2025
Outcomes of transcatheter aortic valve implantation in Africa: A systematic review and meta-analysis
Ahmed A, Safiriyu I, Kaddoura R, Mohyeldin M, Nwokeocha N, Sandeep N, Khalil H, Alhusain R, Zarich S. Outcomes of transcatheter aortic valve implantation in Africa: A systematic review and meta-analysis. International Journal Of Cardiology 2025, 429: 133139. PMID: 40074042, DOI: 10.1016/j.ijcard.2025.133139.Peer-Reviewed Original ResearchTranscatheter aortic valve implantationOutcomes of transcatheter aortic valve implantationAll-cause mortalityAortic valve implantationAdverse eventsValve implantationIn-hospital all-cause mortalitySevere aortic stenosisMeta-analysisProcedural success rateTranscatheter aortic valve implantation outcomesStandard of careSurgical riskAortic stenosisPooled proportionProcedural successFollow-upObservational studyInterquartile rangeNational registryMortality rateGrey literatureHealthcare systemSuccess rateConfidence intervalsPrediction of Hepatitis C Virus Perinatal Transmission in Pregnant Individuals With Hepatitis C Virus Infection
Sandoval G, Saade G, Hughes B, Clifton R, Reddy U, Bartholomew A, Salazar A, Chien E, Tita A, Thorp J, Metz T, Wapner R, Sabharwal V, Simhan H, Swamy G, Heyborne K, Sibai B, Grobman W, El-Sayed Y, Casey B, Parry S, Macones G, Prasad M. Prediction of Hepatitis C Virus Perinatal Transmission in Pregnant Individuals With Hepatitis C Virus Infection. Obstetrics And Gynecology 2025, 145: 449-452. PMID: 40014859, PMCID: PMC11925659, DOI: 10.1097/aog.0000000000005872.Peer-Reviewed Original ResearchConceptsHepatitis C virus infectionPerinatal transmissionHepatitis C virusHepatitis C virus perinatal transmissionPregnant individualsEunice Kennedy Shriver National Institute of Child HealthTransmission of HCV infectionPerinatal transmission rateHCV RNA titersNeonatal follow-upC virus infectionPositive HCV antibodyMulticenter observational studyArea under the curveNational Institute of Child HealthInstitute of Child HealthAntibody-positive participantsAntepartum bleedingHCV infectionHCV antibodiesFollow-upRNA titersC virusObservational studyClinical counselingEffect of Diabetes on Clinical Outcomes in Patients with Peripheral Arterial Disease undergoing Lower Extremity Revascularization: A Systematic Review and Meta-Analysis
Edjimbi J, Shah N, Kwaah P, Grimshaw A, Regan C, Nagpal S, Attaran R, Chaar C, Romain G, Smolderen K, Mena-Hurtado C. Effect of Diabetes on Clinical Outcomes in Patients with Peripheral Arterial Disease undergoing Lower Extremity Revascularization: A Systematic Review and Meta-Analysis. Journal Of Vascular Surgery 2025 PMID: 40015609, DOI: 10.1016/j.jvs.2025.02.018.Peer-Reviewed Original ResearchLower extremity revascularizationPeripheral arterial diseaseHospital readmissionRelative riskDiabetes mellitusRandom-effects meta-analysisIncreased riskMeta-analysisAssociation of DMExtremity revascularizationMortality riskWound infectionRisk estimatesAssociated with diabetes mellitusClinical outcomesSystematic reviewArtery diseaseSystematic searchObservational studyWound infection riskReadmissionEffects of diabetesAmputationRiskHospitalEffect of Sodium-Glucose Cotransporter-2 Inhibitors on the Progression of Aortic Stenosis
Shah T, Zhang Z, Shah H, Fanaroff A, Nathan A, Parise H, Lutz J, Sugeng L, Bellumkonda L, Redfors B, Omerovic E, Petrie M, Vora A, Fiorilli P, Kobayashi T, Ahmad Y, Forrest J, Giri J, Herrmann H, Lansky A. Effect of Sodium-Glucose Cotransporter-2 Inhibitors on the Progression of Aortic Stenosis. JACC Cardiovascular Interventions 2025, 18: 738-748. PMID: 39985508, DOI: 10.1016/j.jcin.2024.11.036.Peer-Reviewed Original ResearchSodium-glucose cotransporter-2 inhibitorsCotransporter-2 inhibitorsAortic stenosisEffects of sodium-glucose cotransporter-2 inhibitorsProgression of aortic stenosisBaseline AS severityAssociated with slower progressionEchocardiographic follow-upRetrospective electronic medical record dataAortic valve sclerosisDisease-related morbidityChronic kidney diseaseSGLT2i usageRates of diabetesSevere ASAS severityEjection fractionFollow-upPrimary outcomeGt;1 yearKidney diseaseMedical record dataYale New Haven Health SystemPatientsObservational studyOpioid Misuse and Suicide-Related Outcomes Among Adolescents and Young Adults: A Systematic Review
