2025
The impact of PGT-A on time to live birth in IVF.
Eliner Y, Foley B, Bayer S, Thornton K, Penzias A, Sakkas D, Vaughan D. The impact of PGT-A on time to live birth in IVF. Fertility And Sterility 2025 PMID: 40222699, DOI: 10.1016/j.fertnstert.2025.04.006.Peer-Reviewed Original ResearchPGT-ALive birth rateLive birthsTime to pregnancyOocyte retrievalAge groupsHazard ratioNon-PGT-A groupPre-implantation genetic testingUniversity-affiliated fertility centerPGT-A groupShorter time to pregnancyPositive pregnancy rateSignificant differenceKaplan-Meier curvesBirth rateOne-year periodStatistically significant differencePropensity score matchingMiscarriage rateYounger age groupsNo significant differenceYounger patientsOlder age groupsEgg retrievalEditorial: Where are the Trials on Adolescent Self-Harm and Suicide?
Kumpf K, Bloch M. Editorial: Where are the Trials on Adolescent Self-Harm and Suicide? Journal Of The American Academy Of Child & Adolescent Psychiatry 2025 PMID: 40088968, DOI: 10.1016/j.jaac.2025.03.002.Peer-Reviewed Original ResearchNonsuicidal self-injurySelf-harmModerators of treatment effectsRandomized controlled trialsPublic health problemEvidence-based treatmentsAdolescent self-harmPrevent self-harmSelf-injuryHealth problemsRandom-effects meta-analysisRandom-effects meta-analysis of studiesTherapeutic interventionsSuicideMeta-analysis of studiesSource of morbidityAdolescentsIndividual patient dataSecondary analysisTreatment effectsNo significant differenceControlled trialsAggregate dataMeta-analysisEffective treatmentObjectifying aesthetic outcomes following face transplantation – the AI research metrics model (CAARISMA ® ARMM)
Knoedler L, Hoch C, Knoedler S, Klimitz F, Schaschinger T, Niederegger T, Heiland M, Koerdt S, Pooth R, Kauke-Navarro M, Lellouch A. Objectifying aesthetic outcomes following face transplantation – the AI research metrics model (CAARISMA ® ARMM). Journal Of Stomatology Oral And Maxillofacial Surgery 2025, 126: 102277. PMID: 39947010, DOI: 10.1016/j.jormas.2025.102277.Peer-Reviewed Original ResearchFacial Aesthetic IndexAesthetic outcomesFT patientsFace transplantationAesthetic IndexAesthetic improvementPatient-surgeon communicationSevere facial disfigurementEnhance surgical planningNo significant differenceFacial aestheticsPreoperative scoresPostoperative scoresSurgical planningReconstructive optionsPatient populationDiverse patient populationsPatientsMetric modelFacial disfigurementSignificant differenceAesthetic successTime pointsTransplantationOutcomesStandard to Handheld: A New Wave in Thoracic Ultrasound and Patient Care—A Direct Comparison of Portable Handheld Against Standard in Thoracic Ultrasound
Halim D, Kelly A, Hayes J, Bennett K, Tzouvelekis A, Ampazis D, Sampsonas F. Standard to Handheld: A New Wave in Thoracic Ultrasound and Patient Care—A Direct Comparison of Portable Handheld Against Standard in Thoracic Ultrasound. Medicina 2025, 61: 313. PMID: 40005430, PMCID: PMC11857366, DOI: 10.3390/medicina61020313.Peer-Reviewed Original ResearchConceptsLevels of experienceNon-inferiorityPortable ultrasound deviceOverall image qualityLung pathologyUltrasound deviceInterquartile rangeRespiratory departmentThoracic ultrasoundAnatomical visualizationHandheld ultrasound devicePatient careImprove healthcareOperator's level of experienceNo significant differenceLikert scaleTrainee levelStatistically significant variablesDiagnostic accuracyClinical decisionsOverall perceptionOnline questionnaireClinical utilityMedian rateClinical settingThe impact of Duration of Untreated Psychosis on functioning and quality of life over one year of Coordinated Specialty Care (CSC)
