2025
Moderate alcohol-associated hepatitis: A real-world multicenter study
Idalsoaga F, Díaz L, Dunn W, Mehta H, Muñoz K, Caldentey V, Arnold J, Ayares G, Mortuza R, Sarin S, Maiwall R, Zhang W, Qian S, Simonetto D, Singal A, Elfeki M, Ramirez-Cadiz C, Malhi G, Ahmed A, Homsi H, Abid Z, Cabezas J, Echavarría V, Poca M, Soriano G, Cuyas B, Cots M, La Tijera M, Ayala-Valverde M, Perez D, Gomez J, Abraldes J, Al-Karaghouli M, Jalal P, Ibrahim M, García-Tsao G, Goyes D, Skladaný L, Havaj D, Sulejova K, Selcanova S, Rincón D, Chacko K, Restrepo J, Yaquich P, Toro L, Shah V, Arrese M, Kamath P, Bataller R, Arab J. Moderate alcohol-associated hepatitis: A real-world multicenter study. Hepatology Communications 2025, 9: e0673. PMID: 40131003, PMCID: PMC11936654, DOI: 10.1097/hc9.0000000000000673.Peer-Reviewed Original ResearchConceptsSevere alcohol-associated hepatitisNeutrophil-to-lymphocyte ratioMaddrey's discriminant functionModerate AHMultiple organ failureOrgan failureMulticenter retrospective cohort studyAlcohol-associated hepatitisCumulative survival rateRetrospective cohort studyReceiver operating characteristic curveLong-term outcomesShort-term mortalityMortality scoring systemsPrognostic factorsSerum bilirubinMELD scoreWell-characterized diseaseClinical profileMedian MELDCohort studyCox regressionMultivariate analysisTherapeutic strategiesSurvival rateIncreasing Omission of Race and Ethnicity in a National Surgical Database.
Hu K, Ihnat J, Zhao K, Oh S, Goss J, Parikh N, Kammien A, Fereydooni S, Butler P, Alperovich M. Increasing Omission of Race and Ethnicity in a National Surgical Database. Journal Of The American College Of Surgeons 2025 PMID: 40035446, DOI: 10.1097/xcs.0000000000001372.Peer-Reviewed Original ResearchBM patientsNSQIP-PHospital lengths-of-stayNational surgical databaseLengths-of-stayNon-BM patientsEthnicity dataCochran-Armitage testOdds of readmissionSurgical databaseSurgical outcomesPatient demographicsSurgery typeNSQIP-P.Multivariate analysisIncreased omissionsPatientsSurgical disparitiesCochran-ArmitageMissing raceSurgical careLinear mixed-effects modelsAccurate data collectionComplicationsMixed-effects modelsSociodemographic and Systems Risk Factors Associated With Nil by Mouth Noncompliance and Day-of-Procedure Cancellations: A Retrospective Multicenter Case-Control Study.
Goldstein D, Jimenez N, Faulk D, Jones J, Reece-Nguyen T, Gooden C, Markowitz D, Dalal P. Sociodemographic and Systems Risk Factors Associated With Nil by Mouth Noncompliance and Day-of-Procedure Cancellations: A Retrospective Multicenter Case-Control Study. Anesthesia & Analgesia 2025 PMID: 40036165, DOI: 10.1213/ane.0000000000007451.Peer-Reviewed Original ResearchCase-control studySystemic risk factorsRisk factorsNPO guidelinesRetrospective multicenter case-control studyMulticenter retrospective case-control studyRetrospective case-control studyMulticenter case-control studySingle-center studyDay of procedureMultivariate logistic regressionPublic health insuranceYears of ageLanguage of carePediatric patientsMulticenter studyAffected patientsNoncompliance eventsHealth insurance typeIncreased riskMultivariate analysisPrimary outcomeSecondary outcomesElective proceduresHealth insuranceOutcomes following single level posterior lumbar fusion in patients with systemic and discoid lupus: A retrospective national database study
