2025
Novel F-18-labeled Tracers of Sympathetic Function for Improved Risk Stratification and Clinical Outcomes
Zohora F, Nazari M, Sinusas A. Novel F-18-labeled Tracers of Sympathetic Function for Improved Risk Stratification and Clinical Outcomes. Current Cardiology Reports 2025, 27: 61. PMID: 40009333, DOI: 10.1007/s11886-025-02197-9.Peer-Reviewed Original ResearchConceptsSudden cardiac deathImplantable cardioverter defibrillatorPositron emission tomographyImplantable cardioverter defibrillator placementMyocardial sympathetic denervationRisk stratificationSympathetic denervationIschemic heart diseaseHeart failurePrevention of sudden cardiac deathRisk stratification of patientsHeart diseaseOptimal risk stratificationLow ejection fractionStratification of patientsSympathetic nerve densityImprove risk stratificationHeart failure patientsPositron emission tomography radiotracersPredicting sudden cardiac deathPositron emission tomography tracersPrognostic benefitEjection fractionClinically practical approachNerve density
2020
Loss of p53 drives neuron reprogramming in head and neck cancer
Amit M, Takahashi H, Dragomir MP, Lindemann A, Gleber-Netto FO, Pickering CR, Anfossi S, Osman AA, Cai Y, Wang R, Knutsen E, Shimizu M, Ivan C, Rao X, Wang J, Silverman DA, Tam S, Zhao M, Caulin C, Zinger A, Tasciotti E, Dougherty PM, El-Naggar A, Calin GA, Myers JN. Loss of p53 drives neuron reprogramming in head and neck cancer. Nature 2020, 578: 449-454. PMID: 32051587, PMCID: PMC9723538, DOI: 10.1038/s41586-020-1996-3.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic AntagonistsAdrenergic NeuronsAnimalsCell DivisionCell TransdifferentiationCellular ReprogrammingDisease Models, AnimalDisease ProgressionFemaleHumansMaleMiceMice, Inbred BALB CMicroRNAsMouth NeoplasmsNerve FibersNeuritesReceptors, AdrenergicRetrospective StudiesSensory Receptor CellsTumor MicroenvironmentTumor Suppressor Protein p53Xenograft Model Antitumor AssaysConceptsOral cancerNerve fibersAdrenergic nerve fibersPoor clinical outcomeTrigeminal sensory neuronsLoss of TP53Sensory denervationAdrenergic nervesChemical sympathectomyNerve densitySensory nervesClinical outcomesSolid tumor microenvironmentLoss of p53Neck cancerPharmacological blockadeEndogenous neuronsRetrospective analysisMouse modelSensory neuronsAdrenergic phenotypeAdrenergic receptorsTumor growthTumor progressionTumor microenvironment
2019
Minimally Invasive Corneal Neurotization With Acellular Nerve Allograft
Leyngold I, Yen M, Tian J, Leyngold M, Vora G, Weller C. Minimally Invasive Corneal Neurotization With Acellular Nerve Allograft. Ophthalmic Plastic And Reconstructive Surgery 2019, Publish Ahead of Print: &na;. PMID: 30059392, DOI: 10.1097/iop.0000000000001181.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAllograftsChildCorneaCorneal DiseasesFemaleFollow-Up StudiesHumansMaleMicroscopy, ConfocalMiddle AgedMinimally Invasive Surgical ProceduresNerve RegenerationNerve TransferOphthalmic NerveOphthalmologic Surgical ProceduresRetrospective StudiesTreatment OutcomeYoung AdultConceptsAcellular nerve allograftsNerve allograftsCorneal neurotizationCorneal sensibilityVivo confocal microscopyInvasive surgical techniquesCorneal epithelial integrityNeurotrophic keratopathyAffected eyeNerve densityClinical outcomesInfraorbital nerveVisual acuityNerve pediclesSurgical techniqueInvasive approachOcular surfaceRetrospective evaluationAllograftsTransconjunctival approachCorneal stromaNeurotizationPatientsEpithelial integrityMonths
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