2025
Prognosis of p16 and Human Papillomavirus Discordant Oropharyngeal Cancers and the Exploration of Using Natural Language Processing to Analyze Free-Text Pathology Reports
Shin E, Choi J, Hung T, Poon C, Riaz N, Yu Y, Kang J. Prognosis of p16 and Human Papillomavirus Discordant Oropharyngeal Cancers and the Exploration of Using Natural Language Processing to Analyze Free-Text Pathology Reports. JCO Clinical Cancer Informatics 2025, 9: e2400177. PMID: 39965177, DOI: 10.1200/cci-24-00177.Peer-Reviewed Original ResearchConceptsProgression-free survivalCancer-specific survivalOropharyngeal cancerHPV testingPathology reportsTreatment de-escalationCurative radiation therapyHPV+ oropharyngeal cancerPrimary end pointMinority of patientsPositive predictive valueStandard-of-careCancer-related deathsIn situ hybridizationStatistically significant differenceP16 statusP16-negativeHPV statusRadiation therapyInferior prognosisOverall survivalConsecutive patientsAcademic cancer centerDiscordant tumorsTreatment deintensification
2024
Autosomal Dominant Polycystic Kidney Disease
Suarez M, Titan S, Dahl N. Autosomal Dominant Polycystic Kidney Disease. Advances In Kidney Disease And Health 2024, 31: 496-503. PMID: 39577883, DOI: 10.1053/j.akdh.2024.07.003.Peer-Reviewed Original ResearchConceptsAutosomal dominant polycystic kidney diseaseDelivery of personalized treatmentKidney diseaseKidney failureMinority of patientsDominant polycystic kidney diseaseEnd-stage kidney diseaseRisk of kidney failureCause of end-stage kidney diseasePolycystic kidney diseaseBlood pressure managementMassive hepatomegalySevere complicationsPolycystic liverIntracranial aneurysmsPersonalized treatmentNatural historyOrgan systemsDiseaseTreatmentKidneyPressure managementLiverSystem conditionsPreimplantationAfter Primary Total Shoulder Arthroplasty, Factors Associated with Returning to the Same Surgeon for Subsequent Total Shoulder Arthroplasty
Gouzoulis M, Halperin S, Seddio A, Wilhelm C, Moran J, Donohue K, Jimenez A, Grauer J. After Primary Total Shoulder Arthroplasty, Factors Associated with Returning to the Same Surgeon for Subsequent Total Shoulder Arthroplasty. JAAOS Global Research And Reviews 2024, 8: e24.00117. PMID: 39401371, PMCID: PMC11473060, DOI: 10.5435/jaaosglobal-d-24-00117.Peer-Reviewed Original ResearchConceptsTotal shoulder arthroplastyShoulder arthroplastyAdverse eventsPrimary total shoulder arthroplastyTotal shoulder arthroplasty patientsAnatomic total shoulder arthroplastyPatient satisfactionDepression diagnosisMinority of patientsPostoperative adverse eventsAssociated with decreased oddsRevision TSAFactors associated with returnSame surgeonContralateral surgeryElixhauser Comorbidity IndexIpsilateral shoulderFemale sexComorbidity indexMultivariate analysisRevision surgeryComorbidity burdenPatientsImprove patient satisfactionSurgeonsCommunication trends over time in new-onset refractory status epilepticus (NORSE): Interim analysis from the NORSE/FIRES Family Registry
Kazazian K, Gaspard N, Hirsch L, Kellogg M, Hocker S, Wong N, Farias-Moeller R, Eschbach K, Gofton T. Communication trends over time in new-onset refractory status epilepticus (NORSE): Interim analysis from the NORSE/FIRES Family Registry. Epilepsy & Behavior 2024, 160: 110023. PMID: 39241640, DOI: 10.1016/j.yebeh.2024.110023.Peer-Reviewed Original ResearchPalliative care servicesFamily RegistryCare servicesImprove overall carePrognostic conversationsAcute hospitalsOverall careEpidemiological informationConsensus definitionPhysician-patient-family relationshipRegistryNORSE/FIRESMinority of patientsPrognostic informationSatisfactionFamilySystematic effortRecovery processServicesCarePatientsHospitalPrevalenceQualityEpilepsy syndromesIntegrated and collaborative care across the spectrum of alcohol-associated liver disease and alcohol use disorder
