2025
Artificial Intelligence-Enhanced Perfusion Scoring Improves the Diagnostic Accuracy of Myocardial Perfusion Imaging.
Miller R, Kavanagh P, Lemley M, Liang J, Sharir T, Einstein A, Fish M, Ruddy T, Kaufmann P, Sinusas A, Miller E, Bateman T, Dorbala S, Di Carli M, Hayes S, Friedman J, Berman D, Dey D, Slomka P. Artificial Intelligence-Enhanced Perfusion Scoring Improves the Diagnostic Accuracy of Myocardial Perfusion Imaging. Journal Of Nuclear Medicine 2025, jnumed.124.268079. PMID: 39978815, DOI: 10.2967/jnumed.124.268079.Peer-Reviewed Original ResearchObstructive coronary artery diseaseCoronary artery diseaseArea under the receiver operating characteristic curveMyocardial perfusion imagingPerfusion scoreDetection of obstructive coronary artery diseaseDiagnostic accuracy of myocardial perfusion imagingPerfusion imagingAccuracy of myocardial perfusion imagingInvasive coronary angiographyCohort of patientsHighest area under the receiver operating characteristic curveLeft main coronary arteryReceiver operating characteristic curveStress TPDDeep learningObstructive CADMedian ageCoronary angiographyArtificial intelligenceDiagnostic performanceDiagnostic accuracyArtery diseaseAI predictionsCoronary artery
2021
Clinical Deployment of Explainable Artificial Intelligence of SPECT for Diagnosis of Coronary Artery Disease
Otaki Y, Singh A, Kavanagh P, Miller RJH, Parekh T, Tamarappoo BK, Sharir T, Einstein AJ, Fish MB, Ruddy TD, Kaufmann PA, Sinusas AJ, Miller EJ, Bateman TM, Dorbala S, Di Carli M, Cadet S, Liang JX, Dey D, Berman DS, Slomka PJ. Clinical Deployment of Explainable Artificial Intelligence of SPECT for Diagnosis of Coronary Artery Disease. JACC Cardiovascular Imaging 2021, 15: 1091-1102. PMID: 34274267, PMCID: PMC9020794, DOI: 10.1016/j.jcmg.2021.04.030.Peer-Reviewed Original ResearchConceptsTotal perfusion deficitMyocardial perfusion imagingStandard clinical softwareStress total perfusion deficitObstructive CADTomography myocardial perfusion imagingSPECT myocardial perfusion imagingStress myocardial perfusionCoronary artery diseaseReceiver-operating characteristic curveInvasive coronary angiographyClinical softwareReader diagnosisSingle photon emissionTypical clinical workflowArtery diseaseCoronary angiographyPerfusion deficitsDiagnostic findingsMyocardial perfusionPerfusion imagingVentricular volumeStandard clinical workstationPatientsDiagnostic accuracy
2015
The Diagnosis of CAD in Women: Addressing the Unmet Need—A Report from the National Expert Roundtable Meeting
Clarke JL, Ladapo JL, Monane M, Lansky A, Skoufalos A, Nash DB. The Diagnosis of CAD in Women: Addressing the Unmet Need—A Report from the National Expert Roundtable Meeting. Population Health Management 2015, 18: 86-92. PMID: 25714757, PMCID: PMC4410448, DOI: 10.1089/pop.2015.0006.Peer-Reviewed Original ResearchConceptsObstructive CADDiagnostic challengeCoronary Artery Disease ResultsMultiple health care stakeholdersPathophysiology of CADLow-risk womenHigh-risk womenLow pretest probabilityRecent clinical trialsDiagnosis of CADEvaluation of womenNegative predictive valueWomen's health researchHealth researchGene expression testFalse-positive findingsPatient's symptomsAtypical symptomsHealth care stakeholdersClinical trialsPretest probabilitySex-specific differencesPredictive valueDisease resultsPositive findings
2009
Minority Women and Cardiovascular Disease
Taylor A, Bellumkonda L. Minority Women and Cardiovascular Disease. Contemporary Cardiology 2009, 297-320. DOI: 10.1007/978-1-59745-410-0_15.Peer-Reviewed Original ResearchDobutamine stress echocardiographyWomen's Health InitiativePrimary Prevention ProjectObstructive CADPhysical activityCV eventsChest painPostmenopausal womenCardiovascular diseaseLow prevalenceHealth initiativesNon-cardiac chest painLeisure-time physical activityWhite non-Hispanic womenNon-Hispanic black womenPrevention ProjectAspirin/dayExercise stress electrocardiographyMajor CV eventsNew randomized studiesTotal CV eventsHeart Failure TrialOpen-label studyOverall survival benefitBlood pressure control
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