology • Biology • Physics 2016, 97: 450-461. PMID: 28011046, PMCID: PMC6044722, DOI: 10.1016/j.ijrobp.2016.10.042.Peer-Reviewed Original ResearchMeSH KeywordsCosts and Cost AnalysisDecision MakingDiffusion of InnovationHumansNational Academies of Science, Engineering, and Medicine, U.S., Health and Medicine DivisionNeoplasmsProgram EvaluationProton TherapyRadiation OncologyRadiotherapyRadiotherapy, Intensity-ModulatedResearch PersonnelTechnology, RadiologicUnited StatesConceptsRadiation oncology communityRadiation oncology treatmentsRadiation oncologyAdvanced radiation technologiesOncology communityOncological treatmentNational Cancer Policy Forum of the National Academies of SciencesNational Cancer Policy ForumPractice of radiation oncologyRadiation oncology practiceProspective registry dataCancer care decisionsGeneration of scientific evidenceRadiation therapyScientific evidenceEvidence-based effortsComparative effectiveness dataCancer careClinical effectsCare decisionsQuality benchmark dataDe-adoptionRegistry dataThe National Academy of SciencesOncology practiceBreast conservation following neoadjuvant therapy for breast cancer in the modern era: Are we losing the opportunity?
Criscitiello C, Curigliano G, Burstein H, Wong S, Esposito A, Viale G, Giuliano M, Veronesi U, Santangelo M, Golshan M. Breast conservation following neoadjuvant therapy for breast cancer in the modern era: Are we losing the opportunity? European Journal Of Surgical Oncology 2016, 42: 1780-1786. PMID: 27825710, DOI: 10.1016/j.ejso.2016.10.011.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic Combined Chemotherapy ProtocolsAxillaBreast NeoplasmsClinical Decision-MakingFemaleGenes, BRCA1Genes, BRCA2Genetic Predisposition to DiseaseHereditary Breast and Ovarian Cancer SyndromeHumansLymph Node ExcisionMastectomyMastectomy, SegmentalMedical OveruseNeoadjuvant TherapyPatient PreferenceSurgical OncologyConceptsBreast conservationNeoadjuvant therapyBreast cancerSystemic therapyPathologic complete response rateComplete response rateBreast conservation ratesEffective systemic treatmentPatient-level variablesInvasive surgical approachNeoadjuvant trialsInoperable patientsSurgical overtreatmentSystemic treatmentSurgical approachSurgical benefitsOncology communityResponse ratePatientsTherapyCancerAggressive optionsMastectomySurgeonsConservation rateSuccess and Failures of Combined Modalities in Glioblastoma Multiforme: Old Problems and New Directions
Corso CD, Bindra RS. Success and Failures of Combined Modalities in Glioblastoma Multiforme: Old Problems and New Directions. Seminars In Radiation Oncology 2016, 26: 281-298. PMID: 27619250, DOI: 10.1016/j.semradonc.2016.06.003.Peer-Reviewed Original ResearchConceptsCurrent standard treatmentGlioblastoma multiformeStandard treatmentTreatment of GBMDistant brain relapseAggressive intracranial tumorBrain relapseAggressive therapyModality therapySurgical resectionCombined modalityIntracranial tumorsModality approachOncology communityTherapyMultiformeTreatmentUnanswered questionsImmunotherapyResectionRelapseFailureTumorsWill academic and community physicians engage and share knowledge in an online physician social network? Lessons from the Radiation Oncology Community
Housri N, Burt L, Lucas J, Housri S. Will academic and community physicians engage and share knowledge in an online physician social network? Lessons from the Radiation Oncology Community. Journal Of Clinical Oncology 2016, 34: e18200-e18200. DOI: 10.1200/jco.2016.34.15_suppl.e18200.Peer-Reviewed Original Research
2015
Tumor profiling and the incidentalome: patient decisions and risks
Hofstatter E, Mehra K, Yushak M, Pusztai L. Tumor profiling and the incidentalome: patient decisions and risks. Future Oncology 2015, 11: 3299-3305. PMID: 26562094, DOI: 10.2217/fon.15.260.BooksConceptsTumor profilingField of oncologyTumor DNA sequencesOncology patientsIncidental discoveryPatient educationPatient's perspectivePatient decisionOncology communityClinical implicationsPatient healthGermline mutationsCancer medicineGenetic sequencingCancer therapyTherapyPotential riskRiskHealthPatientsIncidentalomeMainstayDiseaseOncologyProfiling
