2025
Effects of Long-Term Cocaine Self-Administration on Kappa Opioid Receptors in Socially Housed Cynomolgus Monkeys as Assessed with PET Imaging and Neuronally Derived Exosomes
Johnson B, Allen M, Nader S, Sai K, Kumar A, Su Y, Singh S, Li S, Huang Y, Deep G, Nader M. Effects of Long-Term Cocaine Self-Administration on Kappa Opioid Receptors in Socially Housed Cynomolgus Monkeys as Assessed with PET Imaging and Neuronally Derived Exosomes. Biological Psychiatry 2025 PMID: 40054763, DOI: 10.1016/j.biopsych.2025.02.900.Peer-Reviewed Original ResearchLong-term cocaine self-administrationKappa-opioid receptorsCocaine self-administrationSelf-administrationKappa opioid receptor availabilityPeripheral measuresSocially housed monkeysOpioid receptorsCocaine intakeCocaine SAIntravenous cocaineCocaine misuseBrain regionsCocainePET imagingCynomolgus monkeysSocial rankPET studiesPharmacological interventionsMonkeysPET scansBrainBlood samplesDominant femalesSocial
2024
Lesions to the mediodorsal thalamus, but not orbitofrontal cortex, enhance volatility beliefs linked to paranoia
Suthaharan P, Thompson S, Rossi-Goldthorpe R, Rudebeck P, Walton M, Chakraborty S, Noonan M, Costa V, Murray E, Mathys C, Groman S, Mitchell A, Taylor J, Corlett P, Chang S. Lesions to the mediodorsal thalamus, but not orbitofrontal cortex, enhance volatility beliefs linked to paranoia. Cell Reports 2024, 43: 114355. PMID: 38870010, PMCID: PMC11231991, DOI: 10.1016/j.celrep.2024.114355.Peer-Reviewed Original ResearchOrbitofrontal cortexMediodorsal thalamusReward learning rateAssociated with paranoiaExcitotoxic lesionsBrain regionsUnoperated monkeysAction selectionAdaptive behaviorParanoiaBelief updatingMDmcMeaningful changeCortexThalamusBeliefsLearning rateRobust to variabilityCompare performanceRewardBehaviorBrainMonkeysAction policiesPerceptionPilot PET study of vaginally administered bioadhesive nanoparticles in cynomolgus monkeys: Kinetics and safety evaluation
Grun M, Honhar P, Wang Y, Rossano S, Khang M, Suh H, Fowles K, Kliman H, Cavaliere A, Carson R, Marquez‐Nostra B, Saltzman W. Pilot PET study of vaginally administered bioadhesive nanoparticles in cynomolgus monkeys: Kinetics and safety evaluation. Bioengineering & Translational Medicine 2024, 9: e10661. PMID: 39553429, PMCID: PMC11561825, DOI: 10.1002/btm2.10661.Peer-Reviewed Original ResearchVaginal dosage formsBioadhesive nanoparticlesCynomolgus monkeysAnalysis of inflammatory biomarkersVaginal microbicidesVaginal canalMultiple dosesInflammatory biomarkersTherapeutic efficacyVaginal fluidSystemic circulationLong-term deliveryNoninvasive imagingClinical translationDosage formsNon-human primatesDelivery vehiclesMonkeysDeliveryVaginitisUterusMicrobicidesSafety evaluationBiodistributionDosePredictions About Reward Outcomes in Rhesus Monkeys
Huang Y, Chang H, Santos L, Rosati A. Predictions About Reward Outcomes in Rhesus Monkeys. Behavioral Neuroscience 2024, 138: 43-58. PMID: 38060026, PMCID: PMC11287479, DOI: 10.1037/bne0000573.Peer-Reviewed Original ResearchReward prediction errorReward outcomesNovel behavioral taskReward-based decisionCognitive processesReward sensitivityCognitive evidenceBehavioral tasksUnexpected rewardsSurprising eventsPrediction errorLifespan changesStudy 1Study 2Human infantsNonhuman animalsAdolescent monkeysRewardDevelopmental signaturesNeurobiological techniquesOlder ageMonkeysPossible outcomesRhesus monkeysTask
2023
Brain developmental and cortical connectivity changes in transgenic monkeys carrying the human-specific duplicated gene SRGAP2C