Cance J, Hairgrove S, Saavedra L, Bonar E, Walton M, Patel S, Yule A, King C, Chavez L, Slesnick N, Fernandes C. Opioid Misuse and Suicide-Related Outcomes Among Adolescents and Young Adults: A Systematic Review. Journal Of Adolescent Health 2025 PMID: 39945684, DOI: 10.1016/j.jadohealth.2024.10.026.Peer-Reviewed Original ResearchSuicide-related outcomesOpioid misuseSystematic reviewYoung adultsHigh risk of biasRisk of biasBoolean search strategyAdministrative dataConfounding biasInclusion criteriaReporting biasEligible publicationsObservational studyLongitudinal researchHigh riskAdultsOpioidAssociationSearch strategyOutcomesMisuseData studiesPotential mechanismsYouthConfoundingObservational research in epidemic settings: a roadmap to reform
Ricotta E, Carrillo F, Angelli-Nichols S, Barugahare J, Benton A, Carlson C, Chang-Rabley E, Dean N, Duda S, Federer L, Fill M, LeRoy E, Linton N, Lipsitch M, Mathur M, Phelan A, Rid A, Rosen J, Sauer L, Sullivan S, Zendt M, Evans N. Observational research in epidemic settings: a roadmap to reform. BMJ Global Health 2025, 10: e017981. PMID: 39929534, PMCID: PMC11815396, DOI: 10.1136/bmjgh-2024-017981.Peer-Reviewed Original ResearchThe REpeated ASSEssment of SurvivorS in intracerebral haemorrhage: protocol for a multicentre, prospective observational study
Ziai W, Woo D, Sansing L, Hanley D, Ostapkovich N, Triene K, Gilkerson L, Thompson R, Walborn N, Lane K, McBee N, Langefeld C, Howard T, Vagal A, Flaherty M, Consortium F. The REpeated ASSEssment of SurvivorS in intracerebral haemorrhage: protocol for a multicentre, prospective observational study. BMJ Open 2025, 15: e094322. PMID: 39915023, PMCID: PMC11800296, DOI: 10.1136/bmjopen-2024-094322.Peer-Reviewed Original ResearchConceptsMinimally invasive surgeryIntracerebral haemorrhageInvasive surgeryNon-surgical standard of careProspective observational studySpontaneous intracerebral haemorrhageStandard of careRepeated assessmentsCognitive declineICH volumeInstitutional review boardHaematoma volumeMISTIE IIITreated patientsInflammatory stateTreatment strategiesEthnic/Racial VariationsRt-PAAssessment of survivorsObservational studyRate of cognitive declineUniversity Institutional Review BoardHaemorrhageReview boardPeer-reviewed journalsAssociations between colonization with Helicobacter pylori and risk of gastrointestinal tract cancers: An umbrella review of meta‐analyses
Prudente T, Mezaiko E, Oliva H, Yamamoto‐Silva F, de Freitas Silva B, Oliva I, Risch H. Associations between colonization with Helicobacter pylori and risk of gastrointestinal tract cancers: An umbrella review of meta‐analyses. European Journal Of Clinical Investigation 2025, e14394. PMID: 39878420, DOI: 10.1111/eci.14394.Peer-Reviewed Original ResearchMeta-analysesUmbrella reviewUmbrella review of meta-analysesMeta-analyses of observational studiesHelicobacter pylori colonizationHigher quality primary studiesReview of meta-analysesCochrane Library of Systematic ReviewsAMSTAR 2 toolQuality primary studiesPrimary study overlapAssociated with EACPylori colonizationBiliary tractAssociated with biliary tractGastric cancerOesophageal squamous cell carcinomaSquamous cell carcinomaHelicobacter pyloriGI tract cancersGastrointestinal tract cancerPrimary studiesSystematic reviewCochrane LibraryObservational studyRadiologist, trainee, and logistical factors impacting the timeliness of CTA head and neck reporting in stroke code activations.
