2025
The Central Vein Sign as a Radiologic Tool to Predict the Diagnosis of Radiation Necrosis in Intracranial Metastatic Cancer Patients
Antonios J, Adenu-Mensah N, Theriault B, Millares-Chavez M, Huttner A, Aboian M, Chiang V. The Central Vein Sign as a Radiologic Tool to Predict the Diagnosis of Radiation Necrosis in Intracranial Metastatic Cancer Patients. Clinical And Translational Neuroscience 2025, 9: 10. DOI: 10.3390/ctn9010010.Peer-Reviewed Original ResearchCentral vein signRadiation necrosisTumor progressionDiagnosis of radiation necrosisDifferentiate RNCerebral radiation necrosisIntracranial metastatic diseaseCancer therapy responseMetastatic cancer patientsNon-invasive markerMetastatic diseaseSurgical biopsyTherapy responsePredictive markerPatient cohortPrimary treatmentRadiological toolsCancer patientsRadiological imagingTreatment decisionsPerivascular spacesPatientsTreatmentNecrosisMarkers
2024
Successful Management of Impending Skin Necrosis After a Posterolateral Knee Dislocation
Santos E, Schneble C, Kim D, Medvecky M. Successful Management of Impending Skin Necrosis After a Posterolateral Knee Dislocation. JAAOS Global Research And Reviews 2024, 8: e23.00149. PMID: 38648386, PMCID: PMC11037736, DOI: 10.5435/jaaosglobal-d-23-00149.Peer-Reviewed Case Reports and Technical NotesConceptsImpending skin necrosisSkin necrosisKnee dislocationPosterolateral knee dislocationFull-thickness skin necrosisComplicating treatment optionsSoft tissueSoft tissue envelopeMedial soft tissuesTreatment optionsPerioperative periodMedial ligamentous structuresCutaneous injuryIncarcerationNecrosisSkin injuryPatientsSuccessful managementLigamentous structuresKneeInjuryFabricating patient-specific 3D printed drill guides to treat femoral head avascular necrosis
Bell C, Feizi A, Roytman G, Ramji A, Tommasini S, Wiznia D. Fabricating patient-specific 3D printed drill guides to treat femoral head avascular necrosis. 3D Printing In Medicine 2024, 10: 10. PMID: 38564090, PMCID: PMC10986134, DOI: 10.1186/s41205-024-00208-z.Peer-Reviewed Original ResearchUsing Computed Tomography-Based Three-dimensional Modeling and Computer Navigation for Minimally Invasive Core Decompression and Adjuvant Orthobiologic Therapy of Femoral Head Avascular Necrosis
Feizi A, Bell C, Roytman G, Park N, Wang A, Tommasini S, Wiznia D. Using Computed Tomography-Based Three-dimensional Modeling and Computer Navigation for Minimally Invasive Core Decompression and Adjuvant Orthobiologic Therapy of Femoral Head Avascular Necrosis. Arthroplasty Today 2024, 26: 101337. PMID: 38497084, PMCID: PMC10940782, DOI: 10.1016/j.artd.2024.101337.Peer-Reviewed Original ResearchFemoral head avascular necrosisAvascular necrosisSurgical techniqueCore decompressionBone marrow aspirate concentrateDelay disease progressionOutcome of core decompressionAdjuvant therapyCellular therapyAspirate concentrateDisease progressionFemoral head collapseImprove outcomesLesionsDebilitating conditionTherapyComputer navigationNecrosisDecompressionHead collapseThree-dimensional modelFemoral head
2022
Lymphomatoid Granulomatosis Versus Granulomatosis with Polyangiitis