Dhodapkar M, Halperin S, Day W, Saifi C, Rubio D, Koumpouras F, Grauer J, Varthi A. Outcomes following single level posterior lumbar fusion in patients with systemic and discoid lupus: A retrospective national database study. North American Spine Society Journal (NASSJ) 2025, 100604. DOI: 10.1016/j.xnsj.2025.100604.Peer-Reviewed Original ResearchPosterior lumbar fusionSystemic lupus erythematosusDiscoid lupus erythematosusSingle-level posterior lumbar fusionPostoperative adverse eventsMinor adverse eventsAdverse eventsIncreased oddsLupus erythematosusLumbar fusionDiagnosis of discoid lupus erythematosusCohort of systemic lupus erythematosusLevel posterior lumbar fusionsMultivariate analysisDiagnosis of systemic lupus erythematosusDiscoid lupus erythematosus patientsUrinary tract infectionPerioperative adverse outcomesSurgical site infectionAcute kidney injuryDeep vein thrombosisNational database studyHistory of infectionSampled adult patientsMultivariate logistic regressionComparison of prognostic accuracy of HCC staging systems in patients undergoing TACE
Kasolowsky V, Gross M, Madoff D, Duncan J, Taddei T, Strazzabosco M, Jaffe A, Chapiro J. Comparison of prognostic accuracy of HCC staging systems in patients undergoing TACE. Clinical Imaging 2025, 120: 110438. PMID: 40049074, DOI: 10.1016/j.clinimag.2025.110438.Peer-Reviewed Original ResearchConceptsOverall survival of patientsBCLC staging systemTransarterial chemoembolizationOverall survivalStaging systemHepatocellular carcinomaStaging systems of hepatocellular carcinomaHepatocellular carcinoma staging systemsRetrospective single center studyKaplan Meier survival analysisInternational Staging SystemSingle center studyLog-rank testTertiary care centerPredicting overall survivalMeier survival analysisConsecutive patientsPrognostic stratificationStudy endpointPrognostic accuracyCenter studyPrognostic powerStratify outcomesMultivariate analysisPatientsDocumented Cannabis Use Is a Risk Factor for Nonunion After Nonoperative Management of Scaphoid Fractures: A Retrospective Review of 159 998 Patients.
Pathak N, Ratnasamy P, Oghenesume O, Luo X, Grauer J, Halim A. Documented Cannabis Use Is a Risk Factor for Nonunion After Nonoperative Management of Scaphoid Fractures: A Retrospective Review of 159 998 Patients. Hand 2025, 15589447251317225. PMID: 39968879, PMCID: PMC11840816, DOI: 10.1177/15589447251317225.Peer-Reviewed Original ResearchDocumented cannabis useCannabis useNonunion surgeryScaphoid fracturesNonunion rateNon-user groupNonoperative managementMultivariate analysisTreated with nonoperative managementIncreased riskScaphoid nonunionNon-usersPotential associationElectronic medical recordsManagement of scaphoid fracturesAcute scaphoid fracturesIndex fractureTobacco useRetrospective reviewTobacco-onlyFracture patientsAdult patientsFracture diagnosisMatched cohortCannabis-onlyA pooled analysis evaluating prognostic significance of Residual Cancer Burden in invasive lobular breast cancer
Mukhtar R, Gottipati S, Yau C, López-Tarruella S, Earl H, Hayward L, Hiller L, Osdoit M, van der Noordaa M, de Croze D, Hamy A, Laé M, Reyal F, Sonke G, Steenbruggen T, van Seijen M, Wesseling J, Martín M, del Monte-Millán M, Boughey J, Goetz M, Hoskin T, Valero V, Edge S, Abraham J, Bartlett J, Caldas C, Dunn J, Provenzano E, Sammut S, Thomas J, Graham A, Hall P, Mackintosh L, Fan F, Godwin A, Schwensen K, Sharma P, DeMichele A, Cole K, Pusztai L, Kim M, J van ’t Veer L, Cameron D, Esserman L, Fraser Symmans W. A pooled analysis evaluating prognostic significance of Residual Cancer Burden in invasive lobular breast cancer. Npj Breast Cancer 2025, 11: 14. PMID: 39948079, PMCID: PMC11825822, DOI: 10.1038/s41523-025-00720-3.Peer-Reviewed Original ResearchResidual cancer burdenInvasive lobular carcinomaEvent-free survivalNeoadjuvant chemotherapyBreast cancerAssociated with worse event-free survivalResidual cancer burden indexInvasive lobular breast cancerCancer burdenLobular breast cancerNodal statusLobular carcinomaNAC responseT categoryPrognostic significanceStratify prognosisPatient-level dataReceptor subtypesPooled analysisMultivariate analysisPooled cohortRecursive partitioningCox modelCancer cellularityCancerPredictors of Delayed Surgery After Distal Radius Fracture: A Large National Database Study.