Hazan H, Tayfur S, Zhou B, Li F, Gibbs-Dean T, Karmani S, Kline E, Ferrara M, Corbera S, Riley S, Sykes L, Tek C, Keshavan M, Srihari V. The impact of Duration of Untreated Psychosis on functioning and quality of life over one year of Coordinated Specialty Care (CSC). PLOS ONE 2025, 20: e0312740. PMID: 39928579, PMCID: PMC11809850, DOI: 10.1371/journal.pone.0312740.Peer-Reviewed Original ResearchConceptsCoordinated specialty careQuality of lifeDuration of untreated psychosisDUP groupWorld Health OrganizationYear of coordinated specialty careGeneralized linear modelConfidence intervalsBinary outcomesGlobal functioningDuration of untreated psychosis groupSymptom severityUntreated psychosisSpecialty careCSC programsImpact of duration of untreated psychosisFunctional gainsModel repeated measuresMixed model repeated measuresOdds ratioNo significant differenceLogit link functionStatus improvementContinuous outcomesSocial functioningImpact of Tumor Stage on Oncologic Outcomes of High-grade Bacillus Calmette-Guérin Unresponsive Non–muscle-invasive Bladder Cancer Undergoing Bladder-sparing Therapies
Annapureddy D, Taylor J, Kamat A, O'Donnell M, Howard J, Tan W, McElree I, Davaro F, Yim K, Harrington S, Dyer E, Black A, Kanabur P, Roumiguié M, Lerner S, Black P, Raman J, Preston M, Steinberg G, Huang W, Li R, Packiam V, Woldu S, Lotan Y. Impact of Tumor Stage on Oncologic Outcomes of High-grade Bacillus Calmette-Guérin Unresponsive Non–muscle-invasive Bladder Cancer Undergoing Bladder-sparing Therapies. European Urology Focus 2025 PMID: 39922753, DOI: 10.1016/j.euf.2025.01.001.Peer-Reviewed Original ResearchNon-muscle-invasive bladder cancerCarcinoma in situBCG-unresponsive NMIBCBladder-sparing therapyOncological outcomesTumor stageBladder cancer mortalityCancer mortalityAssociated with worse oncologic outcomesPresence of carcinoma in situCarcinoma in situ groupImpact of tumor stageTA groupKaplan-Meier methodPapillary diseaseT1 diseaseRadical cystectomyNo significant differenceClinical stageBladder cancerSurvival differencesRetrospective natureCis groupDisease progressionMetastasisAnticoagulants or antiplatelets for secondary prevention of cryptogenic stroke: an updated systematic review and meta-analysis
Chi K, Zarif T, Varrias D, Lee P, Chang Y, Song J, Osabutey A, Borkowski P, Chiang C, Chang Y, Lin Y, Nanna M, Nanna M. Anticoagulants or antiplatelets for secondary prevention of cryptogenic stroke: an updated systematic review and meta-analysis. Heart 2025, heartjnl-2024-325288. PMID: 39915077, DOI: 10.1136/heartjnl-2024-325288.Peer-Reviewed Original ResearchPresence of patent foramen ovaleOral anticoagulantsRandomised controlled trialsCryptogenic strokeAtrial cardiopathyIschaemic strokeIschaemic stroke riskSafety of oral anticoagulantsRisk factorsSecondary prevention of cryptogenic strokeStroke riskMeta-analysisOptimal antithrombotic strategyRisk of recurrent ischaemic strokePatent foramen ovaleInteraction p valuePersonalised treatment strategiesSystematic reviewRecurrent ischaemic strokePreventing ischaemic strokeBleeding riskNo significant differenceAntithrombotic strategiesClinical characteristicsForamen ovaleDoes Resident Gender or Race/Ethnicity Affect Orthopaedic Surgery Case Volume During Residency Training?
