2024
A Hybrid Transformer-Convolutional Neural Network for Segmentation of Intracerebral Hemorrhage and Perihematomal Edema on Non-Contrast Head Computed Tomography (CT) with Uncertainty Quantification to Improve Confidence
Tran A, Desser D, Zeevi T, Abou Karam G, Dierksen F, Dell'Orco A, Kniep H, Hanning U, Fiehler J, Zietz J, Sanelli P, Malhotra A, Duncan J, Aneja S, Falcone G, Qureshi A, Sheth K, Nawabi J, Payabvash S. A Hybrid Transformer-Convolutional Neural Network for Segmentation of Intracerebral Hemorrhage and Perihematomal Edema on Non-Contrast Head Computed Tomography (CT) with Uncertainty Quantification to Improve Confidence. Bioengineering 2024, 11: 1274. PMID: 39768092, PMCID: PMC11672977, DOI: 10.3390/bioengineering11121274.Peer-Reviewed Original ResearchNon-contrast head computed tomographyPerihematomal edemaHead computed tomographyIntracerebral hemorrhageComputed tomographyVolume similarityUniversity Medical Center Hamburg-EppendorfSecondary brain injuryYale cohortInfratentorial locationMulticentre trialCT scanTreatment planningNon-contrastHamburg-EppendorfImaging markersHemorrhagic strokeHemorrhageEdemaCohortBrain injuryDice coefficient
2023
Screening for extranodal extension in HPV-associated oropharyngeal carcinoma: evaluation of a CT-based deep learning algorithm in patient data from a multicentre, randomised de-escalation trial
Kann B, Likitlersuang J, Bontempi D, Ye Z, Aneja S, Bakst R, Kelly H, Juliano A, Payabvash S, Guenette J, Uppaluri R, Margalit D, Schoenfeld J, Tishler R, Haddad R, Aerts H, Garcia J, Flamand Y, Subramaniam R, Burtness B, Ferris R. Screening for extranodal extension in HPV-associated oropharyngeal carcinoma: evaluation of a CT-based deep learning algorithm in patient data from a multicentre, randomised de-escalation trial. The Lancet Digital Health 2023, 5: e360-e369. PMID: 37087370, PMCID: PMC10245380, DOI: 10.1016/s2589-7500(23)00046-8.Peer-Reviewed Original ResearchConceptsExtranodal extensionOropharyngeal carcinomaShort-axis diameterChallenging cohortPathology reportsECOG-ACRIN Cancer Research GroupDe-escalation trialsCancer Research GroupDe-escalation strategiesSurgical pathology reportsNational Cancer InstituteInter-reader agreementLargest short-axis diameterPostoperative chemoradiationProtocol exclusionsConcurrent chemoradiationPrimary endpointMulticentre trialPretreatment CTAdjuvant strategiesHuman papillomavirusTreatment selection toolUS National InstitutesPretreatment identificationStudy protocolIntramyocardial cell-based therapy with Lomecel-B during bidirectional cavopulmonary anastomosis for hypoplastic left heart syndrome: the ELPIS phase I trial
Kaushal S, Hare J, Hoffman J, Boyd R, Ramdas K, Pietris N, Kutty S, Tweddell J, Husain S, Menon S, Lambert L, Danford D, Kligerman S, Hibino N, Korutla L, Vallabhajosyula P, Campbell M, Khan A, Naioti E, Yousefi K, Mehranfard D, McClain-Moss L, Oliva A, Davis M. Intramyocardial cell-based therapy with Lomecel-B during bidirectional cavopulmonary anastomosis for hypoplastic left heart syndrome: the ELPIS phase I trial. European Heart Journal Open 2023, 3: oead002. PMID: 36950450, PMCID: PMC10026620, DOI: 10.1093/ehjopen/oead002.Peer-Reviewed Original ResearchCardiac magnetic resonance imagingGlobal longitudinal strainMedicinal signaling cellsEjection fractionRight ventricleOpen-label multicentre trialMajor adverse cardiac eventsHypoplastic left heart syndromeAdverse cardiac eventsInvestigational cell therapyBidirectional cavopulmonary anastomosisPhase I trialRV ejection fractionRisk of deathMagnetic resonance imagingPrimary endpointCardiac eventsRV functionSurgical palliationI trialMulticentre trialCavopulmonary anastomosisCell-based therapiesHeart syndromeRibonucleic acid
