2025
Structural Brain Changes Associated With Risky Drinking in Late-Life Depression
Steffens D, Wang L, Manning K, Pearlson G. Structural Brain Changes Associated With Risky Drinking in Late-Life Depression. The American Journal Of Geriatric Psychiatry Open Science Education And Practice 2025, 6: 1-14. DOI: 10.1016/j.osep.2025.01.003.Peer-Reviewed Original ResearchStructural brain changesBrain changesAlcohol useAlcohol consumptionCortical thicknessFronto-striatal circuitsInferior parietal sulcusVolumetric brain changesFrontal cortical regionsLate-life depressionDecreased depression severityModerate drinkersDecreased alcohol consumptionOlder adultsRisky drinkersRisky alcohol useImpact of alcohol useCognitive batteryDepression severityDepressive episodeDSM criteriaStudy psychiatristClinical interviewOlder depressivesPosterior cingulateBenzodiazepine Initiation and the Risk of Falls or Fall-Related Injuries in Older Adults Following Acute Ischemic Stroke
Sun S, Lomachinsky V, Smith L, Newhouse J, Westover M, Blacker D, Schwamm L, Haneuse S, Moura L. Benzodiazepine Initiation and the Risk of Falls or Fall-Related Injuries in Older Adults Following Acute Ischemic Stroke. Neurology Clinical Practice 2025, 15: e200452. PMID: 40144887, DOI: 10.1212/cpj.0000000000200452.Peer-Reviewed Original ResearchFall-related injuriesRisk of fallsOlder adultsAcute ischemic strokeRisk differenceAcute ischemic stroke admissionsElectronic health recordsHypothetical randomized trialInverse probability weightingIschemic strokeRecovery periodHealth recordsBenzodiazepine initiationPoststroke periodConfounding biasImmortal timeMild strokeBenzodiazepine prescriptionsBZD useDay of admissionProbability weightingSubgroup analysisAnalyzed dataStrokeAdultsDevelopment and evaluation of a healthcare decision-making intervention for African American parent-adult daughter dementia dyads: a mixed-methods study protocol
Johnson K, Lyons K, Epps F, Daniel G, Monin J, Powell W, Hepburn K. Development and evaluation of a healthcare decision-making intervention for African American parent-adult daughter dementia dyads: a mixed-methods study protocol. BMJ Open 2025, 15: e099976. PMID: 40081986, PMCID: PMC11906994, DOI: 10.1136/bmjopen-2025-099976.Peer-Reviewed Original ResearchConceptsQuality of lifeDementia dyadsPrototype interventionQualitative data collectionQuantitative data collectionOlder adultsMixed-methods study protocolNon-Hispanic White older adultsAfrican American older adultsSelf-efficacyPretest-post-test designWhite older adultsAmerican older adultsDecision-making interventionsHealth-related decisionsSequential mixed-methods designUniversity Institutional Review BoardPrevalence of Alzheimer's diseaseAfrican American personsData collectionExplanatory sequential mixed-methods designMixed-methods designRandomised controlled trialsCare partnersIntervention MappingReduced removal of waste products from energy metabolism takes center stage in human brain aging
Mangia S, DiNuzzo M, Ponticorvo S, Dienel G, Behar K, Benveniste H, Hyder F, Giove F, Herculano-Houzel S, Petroff O, Eberly L, Filip P, Michaeli S, Rothman D. Reduced removal of waste products from energy metabolism takes center stage in human brain aging. Scientific Reports 2025, 15: 8127. PMID: 40057554, PMCID: PMC11890754, DOI: 10.1038/s41598-025-90342-3.Peer-Reviewed Original ResearchA biomarker framework for auditory system aging: the Aging Biomarker Consortium consensus statement