Baine M, Zhang X. Lymphomatoid Granulomatosis Versus Granulomatosis with Polyangiitis. Practical Anatomic Pathology 2022, 213-218. DOI: 10.1007/978-3-031-14402-8_35.Peer-Reviewed Original ResearchLymphomatoid granulomatosisLarge neoplastic B cellsB-cell lymphoproliferative disordersPulmonary lymphomatoid granulomatosisVessel wall necrosisEpstein-Barr virusNeoplastic B cellsB-cell clonalityWall necrosisImmunophenotypic differencesLymphoproliferative disordersGranulomatosisCoagulative necrosisB cellsGiant cellsPolyangiitisLungNecrosisAngiocentricityAngiodestructionCellsGranulomasDiagnosisHistomorphologyPredilection
2021
Recognition and Management of Adverse Radiation Effects
Cheok S, Hansen J, Chiang V. Recognition and Management of Adverse Radiation Effects. 2021, 391-404. DOI: 10.1201/9781003167464-36.ChaptersAdverse radiation effectsRadiation necrosisStereotactic radiosurgeryRole of SRSImmune-mediated componentLaser interstitial thermotherapyMore brain lesionsBrain metastasesSystemic therapyIntracranial pathologyMalignant pathologyBrain lesionsNecrosisInterstitial thermotherapyPathologyContemporary evidenceBevacizumabCraniotomyMetastasisTherapyLesionsRadiosurgerySteroidsFocal renal infections and papillary necrosis
Fisher A, Dembry L. Focal renal infections and papillary necrosis. 2021, 433-438. DOI: 10.1093/med/9780190888367.003.0067.Peer-Reviewed Original ResearchAcute focal bacterial nephritisPapillary necrosisIntrarenal abscessXanthogranulomatous pyelonephritisRenal infectionAcute multifocal bacterial nephritisRenal cortical abscessRenal medullary vasculatureUrinary tract obstructionFocal bacterial nephritisVariety of syndromesCortical abscessesRenal corticomedullaryPerirenal abscessRenal impairmentTract obstructionClinicopathologic syndromeIschemic necrosisFocal infectionMedullary vasculatureAbscessRenal medullaNecrosisInfectionPerinephric fasciaSubcutaneous Fat Necrosis During Nivolumab Therapy for Metastatic Melanoma
Pach J, Olamiju B, Weiss S, Damsky W, Leventhal J. Subcutaneous Fat Necrosis During Nivolumab Therapy for Metastatic Melanoma. JAMA Dermatology 2021, 157: 468-469. PMID: 33688919, DOI: 10.1001/jamadermatol.2021.0058.Peer-Reviewed Original Research
2020
Talar Avascular Necrosis After Calcium Phosphate Injection Treatment of Talar Bone Marrow Lesions: A Report of 2 Cases.
Kohring JM, Oh I, Baumhauer JF. Talar Avascular Necrosis After Calcium Phosphate Injection Treatment of Talar Bone Marrow Lesions: A Report of 2 Cases. JBJS Case Connector 2020, 10: e19.00389. PMID: 32649148, DOI: 10.2106/jbjs.cc.19.00389.Peer-Reviewed Original ResearchConceptsCalcium phosphate injectionBone marrow lesionsAvascular necrosisMarrow lesionsExtensive avascular necrosisBone marrow edemaTalar avascular necrosisPoor patient outcomesPhosphate injectionEquivocal improvementPatient's symptomsMarrow edemaPatient outcomesInjection treatmentAnkle jointPatientsLesionsNecrosisPoor qualityOutcomesTreatmentInjectionAvailable researchSubchondroplastyEdemaRadiation Necrosis Following the Radiosurgical Treatment of Brain Metastases
Robert S, Chiang V. Radiation Necrosis Following the Radiosurgical Treatment of Brain Metastases. 2020, 393-405. DOI: 10.1007/978-3-030-42958-4_28.ChaptersMetastatic brain lesionsRadiation necrosisBrain lesionsStereotactic radiosurgeryRadiation-induced side effectsImmune system involvementEffective treatment modalityMetastatic intracranial tumorsBrain metastasesSystemic cancerTreatment modalitiesUnderlying pathophysiologySystem involvementDisease entityIntracranial tumorsRadiosurgical treatmentSide effectsTumor progressionBrain tissueNecrosisConcurrent useLesionsRadiosurgeryImaging modalitiesLife expectancy
