2025
Connectome-based predictive modeling of early and chronic psychosis symptoms
Foster M, Ye J, Powers A, Dvornek N, Scheinost D. Connectome-based predictive modeling of early and chronic psychosis symptoms. Neuropsychopharmacology 2025, 1-9. PMID: 40016363, DOI: 10.1038/s41386-025-02064-9.Peer-Reviewed Original ResearchConnectome-based predictive modelingPositive and Negative Syndrome ScalePsychosis symptomsSymptom networksSymptom severityBrain networksNeural correlates of CPResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingNegative Syndrome ScaleIdentified group differencesPredicted effect sizeCorrelates of CPGeneral psychopathologyNegative symptomsPositive symptomsSyndrome ScaleFrontoparietal networkNeural correlatesVirtual lesion analysisGroup differencesConnectivity changesEffect sizeLesion analysisLongitudinal studyDeep multimodal representations and classification of first-episode psychosis via live face processing
Singh R, Zhang Y, Bhaskar D, Srihari V, Tek C, Zhang X, Noah J, Krishnaswamy S, Hirsch J. Deep multimodal representations and classification of first-episode psychosis via live face processing. Frontiers In Psychiatry 2025, 16: 1518762. PMID: 40134976, PMCID: PMC11934110, DOI: 10.3389/fpsyt.2025.1518762.Peer-Reviewed Original ResearchFirst-episode psychosisPositive and Negative Syndrome ScaleFunctional near-infrared spectroscopyGlobal Assessment of FunctioningEarly psychosisNeural correlates of social cognitionFirst-episode psychosis individualsNegative Syndrome ScaleBehavior recordsAssessment of FunctioningSevere psychiatric disordersSyndrome ScaleFace processingPsychosis symptomsNeural underpinningsSocial cognitionNeural correlatesPsychiatric disordersBrain activitySocial difficultiesNeurophysiological dysfunctionPsychosisNeural characteristicsMultimodal representationsAcquisition paradigmDiminished reward circuit response underlies pain avoidance learning deficits in problem drinkers
Le T, Oba T, Li C. Diminished reward circuit response underlies pain avoidance learning deficits in problem drinkers. NeuroImage Clinical 2025, 45: 103762. PMID: 40009903, PMCID: PMC11908557, DOI: 10.1016/j.nicl.2025.103762.Peer-Reviewed Original ResearchConceptsPosterior cingulate cortexAvoidance learningReward circuitDrinking severityReward deficiencyLearning deficitsPain avoidanceProblem drinkersAlcohol useAvoidance learning deficitMedial orbitofrontal cortexReward circuit dysfunctionVentral tegmental areaPoor avoidance learningAssociated with problem drinkingOrbitofrontal cortexTegmental areaGo/NoGo taskCingulate cortexNeural correlatesBehavioral findingsCircuit dysfunctionAdult drinkersBrain regionsNeural processesNeural, Motivational, and Psychological Measures of Pain Avoidance Predict Future Alcohol Use in Adult Drinkers
Le T, Hughes F, Oba T, Li C. Neural, Motivational, and Psychological Measures of Pain Avoidance Predict Future Alcohol Use in Adult Drinkers. Addiction Biology 2025, 30: e70020. PMID: 39952897, PMCID: PMC11828665, DOI: 10.1111/adb.70020.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulate cortexDrinking motivesAlcohol usePsychological measuresPercentage of heavy drinking daysRisk of alcohol use disorderAlcohol use severityAnterior cingulate cortexHeavy drinking daysAlcohol use disorderPain-related psychological measuresParticipants' alcohol usePromote alcohol usePainful electric shocksLevels of drinkingPain sensitivityAlcohol cravingDrinking severityGo/NoGo taskCingulate cortexNeural correlatesDrinking daysUse disorderAdult drinkersOvert actions
2024
The impact of functional correlations on task information coding