Ratnasamy P, Allam O, Kammien A, Joo P, Luo X, Grauer J. Predictors of Delayed Surgery After Distal Radius Fracture: A Large National Database Study. Orthopedics 2025, 48: e75-e80. PMID: 39933104, DOI: 10.3928/01477447-20250204-01.Peer-Reviewed Original ResearchConceptsDistal radius fracturesDelayed surgeryRadius fracturesImmediate surgeryClinical factorsDistal radius fracture surgeryTime of surgeryCohort of patientsDemographics of patientsNon-clinical factorsFracture surgeryIndependent predictorsRetrospective studySurgical timeImpact patient outcomesMultivariate analysisSurgerySmoking statusComorbidity burdenPatientsWeek 0 to 2Patient outcomesWeek 3WeeksNon-clinicalEvaluating clinical and pathologic predictors for pathologic lymph node positivity (pN+) in patients with clinical T1-4N0M0 bladder cancer undergoing cystectomy.
Jaime-Casas S, Barragan-Carrillo R, Zugman M, Zang P, Ebrahimi H, Castro D, Mercier B, Li X, Dizman N, Salgia N, Hsu J, Nguyen C, Yip W, Chehrazi-Raffle A, Zengin Z, Meza L, Pal S, Tripathi A. Evaluating clinical and pathologic predictors for pathologic lymph node positivity (pN+) in patients with clinical T1-4N0M0 bladder cancer undergoing cystectomy. Journal Of Clinical Oncology 2025, 43: 877-877. DOI: 10.1200/jco.2025.43.5_suppl.877.Peer-Reviewed Original ResearchConcomitant carcinoma in situRecurrence-free survivalPositive surgical marginsLymph node positivityRadical cystectomyLymphovascular invasionOverall survivalPreoperative hydronephrosisSurgical marginsPathologic predictorsBladder cancerPredictors of lymph node positivityConcomitant CISMultivariate analysisPathologic lymph node positivityPelvic lymph node dissectionPathological lymph node involvementMultivariate Cox proportional hazards modelMultivariate Cox regression modelNode-positiveBladder-preserving approachPreoperative renal functionLymph node dissectionLymph node involvementCarcinoma in situThe Use of Acellular Dermal Matrix May Not Increase 30-Day Complications in Direct-to-Implant Breast Reconstruction: A Multi-institutional Analysis of 10,177 Cases.
Knoedler S, Klimitz F, Friedrich S, Schemet L, Broer P, Cherubino M, Könneker S, Kim B, Pomahac B, Kauke-Navarro M. The Use of Acellular Dermal Matrix May Not Increase 30-Day Complications in Direct-to-Implant Breast Reconstruction: A Multi-institutional Analysis of 10,177 Cases. Annals Of Plastic Surgery 2025 PMID: 39874559, DOI: 10.1097/sap.0000000000004234.Peer-Reviewed Original ResearchDirect-to-implant breast reconstructionDirect-to-implantAcellular dermal matrixBreast reconstructionPropensity score matchingHigher risk of short-term complicationsMedical complicationsAmerican College of Surgeons National Surgical Quality Improvement Program databaseSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseIncreased 30-day complicationsMultivariate analysisRisk of short-term complicationsQuality Improvement Program databaseThirty-day postoperative complicationsSurgical complication rateIncorporation of acellular dermal matrixScore matchingMulti-institutional analysisMulti-institutional databaseShort-term complicationsComplication ratePostoperative complicationsWound dehiscenceNo significant differenceDeclining postoperative ninety-day opioid prescriptions from 2010 to 2021 following hip arthroscopy for femoroacetabular impingement syndrome
Day W, Halperin S, Surucu S, Jimenez A, Katsnelson B, Zhu J, Grauer J. Declining postoperative ninety-day opioid prescriptions from 2010 to 2021 following hip arthroscopy for femoroacetabular impingement syndrome. Arthroscopy Sports Medicine And Rehabilitation 2025, 101078. DOI: 10.1016/j.asmr.2025.101078.Peer-Reviewed Original ResearchPostoperative opioid prescriptionsFemoroacetabular impingement syndromeOpioid prescriptionsPostoperative mmeElixhauser Comorbidity IndexHip arthroscopyNinety-dayHistory of chronic painImpingement syndromeAmount of narcoticsNational administrative databaseChronic painAdult patientsPatient sexPostoperative recoveryMultivariate linear regressionComorbidity indexMultivariate analysisComorbidity burdenClinical relevancePatientsExclusion criteriaSurgeryPatient variablesAdministrative databases
2024
Association of Safety-Net hospital status and hospital outcomes following ACDF or PCDF for CSM