Zaree O, Nguyen J, de Oliveira Santo I, Kertam A, Rahmani S, Johnson J, Tu L. Radiologist, trainee, and logistical factors impacting the timeliness of CTA head and neck reporting in stroke code activations. American Journal Of Neuroradiology 2025, ajnr.a8660. PMID: 39832953, DOI: 10.3174/ajnr.a8660.Peer-Reviewed Original ResearchStroke code activationAttending radiologistsTimeliness of reportingEmergency department settingRadiologist characteristicsCare settingsMultivariate regression modelImprove workflow efficiencyDepartment settingStroke codeModifiable factorsDescriptive statisticsSecondary analysisCoding activitiesReport factorsPatient ageObservational studyWorkflow efficiencyShift typeMedian TATMultivariate regressionInterquartile rangeRegression modelsCTA reportsLogistical factorsSystematic Review: Efficacy of Medical Therapy on Outcomes Important to Pediatric Patients With X-Linked Hypophosphatemia
Ali D, Mirza R, Hussein S, Alsarraf F, Alexander R, Abu Alrob H, Appelman-Dijkstra N, Biosse-Duplan M, Brandi M, Carpenter T, Chaussain C, Dandurand K, Filler G, Florenzano P, Fukumoto S, Grasemann C, Imel E, de Beur S, Morgante E, Ward L, Khan A, Guyatt G. Systematic Review: Efficacy of Medical Therapy on Outcomes Important to Pediatric Patients With X-Linked Hypophosphatemia. The Journal Of Clinical Endocrinology & Metabolism 2025, dgaf011. PMID: 39787354, DOI: 10.1210/clinem/dgaf011.Peer-Reviewed Original ResearchX-linked hypophosphatemiaConventional therapyLower limb deformitiesNo treatmentMedical therapyAdverse eventsManagement of "X-linked hypophosphatemiaTreatment-emergent adverse eventsObservational study of individualsObservational studyEfficacy of medical therapyPhysical health QoLAssessed risk of biasBurden of symptomsEffects of medical therapyOpen-label RCTRisk of biasCertainty of evidenceIncreased adverse eventsLimb deformitiesPost hoc studyWeb of ScienceHealth QoLStudy of individualsDental abscessA framework for monitoring RSV prevention product effectiveness in the United States
Roper L, Link-Gelles R, Surie D, DeCuir J, Zambrano L, Prill M, Havers F, Jones J, Melgar M, Hall A, Whitehead R, McMorrow M, Ioannou G, Hernandez-Romieu A, Britton A, Novosad S, Martin A, Feldstein L, Bajema K, Kirking H, Moline H, Campbell A, Aslan M, Hatfield K, Dawood F, Slayton R, Reddy S, Gomes D, Fleming-Dutra K, Payne A. A framework for monitoring RSV prevention product effectiveness in the United States. Vaccine 2025, 45: 126633. PMID: 39755055, DOI: 10.1016/j.vaccine.2024.126633.Peer-Reviewed Original ResearchDeterminants of increased muscle insulin sensitivity of exercise-trained versus sedentary normal weight and overweight individuals
Pesta D, Anadol-Schmitz E, Sarabhai T, Kamp Y, Gancheva S, Trinks N, Zaharia O, Mastrototaro L, Lyu K, Habets I, Kamp-Bruls Y, Dewidar B, Weiss J, Schrauwen-Hinderling V, Zhang D, Gaspar R, Strassburger K, Kupriyanova Y, Al-Hasani H, Szendroedi J, Schrauwen P, Phielix E, Shulman G, Roden M. Determinants of increased muscle insulin sensitivity of exercise-trained versus sedentary normal weight and overweight individuals. Science Advances 2025, 11: eadr8849. PMID: 39742483, PMCID: PMC11691647, DOI: 10.1126/sciadv.adr8849.Peer-Reviewed Original ResearchConceptsOverweight-to-obeseNormal weightEndurance-trained humansMuscle mitochondrial contentAthlete's paradoxTrained athletesExercise-trainedOverweight individualsAthletesObesity subtypesObservational studyIntramyocellular triglyceride accumulationInsulin sensitivityHigher insulin sensitivityMitochondrial contentIncreased insulin sensitivityMuscleFemale individualsIndividualsInsulin resistanceObesityMitochondrial partitioningIncreased calpainNPKC activityProtein kinase C