Ito T, Murray J. The impact of functional correlations on task information coding. Network Neuroscience 2024, 8: 1331-1354. PMID: 39735511, PMCID: PMC11675092, DOI: 10.1162/netn_a_00402.Peer-Reviewed Original ResearchNoise correlationsTrial-to-trialBrain networksFunctional brain networksFunctional correlatesFMRI networksSignal correlationNeural correlatesBrain regionsInformation codingTask selectionFMRI datasetsTask informationNeural unitsCorrelated changesCoding frameworkBrainInvestigate relationshipsNetworkFMRINoiseDevelopmental Differences in a Hippocampal-Cingulate Pathway Involved in Learned Safety Following Interpersonal Trauma Exposure
Kribakaran S, DeCross S, Odriozola P, McLaughlin K, Gee D. Developmental Differences in a Hippocampal-Cingulate Pathway Involved in Learned Safety Following Interpersonal Trauma Exposure. Journal Of The American Academy Of Child & Adolescent Psychiatry 2024 PMID: 39368629, DOI: 10.1016/j.jaac.2024.07.928.Peer-Reviewed Original ResearchSafety signal learningInterpersonal trauma exposureTrauma exposureFunctional connectivityHippocampal activityNeural correlatesConditioned safetyFunctional magnetic resonance imaging dataAnterior hippocampal activationDevelopment of psychopathologyAnterior cingulate subregionsTask-based functional magnetic resonance imaging dataExploratory analysisMagnetic resonance imaging dataMental health sequelaeAmygdala activationAge-related associationsAnterior hippocampalContingency awarenessPTSD symptomsInhibit fearAttenuating fearCingulate subregionsSignal learningFear reductionAnxiety and neural correlates of attention and self-regulation in pregnancy: a resting-state EEG study
Levy J, Yatziv T, Bunderson M, Bartz C, Vancor E, Rutherford H. Anxiety and neural correlates of attention and self-regulation in pregnancy: a resting-state EEG study. Archives Of Women's Mental Health 2024, 28: 43-53. PMID: 39214911, DOI: 10.1007/s00737-024-01505-6.Peer-Reviewed Original ResearchPregnancy-related anxietySelf-regulationBeta oscillationsNeural markersNeural markers of attentionNeural correlates of attentionSelf-regulation difficultiesMarkers of attentionDelta-beta couplingMental health difficultiesCorrelates of attentionResting-state EEG studiesGeneral populationPrefrontal regionsAttentional processesNeural correlatesAttentional controlGeneralized anxietyMind-wanderingCognitive functionHealth difficultiesNeural patternsAnxietyEEG sessionEEG studiesNeural correlates of proactive avoidance deficits and alcohol use motives in problem drinking
Le T, Oba T, Couch L, McInerney L, Li C. Neural correlates of proactive avoidance deficits and alcohol use motives in problem drinking. Translational Psychiatry 2024, 14: 336. PMID: 39168986, PMCID: PMC11339324, DOI: 10.1038/s41398-024-03039-y.Peer-Reviewed Original ResearchConceptsAvoidance deficitNegative emotionsDrinking motivesAlcohol useNeural correlatesProblem drinkingRight anterior insula activityAssociated with greater alcohol useAnterior insula activityAlcohol use motivesGreater alcohol useProblem drinking groupInfluence alcohol usePhysical painInsula activationDrinking severityGo/NoGo taskNeural underpinningsPutamen responseSocial drinkersBehavioral measuresAvoidance performanceBehavioral resultsFunctional connectivityDrinking behaviorRisk avoidance and social anxiety in adolescence: Examination of event-related potentials and theta-dynamics on the Balloon Risk Avoidance Task
Edgar E, Waugh A, Wu J, Castagna P, Potenza M, Mayes L, Crowley M. Risk avoidance and social anxiety in adolescence: Examination of event-related potentials and theta-dynamics on the Balloon Risk Avoidance Task. Brain And Cognition 2024, 180: 106209. PMID: 39137602, PMCID: PMC11371477, DOI: 10.1016/j.bandc.2024.106209.Peer-Reviewed Original ResearchLevels of social anxietySocially anxious youthSocial anxietyAnxious youthAvoidance taskSocial Phobia and Anxiety InventoryLow levels of social anxietyRisk avoidanceNeural correlatesAvoidance conditioningSuccessful avoidanceTheta dynamicsAnxiety InventoryTheta powerBehavioral correlatesAnxietyTheta responseFRNAdolescentsAvoidanceConcurrent electroencephalographySlow-waveYouthOscillatory dynamicsTaskNeurobiological Correlates of Psychedelic Experiences and Psychedelic-Associated Adverse Effects