Elsamadicy A, Sayeed S, Sherman J, Craft S, Reeves B, Hengartner A, Ghanekar S, Sadeghzadeh S, Larry Lo S, Sciubba D. Association of Safety-Net hospital status and hospital outcomes following ACDF or PCDF for CSM. Journal Of Clinical Neuroscience 2024, 133: 111001. PMID: 39742780, DOI: 10.1016/j.jocn.2024.111001.Peer-Reviewed Original ResearchConceptsCervical spondylotic myelopathySafety net hospitalProportion of patientsNon-routine dischargeNon-SNHsAdverse eventsMultivariate analysisPosterior cervical decompressionAnterior cervical discectomyDischarge dispositionNational Inpatient Sample databaseRetrospective cohort studyNon-routine discharge dispositionPredictors of prolonged LOSICD-10-CM codesInpatient Sample databaseICD-10-CMTreating hospital characteristicsACDF cohortElective ACDFCervical decompressionCervical discectomySpondylotic myelopathyStudy patientsIndependent predictorsThe Perceived Impact of Global Surgery Engagement on Career Advancement among US Medical Students
Serrato P, Solaiman R, Vohra H, Hu K, Jain A, Alamdeen Y, Fagla B, Peck C, Hill S, Wariso B, Rehman S, Subhedar S, Kersh L, Anderson C, Clune J, Alliance G. The Perceived Impact of Global Surgery Engagement on Career Advancement among US Medical Students. Journal Of Surgical Education 2024, 82: 103404. PMID: 39740592, DOI: 10.1016/j.jsurg.2024.103404.Peer-Reviewed Original ResearchConceptsAssociated with increased oddsGlobal surgeryResidency applicantsMultivariate logistic regression modelGlobal surgery programsAcademic global surgeryLogistic regression modelsUS medical studentsMultivariate analysisSurgeryMedical studentsSurgery interest groupSurgery programsSurgery trainingPerceived impactCross-sectional survey studyMedical school curriculumSurgeonsMedical institutionsMedical students' perceptionsSurgery participantsHealth equityOddsCareer advancementMedical schoolsEmergency Department Use Within 90 Days After Single-Level Posterior Cervical Foraminotomy.
Jayaram R, Oghenesume O, Day W, Kammien A, Grauer J. Emergency Department Use Within 90 Days After Single-Level Posterior Cervical Foraminotomy. Orthopedics 2024, 48: 51-56. PMID: 39699166, DOI: 10.3928/01477447-20241213-04.Peer-Reviewed Original ResearchConceptsSingle-level posterior cervical foraminotomyPosterior cervical foraminotomyElixhauser Comorbidity IndexCervical foraminotomyEmergency departmentPredictive factorsMultivariate analysisED visitsAcute postoperative periodPrimary ED diagnosisPatient agePostoperative periodPatient characteristicsSurgical siteFemale sexComorbidity indexIndications of traumaED diagnosisED useRisk factorsYounger agePatientsMultilevel proceduresForaminotomySurgeryPatients on Antidepressants Are at an Increased Risk of Adverse Events following Total Knee Arthroplasty.
Ratnasamy P, Diatta F, Oghenesume O, Sanchez J, Gouzoulis M, Grauer J. Patients on Antidepressants Are at an Increased Risk of Adverse Events following Total Knee Arthroplasty. Journal Of The American Academy Of Orthopaedic Surgeons 2024 PMID: 39637418, DOI: 10.5435/jaaos-d-24-00743.Peer-Reviewed Original ResearchTime of surgeryTotal knee arthroplasty patientsAdverse eventsRevision surgeryTotal knee arthroplastyPatient ageIncreased risk of adverse eventsRisk of adverse eventsElixhauser Comorbidity Index scorePostoperative adverse eventsInferior perioperative outcomesComorbidity Index scoreKnee arthroplastyPerioperative outcomesElixhauser Comorbidity IndexPostoperative outcomesAntidepressant medicationAntidepressantsComorbidity indexMultivariate analysisPatient populationSurgeryIncreased riskLevel IIIPatientsA Substantial Increase in Injuries and Hospitalizations Associated with Playing Pickleball from 2020 to 2022: A National Database Study
Cheng R, Moran J, Kim B, Yuan M, O’Leary C, Wang C, Dines J, Katt B, Jimenez A. A Substantial Increase in Injuries and Hospitalizations Associated with Playing Pickleball from 2020 to 2022: A National Database Study. Arthroscopy Sports Medicine And Rehabilitation 2024, 101067. DOI: 10.1016/j.asmr.2024.101067.Peer-Reviewed Original ResearchNational Electronic Injury Surveillance SystemU.S. emergency departmentsEmergency departmentHospital admissionNEISS databaseElectronic Injury Surveillance SystemInjury Surveillance SystemEmergency department visitsIncreased riskTime of injuryNational database studyDepartment visitsInjury typeYears of ageMultivariate analysisSurveillance systemHospitalDatabase studyPlaying pickleballAdmissionDepartmentCategorize injuriesSite of injuryRiskUnited StatesCognition in patients with mild autonomous cortisol secretion at baseline and post-adrenalectomy