Haque L, Leggio L. Integrated and collaborative care across the spectrum of alcohol-associated liver disease and alcohol use disorder. Hepatology 2024, 80: 1408-1423. PMID: 38935926, PMCID: PMC11841743, DOI: 10.1097/hep.0000000000000996.Peer-Reviewed Original ResearchAUD careAlcohol-associated liver diseaseAlcohol use disorderCollaborative careImpact of health disparitiesAlcohol-related deathsImpact of comorbid conditionsPublic health impactUse disorderHarm reduction approachesLiver diseaseInterprofessional teamHealth disparitiesTreatment of alcohol use disordersComprehensive careProblematic alcohol useSubstance use disordersSpectrum of alcohol-associated liver diseasesTreatment gapLiver-related outcomesMinority of patientsLiver-related morbidityAlcohol use disorder treatmentCareAlcohol useTaste dysfunction after endoscopic endonasal resection of olfactory groove meningioma: Case series and review of the literature
Fecker A, Studer M, Manes R, Omay S, Detwiller K, Smith T, Andersen P, Sanusi O, Collins K, Geltzeiler M, Rimmer R. Taste dysfunction after endoscopic endonasal resection of olfactory groove meningioma: Case series and review of the literature. American Journal Of Otolaryngology 2024, 45: 104302. PMID: 38678798, DOI: 10.1016/j.amjoto.2024.104302.Peer-Reviewed Original ResearchResection of olfactory groove meningiomasOlfactory groove meningiomasEndoscopic endonasal resectionMinority of patientsSense of tasteTaste changesSeverity of symptomsOlfactory dysfunctionTaste dysfunctionMedian timeCase seriesClinical characteristicsOlfactory functionPatient counselingPatientsSense of smellAssociated with lateralizationResectionMeningiomasSurgeryDysfunctionRated severityNeoplasmsSurvey responsesAgeusiaClinical outcomes among initial survivors of cryptogenic new‐onset refractory status epilepsy (NORSE)
Costello D, Matthews E, Aurangzeb S, Doran E, Stack J, Wesselingh R, Dugan P, Choi H, Depondt C, Devinsky O, Doherty C, Kwan P, Monif M, O'Brien T, Sen A, Gaspard N. Clinical outcomes among initial survivors of cryptogenic new‐onset refractory status epilepsy (NORSE). Epilepsia 2024, 65: 1581-1588. PMID: 38498313, DOI: 10.1111/epi.17950.Peer-Reviewed Original ResearchActive epilepsyClinical outcomesMental health outcomesMonths post-dischargeMonths of dischargeTreatment strategiesAcute phaseHealth outcomesLonger-term outcomesGlobal disabilityPost-dischargeMinority of patientsTertiary care centerTailored treatment strategiesNature of treatmentSevere clinical syndromeCare centerDeterminants of outcomePsychiatric comorbiditiesWell-characterized casesFunctional outcomesSurvivorsInvestigated patientsFollow-upSpecialist centersPhysical Therapy Utilization After Single-level Posterior Lumbar Fusion
Gouzoulis M, Moran J, Jeong S, Galivanche A, Kammien A, Jabbouri S, Grauer J. Physical Therapy Utilization After Single-level Posterior Lumbar Fusion. Spine 2024, 49: e272-e278. PMID: 38349019, DOI: 10.1097/brs.0000000000004958.Peer-Reviewed Original ResearchSingle-level posterior lumbar fusionPosterior lumbar fusionPhysical therapyOdds ratioLumbar fusionPhysical therapy utilizationFemale sexLevel posterior lumbar fusionsReturn to activityDecreased odds ratioOutpatient therapyPredictors of therapyTiming of therapyMinority of patientsOutpatient PTNonmedical factorsAdministrative databasesMedicaid insuranceTherapy utilizationPractice patternsCommercial insuranceInsurance plansPatient characteristicsSurgeryTherapyClinical Outcomes of Intravenous Ketamine Treatment for Depression in the VA Health System.