2019
Presentation of Ischaemic Foot
Edmonds M, Simmgen M, Sumpio B. Presentation of Ischaemic Foot. 2019, 213-219. DOI: 10.1007/978-3-319-17918-6_18.Peer-Reviewed Original ResearchDiagnosing acute interstitial nephritis: considerations for clinicians
Nussbaum E, Perazella M. Diagnosing acute interstitial nephritis: considerations for clinicians. Clinical Kidney Journal 2019, 12: 808-813. DOI: 10.1093/ckj/sfz080.Peer-Reviewed Original ResearchAcute interstitial nephritisAcute kidney injuryAcute tubular necrosisInterstitial nephritisCommon causeDirect further managementKidney injuryMost patientsTubular necrosisKidney biopsyClinical historyFurther managementCliniciansLaboratory dataNephritisPatientsInjuryDiagnosisSingle testCauseBiopsyNecrosisBiomarkersStep-up approach for the management of pancreatic necrosis: a review of the literature
Sion MK, Davis KA. Step-up approach for the management of pancreatic necrosis: a review of the literature. Trauma Surgery & Acute Care Open 2019, 4: e000308. PMID: 31245622, PMCID: PMC6560663, DOI: 10.1136/tsaco-2019-000308.Peer-Reviewed Original ResearchProfound inflammatory responseOptimal treatment strategyTiming of interventionLaparoscopic debridementPercutaneous drainageInvasive optionPancreatic necrosisInflammatory responseTreatment strategiesEndoscopic drainageHeterogenous conditionMethods of interventionPatientsInterventionTreatmentChallenging conditionsDrainageDebridementPancreatitisNecrosis
2018
Radiographic patterns of recurrence and pathologic correlation in malignant gliomas treated with bevacizumab
Thomas A, Rosenblum M, Karimi S, DeAngelis LM, Omuro A, Kaley TJ. Radiographic patterns of recurrence and pathologic correlation in malignant gliomas treated with bevacizumab. CNS Oncology 2018, 07: 7-13. PMID: 29388793, PMCID: PMC6001559, DOI: 10.2217/cns-2017-0025.Peer-Reviewed Original ResearchConceptsMalignant gliomasRecurrence patternsDiffusion-weighted imaging abnormalitiesDiffusion-weighted imagingStandard clinical settingMG patientsImaging abnormalitiesMRI abnormalitiesPathologic findingsTumor recurrenceRadiographic patternsPathologic correlationBevacizumabClinical settingNecrosisPatientsRecurrenceRecent reportsTumorsGliomasAbnormalitiesLeptomeningealSurgery
2017
Anti-tumor Activity of miniPEG-γ-Modified PNAs to Inhibit MicroRNA-210 for Cancer Therapy
Gupta A, Quijano E, Liu Y, Bahal R, Scanlon SE, Song E, Hsieh WC, Braddock DE, Ly DH, Saltzman WM, Glazer PM. Anti-tumor Activity of miniPEG-γ-Modified PNAs to Inhibit MicroRNA-210 for Cancer Therapy. Molecular Therapy - Nucleic Acids 2017, 9: 111-119. PMID: 29246289, PMCID: PMC5633812, DOI: 10.1016/j.omtn.2017.09.001.Peer-Reviewed Original ResearchMiR-210Human tumor xenograftsAnti-tumor activityHistopathological analysisTherapeutic approachesMicroRNA-210Tumor xenograftsOncogenic miRTumor cellsHypoxic cellsAnticancer therapyHuman cancersCell proliferationCancer therapyConsiderable necrosisSignificant delayTherapyOncogenic microRNAsInhibition strategiesCellsMicroRNAsFibrosisXenograftsNecrosisTumorsDoes Smoking History Confer a Higher Risk for Reconstructive Complications in Nipple‐Sparing Mastectomy?