Saini J, Nathani R, Singh S, Ebbehoj A, Thangamuthu K, Suresh M, Zhang C, Nevin S, Fell V, Atkinson E, Achenbach S, Stricker N, Bancos I. Cognition in patients with mild autonomous cortisol secretion at baseline and post-adrenalectomy. European Journal Of Endocrinology 2024, 191: 636-645. PMID: 39671564, PMCID: PMC11662234, DOI: 10.1093/ejendo/lvae157.Peer-Reviewed Original ResearchConceptsMild autonomous cortisol secretionReference subjectsT-scorePost-adrenalectomyBeck Depression InventoryComposite T-scoreAutonomous cortisol secretionSF-36Urine steroid profileImpact of adrenalectomyFrailty indexCross-sectional studyShort Form-36Longitudinal cohort studyNational Institutes of Health Toolbox Cognition BatteryCohort studyMultivariate analysisSteroid profileLower cognitionCortisol secretionPatientsAssociated with lower cognitionStandardized T scoresAdrenalectomyCognitive batteryPatients With Diabetes on Sodium-Glucose Cotransporter-2 Inhibitors Undergoing Total Knee Arthroplasty Are at Increased Odds for a Number of Postoperative Adverse Events But Reduced Risk of Transfusion.
Kim L, Wiznia D, Grauer J. Patients With Diabetes on Sodium-Glucose Cotransporter-2 Inhibitors Undergoing Total Knee Arthroplasty Are at Increased Odds for a Number of Postoperative Adverse Events But Reduced Risk of Transfusion. Journal Of The American Academy Of Orthopaedic Surgeons 2024 PMID: 39630933, DOI: 10.5435/jaaos-d-24-00299.Peer-Reviewed Original ResearchSodium-glucose cotransporter 2 inhibitorsDM patientsAdverse eventsDiabetes mellitusTotal knee arthroplastySGLT2i useElixhauser Comorbidity IndexComorbidity indexMultivariate analysisIncidence of blood transfusionReduced risk of transfusionAssociated with multiple complicationsOdds of transfusionUrinary tract infectionAssociated with increased riskPerioperative adverse outcomesRisk of transfusionAssociated with reduced incidenceAcute kidney injuryPostoperative adverse eventsSurgical decision makingControlled DM patientsActive tobacco useGroup of medicationsAssociated with higher oddsComplications following open treatment of frontal sinus fracture: A nationwide analysis of 1492 patients
Kammien A, Noel O, Aregbe A, Clune J. Complications following open treatment of frontal sinus fracture: A nationwide analysis of 1492 patients. Journal Of Cranio-Maxillofacial Surgery 2024, 53: 129-133. PMID: 39592374, DOI: 10.1016/j.jcms.2024.11.012.Peer-Reviewed Original ResearchConceptsTreatment of frontal sinus fracturesFrontal sinus fracturesCerebrospinal fluid leakSinus fracturesFrontal sinus obliterationSurgical site infectionOpen treatmentSinus obliterationBrain abscessComplication rateSite infectionFluid leakConcomitant fracturesDays of follow-upSingle-institution studyDay of surgeryType of fractureAssociated with increased likelihoodPosterior tableAdult patientsConcomitant injuriesIncreased injury severityNationwide cohortFollow-upMultivariate analysisEmergency Department Visits Following Supracondylar Humerus Fractures
Gouzoulis M, Yang A, Joo P, Kaszuba S, Frumberg D, Grauer J. Emergency Department Visits Following Supracondylar Humerus Fractures. Journal Of Pediatric Orthopaedics 2024, 45: 128-133. PMID: 39808740, DOI: 10.1097/bpo.0000000000002866.Peer-Reviewed Original ResearchPediatric supracondylar humerus fracturesSupracondylar humerus fracturesHumerus fracturesEmergency departmentSurgical interventionManagement of pediatric supracondylar humerus fracturesHistory of ED visitsOdds ratioED visitsMultivariate logistic regressionPediatric patientsInitial managementPediatric fracturesPredictive factorsEmergency department visitsMultivariate analysisQuality improvement measuresRisk factorsPatientsTime of visitClinical interestMedicaid insuranceAdministrative databasesLogistic regressionDepartment visits
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