2025
The Effect of Early Warning Systems for Sepsis on Mortality: A Systematic Review and Meta-analysis
Ein Alshaeba S, Marhoffer E, Holleck J, Theisen-Toupal J, Grimshaw A, Gunderson C. The Effect of Early Warning Systems for Sepsis on Mortality: A Systematic Review and Meta-analysis. Journal Of General Internal Medicine 2025, 1-6. PMID: 40360868, DOI: 10.1007/s11606-025-09569-5.Peer-Reviewed Original ResearchStrength of evidenceLength of stayScreening groupRandomized controlled studyCochrane risk of bias toolRisk of bias toolRandom-effects meta-analysisLow due to riskMeta-analysisEffectiveness of screeningEffectiveness of early warning systemsRisk of biasEffects meta-analysisMethodsA systematic literature searchPooled odds ratioControlled studiesScreened adult patientsSystematic literature searchSurviving Sepsis CampaignRecommendations AssessmentCochrane riskBias toolWeb of Science Core CollectionOdds ratioOvid MEDLINEThe association between internet-use-disorder symptoms and loneliness: a systematic review and meta-analysis with a categorical approach
Mestre-Bach G, Paiva U, San Martín Iniguez L, Beranuy M, Martín-Vivar M, Mallorquí-Bagué N, Normand E, Chicote M, Potenza M, Arrondo G. The association between internet-use-disorder symptoms and loneliness: a systematic review and meta-analysis with a categorical approach. Psychological Medicine 2025, 55: e77. PMID: 40071718, DOI: 10.1017/s0033291725000376.Peer-Reviewed Original ResearchConceptsInternet-use disordersSystematic reviewMeta-analysisInternet-useInternet use disorderRandom-effects modelWeb of ScienceDegree of lonelinessUCLA Loneliness ScaleStatistical poolingQuantify associationsOdds ratioCohen's dDisorder symptomsGreater lonelinessMeta-regressionPooled differenceEffect sizePre-registeredUCLA-LonelinessLonelinessEffects of ageCategorical approachSymptomsGroup of individualsPeriods of susceptibility for associations between phthalate exposure and preterm birth: Results from a pooled analysis of 16 US cohorts
Friedman A, Welch B, Keil A, Bloom M, Braun J, Buckley J, Dabelea D, Factor-Litvak P, Meeker J, Michels K, Padmanabhan V, Starling A, Weinberg C, Aalborg J, Alshawabkeh A, Barrett E, Binder A, Bradman A, Bush N, Calafat A, Cantonwine D, Christenbury K, Cordero J, Engel S, Eskenazi B, Harley K, Hauser R, Herbstman J, Holland N, James-Todd T, Jukic A, Lanphear B, McElrath T, Messerlian C, Newman R, Nguyen R, O'Brien K, Rauh V, Redmon J, Rich D, Rosen E, Sathyanarayana S, Schmidt R, Sparks A, Swan S, Wang C, Watkins D, Weinberger B, Wenzel A, Wilcox A, Yolton K, Zhang Y, Zota A, Ferguson K. Periods of susceptibility for associations between phthalate exposure and preterm birth: Results from a pooled analysis of 16 US cohorts. Environment International 2025, 198: 109392. PMID: 40132438, DOI: 10.1016/j.envint.2025.109392.Peer-Reviewed Original ResearchUrinary phthalate metabolite concentrationsPreterm birthPhthalate metabolite concentrationsGeneralized estimating equationsPhthalate metabolitesOdds ratioMono (2-ethylhexyl) phthalateUS cohortAssociation of preterm birthPhthalate exposureAssociated with preterm birthAssociated with odds ratiosInterquartile range increaseMetabolite concentrationsIndividual-level dataLogistic regression modelsThird trimesterTrimester-specific associationsMechanism of actionPretermPeriod of susceptibilityTime of exposurePooled analysisTrimesterTrimester exposurePerinatal exposure to ambient fine particle air pollution and risk of childhood ewing sarcoma in a population-based case-control study in California (1988–2015)
Clark C, Wang R, Wiemels J, Metayer C, Deziel N, Ma X. Perinatal exposure to ambient fine particle air pollution and risk of childhood ewing sarcoma in a population-based case-control study in California (1988–2015). Environmental Health 2025, 24: 6. PMID: 40055781, DOI: 10.1186/s12940-025-01159-6.Peer-Reviewed Original ResearchConceptsHispanic childrenSarcoma riskControls frequency-matched to casesFrequency-matched to casesBirth yearPopulation-based case-control studyOdds ratioPM2.5 exposureConfidence intervalsAir pollution exposureCalifornia birth cohortNon-Hispanic childrenAmbient PM2.5 exposureFine particle air pollutionCase-control studyAmbient fine particulate matterHigher PM2.5 levelsMaternal residenceCancer riskMaternal educationPotential disparitiesBirth cohortHispanic ethnicityElevated oddsLinkage studiesEvaluating the effect of routine lethal means counseling in the emergency department on suicide mortality among mental health patients
