2025
PTEN mutations impair CSF dynamics and cortical networks by dysregulating periventricular neural progenitors
DeSpenza T, Kiziltug E, Allington G, Barson D, McGee S, O’Connor D, Robert S, Mekbib K, Nanda P, Greenberg A, Singh A, Duy P, Mandino F, Zhao S, Lynn A, Reeves B, Marlier A, Getz S, Nelson-Williams C, Shimelis H, Walsh L, Zhang J, Wang W, Prina M, OuYang A, Abdulkareem A, Smith H, Shohfi J, Mehta N, Dennis E, Reduron L, Hong J, Butler W, Carter B, Deniz E, Lake E, Constable R, Sahin M, Srivastava S, Winden K, Hoffman E, Carlson M, Gunel M, Lifton R, Alper S, Jin S, Crair M, Moreno-De-Luca A, Luikart B, Kahle K. PTEN mutations impair CSF dynamics and cortical networks by dysregulating periventricular neural progenitors. Nature Neuroscience 2025, 28: 536-557. PMID: 39994410, DOI: 10.1038/s41593-024-01865-3.Peer-Reviewed Original ResearchConceptsNeural progenitor cellsCongenital hydrocephalusCSF dynamicsIncreased CSF productionDe novo mutationsFrequent monogenic causeEverolimus treatmentCSF shuntingNonsurgical treatmentPTEN mutationsAqueductal stenosisInhibitory interneuronsVentriculomegalyProgenitor cellsChoroid plexusMonogenic causeCortical networksIncreased survivalBrain ventriclesCortical deficitsNeural progenitorsGene PTENCSF productionNkx2.1PTEN
2024
Trends in management of odontoid fractures 2010–2021
Gouzoulis M, Seddio A, Rancu A, Jabbouri S, Moran J, Varthi A, Rubio D, Grauer J. Trends in management of odontoid fractures 2010–2021. North American Spine Society Journal (NASSJ) 2024, 20: 100553. PMID: 39381260, PMCID: PMC11459689, DOI: 10.1016/j.xnsj.2024.100553.Peer-Reviewed Original ResearchOdontoid fracturesSurgical interventionPredictive factorsAdult patientsManagement of odontoid fracturesPosterior stabilizationMethods Adult patientsNon-clinical factorsRate of surgerySampled adult patientsYearly rateAnterior surgeryPosterior surgeryNonoperative careSurgical managementNonsurgical treatmentClinical factorsMale sexPosterior approachMultivariate analysisMedicare insuranceFracture managementSurgeryPatientsMidwest United StatesSurgical Approach to Patellofemoral Pain
Schneble C, Fulkerson J. Surgical Approach to Patellofemoral Pain. 2024, 1-17. DOI: 10.1007/978-3-030-82869-1_69-1.ChaptersPatellofemoral painSurgical treatmentTreatment of patellofemoral painPeripatellar soft tissuesAnterior knee painSource of painPain improvementPersistent painPain sourceSurgical approachNonsurgical treatmentSurgical interventionKnee painOrthopedic providersPainPatellofemoral syndromeRealignment proceduresAlleviate symptomsSoft tissue releaseSoft tissuePatellofemoral jointTissue releaseArticular cartilageTreatmentSubchondral bone
2022
Evidence-Based Clinical Practice Guidelines for Extramammary Paget Disease
Kibbi N, Owen J, Worley B, Wang J, Harikumar V, Downing M, Aasi S, Aung P, Barker C, Bolotin D, Bordeaux J, Cartee T, Chandra S, Cho N, Choi J, Chung K, Cliby W, Dorigo O, Eisen D, Fujisawa Y, Golda N, Halfdanarson T, Iavazzo C, Jiang S, Kanitakis J, Khan A, Kim J, Kuzel T, Lawrence N, Leitao M, MacLean A, Maher I, Mittal B, Nehal K, Ozog D, Pettaway C, Ross J, Rossi A, Servaes S, Solomon M, Thomas V, Tolia M, Voelzke B, Waldman A, Wong M, Zhou Y, Arai N, Brackett A, Ibrahim S, Kang B, Poon E, Alam M. Evidence-Based Clinical Practice Guidelines for Extramammary Paget Disease. JAMA Oncology 2022, 8: 618-628. PMID: 35050310, DOI: 10.1001/jamaoncol.2021.7148.Peer-Reviewed Original ResearchConceptsExtramammary Paget's diseaseSecondary extramammary Paget's diseaseClinical practice guidelinesNonsurgical treatmentPaget's diseaseMalignant neoplasmsPractice guidelinesEvidence-based clinical practice guidelinesInvasive extramammary Paget's diseaseCarbon dioxide laser therapyClinical care recommendationsInternal malignant neoplasmsMultiple skin biopsiesDistant metastatic diseaseLymph node dissectionHigh-risk tumorsCare of adultsSuperior management approachCurative intentNode dissectionProspective registryMetastatic diseaseSentinel lymphSurgical resectionTumor characteristics
2021
Correction of a Squeaky Knee After ACL Reconstruction Surgery: A Case Report.