Consortium A, Fu X, Wang S, Wu Y, Sun Y, Liu W, Xi X, Li G, Liu K, Yuan W, Chen F, Wang H, Yang T, Liu Y, Zheng J, Shi H, Qu J, Chen X, Suo L, Huang Y, Xu X, Tang X, Li X, Xu L, Gao X, Yu L, Shu Y, Zhang W, Sun J, Yuan H, Gong S, Li W, Ma X, Zha D, Gao J, Li H, He Z, Liu G, Pei G, Kong W, Wang H, Chai R. A biomarker framework for auditory system aging: the Aging Biomarker Consortium consensus statement. Life Medicine 2025, lnaf011. DOI: 10.1093/lifemedi/lnaf011.Peer-Reviewed Original ResearchAuditory healthAuditory systemAssociated with cognitive declineQuality of lifeHearing lossOlder adultsPsychosocial disordersSensory impairmentElderly populationConsensus statementCognitive declineHearingHealthAging societyVerbal communicationAgeSensory functionAbstract HearingHumoral biomarkersBiomarkers ConsortiumBiomarkersInterventionAging biomarkersAdultsComprehensive evaluationMendelian non-syndromic and syndromic hearing loss genes contribute to presbycusis
Cornejo-Sanchez D, Bharadwaj T, Dong R, Wang G, Schrauwen I, DeWan A, Leal S. Mendelian non-syndromic and syndromic hearing loss genes contribute to presbycusis. European Journal Of Human Genetics 2025, 1-10. PMID: 40055553, DOI: 10.1038/s41431-025-01789-x.Peer-Reviewed Original ResearchRare-variantsHearing loss genesAssociated with HLNon-syndromicAssociation analysisHL geneHearing phenotypeUK BiobankMinor allele frequencyOlder adultsSensorineural disorderARHLEffect sizeWhite EuropeansAssociated with genesAge-relatedIn silico analysisAnalysis of variantsExome dataAssociationGenes i.Allele frequenciesHLGenesPresbycusisMoving towards precision medicine for older adults with non-ST-segment elevation myocardial infarction
Nouri A, Nanna M. Moving towards precision medicine for older adults with non-ST-segment elevation myocardial infarction. Heart 2025, heartjnl-2025-325817. PMID: 40037762, DOI: 10.1136/heartjnl-2025-325817.Commentaries, Editorials and LettersAssociation of social relationships and genetic risk with frailty
Song W, Zhong W, Yan H, Li Z, Gao J, Wang X, Chen P, You F, Li C, Chen H, Xie J, Lv Y, Shi X, Mao C. Association of social relationships and genetic risk with frailty. American Journal Of Geriatric Psychiatry 2025 DOI: 10.1016/j.jagp.2025.02.015.Peer-Reviewed Original ResearchPolygenic risk scoresFrailty riskGenetic riskMendelian randomizationOlder adultsChinese Longitudinal Healthy Longevity SurveyTwo-sample Mendelian randomizationAssociations of social relationshipsSocial relationshipsEffects of social relationshipsSocial activitiesCox proportional hazards modelsIncreased frailty riskLongevity SurveyHigh frailty riskProportional hazards modelUnfavorable relationshipSocial supportTwo-time pointsRisk scoreFrailtyHazards modelGenetic susceptibilityAdditive interactionSingle-nucleotideInformal Care Receiving among Older Adults: The Role of Multimorbidity and Intersectional Social Position
Liu R, Nagel C, Chen S, Allore H, Quiñones A. Informal Care Receiving among Older Adults: The Role of Multimorbidity and Intersectional Social Position. The Gerontologist 2025, gnaf071. PMID: 40036606, DOI: 10.1093/geront/gnaf071.Peer-Reviewed Original ResearchCare receiver characteristicsMultimorbidity groupsOlder adultsInformal careNational Health and Aging Trends StudyIntensity of informal careIntersecting social positionsWhite female counterpartsNon-Hispanic black femalesNon-Hispanic whitesFamily-centered interventionsMultimorbidity categoryNegative binomial regressionMultimorbidity combinationsCare recipientsMultimorbidity patternsADL activitiesTrends StudySocial positionMultimorbidityIntersectional groupsADL/IADLBlack malesBinomial regressionRace/ethnicityPalliative Care Initiated in the Emergency Department
Grudzen C, Siman N, Cuthel A, Adeyemi O, Yamarik R, Goldfeld K, Abella B, Bellolio F, Bourenane S, Brody A, Cameron-Comasco L, Chodosh J, Cooper J, Deutsch A, Elie M, Elsayem A, Fernandez R, Fleischer-Black J, Gang M, Genes N, Goett R, Heaton H, Hill J, Horwitz L, Isaacs E, Jubanyik K, Lamba S, Lawrence K, Lin M, Loprinzi-Brauer C, Madsen T, Miller J, Modrek A, Otero R, Ouchi K, Richardson C, Richardson L, Ryan M, Schoenfeld E, Shaw M, Shreves A, Southerland L, Tan A, Uspal J, Venkat A, Walker L, Wittman I, Zimny E. Palliative Care Initiated in the Emergency Department. JAMA 2025, 333: 599-608. PMID: 39813042, PMCID: PMC11836764, DOI: 