Rieser N, Schmidt T, Preller K. Neurobiological Correlates of Psychedelic Experiences and Psychedelic-Associated Adverse Effects. Current Topics In Behavioral Neurosciences 2024, 1-20. PMID: 39080245, DOI: 10.1007/7854_2024_507.Peer-Reviewed Original ResearchCortico-striato-thalamo-corticalPsychedelic experiencePathophysiology of psychiatric illnessPsychedelic drug actionEffects of psychedelicsHuman neuroimaging studiesAcute drug effectsEffects of psychedelic drugsEntropic brain hypothesisNeurobiological correlatesEgo dissolutionNeural correlatesNeurobiological mechanismsNeuroimaging studiesNeural mechanismsPsychiatric illnessPsychedelic drugsBrain hypothesisDrug effectsPET measurementsSubacute adverse effectsDrug actionGeneral effectEmotional impactLong-term adverse effectsThe inter-related effects of alcohol use severity and sleep deficiency on semantic processing in young adults
Li G, Zhong D, Zhang N, Dong J, Yan Y, Xu Q, Xu S, Yang L, Hao D, Li C. The inter-related effects of alcohol use severity and sleep deficiency on semantic processing in young adults. Neuroscience 2024, 555: 116-124. PMID: 39059740, DOI: 10.1016/j.neuroscience.2024.07.025.Peer-Reviewed Original ResearchMiddle frontal gyrusSemantic processingPittsburgh Sleep Quality IndexPrecentral gyrusPittsburgh Sleep Quality Index scoreAlcohol misuseNeural correlates of semantic processingMiddle frontal gyrus activationRight middle frontal gyrusSeverity of alcohol useAlcohol use severityAssociated with deficitsPrecentral gyrus activationLeft precentral gyrusInfluence of sleep qualityYoung adultsWord comprehensionHuman Connectome Project dataFrontal gyrusNeural correlatesConsumption severityLanguage tasksSleep deficiencyNeural mechanismsMediation analysisComputational modeling of social evaluative decision‐making elucidates individual differences in adolescent anxiety
Castagna P, Edgar E, Delpech R, Topel S, Kortink E, van der Molen M, Crowley M. Computational modeling of social evaluative decision‐making elucidates individual differences in adolescent anxiety. Journal Of Research On Adolescence 2024, 34: 1365-1377. PMID: 38961725, DOI: 10.1111/jora.12999.Peer-Reviewed Original ResearchSocial judgment paradigmElevated levels of social anxietySelf-report measures of anxietyLevels of social anxietySocial judgment taskInformation processing biasesMeasures of anxietyParent-report measuresSelf-report measuresSelf-reported anxietyDecision threshold parameterDecision-making taskSignificant developmental changesProcessing biasesSocial anxietyJudgment paradigmAdolescent anxietyAnxiety symptomsEvaluate decision-makingNeural correlatesJudgment taskCognitive processesSocial cuesTask performanceDrift-diffusion modelSex differences in dorsolateral prefrontal cortical and superior colliculus activities support the impact of alcohol use severity and sleep deficiency on two-back memory
Li G, Cao Y, Yang C, Li X, Yang Y, Yang L, Hao D, Li C. Sex differences in dorsolateral prefrontal cortical and superior colliculus activities support the impact of alcohol use severity and sleep deficiency on two-back memory. Quantitative Imaging In Medicine And Surgery 2024, 14: 4972986-4974986. PMID: 39022273, PMCID: PMC11250293, DOI: 10.21037/qims-24-156.Peer-Reviewed Original ResearchAlcohol use severityWorking memoryPittsburgh Sleep Quality IndexAlcohol misuseSex differencesHuman Connectome ProjectPath modelAssociated with working memory deficitsNeural correlates of working memoryPittsburgh Sleep Quality Index scoreCorrelates of working memoryPrefrontal cortex responsesImpact working memoryWhole-brain regressionComorbid alcohol misusePotential sex differencesManipulation of informationImpact of drinkingDLPFC activationDrinking severityPublished routinesNeural correlatesMemory deficitsNeural measuresSleep deficiencyLocus coeruleus integrity and left frontoparietal connectivity provide resilience against attentional decline in preclinical alzheimer’s disease