Moran J, Kahan JB, Gardner E. Correction of a Squeaky Knee After ACL Reconstruction Surgery: A Case Report. JBJS Case Connector 2021, 11: e20.00856. PMID: 33950635, DOI: 10.2106/jbjs.cc.20.00856.Peer-Reviewed Original ResearchConceptsReconstruction surgeryKnee complicationsAnterior cruciate ligament reconstruction surgeryLigament reconstruction surgeryACL reconstruction surgeryNonsurgical treatmentCase reportFemoral tunnelSurgical correctionSurgeryYoung adultsPsychological distressFiberWire suturesComplicationsPatientsKneeNonsurgical treatment of skin cancer with local delivery of bioadhesive nanoparticles
Hu JK, Suh HW, Qureshi M, Lewis JM, Yaqoob S, Moscato ZM, Griff S, Lee AK, Yin ES, Saltzman WM, Girardi M. Nonsurgical treatment of skin cancer with local delivery of bioadhesive nanoparticles. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2020575118. PMID: 33526595, PMCID: PMC7896333, DOI: 10.1073/pnas.2020575118.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaNonsurgical treatmentSkin cancerTumor cell surfaceIntratumoral drug deliveryHistologic cureCutaneous malignanciesSurgical excisionTherapeutic standardTumor burdenTumor immunotherapyTumor injectionCommon malignancyCell carcinomaSCC tumorsNonsurgical alternativeTherapeutic efficacyD postinjectionNanoparticle drug delivery systemsChemotherapeutic agentsSuperficial tumorsTumorsLocal deliveryEnhanced survivalPercutaneous delivery
2020
The 3 Bs of cancer care amid the COVID‐19 pandemic crisis: “Be safe, be smart, be kind”—A multidisciplinary approach increasing the use of radiation and embracing telemedicine for head and neck cancer
Kang JJ, Wong RJ, Sherman EJ, Rybkin A, McBride SM, Riaz N, Tsai CJ, Yu Y, Chen L, Zakeri K, Gelblum DY, Gillespie EF, Cohen MA, Cracchiolo JR, Ganly I, Patel S, Singh B, Boyle JO, Roman BR, Morris LG, Shaha AR, Dunn LA, Ho AL, Fetten JV, Shah JP, Pfister DG, Lee NY. The 3 Bs of cancer care amid the COVID‐19 pandemic crisis: “Be safe, be smart, be kind”—A multidisciplinary approach increasing the use of radiation and embracing telemedicine for head and neck cancer. Cancer 2020, 126: 4092-4104. PMID: 32639615, PMCID: PMC7361524, DOI: 10.1002/cncr.33031.Peer-Reviewed Original ResearchConceptsSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2High-volume cancer centerRespiratory syndrome coronavirus 2Coronavirus disease 2019 (COVID-19) pandemicSyndrome coronavirus 2Neck cancer treatmentDisease 2019 pandemicPersonal protective equipmentPublic health directivesEndoscopic evaluationNonsurgical treatmentCancer CenterCoronavirus 2Cancer careNeck cancerHNC treatmentOropharyngeal tractUse of radiationFeasibility dataMultidisciplinary conferenceCancer treatmentProtective equipmentRadiation oncologyMultidisciplinary approach
2019
1019 Biodegradable bioadherent nanoparticle formulation for the local nonsurgical treatment of cutaneous malignancy
Hu J, Suh H, Lewis J, Lee A, Saltzman W, Girardi M. 1019 Biodegradable bioadherent nanoparticle formulation for the local nonsurgical treatment of cutaneous malignancy. Journal Of Investigative Dermatology 2019, 139: s176. DOI: 10.1016/j.jid.2019.03.1095.Peer-Reviewed Original Research
2018
Considering Spine Surgery