Pfeiffer P, Geller J, Ganoczy D, Jagusch J, Carty J, Festin F, Gilmer W, Martis B, Ranganathan M, Wiechers I, Hosanagar A. Clinical Outcomes of Intravenous Ketamine Treatment for Depression in the VA Health System. The Journal Of Clinical Psychiatry 2024, 85 PMID: 38206011, DOI: 10.4088/jcp.23m14984.Peer-Reviewed Original ResearchConceptsPHQ-9 scoresKetamine infusionClinical outcomesSymptom improvementInfusion frequencyPatient Health Questionnaire-9 scoreVeterans Health Administration electronic medical recordsBaseline PHQ-9 scoreShort-term clinical trialsAntidepressant medication trialsFirst ketamine infusionIntravenous ketamine treatmentMonths of infusionFrequency of infusionsMinority of patientsVA health systemWeeks of treatmentRoutine clinical practiceMajor depressive disorderNumber of infusionsElectronic medical recordsIntravenous ketamineKetamine treatmentFirst infusionMedication trials
2023
Trends in and Factors Associated With Surgical Management for Closed Clavicle Fractures
Dhodapkar M, Modrak M, Halperin S, Joo P, Luo X, Grauer J. Trends in and Factors Associated With Surgical Management for Closed Clavicle Fractures. JAAOS Global Research And Reviews 2023, 7: e23.00226. PMID: 38149938, PMCID: PMC10752468, DOI: 10.5435/jaaosglobal-d-23-00226.Peer-Reviewed Original ResearchConceptsElixhauser Comorbidity IndexSurgical managementClavicle fracturesAnatomic locationFracture diagnosisClosed clavicle fractureMinority of patientsComorbidity indexAdult patientsClinical factorsPatient ageIndependent predictorsMultivariable analysisNonsurgical managementOpen reductionNonclinical factorsFirst diagnosisInternal fixationSurgical considerationsSuch injuriesPatientsStudy periodDiagnosisInsurance coverageFracturesClinical Data Do Not Reliably Predict Duodenal Histology at Follow-up in Celiac Disease
Patel N, Leffler D, Al-Toma A, Mulder C, Elli L, Gan G, Patil P, Atsawarungruangkit A, Kuijpers K, Del Gobbo A, Goldsmith J, Hintze Z, Pacheco M, Vieth M, Melcher B, Salomao M, Pai R, Hart J, Olivas A, Naini B, Meyerson C, Choi W, Kakar S, Westerhoff M, Cheng J, Gopal P, Hammer S, Prats M, Bronner M, Robert M. Clinical Data Do Not Reliably Predict Duodenal Histology at Follow-up in Celiac Disease. The American Journal Of Surgical Pathology 2023, 48: 212-220. PMID: 37994653, DOI: 10.1097/pas.0000000000002150.Peer-Reviewed Original ResearchIntraepithelial lymphocytesCeliac diseaseClinical dataMarsh scoreMucosal recoveryVillous bluntingDuodenal biopsiesMucosal injuryDiet adherenceGluten-free diet adherenceComplete histologic remissionPersistent mucosal injuryMinority of patientsCeliac disease patientsDuodenal histologyHistologic remissionPathologists' awarenessMucosal statusMucosal healingGastrointestinal pathologistsDisease patientsFollow-upPatient managementEligibility criteriaPatientsImaging Acute and Chronic Cardiac Complications of COVID-19 and after COVID-19 Vaccination.
