2025
Deuterium MRS for In Vivo Measurement of Lipogenesis in the Liver
Gursan A, de Graaf R, Thomas M, Prompers J, De Feyter H. Deuterium MRS for In Vivo Measurement of Lipogenesis in the Liver. NMR In Biomedicine 2025, 38: e70014. PMID: 39994887, DOI: 10.1002/nbm.70014.Peer-Reviewed Original ResearchConceptsH-MRSHepatic DNLMRS dataLiver tissueMeasurement of lipogenesisDietary interventionLiver lipidsHepatic de novo lipogenesisLow density lipoproteinDetection of deuteriumGold standard measureMetabolic diseasesIncreased hepatic DNLLiverDensity lipoproteinDrinking waterDeuterium labelingIn vivo measurementsNMR dataExcised liver tissueTissueDeuteriumMRSMethylene resonancesDeuterated water
2014
Function-oriented investigations of a peptide-based catalyst that mediates enantioselective allylic alcohol epoxidation.
Abascal NC, Lichtor PA, Giuliano MW, Miller SJ. Function-oriented investigations of a peptide-based catalyst that mediates enantioselective allylic alcohol epoxidation. Chemical Science 2014, 5: 4504-4511. PMID: 25386335, PMCID: PMC4224318, DOI: 10.1039/c4sc01440e.Peer-Reviewed Original Research
2011
Synthesis and coordination chemistry of tri-substituted benzamidrazones
Crimmin MR, Colby DA, Ellman JA, Bergman RG. Synthesis and coordination chemistry of tri-substituted benzamidrazones. Dalton Transactions 2011, 40: 514-522. PMID: 21109860, PMCID: PMC3063360, DOI: 10.1039/c0dt01267j.Peer-Reviewed Original ResearchConceptsCoordination modeDFT calculationsSingle-crystal X-ray diffractionWeak intramolecular hydrogen bondCrystal X-ray diffractionMultinuclear NMR dataCharge-neutral complexesIntramolecular hydrogen bondsX-ray crystallographic studiesPresence of NaOAcSeries of saltsReaction of 1aReaction of 1cX-ray diffractionCoordination chemistryDeprotonation productsNeutral complexesCorresponding imidoyl chloridesCyclometallated productsLatter tautomerSolid stateLatter complexHydrogen bondsSingle tautomerNMR data
2010
Hypercoordination in triphenyl oxinates of the group 14 elements
Yoder C, Griffith A, DeToma A, Gettel C, Schaeffer C. Hypercoordination in triphenyl oxinates of the group 14 elements. Journal Of Organometallic Chemistry 2010, 695: 518-523. DOI: 10.1016/j.jorganchem.2009.11.027.Peer-Reviewed Original ResearchGroup 14 elementsChemical shiftsNMR spectraGeometrical isomersNMR chemical shiftsCentral metal atomBond coupling constantsOne-bond coupling constantsCentral metalMonodentate fashionIpso carbonMetal atomsCentral atomNMR dataMolecular modelingSodium saltOxinateStrong interactionRapid exchangeCoupling constantsCase of leadAtomsLigandsRoom temperatureSodium acetate
1995
Small angle x-ray scattering studies of magnetically oriented lipid bilayers
Hare B, Prestegard J, Engelman D. Small angle x-ray scattering studies of magnetically oriented lipid bilayers. Biophysical Journal 1995, 69: 1891-1896. PMID: 8580332, PMCID: PMC1236422, DOI: 10.1016/s0006-3495(95)80059-7.Peer-Reviewed Original ResearchConceptsNuclear magnetic resonanceLipid bilayersMembrane-associated moleculesBilayer thicknessLipid particlesSmall-angle X-rayX-ray scatteringAngle X-rayNMR dataDLPC vesiclesOrientational parametersX-ray solutionMolar ratioPhospholipid moleculesStructural studiesOrientational energyPhospholipid bilayersAnalogue 3MoleculesBilayersInterparticle spacingX-rayMagnetic resonanceParticlesComplexes
1994
Structural and thermodynamic characterization of a bioactive peptide model of apolipoprotein E: side-chain lactam bridges to constrain the conformation.
Luo P, Braddock D, Subramanian R, Meredith S, Lynn D. Structural and thermodynamic characterization of a bioactive peptide model of apolipoprotein E: side-chain lactam bridges to constrain the conformation. Biochemistry 1994, 33: 12367-77. PMID: 7918459, DOI: 10.1021/bi00207a003.Peer-Reviewed Original ResearchConceptsSide-chain lactam bridgePeptide modelsAlpha-helical peptidesLoss of entropyModel peptidesBioactive structuresNMR dataAlpha-helical structureLactam constraintsConformational flexibilityLactam bridgeKcal/Thermodynamic characterizationAlpha-helical domainBiological activityPlasma lipoprotein clearanceUnfolded stateCell surface receptorsBiological functionsPeptidesSurface receptorsStructureResiduesCentral bendCritical role
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