Moulton H, Tosteson TD, Zhao W, Pearson L, Mycek K, Scherer E, Weinstein JN, Pearson A, Abdu W, Schwarz S, Kelly M, McGuire K, Milam A, Lurie JD. Considering Spine Surgery. Spine 2018, 43: 1731-1738. PMID: 29877995, PMCID: PMC6279474, DOI: 10.1097/brs.0000000000002723.Peer-Reviewed Original ResearchConceptsTreatment optionsPatient participantsTreatment outcomesKnowledge scoreIntervertebral disc herniationComprehensive decision aidWeb-based calculatorNonsurgical treatmentDegenerative spondylolisthesisSpinal stenosisSpine centerBack surgeryClinical evidenceDisc herniationProspective evaluationProspective mannerSpine surgeryBACKGROUND DATAIndividualized riskInitial appointmentDecisional conflictTrial dataIndividualized toolSurgeryOutcomesCentral artery stiffness and thoracic aortopathy
Humphrey J, Tellides G. Central artery stiffness and thoracic aortopathy. AJP Heart And Circulatory Physiology 2018, 316: h169-h182. PMID: 30412443, PMCID: PMC6880196, DOI: 10.1152/ajpheart.00205.2018.Peer-Reviewed Original ResearchConceptsCentral arteriesEnd-organ diseaseProximal thoracic aortaCentral artery stiffnessPrimary risk factorUncontrolled hypertensionAntihypertensive medicationsNonsurgical treatmentSignificant morbidityArtery stiffnessAortic aneurysmPulse pressureRisk factorsThoracic aortaDisease progressionStrenuous exerciseMouse modelMarfan syndromeWeight liftingGlobal hemodynamicsDysfunctional mechanosensingLethal conditionAortaGenetic mutationsArtery
2017
Treatment guidelines and patterns of care in oral cavity squamous cell carcinoma: Primary surgical resection vs. nonsurgical treatment
Fujiwara RJT, Burtness B, Husain ZA, Judson BL, Bhatia A, Sasaki CT, Yarbrough WG, Mehra S. Treatment guidelines and patterns of care in oral cavity squamous cell carcinoma: Primary surgical resection vs. nonsurgical treatment. Oral Oncology 2017, 71: 129-137. PMID: 28688680, DOI: 10.1016/j.oraloncology.2017.06.013.Peer-Reviewed Original ResearchConceptsOral cavity squamous cell carcinomaNational Cancer Data BaseLate-stage diseasePrimary nonsurgical treatmentOral cavity malignancyNonsurgical treatmentSquamous cell carcinomaOverall survivalSurgical resectionCell carcinomaTreatment modalitiesNational Comprehensive Cancer Network Clinical Practice GuidelinesAcademic/research programMultimodality clinical trialsDefinitive radiation therapyImproved overall survivalDecreased overall survivalPrimary surgical resectionOral cavity cancerNon-randomized natureClinical practice guidelinesPatterns of careNon-white raceProportional hazards modelBinary logistic regression
2016
Randomized Controlled Trial of Minimally Invasive Sacroiliac Joint Fusion Using Triangular Titanium Implants vs. NonSurgical Management for Sacroiliac Joint Dysfunction
Polly D, Cher D, Wine K, Whang P, Frank C, Lockstadt H, Harvey C, Sembrano J. Randomized Controlled Trial of Minimally Invasive Sacroiliac Joint Fusion Using Triangular Titanium Implants vs. NonSurgical Management for Sacroiliac Joint Dysfunction. Global Spine Journal 2016, 6: s-0036-1583136-s-0036-1583136. DOI: 10.1055/s-0036-1583136.Peer-Reviewed Original ResearchTriangular titanium implantsSI joint dysfunctionSI joint fusionSacroiliac joint dysfunctionSurgical groupJoint dysfunctionNonsurgical managementQuality of lifeJoint fusionSIJ fusionInvasive SI joint fusionInvasive Sacroiliac Joint FusionSacroiliac joint fusionLow back painRandomized Controlled TrialsImmediate revision surgerySuccess rateTitanium implantsODI improvementNeuropathic painSIJ painAdverse eventsNSM groupControlled TrialsNonsurgical treatment