2024
Increasing patient viewership of complex imaging reports: The paradox of the Cures Act
Amin K, Davis M, Naderi A, Forman H. Increasing patient viewership of complex imaging reports: The paradox of the Cures Act. Clinical Imaging 2024, 119: 110398. PMID: 39756146, DOI: 10.1016/j.clinimag.2024.110398.Peer-Reviewed Original ResearchConceptsElectronic health recordsCentury Cures ActCures ActImprove patient experienceRadiology reportsReading grade levelPatient experienceHealth recordsHealth informationRecommended levelsRetrospective observational studyObservational studyPatientsViewing probabilityRadiologyOddsHealthYearsIncrease viewershipReportsGrade levelModalitiesProvisionEfficacy of antiobesity medications for weight reduction in older adults: a systematic review
Chen A, Hajduk A, Grimshaw A, Fried T, Jastreboff A, Lipska K. Efficacy of antiobesity medications for weight reduction in older adults: a systematic review. Obesity 2024 PMID: 39725567, DOI: 10.1002/oby.24160.Peer-Reviewed Original ResearchOlder adultsAntiobesity medicationsStudy of older adultsOlder adults ageAdult ageCardiovascular diseaseRisk of biasAdverse events associated with useWeight reductionStatistically significant weight reductionFood and Drug AdministrationClinical careSystematic reviewInclusion criteriaLimited evidenceBaseline weightPlacebo groupObservational studySeven medicationsAdverse eventsAdultsDrug AdministrationEvaluation studiesMedicationSignificant weight reductionAccuracy of a Rapid-Response EEG's Automated Seizure-Burden Estimator
Sheikh Z, Dhakar M, Fong M, Fang W, Ayub N, Molino J, Haider H, Foreman B, Gilmore E, Mizrahi M, Karakis I, Schmitt S, Osman G, Yoo J, Hirsch L. Accuracy of a Rapid-Response EEG's Automated Seizure-Burden Estimator. Neurology 2024, 104: e210234. PMID: 39724534, DOI: 10.1212/wnl.0000000000210234.Peer-Reviewed Original ResearchConceptsElectrographic status epilepticusNegative predictive valueStatus epilepticusTreat nonconvulsive status epilepticusPredictive valueCo-primary outcome measuresNonconvulsive status epilepticusPositive predictive valueRetrospective observational studyClass II evidenceLow-to-moderate sensitivityLimited-resource settingsII evidenceTriage patientsObservational studyPatientsRegional hospitalOutcome measuresExpert reviewEpilepticusScreening toolCommunity hospitalBurden estimatesEEGPPVRobust, fully-automated assessment of cerebral perivascular spaces and white matter lesions: a multicentre MRI longitudinal study of their evolution and association with risk of dementia and accelerated brain atrophy
Barisano G, Iv M, Choupan J, Hayden-Gephart M, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Saykin A, Morris J, Shaw L, Liu E, Montine T, Thomas R, Donohue M, Walter S, Gessert D, Sather T, Jiminez G, Harvey D, Donohue M, Bernstein M, Fox N, Thompson P, Schuff N, DeCarli C, Borowski B, Gunter J, Senjem M, Vemuri P, Jones D, Kantarci K, Ward C, Koeppe R, Foster N, Reiman E, Chen K, Mathis C, Landau S, Cairns N, Householder E, Reinwald L, Lee V, Korecka M, Figurski M, Crawford K, Neu S, Foroud T, Potkin S, Shen L, Kelley F, Kim S, Nho K, Kachaturian Z, Frank R, Snyder P, Molchan S, Kaye J, Quinn J, Lind B, Carter R, Dolen S, Schneider L, Pawluczyk S, Beccera M, Teodoro L, Spann B, Brewer J, Vanderswag H, Fleisher A, Heidebrink J, Lord J, Petersen R, Mason S, Albers C, Knopman D, Johnson