10.1001/jama.2024.23696.Peer-Reviewed Original ResearchConceptsInitiate palliative careLife-limiting illnessHealth care usePalliative carePostintervention periodPreintervention periodMulticomponent interventionCare useEmergency departmentOlder adultsHospital admissionRates of hospice useShort-term mortalitySecondary outcomesRate of hospital admissionsED clinical staffHome health useClinical decision supportNursing home patientsSimulation-based workshopGagne comorbidity scoreRate of admissionRisk of short-term mortalityHospice useIllness communicationIndividualized Net Benefit of Intensive Blood Pressure Lowering Among Community‐Dwelling Older Adults in SPRINT
Jamshidian M, Scherzer R, Estrella M, Kravitz R, Boxer R, Tancredi D, Berry J, de Lemos J, Ginsberg C, Ix J, Shlipak M, Ascher S. Individualized Net Benefit of Intensive Blood Pressure Lowering Among Community‐Dwelling Older Adults in SPRINT. Journal Of The American Geriatrics Society 2025 PMID: 39967308, DOI: 10.1111/jgs.19395.Peer-Reviewed Original ResearchSystolic Blood Pressure Intervention TrialCommunity-dwelling older adultsIntensive blood pressureSystolic BP targetOlder adultsBlood pressureIndividual net benefitsIntensive BPBP targetsAdvanced ageSystolic Blood Pressure Intervention Trial participantsBenefits of BPOptimal blood pressureTreatment-related harmsCategories of ageAdverse eventsPositive net benefitsFrailty statusCardiovascular outcomesCognitive outcomesIntervention trialsCox modelRisk differenceSystolicPolypharmacyRealigning diabetes regimens in older adults: a 4S Pathway to guide simplification and deprescribing strategies
Munshi M, Kahkoska A, Neumiller J, Alexopoulos A, Allen N, Cukierman-Yaffe T, Huang E, Lee S, Lipska K, McCarthy L, Meneilly G, Pandya N, Pratley R, Rodriguez-Mañas L, Sinclair A, Sy S, Toschi E, Weinstock R. Realigning diabetes regimens in older adults: a 4S Pathway to guide simplification and deprescribing strategies. The Lancet Diabetes & Endocrinology 2025 PMID: 39978368, DOI: 10.1016/s2213-8587(24)00372-3.Peer-Reviewed Original ResearchOlder adultsCare of older individualsHigh-risk medicationsTreating older peopleClinical practice gapsInterfere with patients' abilityReduce medication burdenDiabetes treatment regimensImprove carePatient's current needsSelf-careDe-prescribingDiabetes guidelinesDeprescribing strategiesSimplification of regimensOlder peoplePractice gapType 2 diabetesDeprescribingPatient's abilityMultiple medical comorbiditiesDiabetes regimensOlder individualsDiabetes SocietyMedical burdenUS Geriatric Assessment Practices for Older Adults Undergoing Hematopoietic Cell Transplantation or CAR T- cell therapy: An ASTCT Physician Survey from the Aging Special Interest Group and Committee on Practice Guidelines
Munshi P, Olin R, Wall S, McCurdy S, Al-Juhaishi T, Baker J, Bhatt V, Chokr N, Dahi P, DeFilipp Z, Espinoza-Gutarra M, Farhan S, Gowda L, Hamilton B, Inamoto Y, Jayani R, Kharfan-Dabaja M, Lin R, Meyers G, Mishra A, Murthy H, Nawas M, Rosko A, Ruiz M, Sorror M, Sung A, Carpenter P, Hamadani M, Artz A. US Geriatric Assessment Practices for Older Adults Undergoing Hematopoietic Cell Transplantation or CAR T- cell therapy: An ASTCT Physician Survey from the Aging Special Interest Group and Committee on Practice Guidelines. Transplantation And Cellular Therapy 2025 PMID: 39961473, DOI: 10.1016/j.jtct.2025.02.014.Peer-Reviewed Original ResearchHematopoietic cell transplantationT-cell therapyCAR-T cell therapyCAR-TCell transplantationGeriatric assessmentCellular therapyChimeric antigen T-cell therapyAmerican Society for TransplantationPromote risk stratificationAllo-HCTRisk stratificationCell therapyOlder patientsRoutine GAOlder adultsGa uptakeTherapyPhysician practice patternsTransplantationPractice patternsClinical support staffCross-sectional surveyPhysician membersDomain of GAAlpha rhythm and Alzheimer’s disease: Has Hans Berger’s dream come true?