Shoga P, Van Heest A, Ames S, Hogan S, Holmboe E, Klingensmith M, Park Y, Parker C, Solberg E, Templeton K. Does Resident Gender or Race/Ethnicity Affect Orthopaedic Surgery Case Volume During Residency Training? JBJS Open Access 2025, 10: e24.00146. PMID: 39901939, PMCID: PMC11778099, DOI: 10.2106/jbjs.oa.24.00146.Peer-Reviewed Original ResearchCase volumeOrthopaedic surgery residentsNo significant differenceSignificant differenceSurgery residentsStudy periodDescription of levels of evidenceAnterior cruciate ligament reconstructionAnkle fracture fixationCruciate ligament reconstructionLevel of evidenceYears of cohortsForearm fracturesYears of study periodMen per yearLevel IIILigament reconstructionFracture fixationAnatomical areasTotal knee arthroplastyURiM traineesSurgical specialtiesResident genderResidency trainingRacial/ethnic disparitiesRisk of aortic aneurysm or dissection following use of fluoroquinolones: a retrospective multinational network cohort study
Janetzki J, Kim J, Minty E, Lee J, Morales D, Khera R, Kim C, Alshammari T, DuVall S, Matheny M, Falconer T, Kim S, Phan T, Nguyen P, Hsu M, Hsu J, Park R, Man K, Seager S, Van Zandt M, Gilbert J, Ryan P, Schuemie M, Suchard M, Hripcsak G, Pratt N, You S. Risk of aortic aneurysm or dissection following use of fluoroquinolones: a retrospective multinational network cohort study. EClinicalMedicine 2025, 81: 103096. PMID: 39975698, PMCID: PMC11836508, DOI: 10.1016/j.eclinm.2025.103096.Peer-Reviewed Original ResearchUrinary tract infectionRisk of aortic aneurysmTreat urinary tract infectionsOutpatient settingAortic aneurysmIndex dateCohort studyHazard ratioUrinary tract infection treatmentYonsei University College of MedicineRetrospective cohort studyPropensity scoreCox proportional hazards modelsPropensity-matched pairsRandom-effects meta-analysisProportional hazards modelNational Health and Medical Research Council (NHMRCUniversity College of MedicineSystemic fluoroquinolonesTract infectionsNo significant differenceBayesian random-effects meta-analysisFollow-upPrimary outcomeIncreased riskGender Disparities in Cardiothoracic Surgical Conference Scholarly Interactions: A Prime Opportunity for Change in Culture
Ries S, Zolfaghari E, Higaki A, Olivera J, Cangut B, Ahmed A, Hsiung T, Carducci J, Chidi A, Elshiekh M, Degife E, Arrington R, Jindani R, Perkins A, Rodriguez E, Eisenberg M, Servais E, Woodard G, Antonoff M. Gender Disparities in Cardiothoracic Surgical Conference Scholarly Interactions: A Prime Opportunity for Change in Culture. JTCVS Open 2025 DOI: 10.1016/j.xjon.2025.02.008.Peer-Reviewed Original ResearchAdult cardiac surgeryCardiac surgeryNo significant differenceGeneral thoracicWomen presentersSurgical meetingsSurgical residentsSignificant differenceObserved presentationWomenPresentationMenEvaluate presentationObservance of professional behaviorUnprofessional behaviorGender-related inequalitiesSurgeryThe Use of Acellular Dermal Matrix May Not Increase 30-Day Complications in Direct-to-Implant Breast Reconstruction: A Multi-institutional Analysis of 10,177 Cases.