Frey JD, Alperovich M, Levine JP, Choi M, Karp NS. Does Smoking History Confer a Higher Risk for Reconstructive Complications in Nipple‐Sparing Mastectomy? The Breast Journal 2017, 23: 415-420. PMID: 28097778, DOI: 10.1111/tbj.12760.Peer-Reviewed Original ResearchConceptsPack-year smoking historyNipple-sparing mastectomyComplete NAC necrosisHistory of smokingSmoking historyReconstructive complicationsNAC necrosisHigh riskNipple-areola complex necrosisNew York University Langone Medical CenterPack-year historyMastectomy flap necrosisActive smokersFlap necrosisRisk factorsMedical CenterReconstructive outcomesComplicationsMastectomyNecrosisNonsmokersOutcomesSmokersSmokingPatientsAvascular necrosis of the humeral head following bilateral upper extremity vascular composite allotransplantation: a case report
Rinkinen J, Molway D, Carty M, Dyer G, Pomahac B, Chandraker A, Talbot S. Avascular necrosis of the humeral head following bilateral upper extremity vascular composite allotransplantation: a case report. Case Reports In Plastic Surgery And Hand Surgery 2017, 4: 60-64. PMID: 28804740, PMCID: PMC5532758, DOI: 10.1080/23320885.2017.1345635.Peer-Reviewed Original Research
2016
Novel biomarker identification using metabolomic profiling to differentiate radiation necrosis and recurrent tumor following Gamma Knife radiosurgery.
Lu AY, Turban JL, Damisah EC, Li J, Alomari AK, Eid T, Vortmeyer AO, Chiang VL. Novel biomarker identification using metabolomic profiling to differentiate radiation necrosis and recurrent tumor following Gamma Knife radiosurgery. Journal Of Neurosurgery 2016, 127: 388-396. PMID: 27885954, DOI: 10.3171/2016.8.jns161395.Peer-Reviewed Original ResearchConceptsGamma knife radiosurgeryRadiation necrosisRecurrent tumorsKnife radiosurgeryBrain metastasesSamples of tumorMetabolic imaging techniquesMetabolite profilesUnique metabolite profilesNovel biomarker identificationBrain biopsyPure tumorEnhancing lesionsSurgical biopsyLevels of metabolitesTumorsNecrosisTumor samplesDifferential metabolite profilesElevated levelsRadiosurgeryNoninvasive imagingComparison groupTissue samplesMetabolomic profilingDiffuse Dermal Angiomatosis of the Breast With an Apparent Etiology of Underlying Calcified Thrombosed Artery With Adjacent Fat Necrosis
Strausburg M, Gehlhausen J, Ludwig K, Warren S. Diffuse Dermal Angiomatosis of the Breast With an Apparent Etiology of Underlying Calcified Thrombosed Artery With Adjacent Fat Necrosis. American Journal Of Dermatopathology 2016, 38: 838-841. PMID: 27097335, DOI: 10.1097/dad.0000000000000581.Peer-Reviewed Original ResearchConceptsDiffuse dermal angiomatosisAssociated with various underlying conditionsCases of diffuse dermal angiomatosisLocal tissue ischemiaThrombosed arteryOral corticosteroidsApparent etiologyMass lesionFat necrosisUnderlying conditionTissue ischemiaHyperplastic vesselsVascular luminaSmoking cessationLower extremitiesBreastAngiomatosisArteryNecrosisOcular Syphilis Presenting as Bilateral Acute Retinal Necrosis in an Immunocompetent Host.
Hussnain SA, Ketner S, Coady PA, Kombo N, Nwanyanwu K. Ocular Syphilis Presenting as Bilateral Acute Retinal Necrosis in an Immunocompetent Host. Connecticut Medicine 2016, 80: 533-536. PMID: 29772137.Peer-Reviewed Original ResearchConceptsBilateral acute retinal necrosisAcute retinal necrosisOcular syphilisRetinal necrosisCases of syphilisOphthalmic testingOcular inflammationGreat masqueraderImmunocompetent hostsDiagnostic dilemmaClinical signsHigh indexSyphilisNecrosisSignsInflammationPatientsPresentingOphthalmologistsSymptomsCliniciansSuspicion
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