Babiloni C, Arakaki X, Baez S, Barry R, Benussi A, Blinowska K, Bonanni L, Borroni B, Bayard J, Bruno G, Cacciotti A, Carducci F, Carino J, Carpi M, Conte A, Cruzat J, D'Antonio F, Della Penna S, Del Percio C, De Sanctis P, Escudero J, Fabbrini G, Farina F, Fraga F, Fuhr P, Gschwandtner U, Güntekin B, Guo Y, Hajos M, Hallett M, Hampel H, Hanoğlu L, Haraldsen I, Hassan M, Hatlestad-Hall C, Horváth A, Ibanez A, Infarinato F, Jaramillo-Jimenez A, Jeong J, Jiang Y, Kamiński M, Koch G, Kumar S, Leodori G, Li G, Lizio R, Lopez S, Ferri R, Maestú F, Marra C, Marzetti L, McGeown W, Miraglia F, Moguilner S, Moretti D, Mushtaq F, Noce G, Nucci L, Ochoa J, Onorati P, Padovani A, Pappalettera C, Parra M, Pardini M, Pascual-Marqui R, Paulus W, Pizzella V, Prado P, Rauchs G, Ritter P, Salvatore M, Santamaria-García H, Schirner M, Soricelli A, Taylor J, Tankisi H, Tecchio F, Teipel S, Kodamullil A, Triggiani A, Valdes-Sosa M, Valdes-Sosa P, Vecchio F, Vossel K, Yao D, Yener G, Ziemann U, Kamondi A. Alpha rhythm and Alzheimer’s disease: Has Hans Berger’s dream come true? Clinical Neurophysiology 2025, 172: 33-50. PMID: 39978053, DOI: 10.1016/j.clinph.2025.02.256.Peer-Reviewed Original ResearchConceptsPathological agingAlzheimer's diseaseExpert panelAlpha rhythmAD patient’s qualityQuality of lifeAging-Alzheimer's AssociationCognitive impairmentCognitive declineClinical workupNeuroscience SocietyCortical circuitsAD patientsUS National InstitutesOlder adultsRoutine useSenile dementiaDecades of researchPatients' qualityClinical guidelinesOscillatory synchronizationCause of dementiaClinical applicationNIA-AADementia[Association of urine cadmium levels with thyroid hormone levels among middle-aged and older adults aged 40-89 years in selected areas of China].
Wu C, Wang X, Chen Y, Li Z, Zhang Y, Wei Y, Wu B, Zhang W, Yang Z, Dong X, Hao R, Ye X, Wei L, Qu Y, Chu H, Lyu Y, Zhu Y, Xu D, Shi X. [Association of urine cadmium levels with thyroid hormone levels among middle-aged and older adults aged 40-89 years in selected areas of China]. Chinese Preventive Medicine 2025, 59: 209-215. PMID: 39938993, DOI: 10.3760/cma.j.cn112150-20240625-00500.Peer-Reviewed Original ResearchConceptsThyroid hormone levelsRestricted cubic splinesUrinary cadmium levelsHormone levelsUrinary cadmiumFasting venous bloodAssociated with T3Dose-response relationshipMiddle-agedMidstream urineCadmium levelsUrine cadmium levelsMixed effects modelsLinear mixed effects modelsPositive nonlinear associationOlder adultsMulti-stage stratified random sampling methodPhysical examinationUrinary creatinineVenous bloodDietary frequencyDisease statusEffects modelOne-unit increaseCubic splinesMedications for opioid use disorder in traditional medicare beneficiaries: associations with age
Ganz D, Lai J, Cantor J, Agniel D, Simon K, Stein B, Taylor E. Medications for opioid use disorder in traditional medicare beneficiaries: associations with age. Health Affairs Scholar 2025, 3: qxaf036. PMID: 40040649, PMCID: PMC11878533, DOI: 10.1093/haschl/qxaf036.Peer-Reviewed Original ResearchOpioid use disorderMOUD initiationIndex eventUse disorderTreat opioid use disorderAssociated with female sexRates of opioid use disorderIncreasing comorbidity scoreMultivariate logistic regressionAssociated with ageComorbidity scoreMedicare beneficiariesFemale sexOlder adultsAge-specific strategiesIncreased uptakeLogistic regressionOlder ageTraditional Medicare beneficiariesMOUDClaims dataMedicationAssociation of workforce participation with depression among US older adults: results from NHANES 2005–2018