Marcus S, Cullen S, Xie M, Bridge J, Caterino J, Schmutte T, Olfson M. Evaluating the effect of routine lethal means counseling in the emergency department on suicide mortality among mental health patients. AJPM Focus 2025, 100336. DOI: 10.1016/j.focus.2025.100336.Peer-Reviewed Original ResearchLethal means counselingMental health disordersEmergency departmentHealth disordersNational Medicaid claims dataSuicide deathsMental health patientsPeriod post-dischargeStorage of firearmsOdds ratio of deathMedicaid claims dataRisk of suicideHealth patientsObservational cohort studyRatio of deathED episodesED visitsSuicide mortalityPost-dischargeLethal meansOdds ratioED patientsStored firearmsCohort studyED managementUsing Radiology as a Screening Tool to Identify Intimate Partner Violence
Lenehan P, Tang A, Watane G, Gujrathi R, Park H, Gosangi B, Thomas R, Franco F, Patel K, Warsofsky I, Rosner B, Khurana B. Using Radiology as a Screening Tool to Identify Intimate Partner Violence. Journal Of The American College Of Radiology 2025, 22: 395-404. PMID: 40044319, PMCID: PMC11887577, DOI: 10.1016/j.jacr.2025.01.003.Peer-Reviewed Original ResearchConceptsAdjusted incidence rate ratiosEmergency departmentRetrospective case-control studyImaging utilization patternsEvident injuriesCox proportional hazards regressionRace-matched controlsCase-control studyTime-to-event analysisProportional hazards regressionImaging utilizationIncidence rate ratiosCumulative incidenceAnatomical sitesScreening mammogramsHazards regressionOdds ratioImaging studiesIntimate partner violencePatientsInjury patternsLogistic regressionInjuryOrgan systemsPoisson regressionTeen Dating Violence Among Asian American Adolescents: Insights from a National Survey (2015–2021)
Weerakoon S, Srikanth N, Hansoti E, Takenaka B, Wan X, Opara I, Markham C, Lau M. Teen Dating Violence Among Asian American Adolescents: Insights from a National Survey (2015–2021). Journal Of Aggression Maltreatment & Trauma 2025, 34: 331-347. DOI: 10.1080/10926771.2025.2471348.Peer-Reviewed Original ResearchTeen dating violenceSexual dating violenceDating violenceSchool violenceBullying victimizationAmerican adolescentsPhysical dating violenceSubstance useAsian American adolescentsU.S. high school studentsOdds ratioViolenceAssociated with increased oddsLogistic regression analysisCluster sampling studyVictimsBullyingSexual behaviorPublic health problemDepressive symptomsAdolescent malesUnited StatesAdolescent femalesHigh school studentsNational surveySolvent exposure, genetic susceptibility, and risk of bladder cancer.
Tadesse D, Rothman N, Xie S, Hurwitz L, Friesen M, Baris D, Schwenn M, Johnson A, Karagas M, Silverman D, Koutros S. Solvent exposure, genetic susceptibility, and risk of bladder cancer. Cancer Prevention Research 2025, of1-of8. PMID: 39995157, DOI: 10.1158/1940-6207.capr-24-0434.Peer-Reviewed Original ResearchBladder cancer riskRisk of bladder cancerNew England Bladder Cancer StudyCancer riskPopulation-based case-control studyOdds ratioIncreased bladder cancer riskIncreased risk of bladder cancerConfidence intervalsCumulative exposure to benzeneCancer susceptibility lociJob-exposure matrixCalculate odds ratiosBladder cancerLifetime occupational exposureGenetic risk variantsCase-control studyMultivariate logistic regressionBladder Cancer StudyExposure to benzeneSusceptibility lociLogistic regressionOccupational historyRisk variantsCancer studiesElevated initial blood kynurenine is associated with increased odds of post-stroke infection Kynurenine and post-stroke infection