Meng X, Lin Q, Zeng X, Jiang J, Li M, Luo X, Chen K, Wu H, Hu Y, Liu C, Su B. Brain developmental and cortical connectivity changes in transgenic monkeys carrying the human-specific duplicated gene SRGAP2C. National Science Review 2023, 10: nwad281. PMID: 38090550, PMCID: PMC10712708, DOI: 10.1093/nsr/nwad281.Peer-Reviewed Original ResearchTransgenic monkeysDeep layer neuronsFetal neurogenesisMyelination levelsSynaptic maturationLongitudinal MRITransgenic miceSynaptic connectionsBrain developmentConnectivity changesBrain connectivityOccipital regionMolecular pathwaysBrainMotor planningMonkeysEnergy metabolismHuman brainCellular levelEnlarged brainExtracellular matrixPrior studiesHumansNeurogenesisGenes
2022
Macaques preferentially attend to intermediately surprising information
Wu S, Blanchard T, Meschke E, Aslin RN, Hayden BY, Kidd C. Macaques preferentially attend to intermediately surprising information. Biology Letters 2022, 18: 20220144. PMID: 35857891, PMCID: PMC9256086, DOI: 10.1098/rsbl.2022.0144.Peer-Reviewed Original Research
2021
Molecular evidence of Anaplasma phagocytophilum in olive baboons and vervet monkeys in Kenya
Masika SJ, Muchemi GM, Okumu TA, Mutura S, Zimmerman D, Kamau J. Molecular evidence of Anaplasma phagocytophilum in olive baboons and vervet monkeys in Kenya. BMC Veterinary Research 2021, 17: 385. PMID: 34906141, PMCID: PMC8669034, DOI: 10.1186/s12917-021-03095-2.Peer-Reviewed Original ResearchConceptsPolymerase chain reactionAnaplasma phagocytophilumConventional polymerase chain reactionA. phagocytophilumTick-borne infectionsVervet monkeysPublic health implicationsZoonotic A. phagocytophilumOlive baboonsOverall prevalenceBlood samplesConclusionThis studyTropical diseasesGranulocytic anaplasmosisAnaplasma speciesChain reactionHealth implicationsIntracellular bacteriaBaboonsPhagocytophilumMonkeysPrevalenceObligate intracellular bacteriaIxodid ticksInfectionSimple, Single-Shot Phosphoproteomic Analysis of Heat-Stable Tau Identifies Age-Related Changes in pS235- and pS396-Tau Levels in Non-human Primates
Leslie SN, Kanyo J, Datta D, Wilson RS, Zeiss C, Duque A, Lam TT, Arnsten AFT, Nairn AC. Simple, Single-Shot Phosphoproteomic Analysis of Heat-Stable Tau Identifies Age-Related Changes in pS235- and pS396-Tau Levels in Non-human Primates. Frontiers In Aging Neuroscience 2021, 13: 767322. PMID: 34867294, PMCID: PMC8637411, DOI: 10.3389/fnagi.2021.767322.Peer-Reviewed Original ResearchTau phosphorylationPrefrontal cortexAlzheimer's diseaseAge-related changesLayer III pyramidal cellsRhesus monkey prefrontal cortexSignificant risk factorsMonkey prefrontal cortexNon-human primatesAD pathologyTau levelsRisk factorsPyramidal cellsRodent modelsIdentifies ageRhesus monkeysLiquid chromatography-tandem mass spectrometryTherapeutic developmentNatural aging processSignificant increaseTauAgeDiseaseRobust labelingMonkeysAssociations between fecal cortisol and biparental care in a pair‐living primate
Corley M, Perea‐Rodriguez J, Valeggia C, Fernandez‐Duque E. Associations between fecal cortisol and biparental care in a pair‐living primate. American Journal Of Biological Anthropology 2021, 176: 295-307. PMID: 34272723, PMCID: PMC8429222, DOI: 10.1002/ajpa.24368.Peer-Reviewed Original ResearchSex-based disparity in paraoxonase-2 expression in the brains of African green monkeys
Jamwal S, Blackburn JK, Elsworth JD. Sex-based disparity in paraoxonase-2 expression in the brains of African green monkeys. Free Radical Biology And Medicine 2021, 167: 201-204. PMID: 33722626, PMCID: PMC8096713, DOI: 10.1016/j.freeradbiomed.2021.03.003.Peer-Reviewed Original ResearchConceptsAfrican green monkeysParaoxonase 2Parkinson's diseaseBrain regionsGreen monkeysOxidative stressReactive oxygen speciesAnti-inflammatory propertiesSex-based disparitiesParaoxonase-2 expressionDifferent brain regionsNigrostriatal systemPON2 expressionDevelopment of therapeuticsNeurodegenerative disordersDiseaseProtein levelsROS levelsLower ROS levelsMitochondrial performanceSex-based variationDisordersMonkeysOxygen speciesMales