Pahl J, Prokopiou P, Bueichekú E, Schultz A, Papp K, Farrell M, Rentz D, Sperling R, Johnson K, Jacobs H. Locus coeruleus integrity and left frontoparietal connectivity provide resilience against attentional decline in preclinical alzheimer’s disease. Alzheimer's Research & Therapy 2024, 16: 119. PMID: 38822365, PMCID: PMC11140954, DOI: 10.1186/s13195-024-01485-w.Peer-Reviewed Original ResearchConceptsDigit Symbol Substitution TestLC integrityLocus coeruleusAttentional declineCognitive declineDigit-symbol substitution test performanceHarvard Aging Brain StudyResting-state functional MRILocus coeruleus integrityNetwork functional connectivityAlzheimer's diseaseAging Brain StudyPreclinical Alzheimer's diseaseCognitive follow-upYears of educationNeural reserveNeural correlatesAttentional performanceAttention deficitMixed effects analysisCortical target regionsSubstitution TestCognitive changesFrontoparietal connectivityFunctional MRIDifferences in the neural correlates of schizophrenia with positive and negative formal thought disorder in patients with schizophrenia in the ENIGMA dataset
Sharkey R, Bacon C, Peterson Z, Rootes-Murdy K, Salvador R, Pomarol-Clotet E, Karuk A, Homan P, Ji E, Omlor W, Homan S, Georgiadis F, Kaiser S, Kirschner M, Ehrlich S, Dannlowski U, Grotegerd D, Goltermann J, Meinert S, Kircher T, Stein F, Brosch K, Krug A, Nenadic I, Sim K, Spalletta G, Banaj N, Sponheim S, Demro C, Ramsay I, King M, Quidé Y, Green M, Nguyen D, Preda A, Calhoun V, Turner J, van Erp T, Nickl-Jockschat T. Differences in the neural correlates of schizophrenia with positive and negative formal thought disorder in patients with schizophrenia in the ENIGMA dataset. Molecular Psychiatry 2024, 29: 3086-3096. PMID: 38671214, PMCID: PMC11449795, DOI: 10.1038/s41380-024-02563-z.Peer-Reviewed Original ResearchNegative FTDBrain structural changesPositive FTDSymptom dimensionsBrain regionsENIGMA Schizophrenia Working GroupNegative formal thought disorderNeural correlates of schizophreniaRegional brain volume lossFormal thought disorderSchizophrenia Working GroupCorrelates of schizophreniaLateral temporal cortexBrain volume lossThought disorderNeurobiological underpinningsNeural correlatesNeuroimaging studiesTemporal cortexSchizophreniaCortical regionsCortical thicknessCellular underpinningsFTDMulti-site cohortNeural Correlates of Novelty-Evoked Distress in 4-Month-Old Infants: A Synthetic Cohort Study
Filippi C, Winkler A, Kanel D, Elison J, Hardiman H, Sylvester C, Pine D, Fox N. Neural Correlates of Novelty-Evoked Distress in 4-Month-Old Infants: A Synthetic Cohort Study. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2024, 9: 905-914. PMID: 38641209, PMCID: PMC11381178, DOI: 10.1016/j.bpsc.2024.03.008.Peer-Reviewed Original ResearchBrain-behavior associationsParent-report measuresInfant temperamentNetwork pairsDorsal attention network connectivityAssessment of infant temperamentParent-reported temperamentAttention network connectivityControl network connectivitySocial anxietyFMRI studyNeural correlatesNeural basisFunctional connectivityParent reportNeuroimaging dataTemperamentAttention-controlComposite scoreDistressNetwork connectivityObservational assessmentNegative associationBehavior estimationDorsalThe Neural Correlates of Individual Differences in Reinforcement Learning during Pain Avoidance and Reward Seeking