Knoedler S, Klimitz F, Friedrich S, Schemet L, Broer P, Cherubino M, Könneker S, Kim B, Pomahac B, Kauke-Navarro M. The Use of Acellular Dermal Matrix May Not Increase 30-Day Complications in Direct-to-Implant Breast Reconstruction: A Multi-institutional Analysis of 10,177 Cases. Annals Of Plastic Surgery 2025 PMID: 39874559, DOI: 10.1097/sap.0000000000004234.Peer-Reviewed Original ResearchDirect-to-implant breast reconstructionDirect-to-implantAcellular dermal matrixBreast reconstructionPropensity score matchingHigher risk of short-term complicationsMedical complicationsAmerican College of Surgeons National Surgical Quality Improvement Program databaseSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseIncreased 30-day complicationsMultivariate analysisRisk of short-term complicationsQuality Improvement Program databaseThirty-day postoperative complicationsSurgical complication rateIncorporation of acellular dermal matrixScore matchingMulti-institutional analysisMulti-institutional databaseShort-term complicationsComplication ratePostoperative complicationsWound dehiscenceNo significant differenceP0442 Prevalence and Impact of E-cigarettes on Disease Outcomes in Patients with Inflammatory Bowel Disease
Almuhaya H, Alashkar R, Alsebaai D, Albadawi N, Almutairdi A, Attamimi M, Desai S, Al-Bawardy B. P0442 Prevalence and Impact of E-cigarettes on Disease Outcomes in Patients with Inflammatory Bowel Disease. Journal Of Crohn's And Colitis 2025, 19: i951-i951. DOI: 10.1093/ecco-jcc/jjae190.0616.Peer-Reviewed Original ResearchTraditional cigarette smokingPrevalence of EC useClinical outcomesCrohn's diseaseEC useAdvanced therapiesIBD patientsCigarette smokingUlcerative colitisElectronic cigarettesPenetrating diseaseComposite outcomeIBD-unclassifiedHistory of intestinal surgeryAssociated with male sexFollow-up durationImpact of e-cigarettesDiagnosis of IBDCross-sectional studyCigarette smoking historyInflammatory bowel diseaseNo significant differencePerianal diseaseIBD registrySurgical interventionReliability of Central Vein Sign Imaging With 3T FLAIR* in a Multicenter Study
Martin M, Cao Q, Luskin E, Renner B, Daboul L, O'Donnell C, Rodrigues P, Derbyshire J, Azevedo C, Bar‐Or A, Caverzasi E, Calabresi P, Cree B, Freeman L, Henry R, Longbrake E, Oh J, Papinutto N, Pelletier D, Prchkovska V, Ramos M, Samudralwar R, Schindler M, Sotirchos E, Sicotte N, Solomon A, Reich D, Ontaneda D, Shinohara R, Sati P. Reliability of Central Vein Sign Imaging With 3T FLAIR* in a Multicenter Study. Journal Of Neuroimaging 2025, 35: e70011. PMID: 39838609, DOI: 10.1111/jon.70011.Peer-Reviewed Original ResearchConceptsCentral vein signMulticenter studyMultiple sclerosisT2-weighted fluid-attenuated inversion recoveryClinical settingMRI vendorsFluid-attenuated inversion recoveryDiagnosis of MSPost-GdContrast-to-noise ratioGd-based contrast agentsNo significant differenceT2*-weightedImaging sitesDiagnostic imaging biomarkersImaging biomarkersInversion recoverySignificant differenceMRIFLAIRContrast agentsA randomized controlled trial comparing embryo vitrification with slush nitrogen to liquid nitrogen in women undergoing frozen embryo transfer: embryology and clinical outcomes