2014
Considerations for Observational Research Using Large Data Sets in Radiation Oncology
Jagsi R, Bekelman J, Chen A, Chen R, Hoffman K, Shih Y, Smith B, Yu J. Considerations for Observational Research Using Large Data Sets in Radiation Oncology. International Journal Of Radiation Oncology • Biology • Physics 2014, 90: 11-24. PMID: 25195986, PMCID: PMC4159773, DOI: 10.1016/j.ijrobp.2014.05.013.Peer-Reviewed Original ResearchMeSH KeywordsChecklistComparative Effectiveness ResearchDatabases, FactualDiffusion of InnovationHealth Care CostsHealth Services ResearchHealth SurveysInsurance Claim ReviewMedicareNeoplasmsNomogramsObservational Studies as TopicProfessional PracticePropensity ScorePublication BiasRadiation OncologyRare DiseasesRegistriesResearch DesignSEER ProgramUnited StatesConceptsRadiation oncology communityRadiation oncologyObservational researchHealth services researchObservational studyWell-designed observational studiesOncology communityField of radiation oncologyHealth careServices researchEvaluate causalityObservational analysisData sourcesInternational Journal of Radiation OncologyMethodological expertiseRadiation oncology researchEvaluate evidenceRecognition of limitationsOncologyClinical trialsPotential data sourcesResearch questionsOncology researchHealthMethodological considerationsMolecular Imaging of Tumor Hypoxia with Positron Emission Tomography
Kelada OJ, Carlson DJ. Molecular Imaging of Tumor Hypoxia with Positron Emission Tomography. Radiation Research 2014, 181: 335-349. PMID: 24673257, PMCID: PMC5555673, DOI: 10.1667/rr13590.1.Peer-Reviewed Original ResearchConceptsTumor hypoxiaOncology communityTumor hypoxic volumeImportant prognostic factorOverall treatment responseRisk of metastasisTypes of tumorsEmission Tomography ImagingPositron emission tomography (PET) imagingClinical oncology communityPositron emission tomographyConventional cancer therapiesMagnitude of hypoxiaPrognostic factorsCancer patientsTreatment responseField of PETChemotherapy resistanceEmission tomographyClinical settingRadiolabelled agentsCancer typesPatientsHypoxia tracerHypoxia
2009
The changing face of Phase 1 cancer clinical trials
Craft BS, Kurzrock R, Lei X, Herbst R, Lippman S, Fu S, Karp DD. The changing face of Phase 1 cancer clinical trials. Cancer 2009, 115: 1592-1597. PMID: 19165808, PMCID: PMC2668727, DOI: 10.1002/cncr.24171.Peer-Reviewed Original ResearchConceptsPhase 2 trialEarly phase clinical trialsPhase 1 studyPhase 1 trialClinical trialsVital sign determinationsCancer clinical trialsPhysical examinationEarly phase cancer clinical trialsWeeks of protocolPhase 2 studyPhase 1 cancer clinical trialsNew drug studyStudy requirementsPhase 1Pharmacokinetic samplingMore patientsMedical oncologyOncology communityLaboratory testsSuch trialsDrug studiesTrialsPhase 1 programElectrocardiogram
2006
Use of experimental therapy outside of clinical trials among U.S. oncologists
Peppercorn J, Joffe S, Burstein H, Winer E. Use of experimental therapy outside of clinical trials among U.S. oncologists. Journal Of Clinical Oncology 2006, 24: 6047-6047. DOI: 10.1200/jco.2006.24.18_suppl.6047.Peer-Reviewed Original ResearchClinical trialsPractice settingsInvestigational cancer therapiesAttitudes of physiciansDemographic factorsU.S. oncologistsCommunity oncologistsMedical oncologistsTrial enrollmentAcademic oncologistsRecent trialsExperimental therapiesPatient's requestAmerican oncologistsOncology communityGuideline developmentOncologistsPatientsSignificant financial relationshipTrialsMonthsCancer therapyTherapyRandom sampleCare
1994
Quality‐of‐life research in patients with breast cancer
Winer E. Quality‐of‐life research in patients with breast cancer. Cancer 1994, 74: 410-415. PMID: 8004614, DOI: 10.1002/cncr.2820741328.Peer-Reviewed Original ResearchConceptsBreast cancerClinical trialsPatient-rated assessmentsBreast cancer treatmentLife studiesActive treatmentOncology communityStatus of qualityPatient's lifePatientsLife researchCancerCancer treatmentPersistent distressTraditional endpointsTreatmentLife assessmentTrialsWomenLife evaluationEndpoint
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