2018
Prospective plasma efavirenz concentration assessment in Chinese HIV‐infected adults enrolled in a large multicentre study
Guo F, Cheng X, Hsieh E, Du X, Fu Q, Peng W, Li Y, Song X, Routy J, Li T. Prospective plasma efavirenz concentration assessment in Chinese HIV‐infected adults enrolled in a large multicentre study. HIV Medicine 2018, 19: 440-451. PMID: 29761920, PMCID: PMC6538474, DOI: 10.1111/hiv.12607.Peer-Reviewed Original ResearchLower body weightEfavirenz concentrationsBody weightWeek 4Chinese HIVMedian efavirenz concentrationPlasma efavirenz concentrationsAntiretroviral therapy initiationProspective multicentre trialProportion of patientsLarge multicentre studyPlasma samplesMultivariable regression analysisHigh efavirenz concentrationsNon-Han ethnicityEfavirenz 600Therapy initiationMulticentre trialMulticentre studyDosage reductionOptimal dosingTherapeutic windowPatientsSubstantial proportionHIV
2017
Feasibility and acceptability of a text message intervention used as an adjunct tool by WIC breastfeeding peer counsellors: The LATCH pilot
Harari N, Rosenthal MS, Bozzi V, Goeschel L, Jayewickreme T, Onyebeke C, Griswold M, Perez‐Escamilla R. Feasibility and acceptability of a text message intervention used as an adjunct tool by WIC breastfeeding peer counsellors: The LATCH pilot. Maternal And Child Nutrition 2017, 14 PMID: 28766913, PMCID: PMC6866153, DOI: 10.1111/mcn.12488.Peer-Reviewed Original ResearchMeSH KeywordsAdultBreast FeedingConnecticutFeasibility StudiesFemaleFocus GroupsFood AssistanceHumansMalePatient Acceptance of Health CarePatient Education as TopicPatient SatisfactionPeer InfluencePilot ProjectsPostpartum PeriodPregnancyPregnancy Trimester, SecondPregnancy Trimester, ThirdSocial SupportTelemedicineText MessagingWorkforceYoung AdultConceptsLactation AdviceEBF ratesControl armWeeks PPHr of deliveryExclusive breastfeeding ratesPeer counselorsText message interventionIntervention group mothersSupplemental Nutrition ProgramMulticentre trialPrimary outcomeTreat analysisWeeks' gestationFeasibility outcomesIntervention armBreastfeeding ratesTexting interventionUnlimited text messagingMessage interventionGroup mothersMothers' satisfactionNutrition ProgramPeer counselling programmeAdjunct tool
2010
Departures from the protocol during conduct of a clinical trial: a pattern from the data record consistent with a learning curve
Taekman J, Stafford-Smith M, Velazquez E, Wright M, Phillips-Bute B, Pfeffer M, Sellers M, Pieper K, Newman M, Van de Werf F, Diaz R, Leimberger J, Califf R. Departures from the protocol during conduct of a clinical trial: a pattern from the data record consistent with a learning curve. BMJ Quality & Safety 2010, 19: 405. PMID: 20702441, PMCID: PMC3258507, DOI: 10.1136/qshc.2008.028605.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMyocardial infarctionClinical trial researchLearning curvePatient rankMulticentre trialSlow enrollmentAcademic research organizationsPatient deathClinical trialsPatientsTrial conductTrial researchClinical researchPatient safetyPatient ordersTrialsInfarctionValsartanFirst yearDeathRecruitment ratesSimilar patternStart dateSafety
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