2020
Is There a ‘Social’ Brain? Implementations and Algorithms
Lockwood PL, Apps MAJ, Chang SWC. Is There a ‘Social’ Brain? Implementations and Algorithms. Trends In Cognitive Sciences 2020, 24: 802-813. PMID: 32736965, PMCID: PMC7501252, DOI: 10.1016/j.tics.2020.06.011.Peer-Reviewed Original ResearchConceptsSocial behaviorNeural processesMotor facultiesInformation processingInfluential frameworkSocial specificitiesAlgorithmic levelGreater integrationPsychologyNeuroscienceBehaviorDifferent levelsImportant new insightsEmpirical approachMarrProcessingFundamental questionsBrainResearchMonkeysFrameworkHumansPositron Emission Tomography Imaging Evaluation of a Novel 18F‑Labeled Sigma‑1 Receptor Radioligand in Cynomolgus Monkeys
Jia H, Cai Z, Holden D, He Y, Lin SF, Li S, Baum E, Shirali A, Kapinos M, Gao H, Ropchan J, Huang Y. Positron Emission Tomography Imaging Evaluation of a Novel 18F‑Labeled Sigma‑1 Receptor Radioligand in Cynomolgus Monkeys. ACS Chemical Neuroscience 2020, 11: 1673-1681. PMID: 32356969, DOI: 10.1021/acschemneuro.0c00171.Peer-Reviewed Original Research
2019
Endemicity of Yaws and Seroprevalence of Treponema pallidum Antibodies in Nonhuman Primates, Kenya - Volume 25, Number 11—November 2019 - Emerging Infectious Diseases journal - CDC
Zimmerman DM, Hardgrove EH, von Fricken ME, Kamau J, Chai D, Mutura S, Kivali V, Hussein F, Ambala P, Surmat A, Maina JG, Knauf S. Endemicity of Yaws and Seroprevalence of Treponema pallidum Antibodies in Nonhuman Primates, Kenya - Volume 25, Number 11—November 2019 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2019, 25: 2147-2149. PMID: 31625860, PMCID: PMC6810213, DOI: 10.3201/eid2511.190716.Peer-Reviewed Original Research
2018
Aromatase and estrogen receptor immunoreactivity in the coronary arteries of monkeys and human subjects
Diano S, Horvath TL, Mor G, Register T, Adams M, Harada N, Naftolin F. Aromatase and estrogen receptor immunoreactivity in the coronary arteries of monkeys and human subjects. Menopause The Journal Of The North American Menopause Society 2018, 25: 1201-1207. PMID: 30358714, DOI: 10.1097/gme.0000000000001219.Peer-Reviewed Original ResearchConceptsCoronary arteryEstrogen receptor immunoreactivityAmount of atherosclerosisHuman placental estrogen synthetaseHuman subjectsSmooth muscle cellsPrecursor androgensReceptor immunoreactivityCardioprotective effectsCoronary circulationEstrogen formationEstrogen receptorArteryCardiovascular systemER αMuscle cellsEndothelial cellsEstrogenEstrogen synthetaseMonkeysFirst evidenceSubjectsCellsAtherosclerosisLocal regulationCRISPR/Cas9-mediated disruption of SHANK3 in monkey leads to drug-treatable autism-like symptoms
Tu Z, Zhao H, Li B, Yan S, Wang L, Tang Y, Li Z, Bai D, Li C, Lin Y, Li Y, Liu J, Xu H, Guo X, Jiang YH, Zhang YQ, Li XJ. CRISPR/Cas9-mediated disruption of SHANK3 in monkey leads to drug-treatable autism-like symptoms. Human Molecular Genetics 2018, 28: 561-571. PMID: 30329048, PMCID: PMC6489410, DOI: 10.1093/hmg/ddy367.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderCynomolgus monkey modelAutism-like symptomsPathogenesis of ASDPostsynaptic scaffold proteinsNon-human primatesFluoxetine treatmentBrain network activityMonkey modelMouse modelBehavioral abnormalitiesCausative roleExperimental therapeuticsSHANK3 mutationsBrain structuresSHANK3 geneTranslational researchMonogenic mutationsBrain activitySpecies-dependent differencesPositron emissionNetwork activityCRISPR/Cas9-mediated disruptionMonkeysSpectrum disorder
2017
Oxytocin under opioid antagonism leads to supralinear enhancement of social attention