Le T, Oba T, Couch L, McInerney L, Li C. The Neural Correlates of Individual Differences in Reinforcement Learning during Pain Avoidance and Reward Seeking. ENeuro 2024, 11: eneuro.0437-23.2024. PMID: 38365840, PMCID: PMC10901196, DOI: 10.1523/eneuro.0437-23.2024.Peer-Reviewed Original ResearchConceptsSuperior frontal gyrusReward-seekingCingulate cortexNeural correlatesPain avoidanceAction biasDorsal anterior cingulate cortexLeft posterior cingulate cortexAction-outcome associationsGo/No-Go taskAnterior cingulate cortexPosterior cingulate cortexImpact of outcomesHigher learning rateReward trialsFrontal gyrusAvoidance learningMidcingulate cortexNeural substratesAssociative learningAction tendenciesPre-SMAAssociated with activationPrecentral gyrusPostcentral gyrusrTMS effects on urges and severity of tobacco use disorder operate independently of a retrieval-extinction component and involve frontal-striatal pathways
Li S, Ma X, Chen H, Wang M, Zheng Y, Yang B, Ni H, Potenza M, Dong G. rTMS effects on urges and severity of tobacco use disorder operate independently of a retrieval-extinction component and involve frontal-striatal pathways. Journal Of Affective Disorders 2024, 349: 21-31. PMID: 38190858, DOI: 10.1016/j.jad.2024.01.048.Peer-Reviewed Original ResearchDorsolateral prefrontal cortexRepetitive transcranial magnetic stimulationSmoking cravingFunctional connectivityTobacco use disorderBrain regionsRetrieval-extinction procedureLeft dorsolateral prefrontal cortexSimilar neural correlatesFrontal-striatal pathwaysStandard repetitive transcranial magnetic stimulationUse disordersMedial frontal gyrusIncreased functional connectivitySham repetitive transcranial magnetic stimulationExecutive controlSmoking cuesNeural correlatesTranscranial magnetic stimulationBrain responsesFrontal gyrusGreater activationLess activationSmoking urgesBilateral insulaPre-scan state anxiety is associated with greater right amygdala-hippocampal response to fearful versus happy faces among trait-anxious Latina girls
Díaz D, Tseng W, Michalska K. Pre-scan state anxiety is associated with greater right amygdala-hippocampal response to fearful versus happy faces among trait-anxious Latina girls. BMC Psychiatry 2024, 24: 1. PMID: 38167015, PMCID: PMC10759434, DOI: 10.1186/s12888-023-05403-6.Peer-Reviewed Original ResearchConceptsState anxietyTrait anxietyHappy facesEmotion processingLatina girlsImplicit emotion processingNon-anxious youthHigh trait anxietyFearful facial affectFearful facesEmotional valenceFacial affectNeural correlatesIndividual differencesBrain activationBrain responsesNeural activationReduced engagementCommunity sampleAnxietyInteractive effectsHigh levelsGirlsMethodsThe present studySystematic differences
2023
Double dissociation between P300 components and task switch error type in healthy but not psychosis participants
Huang L, Parker D, Ethridge L, Hamm J, Keedy S, Tamminga C, Pearlson G, Keshavan M, Hill S, Sweeney J, McDowell J, Clementz B. Double dissociation between P300 components and task switch error type in healthy but not psychosis participants. Schizophrenia Research 2023, 261: 161-169. PMID: 37776647, PMCID: PMC11015813, DOI: 10.1016/j.schres.2023.09.025.Peer-Reviewed Original ResearchConceptsEvent-related potentialsDouble dissociationParietal P300Oddball taskCognitive functionPsychosis participantsInductive reasoningP300 event-related potentialFrontal P300 amplitudePossible neural correlatesMental flexibilityCognitive demandsMemory maintenanceNeural correlatesPerseverative errorsRegressive errorsBehavioral performanceOddball targetsP300 componentP300 amplitudeError typesSubjects' abilityNeural activityP300 reductionHealthy participants
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