Sánchez Tijmes F, Marschner C, de Matos J, Urzua Fresno C, Gutiérrez Chacoff J, Thavendiranathan P, Fuss C, Hanneman K. Imaging Acute and Chronic Cardiac Complications of COVID-19 and after COVID-19 Vaccination. RadioGraphics 2023, 43: e230044. PMID: 37616171, DOI: 10.1148/rg.230044.Peer-Reviewed Original ResearchConceptsLate gadolinium enhancementGadolinium enhancementCardiac MRICOVID-19 vaccinePattern of late gadolinium enhancementCardiac complications of COVID-19MRNA-based COVID-19 vaccinesPresence of cardiovascular diseaseStress-induced cardiomyopathyMultimodality cardiac imagingBasal inferolateral wallMinority of patientsPersistent cardiac symptomsAdverse cardiovascular eventsComplications of COVID-19Chronic cardiac complicationsManifestations of COVID-19Potential mechanisms of injuryMechanism of injuryCardiovascular manifestations of COVID-19Messenger ribonucleic acidAcute COVID-19Cardiac symptomsCardiovascular manifestationsImaging findingsDeveloping a definition of immune exclusion in cancer: results of a modified Delphi workshop
Clifton G, Rothenberg M, Ascierto P, Begley G, Cecchini M, Eder J, Ghiringhelli F, Italiano A, Kochetkova M, Li R, Mechta-Grigoriou F, Pai S, Provenzano P, Puré E, Ribas A, Schalper K, Fridman W. Developing a definition of immune exclusion in cancer: results of a modified Delphi workshop. Journal For ImmunoTherapy Of Cancer 2023, 11: e006773. PMID: 37290925, PMCID: PMC10254706, DOI: 10.1136/jitc-2023-006773.Peer-Reviewed Original ResearchConceptsImmune exclusionTumor microenvironmentCheckpoint inhibitorsImmune checkpoint inhibitorsMinority of patientsT cell infiltrationPoor clinical outcomeImmune regulatory pathwaysEffective treatment approachDevelopment of treatmentsVariety of cancersLack of responseCheckpoint therapyImmune profileClinical outcomesClinical benefitPatient outcomesCancer expertsCancer histologyT cellsConsensus definitionTreatment approachesCancer typesRound questionnaireDelphi processUrgent Care Versus Emergency Department Utilization for Foot and Ankle Fractures
Dhodapkar M, Gouzoulis M, Halperin S, Modrak M, Yoo B, Grauer J. Urgent Care Versus Emergency Department Utilization for Foot and Ankle Fractures. Journal Of The American Academy Of Orthopaedic Surgeons 2023, 31: 984-989. PMID: 37253245, DOI: 10.5435/jaaos-d-22-01097.Peer-Reviewed Original ResearchConceptsUrgent care facilityAnkle fracturesEmergency departmentED utilizationCare facilitiesUrgent careOdds ratioICD-10 diagnosis codesCertain injury typesUrgent care utilizationRetrospective cohort studyUrgent care visitsYears old presentingMinority of patientsEmergency department utilizationOld presentingCare visitsAdult patientsCare algorithmCohort studyIndependent predictorsCare utilizationMultivariable analysisCommon injuriesDiagnosis codesOff-pump surgical thrombectomy for subacute right atrial thrombus: A case report
Shang M, Kumbasar U, B S, Bonde P. Off-pump surgical thrombectomy for subacute right atrial thrombus: A case report. Turkish Journal Of Thoracic And Cardiovascular Surgery 2023, 31: 282-285. PMID: 37484646, PMCID: PMC10357855, DOI: 10.5606/tgkdc.dergisi.2023.24477.Peer-Reviewed Original ResearchSurgical thrombectomyCardiopulmonary bypassRight atrial clotRight atrial thrombectomyRight heart thrombusRight atrial thrombusAcute pulmonary embolismHigh-risk patientsMinority of patientsRisk of strokeOptimal treatment optionsCatheter-based interventionsAtrial clotAtrial thrombectomyAtrial thrombusHeart thrombusPulmonary embolectomyPulmonary embolismOpen surgeryRespiratory dysfunctionTreatment optionsCase reportMortality riskThrombectomyPatientsTwelve-Month Follow-up of the Immune Response After COVID-19 Vaccination in Patients with Genitourinary Cancers: A Prospective Cohort Analysis