K, Doody R, Meyer J, Chowdhury M, Rountree S, Dang M, Stern Y, Honig L, Bell K, Ances B, Morris J, Carroll M, Leon S, Householder E, Mintun M, Schneider S, Oliver A, Marson D, Griffith R, Clark D, Geld-macher D, Brockington J, Roberson E, Grossman H, Mitsis E, deToledo-Morrell L, Shah R, Duara R, Varon D, Greig M, Roberts P, Albert M, Onyike C, D’Agostino D, Kielb S, Galvin J, Pogorelec D, Cerbone B, Michel C, Rusinek H, de Leon M, Glodzik L, De Santi S, Doraiswamy P, Petrella J, Wong T, Arnold S, Karlawish J, Wolk D, Smith C, Jicha G, Hardy P, Sinha P, Oates E, Conrad G, Lopez O, Oakley M, Simpson D, Porsteinsson A, Goldstein B, Martin K, Makino K, Ismail M, Brand C, Mulnard R, Thai G, Mc Adams Ortiz C, Womack K, Mathews D, Quiceno M, Arrastia R, King R, Weiner M, Cook K, DeVous M, Levey A, Lah J, Cellar J, Burns J, Anderson H, Swerdlow R, Apostolova L, Tingus K, Woo E, Silverman D, Lu P, Bartzokis G, Radford N, Parfitt F, Kendall T, Johnson H, Farlow M, Hake A, Matthews B, Herring S, Hunt C, van Dyck C, Carson R, MacAvoy M, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Hsiung G, Feldman H, Mudge B, Assaly M, Kertesz A, Rogers J, Trost D, Bernick C, Munic D, Kerwin D, Mesulam M, Lipowski K, Wu C, Johnson N, Sadowsky C, Martinez W, Villena T, Turner R, Johnson K, Reynolds B, Sperling R, Johnson K, Marshall G, Frey M, Yesavage J, Taylor J, Lane B, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Sirrel S, Kowall N, Killiany R, Budson A, Norbash A, Johnson P, Obisesan T, Wolday S, Allard J, Lerner A, Ogrocki P, Hudson L, Fletcher E, Carmichael O, Olichney J, DeCarli C, Kittur S, Borrie M, Lee T, Bartha R, Johnson S, Asthana S, Carlsson C, Potkin S, Preda A, Nguyen D, Tariot P, Fleisher A, Reeder S, Bates V, Capote H, Rainka M, Scharre D, Kataki M, Adeli A, Zimmerman E, Celmins D, Brown A, Pearlson G, Blank K, Anderson K, Santulli R, Kitzmiller T, Schwartz E, Sink K, Williamson J, Garg P, Watkins F, Ott B, Querfurth H, Tremont G, Salloway S, Malloy P, Correia S, Rosen H, Miller B, Mintzer J, Spicer K, Bachman D, Finger E, Pasternak S, Rachinsky I, Rogers J, Kertesz A, Drost D, Pomara N, Hernando R, Sarrael A, Schultz S, Ponto L, Shim H, Smith K, Relkin N, Chaing G, Raudin L, Smith A, Fargher K, Raj B. Robust, fully-automated assessment of cerebral perivascular spaces and white matter lesions: a multicentre MRI longitudinal study of their evolution and association with risk of dementia and accelerated brain atrophy. EBioMedicine 2024, 111: 105523. PMID: 39721217, PMCID: PMC11732520, DOI: 10.1016/j.ebiom.2024.105523.Peer-Reviewed Original ResearchConceptsRisk of dementiaDementia riskAccelerated brain atrophyLower risk of dementiaMeasures of cognitive functionLongitudinal studyUS National Institutes of HealthNational Institutes of HealthCombat dementiaInstitutes of HealthPerivascular spaces countAlzheimer's disease biomarkersUS National InstitutesClinical measures of cognitive functioningDementiaBrain healthMixed-effects modelsScreening toolClinical measuresConfounding factorsObservational studyCognitive declineLongitudinal trajectoriesParticipantsBrain atrophySystematic Review: Efficacy of Medical Therapy on Outcomes Important to Adult Patients With X-Linked Hypophosphatemia