Dylla L, Reisz J, Poisson S, Herson P, Sansing L, Monte A. Elevated initial blood kynurenine is associated with increased odds of post-stroke infection Kynurenine and post-stroke infection. Journal Of Stroke And Cerebrovascular Diseases 2025, 34: 108268. PMID: 40015349, DOI: 10.1016/j.jstrokecerebrovasdis.2025.108268.Peer-Reviewed Original ResearchConceptsPost-stroke infectionsAssociated with increased oddsTryptophan metabolitesHistory of diabetes mellitusEnd stage renal diseaseNIH Stroke Scale scoreConcentrations of kynurenineAcute ischemic stroke patientsMultivariate logistic regressionStage renal diseaseStroke Scale scoreCirculating kynurenineIschemic stroke onsetIschemic stroke patientsKynurenine concentrationsConcentrations of tryptophanEmergency department admissionsKynurenic acidDiabetes mellitusMortality of ischemic strokeRenal diseaseTryptophan metabolismOdds ratioQuinolinic acidImmune responseWorkplace bullying among medical laboratory professionals in Ghana: insights from self-reported experiences, challenges to mitigation structures, and coping strategies
Duah E, Ephraim R, Kotam G, Kumordzi S, Amoah S, Addy N, Kwashie S, Rahamani A. Workplace bullying among medical laboratory professionals in Ghana: insights from self-reported experiences, challenges to mitigation structures, and coping strategies. BMC Health Services Research 2025, 25: 310. PMID: 40001166, PMCID: PMC11853304, DOI: 10.1186/s12913-025-12458-6.Peer-Reviewed Original ResearchConceptsMedical laboratory professionalsLaboratory professionalsPatient careConfidence intervalsCross-sectional surveyRevised Negative Acts QuestionnaireSelf-reported experiencesBackgroundWorkplace bullyingNegative Acts QuestionnaireConclusionThe high prevalenceWorkplace bullyingHealthcare professionalsUrban counterpartsBachelor's degree holdersDegree holdersHigher oddsNAQ-RCoping strategiesOdds ratioRural professionalsActs QuestionnaireLogistic regressionDemographic informationProfessionalsWorkplace characteristicsMachine learning and computational fluid dynamics derived FFRCT demonstrate comparable diagnostic performance in patients with coronary artery disease; A Systematic Review and Meta-Analysis
Narimani-Javid R, Moradi M, Mahalleh M, Najafi-Vosough R, Arzhangzadeh A, Khalique O, Mojibian H, Kuno T, Mohsen A, Alam M, Shafiei S, Khansari N, Shaghaghi Z, Nozhat S, Hosseini K, Hosseini S. Machine learning and computational fluid dynamics derived FFRCT demonstrate comparable diagnostic performance in patients with coronary artery disease; A Systematic Review and Meta-Analysis. Journal Of Cardiovascular Computed Tomography 2025 PMID: 39988511, DOI: 10.1016/j.jcct.2025.02.004.Peer-Reviewed Original ResearchArea under the curveDiagnostic odds ratioDiagnostic performanceComputed tomography-derived fractional flow reserveDiagnostic performance of FFRCTHemodynamically significant coronary artery stenosisSignificant coronary artery stenosisMeta-analysisPer-patient levelReceiver operating characteristic curveCoronary artery diseaseCoronary artery stenosisPer-vessel levelFractional flow reserveNoninvasive diagnostic techniquesMachine learningInvasive FFRPooled specificityArtery diseaseArtery stenosisFlow reserveOdds ratioCochrane LibraryFFRCTPatientsCharacteristics and Outcomes of Patients with Cardiogenic Shock and Clinically Significant Valvular Heart Disease: From the Critical Care Cardiology Trials Network
Carnicelli A, Miller P, Berg D, Aliyev N, Alviar C, Bohula E, Chaudhry S, Chonde M, Chow C, Cooper H, Daniels L, Fordyce C, Ghafghazi S, Goldfarb M, Gorder K, Hamilton M, Keane R, Kontos M, Kusner J, Leibner E, Loriaux D, Menon V, Nair R, Newby L, Oduah M, Palazzolo M, Patolia H, Pierce J, Pierce M, Potter B, Proudfoot A, Roswel R, Schnell G, Shaw J, Sidhu K, Sinha S, Varshney A, Katz J, Diepen S, Morrow D. Characteristics and Outcomes of Patients with Cardiogenic Shock and Clinically Significant Valvular Heart Disease: From the Critical Care Cardiology Trials Network. Journal Of Cardiac Failure 2025 PMID: 39970998, DOI: 10.1016/j.cardfail.2025.01.019.Peer-Reviewed Original ResearchValvular heart diseaseCardiac intensive care unitCritical Care Cardiology Trials NetworkCardiogenic shockIn-hospital mortalityClinically significant valvular heart diseaseSignificant valvular heart diseaseSevere valvular heart diseaseHeart diseaseHigher in-hospital mortality ratesAssociated with higher in-hospital mortality ratesIn-hospital mortality rateTrials NetworkOutcomes of patientsTertiary cardiac intensive care unitUnadjusted in-hospital mortalityIntensive care unitMitral regurgitationValve interventionAortic stenosisCICU admissionCS admissionsOdds ratioCare unitConsecutive admissionsAssociation between patient primary language, physical restraints, and intramuscular sedation in the emergency department