2015
Comparison of 368 Patients Undergoing Surgery for Lumbar Degenerative Spondylolisthesis From the SPORT Trial With 955 From the NSQIP Database
Golinvaux NS, Basques BA, Bohl DD, Yacob A, Grauer JN. Comparison of 368 Patients Undergoing Surgery for Lumbar Degenerative Spondylolisthesis From the SPORT Trial With 955 From the NSQIP Database. Spine 2015, 40: 342-348. PMID: 25757036, DOI: 10.1097/brs.0000000000000747.Peer-Reviewed Original ResearchConceptsSpine Patient Outcomes Research TrialPerioperative factorsPerioperative outcomesNSQIP databaseDegenerative spondylolisthesisSurgical proceduresNational Surgical Quality Improvement Program databaseQuality Improvement Program databaseAverage body mass indexImprovement Program databaseAverage operative timeLumbar degenerative spondylolisthesisBody mass indexPostoperative mortalityPostoperative transfusionComplication rateRetrospective cohortSurgical patientsNonsurgical treatmentAnalysis of demographicsMass indexOperative timeSmoking statusLumbar pathologyWound infectionStrategy for the Management of Macular Edema in Retinal Vein Occlusion: The European VitreoRetinal Society Macular Edema Study
Adelman RA, Parnes AJ, Bopp S, Othman I, Ducournau D. Strategy for the Management of Macular Edema in Retinal Vein Occlusion: The European VitreoRetinal Society Macular Edema Study. BioMed Research International 2015, 2015: 870987. PMID: 25705695, PMCID: PMC4325227, DOI: 10.1155/2015/870987.Peer-Reviewed Original ResearchConceptsRetinal vein occlusionCentral retinal vein occlusionBranch retinal vein occlusionVein occlusionMacular edemaVisual acuityIntravitreal antivascular endothelial growth factor injectionsAntivascular endothelial growth factor injectionsCases of RVOEndothelial growth factor injectionsGrowth factor injectionsChoice of treatmentMulticenter collaborative studyEdema studyFactor injectionsNonsurgical treatmentNumber of treatmentsVEGF injectionPlana vitrectomyRVO casesILM peelingRetina specialistsVisual gainDiagnostic findingsVisual improvement
2014
Predictive factors for failure of nonoperative management in perforated appendicitis
Maxfield MW, Schuster KM, Bokhari J, McGillicuddy EA, Davis KA. Predictive factors for failure of nonoperative management in perforated appendicitis. Journal Of Trauma And Acute Care Surgery 2014, 76: 976-981. PMID: 24662860, DOI: 10.1097/ta.0000000000000187.Peer-Reviewed Original ResearchConceptsNonoperative managementAbdominal tendernessFailure groupIntensive care unit careUniversity tertiary care hospitalTertiary care hospitalLength of stayUnit careCare hospitalDefinitive treatmentLaboratory markersPerforated appendicitisNonsurgical treatmentClinical findingsPredictive factorsRadiographic findingsTomographic scanTherapeutic studiesAppendicitisEarly operationLevel IIIPatientsAbscessPhlegmonTachycardia
2012
Physical therapy interventions for knee pain secondary to osteoarthritis: a systematic review.