Ali D, Mirza R, Alsarraf F, Hussein S, Abu Alrob H, Appelman-Dijkstra N, Beck-Nielsen S, Biosse-Duplan M, Brandi M, Carpenter T, Chaussain C, Cohen-Solal M, Crowley R, Dandurand K, Florenzano P, Fukumoto S, Gagnon C, Goodyer P, Grasemann C, Imel E, de Beur S, Lehman A, Lewiecki E, Morgante E, Ward L, Khan A, Guyatt G. Systematic Review: Efficacy of Medical Therapy on Outcomes Important to Adult Patients With X-Linked Hypophosphatemia. The Journal Of Clinical Endocrinology & Metabolism 2024, dgae890. PMID: 39715351, DOI: 10.1210/clinem/dgae890.Peer-Reviewed Original ResearchX-linked hypophosphatemiaConventional therapyPatient-important outcomesNo treatmentModerate certaintyObservational studyAdult patientsManagement of "X-linked hypophosphatemiaEfficacy of medical therapyEffects of burosumabLow certaintyObservational study of individualsHigh-certainty evidenceAssessed risk of biasRisk of biasAbscess riskLow RoB.Medical therapyImprove painPain measuresBurosumabWeb of ScienceGRADE methodologyTherapyEvidence certaintyFour targets: an enhanced framework for guiding causal inference from observational data
Lu H, Li F, Lesko C, Fink D, Rudolph K, Harhay M, Rentsch C, Fiellin D, Gonsalves G. Four targets: an enhanced framework for guiding causal inference from observational data. International Journal Of Epidemiology 2024, 54: dyaf003. PMID: 39868475, PMCID: PMC11769716, DOI: 10.1093/ije/dyaf003.Peer-Reviewed Original ResearchCommunication as a key component of deprescribing: Conceptual framework and review of the literature
Fried T, Ouyang N, Gnjidic D, Green A, Hilmer S, Holmes H, Ko S, Mecca M, Reeve E, Reyes C, Schoenborn N, Singh R, Street R, Wahler R, Funaro M. Communication as a key component of deprescribing: Conceptual framework and review of the literature. Journal Of The American Geriatrics Society 2024, 73: 717-727. PMID: 39663187, DOI: 10.1111/jgs.19305.Peer-Reviewed Original ResearchRandomized clinical trialsHealth system levelDeprescribing interventionsAcademic detailingCommunity settingsDeprescribingOlder personsCommunity outreachIntervention studiesCritical literature reviewObservational studyCommunity levelPartner stakeholdersComponents of communicationStudy objectiveCommunity groupsFeedback materialHealthConceptual frameworkInterventionWorking GroupInternational settingsLiterature reviewContent of studiesCommunityInternational Society on Thrombosis and Haemostasis Clinical Practice Guideline for Treatment of Congenital Haemophilia—A Critical Appraisal
Albisetti M, Ardila J, Astermark J, Blatny J, Carcao M, Chowdary P, Connell N, Crato M, Dargaud Y, d'Oiron R, Dunn A, Escobar M, Ettingshausen C, Fischer K, Gouider E, Harroche A, Hermans C, Jimenez‐Yuste V, Kaczmarek R, Kenet G, Khoo L, Klamroth R, Langer F, Lillicrap D, Mahlangu J, Male C, Mancuso M, Matsushita T, Meunier S, Miesbach W, Nolan B, Oldenburg J, O'Mahony B, Ozelo M, Pierce G, Ramos G, Recht M, Romero‐Lux O, Rotellini D, Santoro R, Singleton T, Skinner M, Srivastava A, Susen S, Talks K, Tran H, Valentino L, Windyga J, Yang R, also on behalf of AICE A. International Society on Thrombosis and Haemostasis Clinical Practice Guideline for Treatment of Congenital Haemophilia—A Critical Appraisal. Haemophilia 2024 PMID: 39642092, DOI: 10.1111/hae.15135.Peer-Reviewed Original ResearchClinical practice guidelinesTreatment goalsGRADE methodologyPractice guidelinesClinical practiceEvidence-based clinical practice guidelinesTreatment of hemophiliaWell-designed observational studiesRandomized controlled trialsPatient-relevant outcomesOptimal patient careRare diseaseTherapeutic benefitObservational studyControlled trialsHigh-quality treatmentHealthcare professionalsPatient preferencesPatient careCritical appraisalPatient communityHaemophilia careHemophiliaTreatmentPatients
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