Kumar A, Ryus C, Tartak J, Nath B, Faustino I, Shah D, Robinson L, Desai R, Heckmann R, Taylor R, Wong A. Association between patient primary language, physical restraints, and intramuscular sedation in the emergency department. Academic Emergency Medicine 2025 PMID: 39948714, DOI: 10.1111/acem.70004.Peer-Reviewed Original ResearchPatient's primary languagePortuguese-speaking patientsPhysical restraintEmergency departmentPrimary languageED visitsQuality of clinical interactionsRegional health care networkHealth care networkVerbal de-escalationElectronic medical recordsLogistic regression modelsAdult patients ageLanguage speakersEnglish speakersCare networkSpanish speakersPortuguese speakersCultural interpretationRetrospective cohort analysisAgitation symptomsOdds ratioClinical interactionsEvaluate associationsPrimary outcomeThe impact of Duration of Untreated Psychosis on functioning and quality of life over one year of Coordinated Specialty Care (CSC)
Hazan H, Tayfur S, Zhou B, Li F, Gibbs-Dean T, Karmani S, Kline E, Ferrara M, Corbera S, Riley S, Sykes L, Tek C, Keshavan M, Srihari V. The impact of Duration of Untreated Psychosis on functioning and quality of life over one year of Coordinated Specialty Care (CSC). PLOS ONE 2025, 20: e0312740. PMID: 39928579, PMCID: PMC11809850, DOI: 10.1371/journal.pone.0312740.Peer-Reviewed Original ResearchConceptsCoordinated specialty careQuality of lifeDuration of untreated psychosisDUP groupWorld Health OrganizationYear of coordinated specialty careGeneralized linear modelConfidence intervalsBinary outcomesGlobal functioningDuration of untreated psychosis groupSymptom severityUntreated psychosisSpecialty careCSC programsImpact of duration of untreated psychosisFunctional gainsModel repeated measuresMixed model repeated measuresOdds ratioNo significant differenceLogit link functionStatus improvementContinuous outcomesSocial functioningExtreme Heat and Hospitalization Among Older Persons With Alzheimer Disease and Related Dementias
Delaney S, Stegmuller A, Mork D, Mock L, Bell M, Gill T, Braun D, Zanobetti A. Extreme Heat and Hospitalization Among Older Persons With Alzheimer Disease and Related Dementias. JAMA Internal Medicine 2025, 185 PMID: 39899291, PMCID: PMC11791774, DOI: 10.1001/jamainternmed.2024.7719.Peer-Reviewed Original ResearchCase-crossover designOdds ratioPopulation-based cohort studyMedicare fee-for-serviceBurden of Alzheimer's diseaseConditional logistic regressionFee-for-serviceOR point estimatesRisk of hospitalizationADRDOlder PersonsOlder adultsMain OutcomesPopulation subgroupsWhite beneficiariesDiagnosis codesCohort studyEffect estimatesHealth burdenLogistic regressionCounseling patientsCumulative ORAlzheimer's diseaseIncreased hospitalizationOutdoor heatSex differences in in-hospital outcomes and readmission rates after percutaneous coronary intervention
Gomez J, Park D, Eder M, An S, Lowenstern A, Kelsey M, Rymer J, Douglas P, Nanna M. Sex differences in in-hospital outcomes and readmission rates after percutaneous coronary intervention. Baylor University Medical Center Proceedings 2025, 38: 159-169. PMID: 39990004, PMCID: PMC11845020, DOI: 10.1080/08998280.2025.2452113.Peer-Reviewed Original ResearchIn-hospital outcomesIn-hospital mortalitySecondary outcomesReadmission ratesOdds of in-hospital mortalityPercutaneous coronary interventionCalculate odds ratiosInpatient percutaneous coronary interventionHazard of readmissionUnited States National Readmission DatabaseIn-hospital adverse outcomesPropensity score matchingHealth systemHospital characteristicsOdds of cardiac arrestSocioeconomic statusReimbursement implicationsSex differencesYears of ageOdds ratioReadmission riskCox proportional-hazardsLogistic regressionIn-hospital complicationsScore matchingPrevalence and Risk Factors for Medial Meniscus Ramp Lesions in the Setting of Pediatric Anterior Cruciate Ligament Injuries: A Systematic Review and Meta-analysis