Dal Monte O, Piva M, Anderson KM, Tringides M, Holmes AJ, Chang SWC. Oxytocin under opioid antagonism leads to supralinear enhancement of social attention. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 5247-5252. PMID: 28461466, PMCID: PMC5441805, DOI: 10.1073/pnas.1702725114.Peer-Reviewed Original ResearchConceptsSocial attentionMutual eye contactSocial cognitionReward receiptParticular social importanceEfficacy of oxytocinEye contactSocial dysfunctionOpioid antagonismSocial contextGaze interactionHuman brainEntire sessionOxytocinΚ-opioid receptor geneFacial regionOT geneAttentionCognitionSocial importanceStrong effectMonkeysOpioid systemSessionsContext
2016
Live interaction distinctively shapes social gaze dynamics in rhesus macaques
Dal Monte O, Piva M, Morris JA, Chang SW. Live interaction distinctively shapes social gaze dynamics in rhesus macaques. Journal Of Neurophysiology 2016, 116: 1626-1643. PMID: 27486105, PMCID: PMC5144716, DOI: 10.1152/jn.00442.2016.Peer-Reviewed Original ResearchConceptsMutual eye contactGaze dynamicsEye contactSocial cognitionProportion of fixationsInteractive social contextsPairs of monkeysFocal attentionSustained attentionLive interactionEye regionSeparable componentsFamiliar pairsMeaningful eventsSocial contextReal partnersDominant monkeysSame monkeysCognitionStatic imagesReal-time interactionAttentionMonkeysNeonatal face-to-face interactions promote later social behaviour in infant rhesus monkeys
Dettmer AM, Kaburu SS, Simpson EA, Paukner A, Sclafani V, Byers KL, Murphy AM, Miller M, Marquez N, Miller GM, Suomi SJ, Ferrari PF. Neonatal face-to-face interactions promote later social behaviour in infant rhesus monkeys. Nature Communications 2016, 7: 11940. PMID: 27300086, PMCID: PMC4911675, DOI: 10.1038/ncomms11940.Peer-Reviewed Original ResearchAssociations between early life experience, chronic HPA axis activity, and adult social rank in rhesus monkeys
Dettmer AM, Wooddell LJ, Rosenberg KL, Kaburu SS, Novak MA, Meyer JS, Suomi SJ. Associations between early life experience, chronic HPA axis activity, and adult social rank in rhesus monkeys. Social Neuroscience 2016, 12: 92-101. PMID: 27063359, PMCID: PMC6528805, DOI: 10.1080/17470919.2016.1176952.Peer-Reviewed Original ResearchConceptsChronic HPA axis activityHair cortisol concentrationsHPA axis activityHealth outcomesEarly life experiencesAxis activityAxis regulationRhesus monkeysNeuroendocrine stress regulationSocioeconomic statusHPA axis regulationAdrenal axis regulationAdverse health outcomesFemale rhesus monkeysEarly life adversityRisk factorsAdult social statusNR monkeysCortisol concentrationsLife adversityMonkeysOutcomesEarly experienceMonthsLife experiences
2015
Differential relationships between chronic hormone profiles in pregnancy and maternal investment in rhesus monkey mothers with hair loss in the neonatal period
Dettmer AM, Rosenberg K, Menard MT, El‐Mallah S, Woodward RA, Suomi SJ, Meyer JS. Differential relationships between chronic hormone profiles in pregnancy and maternal investment in rhesus monkey mothers with hair loss in the neonatal period. American Journal Of Primatology 2015, 79: 1-8. PMID: 26496532, PMCID: PMC6528798, DOI: 10.1002/ajp.22489.Peer-Reviewed Original ResearchConceptsHigher hair cortisol concentrationsInfant birth weightHair lossInfant growth rateBirth weightFetal measurementsPregnancy/postpartumSubset of monkeysFemale rhesus monkeysIndicator of wellHair cortisol concentrationsNeonatal periodPregnant monkeysLate pregnancyPerinatal periodPregnancyCortisol concentrationsGreater incidenceRhesus monkeysPostpartum femalesPregnant femalesImportant developmental periodMonkeysMothersPrimate facilities
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