Meza L, Zengin Z, Salgia S, Malhotra J, Karczewska E, Dorff T, Tripathi A, Ely J, Kelley E, Mead H, Hsu J, Dizman N, Salgia N, Chawla N, Chehrazi-Raffle A, Muddasani R, Govindarajan A, Rock A, Liu S, Salgia R, Trent J, Altin J, Pal S. Twelve-Month Follow-up of the Immune Response After COVID-19 Vaccination in Patients with Genitourinary Cancers: A Prospective Cohort Analysis. The Oncologist 2023, 28: e748-e755. PMID: 36971500, PMCID: PMC10485287, DOI: 10.1093/oncolo/oyad067.Peer-Reviewed Original ResearchConceptsCOVID-19 vaccinationGenitourinary cancersRenal cell carcinomaBooster doseCell carcinomaImmune responseBlood samplesSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2T-cell receptor sequencingRespiratory syndrome coronavirus 2Baseline blood samplesMajority of patientsMinority of patientsProspective cohort analysisSyndrome coronavirus 2Twelve-month followAntibody titer analysisCOVID-19 vaccineSeroconversion ratesMedian ageUrothelial cancerCoronavirus 2Prostate cancerCohort analysisExtra-articular Manifestations of Chikungunya
de Oliveira J, Nogueira I, Amaral J, Campos L, Mendonça M, de Brito Ricarte M, de Góes Cavalcanti L, Schoen R. Extra-articular Manifestations of Chikungunya. Revista Da Sociedade Brasileira De Medicina Tropical 2023, 56: e0341-2023. PMID: 38088664, PMCID: PMC10706034, DOI: 10.1590/0037-8682-0341-2023.Peer-Reviewed Original ResearchConceptsExtra-articular manifestationsChikungunya feverAtypical illnessAcute interstitial nephritisAcute anterior uveitisMinority of patientsSelf-limiting conditionAnterior uveitisAbdominal painChronic arthritisCutaneous manifestationsInterstitial nephritisAtypical symptomsUnusual manifestationAtypical featuresTrue diagnosisNatural historyTropical diseasesManifestationsFurther studiesIllnessDiagnosisAffected systemMyocarditisUveitis
2022
How I Manage Transplant Ineligible Patients with Myelodysplastic Neoplasms
Gurnari C, Xie Z, Zeidan A. How I Manage Transplant Ineligible Patients with Myelodysplastic Neoplasms. Clinical Hematology International 2022, 5: 8-20. PMID: 36574201, PMCID: PMC10063738, DOI: 10.1007/s44228-022-00024-4.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMyelodysplastic syndromeMyelodysplastic neoplasmsInternational Prognostic Scoring SystemHematopoietic stem cell transplantManagement of cytopeniasNon-transplant treatmentTransplant-ineligible patientsBone marrow dysplasiaAvailable therapeutic optionsMinority of patientsNew investigational agentsPrognostic scoring systemStem cell transplantMain clinical problemLow-risk groupHigh-risk casesAcute myeloid leukemiaIneligible patientsMarrow dysplasiaCell transplantInvestigational agentsTherapeutic optionsClinical managementCurative approachMyeloid leukemiaLipid‐lowering treatment among older patients with atherosclerotic cardiovascular disease
Nanna M, Nelson A, Haynes K, Shambhu S, Eapen Z, Cziraky M, Calvert S, Pagidipati N, Granger C. Lipid‐lowering treatment among older patients with atherosclerotic cardiovascular disease. Journal Of The American Geriatrics Society 2022, 71: 1243-1249. PMID: 36538393, PMCID: PMC10089944, DOI: 10.1111/jgs.18172.Peer-Reviewed Original ResearchConceptsHigh-intensity statinsLipid-lowering therapyModerate-intensity statinsU.S. older adultsOlder adultsPCSK9 inhibitorsNon-statin lipid-lowering therapyMulticenter retrospective cohort studyRetrospective cohort studyMinority of patientsAtherosclerotic cardiovascular diseaseCoronary artery diseaseEligible older adultsCohort studyOlder patientsOverall cohortArtery diseaseIntensive treatmentCardiovascular diseaseASCVDSecondary measuresStatinsUntreated individualsPatientsTherapyHitting the brakes on accelerated and blast-phase myeloproliferative neoplasms: current and emerging concepts
Bewersdorf J, Rampal R. Hitting the brakes on accelerated and blast-phase myeloproliferative neoplasms: current and emerging concepts. Hematology 2022, 2022: 218-224. PMID: 36485103, PMCID: PMC9820986, DOI: 10.1182/hematology.2022000341.Peer-Reviewed Original ResearchConceptsMyeloproliferative neoplasmsBlast-phase MPNBlast-phase myeloproliferative neoplasmsAllogeneic hematopoietic cell transplantationBCR-ABL-negative myeloproliferative neoplasmsStages of clinical developmentMedian overall survivalHigh-risk molecular featuresHematopoietic cell transplantationCurative therapeutic modalityPrognosis of patientsAcute myeloid leukemiaMinority of patientsClinical trial enrollmentMPN-BPMyeloid blastsCurative intentHypomethylating agentsOverall survivalCell transplantationPeripheral bloodMyeloid leukemiaPalliative treatmentBone marrowClinical development
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