Klimczak A, Osman E, Esbert M, Yildirim R, Whitehead C, Herlihy N, Hanson B, Roberts L, Seli E, Scott R. A randomized controlled trial comparing embryo vitrification with slush nitrogen to liquid nitrogen in women undergoing frozen embryo transfer: embryology and clinical outcomes. Human Reproduction 2025, 40: 426-433. PMID: 39836897, DOI: 10.1093/humrep/deaf003.Peer-Reviewed Original ResearchFrozen embryo transferRandomized controlled trialsPregnancy outcomesIVF stimulationPre-clinical trialsEmbryo transferPregnancy rateFutility analysisPost-warming survival rateDATE OF FIRST PATIENT’S ENROLMENT:University-affiliated infertility centerClinical pregnancy rateEmbryo transfer outcomesSustained implantation ratesPreimplantation genetic testingFIRST PATIENT’S ENROLMENTBlastocyst biopsyEmbryological outcomesBlastocyst survivalEmbryo vitrificationHuman oocytesMiscarriage rateImplantation rateNo significant differenceBaseline characteristicsEffects Of Angiotensin-Neprilysin Inhibition In Women Versus Men With Mildly Reduced Or Preserved Ejection Fraction And Worsening Heart Failure: Insights From PARAGLIDE-HF
Rambarat P, Erickson T, Cyr D, Ward J, Hernandez A, Morrow D, Starling R, Velazquez E, Zieroth S, Williamson K, Solomon S, Braunwald E, Mentz R. Effects Of Angiotensin-Neprilysin Inhibition In Women Versus Men With Mildly Reduced Or Preserved Ejection Fraction And Worsening Heart Failure: Insights From PARAGLIDE-HF. Journal Of Cardiac Failure 2025, 31: 330-331. DOI: 10.1016/j.cardfail.2024.10.383.Peer-Reviewed Original ResearchNT-proBNPHeart failureAmino-terminal pro-B type natriuretic peptideTime-averaged proportional changePro B-type natriuretic peptideTime-averaged reductionIncidence of adverse eventsWorsening heart failureAngiotensin-neprilysin inhibitionCoronary artery diseaseHigh-risk populationDifferential treatment effectsDrug dosage levelsTreatment effectsHFpEF therapyEjection fractionPrimary endpointNatriuretic peptideNo significant differenceRenal functionAdverse eventsSac/ValSubgroup analysisArtery diseaseWeek 4
2024
SWOG S1815: A Phase III Randomized Trial of Gemcitabine, Cisplatin, and Nab-Paclitaxel Versus Gemcitabine and Cisplatin in Newly Diagnosed, Advanced Biliary Tract Cancers
Shroff R, King G, Colby S, Scott A, Borad M, Goff L, Matin K, Mahipal A, Kalyan A, Javle M, Dika I, Tan B, Cheema P, Patel A, Iyer R, Kelley R, Thumar J, El-Khoueiry A, Guthrie K, Chiorean E, Hochster H, Philip P. SWOG S1815: A Phase III Randomized Trial of Gemcitabine, Cisplatin, and Nab-Paclitaxel Versus Gemcitabine and Cisplatin in Newly Diagnosed, Advanced Biliary Tract Cancers. Journal Of Clinical Oncology 2024, 43: 536-544. PMID: 39671534, PMCID: PMC11798714, DOI: 10.1200/jco-24-01383.Peer-Reviewed Original ResearchProgression-free survivalBiliary tract cancerAdvanced biliary tract cancerOverall survivalGallbladder carcinomaExtrahepatic cholangiocarcinomaIntrahepatic cholangiocarcinomaHazard ratioNab-paclitaxelMedian progression-free survivalMetastatic biliary tract cancerProgression-free survival benefitPhase III randomized trialGemcitabine-cisplatin regimenTrial of gemcitabineLocally advanced diseaseExploratory subset analysisDiagnosing BTCEvaluated gemcitabineMedian OSMetastatic diseaseAdvanced diseaseNo significant differenceSubset analysisGemcitabineFinancial Toxicity Among Patients With Advanced Solid Tumors Participating in Early-Phase Clinical Trials.