Sun Z, Wang Y, Chen X, Qian D. Association of workforce participation with depression among US older adults: results from NHANES 2005–2018. BMC Geriatrics 2025, 25: 77. PMID: 39905307, PMCID: PMC11792604, DOI: 10.1186/s12877-025-05712-3.Peer-Reviewed Original ResearchConceptsNational Health and Nutrition Examination SurveyUS older adultsPHQ-9 scoresOlder adultsDepression riskLogistic regression modelsWorkforce participationPatient Health Questionnaire-9 itemsWork statusHealth and Nutrition Examination SurveyAnalysis of subgroupsRegular daytimeMethodsThis cross-sectional studyNutrition Examination SurveyPrevalence of depressionDecrease depression riskPotential reverse causationRegression modelsCross-sectional studyNon-linear associationInstrumental variablesPHQ-9Propensity score matchingExamination SurveyReverse causationExtreme Heat and Hospitalization Among Older Persons With Alzheimer Disease and Related Dementias
Delaney S, Stegmuller A, Mork D, Mock L, Bell M, Gill T, Braun D, Zanobetti A. Extreme Heat and Hospitalization Among Older Persons With Alzheimer Disease and Related Dementias. JAMA Internal Medicine 2025, 185 PMID: 39899291, PMCID: PMC11791774, DOI: 10.1001/jamainternmed.2024.7719.Peer-Reviewed Original ResearchCase-crossover designOdds ratioPopulation-based cohort studyMedicare fee-for-serviceBurden of Alzheimer's diseaseConditional logistic regressionFee-for-serviceOR point estimatesRisk of hospitalizationADRDOlder PersonsOlder adultsMain OutcomesPopulation subgroupsWhite beneficiariesDiagnosis codesCohort studyEffect estimatesHealth burdenLogistic regressionCounseling patientsCumulative ORAlzheimer's diseaseIncreased hospitalizationOutdoor heatProfile of non-invasive physical health indicators associated with cognitive performance in Chinese older adults: evidence from the China Health and Retirement Longitudinal Study
Wei X, Li C, Liu D, Chen J, Ju Y, Liu J, Liu B, Zhang Y. Profile of non-invasive physical health indicators associated with cognitive performance in Chinese older adults: evidence from the China Health and Retirement Longitudinal Study. BMC Public Health 2025, 25: 420. PMID: 39894807, PMCID: PMC11789399, DOI: 10.1186/s12889-025-21479-z.Peer-Reviewed Original ResearchConceptsPhysical health indicatorsHealth indicatorsMild cognitive impairmentOlder adultsChina HealthCognitive performanceRight grip strengthChinese older adultsScreening of cognitive declineCognitive domainsLongitudinal cohort designCognitive performance domainsSubgroup analysisDomains of cognitive performancePhysical functionBackgroundExisting studiesGrip strengthCohort designLinear regression modelsMultiple linear regression modelStandardised interviewMethodsThe present studyResultsPulmonary functionSex-specific factorsGeneral cognitionUtilisation of nursing home care before and after the 2015 Dutch national reform: an interrupted time series analysis
Vroomen J, Wammes J, Wouterse B, Smalbrugge M, Murphy T. Utilisation of nursing home care before and after the 2015 Dutch national reform: an interrupted time series analysis. Age And Ageing 2025, 54: afaf018. PMID: 39902847, PMCID: PMC11791781, DOI: 10.1093/ageing/afaf018.Peer-Reviewed Original ResearchConceptsInterrupted time series analysisLong-term careNH admissionNursing homesOlder adultsAdmission ratesMortality riskAdmitted older adultsNursing home careIncreased mortality riskCox proportional hazards modelsAdmitted residentsAging-in-placePopulation-level studiesProportional hazards modelHome carePromote aging-in-placeStatistics NetherlandsTime series analysisHazards modelPopulation dataCareAdultsFollow-upAdmission
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