Wang SY, Olson-Kellogg B, Shamliyan TA, Choi JY, Ramakrishnan R, Kane RL. Physical therapy interventions for knee pain secondary to osteoarthritis: a systematic review. Annals Of Internal Medicine 2012, 157: 632-44. PMID: 23128863, DOI: 10.7326/0003-4819-157-9-201211060-00007.Peer-Reviewed Original ResearchConceptsLow-strength evidencePhysical therapy interventionsPT interventionsIndividual RCTsAerobic exerciseTherapy interventionPool standardized mean differencesPhysiotherapy Evidence DatabaseRisk of biasCommunity-dwelling adultsStandardized mean differenceMeans of outcomesImproved disabilityKnee painAdverse eventsKnee osteoarthritisNonsurgical treatmentCochrane LibraryPhysical functionEvidence DatabaseLeading causeOutcome measuresSustained benefitPainSynthesis of evidence
2007
National Trends in Adolescent Bariatric Surgical Procedures and Implications for Surgical Centers of Excellence
Schilling PL, Davis MM, Albanese CT, Dutta S, Morton J. National Trends in Adolescent Bariatric Surgical Procedures and Implications for Surgical Centers of Excellence. Journal Of The American College Of Surgeons 2007, 206: 1-12. PMID: 18155562, DOI: 10.1016/j.jamcollsurg.2007.07.028.Peer-Reviewed Original ResearchConceptsAdolescent bariatric proceduresBariatric proceduresBariatric operationsInpatient DatabaseMost hospitalsAdolescent bariatric patientsHospital complication ratesBariatric surgery patientsBariatric surgical proceduresLow-volume centersNationwide Inpatient SampleKids' Inpatient DatabaseNational trendsHospital complicationsHospital deathBariatric surgeryBariatric patientsComplication ratePatient characteristicsSurgery patientsEligible adolescentsNonsurgical treatmentAdult hospitalsPediatric populationAdult centers
2005
935: Single-Blind, Multi-Center, Placebo-Controlled, Parallel Study to Assess the Safety and Efficacy of Intralesional Interferon Alpha-2b in the Nonsurgical Treatment of Peyronie's Disease
Kendirci M, Matern R, Nowfar S, Venable D, Honig S, McCullough A, Hakim L, Nehra A, Pryor J, Templeton L, Hellstrom W. 935: Single-Blind, Multi-Center, Placebo-Controlled, Parallel Study to Assess the Safety and Efficacy of Intralesional Interferon Alpha-2b in the Nonsurgical Treatment of Peyronie's Disease. Journal Of Urology 2005, 173: 253. DOI: 10.1016/s0022-5347(18)35091-2.Peer-Reviewed Original Research
1997
Patterns of Care for Cancer of the Larynx in the United States
Shah J, Karnell L, Hoffman H, Ariyan S, Brown G, Fee W, Glass A, Goepfert H, Ossoff R, Fremgen A. Patterns of Care for Cancer of the Larynx in the United States. JAMA Otolaryngology - Head & Neck Surgery 1997, 123: 475-483. PMID: 9158393, DOI: 10.1001/archotol.1997.01900050021002.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAdvanced-stage patientsRadiation therapyRegional metastasesLaryngeal cancerStage IIIDisease-specific survival outcomesFive-year survival rateStage IV diseaseAmerican Joint CommitteeEarly-stage patientsSeries of patientsSquamous cell carcinomaPatterns of careCase-mix characteristicsRadiochemotherapy protocolHospital recordsN classificationNonsurgical treatmentTreatment patternsSurvival outcomesCell carcinomaTreatment characteristicsLarge seriesPatientsUS hospitals
1995
Ectopic pregnancy
Buster J, Carson S. Ectopic pregnancy. Current Opinion In Obstetrics & Gynecology 1995, 7: 168-176. PMID: 7647267, DOI: 10.1097/00001703-199506000-00003.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsEctopic pregnancyLaparoscopic salpingostomyBeta-human chorionic gonadotropin measurementsSingle dose systemic methotrexateEarly first trimesterSurgical gold standardEffective nonsurgical treatmentSystemic methotrexateDose methotrexateSurgical complicationsNonsurgical treatmentFirst trimesterSimilar patientsDefinitive diagnosisGonadotropin measurementsSerum progesteroneEffective therapySurgical diseaseEarly diagnosisPregnancyDiagnostic algorithmGold standardMedical criteriaSalpingostomyPatients
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