Moran J, Lee M, Fong S, LaPrade C, Kunze K, Fabricant P, Chahla J, Jimenez A, LaPrade R. Prevalence and Risk Factors for Medial Meniscus Ramp Lesions in the Setting of Pediatric Anterior Cruciate Ligament Injuries: A Systematic Review and Meta-analysis. Journal Of Pediatric Orthopaedics 2025, 45: 183-193. PMID: 39840766, DOI: 10.1097/bpo.0000000000002900.Peer-Reviewed Original ResearchMedial meniscus ramp lesionsConcomitant lateral meniscus tearMagnetic resonance imagingPediatric patientsBone marrow edemaLateral meniscus tearsACL reconstructionRisk factorsCollateral ligament injuriesLigament injuriesSystematic reviewRamp lesionsMarrow edemaMale sexMeta-analysisOdds ratioAnterior cruciate ligament (ACL) injuryMeniscus tearsPreoperative magnetic resonance imagingAssociated with anterior cruciate ligament (ACL) injuryAnterior cruciate ligament injuryRisk of graft failureSkeletal maturityCochrane Central Register of Controlled TrialsCentral Register of Controlled TrialsUromodulin and Risk of Upper Urinary Tract Infections: A Mendelian Randomization Study
Liyanarachi K, Flatby H, Hallan S, Åsvold B, Damås J, Rogne T. Uromodulin and Risk of Upper Urinary Tract Infections: A Mendelian Randomization Study. American Journal Of Kidney Diseases 2025 PMID: 39805364, DOI: 10.1053/j.ajkd.2024.11.007.Peer-Reviewed Original ResearchUpper urinary tract infectionGenome-wide association studiesUrinary tract infectionOdds ratioMendelian randomizationTwo-sample Mendelian randomization analysisTwo-sample MR studyEuropean ancestryMichigan Genomics InitiativeInverse variance-weightedAssociation studiesMendelian randomization analysisMendelian randomization studiesAssociated with elevated oddsConfounding factorsSerum uromodulin levelsReduced riskTract infectionsUromodulin levelsSex-specific analysesAbstractText Label="PLAIN-LANGUAGE SUMMARYGenetic instrumentsHealth StudyUK BiobankUrinary uromodulinThe impact of race, ethnicity, and socioeconomic status on early adolescent sleep disturbances for youth exposed to adverse childhood experiences
Senger-Carpenter T, Voepel-Lewis T, Stoddard S, Zhang A, Ordway M. The impact of race, ethnicity, and socioeconomic status on early adolescent sleep disturbances for youth exposed to adverse childhood experiences. Child Abuse & Neglect 2025, 160: 107236. PMID: 39754988, PMCID: PMC11792094, DOI: 10.1016/j.chiabu.2024.107236.Peer-Reviewed Original ResearchConceptsClinically significant sleep disturbanceCommunity socioeconomic statusAdverse childhood experiencesSocioeconomic statusSignificant sleep disturbanceImpact of raceFamily socioeconomic statusSleep disturbanceAdverse childhood experience exposureChildhood experiencesAdjusted odds ratiosMixed effects logistic regression modelsEffects logistic regression modelsMultilevel mixed effects logistic regression modelsSleep Disturbance ScaleInteractive effects of raceAdolescent sleep disturbancesLogistic regression modelsAffecting sleep disturbanceEffects of raceSecondary analysisOdds ratioDisturbance ScaleConfidence intervalsAged 9The comparative efficacy and safety of Tiger II versus judkins catheters in coronary angiogram via the radial artery access: a meta-analysis
Aljabali A, Alawajneh M, Hammad A, Nguyen D, Alkasabrah A, Abuein K, Altibi A. The comparative efficacy and safety of Tiger II versus judkins catheters in coronary angiogram via the radial artery access: a meta-analysis. Acta Cardiologica 2025, 80: 39-43. PMID: 39781598, DOI: 10.1080/00015385.2024.2442799.Peer-Reviewed Original ResearchConceptsStandardised mean differenceFluoroscopy timeContrast volumeProcedure timeJudkins catheterOdds ratioProcedural successCoronary angiogramTiger IIEstimates of odds ratiosRadiation exposureMeta-analysisReduced fluoroscopy timeRadial artery vasospasmRandom-effects modelWeb of ScienceRadial artery accessComplication rateArtery vasospasmSecondary outcomesPrimary outcomeComparative efficacyArterial accessTransfemoral accessCochrane Library
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