Blanter J, Van Hyfte G, Ahmad M, Xu S, Hapanowicz O, Fazilov G, Lu A, Lucas N, Wu K, Shelton G, DeMerchant M, Lachowicz M, Kier M, Werner M, Eder J, Galsky M, Marron T, Smith C, LoRusso P, Hofstatter E, Doroshow D. Financial Toxicity Among Patients With Advanced Solid Tumors Participating in Early-Phase Clinical Trials. JCO Oncology Practice 2024, op2400293. PMID: 39661920, DOI: 10.1200/op.24.00293.Peer-Reviewed Original ResearchEarly-phase clinical trialsSolid tumorsClinical trialsAssociated with higher FTFinancial toxicityBarriers to clinical trial enrollmentAdvanced solid malignanciesAdvanced solid tumorsInverse association with ageBaseline to 2 monthsYale Cancer CenterCOST scoreClinical trial enrollmentProspective survey studySolid malignanciesNo significant differenceBaseline FTTime of consentNovel therapiesPrimary outcomeCancer CenterSurvey 1Trial enrollmentPatientsEarly-phaseChildren and Restraints Study in Emergency Ambulance Transport-Cardiopulmonary Resuscitation (CARSEAT-CPR): An Observational Cohort Study of a Simulated Pediatric Cardiac Arrest.
Cochran-Caggiano N, Tse W, Swinburne C, Lang N, Till S, Donovan S, Woodson M, Dailey M. Children and Restraints Study in Emergency Ambulance Transport-Cardiopulmonary Resuscitation (CARSEAT-CPR): An Observational Cohort Study of a Simulated Pediatric Cardiac Arrest. Pediatric Emergency Care 2024 PMID: 39642211, DOI: 10.1097/pec.0000000000003316.Peer-Reviewed Original ResearchBasic life supportCompression fractionMoving ambulanceSimulated pediatric cardiac arrestBasic life support skillsNo significant differenceChest compression fractionCardiac arrestAmerican Heart Association recommendationsDepth of compressionInfant cardiac arrestSignificant differencePediatric cardiac arrestObservational cohort studyCompression depthProviders' abilityPediatric manikinInfant manikinCohort studyAssociation recommendationsPatient resuscitationPediatric patientsLife supportClinical significanceInfant testingAssociation Between Intrapartum Nitrous Oxide for Labor Analgesia and Short-Term Neonatal Outcomes
Starosta A, Lundsberg L, Culhane J, Partridge C, Grechukhina O, Son M. Association Between Intrapartum Nitrous Oxide for Labor Analgesia and Short-Term Neonatal Outcomes. Obstetric Anesthesia Digest 2024, 44: 227-228. DOI: 10.1097/01.aoa.0001080268.73398.1f.Peer-Reviewed Original ResearchShort-term neonatal outcomesNeonatal outcomesAdverse short-term neonatal outcomesAssociated with adverse neonatal outcomesAdverse neonatal outcomesInhaled nitrous oxideLabor analgesiaNeuraxial analgesiaSystemic opioidsNo significant differenceSignificant differenceIntrapartumShort-term effectsAnalgesiaOutcomesInhaled gasUnited StatesAssociationNeonatesOpioidPlacentaPainNitrous oxideShort Versus One-Year Dual Antiplatelet Therapy After Percutaneous Coronary Intervention: an Updated Meta-Analysis
Joseph M, Krishna M, Ezenna C, Pereira V, Ismayl M, Nanna M, Bangalore S, Goldsweig A. Short Versus One-Year Dual Antiplatelet Therapy After Percutaneous Coronary Intervention: an Updated Meta-Analysis. The American Journal Of Cardiology 2024, 237: 17-28. PMID: 39577682, DOI: 10.1016/j.amjcard.2024.10.038.Peer-Reviewed Original ResearchPost-percutaneous coronary interventionAcute coronary syndromeDrug-eluting stentsPercutaneous coronary interventionCoronary interventionAcute coronary syndrome cohortCochrane Central databasesShortening DAPT durationMonths post-percutaneous coronary interventionClopidogrel subgroupRandomized controlled trialsNo significant differenceCoronary syndromeMonotherapyTicagrelor monotherapyDAPT durationShorter DAPTBleedingStent thrombosisP2Y12iMyocardial infarctionControlled trialsSubgroup interactionsDAPTMeta-analysis
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